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    Method and apparatus for sealing implantable membrane encapsulation devices
    1.
    发明授权
    Method and apparatus for sealing implantable membrane encapsulation devices 失效
    用于密封可植入膜包封装置的方法和装置

    公开(公告)号：US6123700A

    公开(公告)日：2000-09-26

    申请号：US016223

    申请日：1998-01-30

    Applicant: John F. Mills ,  Edward J. Doherty ,  Tyrone F. Hazlett ,  Keith E. Dionne ,  Nicholas F. Warner ,  Brian M. Cain ,  David H. Rein

    Inventor： John F. Mills ,  Edward J. Doherty ,  Tyrone F. Hazlett ,  Keith E. Dionne ,  Nicholas F. Warner ,  Brian M. Cain ,  David H. Rein

    IPC: A61M31/00 ,  A61K9/00 ,  A61K9/22

    CPC classification number: A61K9/0024

    Abstract: A sealed, implantable, encapsulation device (20) for diffusing a biologically active product or function to an individual which includes a substantially non-porous fitting (32) including an inner surface (33) defining an access port (34). A permselective, porous, membrane (21), having an interior surface (22), cooperates with the fitting inner surface (33) to form a storage cavity (23) therebetween. The membrane interior surface (22) is in substantially cell-tight dry sealing engagement with fitting (32) to seal cavity (23). Living cells (24) are disposed in the cavity (23) which are capable of secreting the biologically active product to an individual. The membrane (21) is of a material capable of permitting the passage of substances between the individual and cells required to provide the biological product or function. A plug member (35) is positioned in the access port (34) and seated in cell-tight sealing engagement with the fitting inner surface (33). A method for sealing the implantable encapsulation device (20) is also provided.

    Abstract translation: 一种用于将生物活性产品或功能扩散到个体的密封的可植入的包封装置（20），其包括基本上无孔的配件（32），其包括限定出入口（34）的内表面（33）。 具有内表面（22）的选择性选择性多孔的膜（21）与配合内表面（33）配合以在其间形成储存腔（23）。 膜内表面（22）与配件（32）基本上牢固地密封地密封接合以密封空腔（23）。 活细胞（24）设置在空腔（23）中，其能够将生物活性产物分泌给个体。 膜（21）是能够允许个体与提供生物产物或功能所需的细胞之间的物质通过的材料。 插头构件（35）定位在进入口（34）中并且与配件内表面（33）牢固地密封接合。 还提供了一种用于密封可植入封装装置（20）的方法。

    Inner-supported, biocompatible cell capsules
    5.
    发明授权
    Inner-supported, biocompatible cell capsules 失效
    内支持，生物相容性细胞胶囊

    公开(公告)号：US5786216A

    公开(公告)日：1998-07-28

    申请号：US337555

    申请日：1994-11-10

    Applicant: Keith E. Dionne ,  Orion D. Hegre ,  Thomas R. Flanagan ,  Tyrone F. Hazlett ,  Edward J. Doherty

    Inventor： Keith E. Dionne ,  Orion D. Hegre ,  Thomas R. Flanagan ,  Tyrone F. Hazlett ,  Edward J. Doherty

    IPC: A61F2/02 ,  A61K9/00 ,  A61K35/12 ,  B01J13/02 ,  C12N5/00 ,  C12N5/071 ,  C12N11/04 ,  A61K9/52 ,  A61K9/50

    CPC classification number: A61F2/022 ,  A61K9/0024 ,  B01J13/02 ,  C12N5/0012 ,  C12N5/0614 ,  A61K2035/128 ,  C12N2533/30

    Abstract: A biocompatible capsule for containing cells for implantation is prepared containing an inner support that provides tensile strength to the capsule. The capsule may be a tubular semipermeable membrane such as a hollow fiber membrane having both ends sealed. A rod shaped inner support extends through the lumen and ends of the rod are attached to sealed ends of the fiber. Prior to sealing one fiber end, cells are introduced into the lumen. Cells within the capsule may be suspended in a liquid medium or immobilized in a hydrogel or extracellular matrix material, and biologically active molecules can be delivered from the capsule to surroundings or from the surroundings into the capsule. The inner support may have external features such as flutes or a roughened or irregularly-shaped surface, and may be coated with cell-adhesive substance or a cell-viability-enhancing substance. The inner support may be a hollow tube having two channels, one communicating with a filling port that permits injecting cells through the support into the capsule and the other communicating with another port that allows gas to escape through the support as cells are introduced. Anti-inflammatory agents can be incorporated into the capsule membrane to reduce immune response, and angiogenic factors and cell growth factors may be used to stimulate cell culture. Post-coating of capsule can be used to provide a protective barrier against immunogens. A tether for capsule retrieval can be formed integral with the inner support.

    Abstract translation: 制备用于包含用于植入的细胞的生物相容性胶囊，其包含向胶囊提供拉伸强度的内部支撑物。 胶囊可以是管状半透膜，例如具有两端密封的中空纤维膜。 杆状内部支撑件延伸穿过内腔，杆的端部附接到纤维的密封端。 在密封一个纤维端之前，将细胞引入管腔。 胶囊内的细胞可以悬浮在液体培养基中或固定在水凝胶或细胞外基质材料中，并且生物活性分子可以从胶囊递送到周围环境或从周围环境进入胶囊。 内部支撑件可以具有外部特征，例如凹槽或粗糙或不规则形状的表面，并且可以涂覆有细胞粘附物质或细胞活力增强物质。 内部支撑件可以是具有两个通道的中空管，一个与填充口连通，其允许将细胞通过支撑件注入到胶囊中，另一个与另一个端口连通，允许气体在引入电池时通过支撑件逸出。 可以将抗炎剂并入胶囊膜中以降低免疫应答，并且血管生成因子和细胞生长因子可用于刺激细胞培养。 胶囊的后包衣可用于提供抵抗免疫原的保护性屏障。 用于胶囊回收的系绳可以与内部支撑件一体形成。

    Method and apparatus for sealing implantable membrane encapsulation devices
    7.
    发明授权
    Method and apparatus for sealing implantable membrane encapsulation devices 失效
    用于密封可植入膜包封装置的方法和装置

    公开(公告)号：US5653688A

    公开(公告)日：1997-08-05

    申请号：US490113

    申请日：1995-06-06

    Applicant: John F. Mills ,  Edward J. Doherty ,  Tyrone F. Hazlett ,  Keith E. Dionne ,  Nicholas F. Warner ,  Brian M. Cain ,  David H. Rein

    Inventor： John F. Mills ,  Edward J. Doherty ,  Tyrone F. Hazlett ,  Keith E. Dionne ,  Nicholas F. Warner ,  Brian M. Cain ,  David H. Rein

    IPC: A61M31/00 ,  A61K9/00

    CPC classification number: A61K9/0024

    Abstract: A sealed, implantable, encapsulation device (20) for diffusing a biologically active product or function to an individual which includes a substantially non-porous fitting (32) including an inner surface (33) defining an access port (34). A permselective, porous, membrane (21), having an interior surface (22), cooperates with the fitting inner surface (33) to form a storage cavity (23) therebetween. The membrane interior surface (22) is in substantially cell-tight dry sealing engagement with fitting (32) to seal cavity (23). Living cells (24) are disposed in the cavity (23) which are capable of secreting the biologically active product to an individual. The membrane (21) is of a material capable of permitting the passage of substances between the individual and cells required to provide the biological product or function. A plug member (35) is positioned in the access port (34) and seated in cell-tight sealing engagement with the fitting inner surface (33). A method for sealing the implantable encapsulation device (20) is also provided.

    Abstract translation: 一种用于将生物活性产品或功能扩散到个体的密封的可植入的包封装置（20），其包括基本上无孔的配件（32），其包括限定出入口（34）的内表面（33）。 具有内表面（22）的选择性选择性多孔的膜（21）与配合内表面（33）配合以在其间形成储存腔（23）。 膜内表面（22）与配件（32）基本上牢固地密封地密封接合以密封空腔（23）。 活细胞（24）设置在空腔（23）中，其能够将生物活性产物分泌给个体。 膜（21）是能够允许个体与提供生物产物或功能所需的细胞之间的物质通过的材料。 插头构件（35）定位在进入口（34）中并且与配件内表面（33）牢固地密封接合。 还提供了一种用于密封可植入封装装置（20）的方法。

    CURRENT DENSITY DETECTION AND CONTROL SYSTEM AND METHOD FOR AN ELECTROKINETIC DELIVERY OF MEDICAMENTS
    8.
    发明申请
    CURRENT DENSITY DETECTION AND CONTROL SYSTEM AND METHOD FOR AN ELECTROKINETIC DELIVERY OF MEDICAMENTS 审中-公开
    电流密度检测与控制系统及其药物输送方法

    公开(公告)号：US20080262581A1

    公开(公告)日：2008-10-23

    申请号：US12104515

    申请日：2008-04-17

    Applicant: Michael S. Barsness ,  Edward J. Doherty

    Inventor： Michael S. Barsness ,  Edward J. Doherty

    IPC: A61N1/00

    CPC classification number: A61N1/044 ,  A61N1/0448 ,  A61N1/08 ,  A61N1/325

    Abstract: An apparatus to monitor current density in the application of medicament to a treatment site of a mammalian user of a electrokinetic device including: an applicator cartridge including an active electrode, a matrix carrying a medicament or a medicament and an electrically conductive carrier; a device including an electrical power source connectable to the active electrode, a counter electrode, and an electronic circuit configured to control the application of electrical current through the active electrode to establish a conductive path extending from the power source, through the active electrode, matrix, the treatment site, the user and the counter electrode electrically connected to the power source, and an array of contacts monitoring current density flowing through the matrix and to the treatment site, wherein the array of sensors are arranged monitor the current density at various locations of the matrix and a contact area between the matrix and skin above the treatment site.

    Abstract translation: 一种用于监测将药物施用于电动装置的哺乳动物使用者的治疗部位的电流密度的装置，包括：施用器盒，其包括有源电极，承载药物或药物的基质和导电载体; 包括可连接到有源电极的电源的设备，对电极和被配置为控制通过有源电极的电流的施加以建立从电源延伸通过有源电极矩阵的导电路径的电子电路 电连接到电源的处理部位，用户和对电极以及监测流经矩阵和处理部位的电流密度的触点阵列，其中布置的传感器阵列监视各个位置处的电流密度 的基质和基质和皮肤在治疗部位之上的接触面积。

    Method and apparatus for sealing implantable, membrane encapsulation devices containing living cells
    9.
    发明授权
    Method and apparatus for sealing implantable, membrane encapsulation devices containing living cells 失效
    用于密封可植入的包含活细胞的膜包封装置的方法和装置

    公开(公告)号：US5932460A

    公开(公告)日：1999-08-03

    申请号：US477308

    申请日：1995-06-06

    Applicant: John F. Mills ,  Edward J. Doherty ,  Tyrone F. Hazlett ,  Keith E. Dionne ,  Nicholas F. Warner ,  Brian M. Cain ,  David H. Rein

    Inventor： John F. Mills ,  Edward J. Doherty ,  Tyrone F. Hazlett ,  Keith E. Dionne ,  Nicholas F. Warner ,  Brian M. Cain ,  David H. Rein

    IPC: A61M31/00 ,  A61K9/00 ,  C12N11/04 ,  A61K9/22 ,  C12N5/00 ,  A61E2/00

    CPC classification number: A61K9/0024

    Abstract: A sealed, implantable, encapsulation device (20) for diffusing a biologically active product or function to an individual which includes a substantially non-porous fitting (32) including an inner surface (33) defining an access port (34). A permselective, porous, membrane (21), having an interior surface (22), cooperates with the fitting inner surface (33) to form a storage cavity (23) therebetween. The membrane interior surface (22) is in substantially cell-tight dry sealing engagement with fitting (32) to seal cavity (23). Living cells (24) are disposed in the cavity (23) which are capable of secreting the biologically active product to an individual. The membrane (21) is of a material capable of permitting the passage of substances between the individual and cells required to provide the biological product or function. A plug member (35) is positioned in the access port (34) and seated in cell-tight sealing engagement with the fitting inner surface (33). A method for sealing the implantable encapsulation device (20) is also provided.

    Abstract translation: 一种用于将生物活性产品或功能扩散到个体的密封的可植入的包封装置（20），其包括基本上无孔的配件（32），其包括限定出入口（34）的内表面（33）。 具有内表面（22）的选择性选择性多孔的膜（21）与配合内表面（33）配合以在其间形成储存腔（23）。 膜内表面（22）与配件（32）基本上牢固地密封地密封接合以密封空腔（23）。 活细胞（24）设置在空腔（23）中，其能够将生物活性产物分泌给个体。 膜（21）是能够允许个体与提供生物产物或功能所需的细胞之间的物质通过的材料。 插头构件（35）定位在进入口（34）中并且与配件内表面（33）牢固地密封接合。 还提供了一种用于密封可植入封装装置（20）的方法。

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