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    Peptide protection against ultraviolet light toxicity
    2.
    发明授权
    Peptide protection against ultraviolet light toxicity 有权
    肽防紫外线毒性

    公开(公告)号：US08597902B2

    公开(公告)日：2013-12-03

    申请号：US13508564

    申请日：2010-11-18

    申请人： Lijuan Zhang ,  Timothy J. Falla

    发明人： Lijuan Zhang ,  Timothy J. Falla

    IPC分类号： G01N33/53 ,  A01N61/00 ,  A61K31/00 ,  A61K38/00 ,  C07K14/47

    CPC分类号： A61K38/08 ,  A61K8/64 ,  A61K9/0014 ,  A61Q7/00 ,  A61Q19/004 ,  A61Q19/08

    摘要： Short peptides having biological and therapeutic activity are disclosed. Specifically, the activity of the disclosed peptides is directed to reducing or protecting against mutagen-induced cellular/tissue toxicity (i.e., chemopreventive). For example, the disclosed peptides protect against skin toxicity and/or mutagenesis that occurs from ultraviolet (UV) light exposure. The disclosed peptides also block the activation of certain cell cycle regulatory proteins such as Chk2. An example of such a peptide is Ser-Leu-Tyr-Gln-Ser (SEQ ID NO: 10). The disclosed peptides are also useful for methods of reducing or protecting against cellular toxicity and mutation accumulation that would otherwise occur following mutagen exposure. One such method is drawn to applying a peptide to the skin to prevent or reduce mutagenic damage resulting from UV light (e.g., sunlight) exposure.

    摘要翻译： 公开了具有生物和治疗活性的短肽。 具体地，所公开的肽的活性是针对减少或防止诱变剂诱导的细胞/组织毒性（即化学预防）。 例如，所公开的肽可防止由紫外线（UV）光照射而发生的皮肤毒性和/或诱变。 所公开的肽还阻断某些细胞周期调节蛋白如Chk2的活化。 这种肽的实例是Ser-Leu-Tyr-Gln-Ser（SEQ ID NO：10）。 所公开的肽也可用于减少或防止细胞毒性和突变积累的方法，否则在诱变剂暴露后会发生。 绘制一种这样的方法以将肽施加到皮肤上以防止或减少由UV光（例如阳光）暴露引起的诱变性损伤。

    Short bio-active peptides for cellular and immunological modulation
    3.
    发明授权
    Short bio-active peptides for cellular and immunological modulation 有权
    用于细胞和免疫调节的短生物活性肽

    公开(公告)号：US07696174B2

    公开(公告)日：2010-04-13

    申请号：US12005653

    申请日：2007-12-27

    申请人： Scott M. Harris ,  Lijuan Zhang ,  Timothy J. Falla

    发明人： Scott M. Harris ,  Lijuan Zhang ,  Timothy J. Falla

    IPC分类号： A61K38/08 ,  A61K31/74

    CPC分类号： C07K14/43563 ,  A61K38/00 ,  C07K5/1024 ,  C07K7/08

    摘要： Peptides having four to fourteen residues are disclosed that possess biological activity. These peptides constitute short fragments of the peptide HB-107 (SEQ ID NO:1), which itself is a fragment of the antimicrobial protein cecropin B, and exhibit cell stimulatory, migratory and anti-inflammatory properties. As keratinocytes are especially sensitive to these effects, the disclosed peptides comprise a useful agent for the medical treatment of injury to the skin, such as from diabetic ulcers. The peptides also are effective in preventing and reversing skin surface damage resulting from various environmental insults. Importantly, the therapeutic effects of the peptides manifest at concentrations equal to or greater than those of peptide HB-107, and thus represent a less expensive, more versatile means for developing effective therapies. Methods for the production and use of these peptides are also disclosed.

    摘要翻译： 披露具有四至十四个残基的肽具有生物活性。 这些肽构成肽HB-107（SEQ ID NO：1）的短片段，其本身是抗微生物蛋白质天蚕素B的片段，并且具有细胞刺激性，迁移性和抗炎性质。 由于角质形成细胞对这些作用特别敏感，所公开的肽包括用于治疗皮肤损伤（例如糖尿病性溃疡）的有用试剂。 这些肽也有效地预防和逆转由各种环境污染引起的皮肤表面损伤。 重要的是，肽的治疗效果以等于或大于肽HB-107的浓度表现，因此代表开发有效疗法的较便宜，更通用的手段。 还公开了生产和使用这些肽的方法。

    PEPTIDE PROTECTION AGAINST ULTRAVIOLET LIGHT TOXICITY
    6.
    发明申请
    PEPTIDE PROTECTION AGAINST ULTRAVIOLET LIGHT TOXICITY 有权
    抗紫外线防紫外线防毒素

    公开(公告)号：US20120225023A1

    公开(公告)日：2012-09-06

    申请号：US13508564

    申请日：2010-11-18

    申请人： Lijuan Zhang ,  Timothy J. Falla

    发明人： Lijuan Zhang ,  Timothy J. Falla

    IPC分类号： A61K38/08 ,  C07K7/06 ,  A61P17/16 ,  C12N9/99

    CPC分类号： A61K38/08 ,  A61K8/64 ,  A61K9/0014 ,  A61Q7/00 ,  A61Q19/004 ,  A61Q19/08

    摘要： Short peptides having biological and therapeutic activity are disclosed. Specifically, the activity of the disclosed peptides is directed to reducing or protecting against mutagen-induced cellular/tissue toxicity (i.e., chemopreventive). For example, the disclosed peptides protect against skin toxicity and/or mutagenesis that occurs from ultraviolet (UV) light exposure. The disclosed peptides also block the activation of certain cell cycle regulatory proteins such as Chk2. An example of such a peptide is Ser-Leu-Tyr-Gln-Ser (SEQ ID NO: 10). The disclosed peptides are also useful for methods of reducing or protecting against cellular toxicity and mutation accumulation that would otherwise occur following mutagen exposure. One such method is drawn to applying a peptide to the skin to prevent or reduce mutagenic damage resulting from UV light (e.g., sunlight) exposure.

    摘要翻译： 公开了具有生物和治疗活性的短肽。 具体地，所公开的肽的活性是针对减少或防止诱变剂诱导的细胞/组织毒性（即化学预防）。 例如，所公开的肽可防止由紫外线（UV）光照射而发生的皮肤毒性和/或诱变。 所公开的肽还阻断某些细胞周期调节蛋白如Chk2的活化。 这种肽的实例是Ser-Leu-Tyr-Gln-Ser（SEQ ID NO：10）。 所公开的肽也可用于减少或防止细胞毒性和突变积累的方法，否则在诱变剂暴露后会发生。 绘制一种这样的方法以将肽施加到皮肤上以防止或减少由UV光（例如阳光）暴露引起的诱变性损伤。

    Short bio-active peptides for cellular and immunological modulation
    8.
    发明申请
    Short bio-active peptides for cellular and immunological modulation 有权
    用于细胞和免疫调节的短生物活性肽

    公开(公告)号：US20080206160A1

    公开(公告)日：2008-08-28

    申请号：US12005653

    申请日：2007-12-27

    申请人： Scott M. Harris ,  Lijuan Zhang ,  Timothy J. Falla

    发明人： Scott M. Harris ,  Lijuan Zhang ,  Timothy J. Falla

    IPC分类号： A61K9/12 ,  C07K2/00 ,  C07K7/06 ,  A61K38/02 ,  A61K38/08 ,  A61P17/02 ,  A61K38/10

    CPC分类号： C07K14/43563 ,  A61K38/00 ,  C07K5/1024 ,  C07K7/08

    摘要： Peptides having four to fourteen residues are disclosed that possess biological activity. These peptides constitute short fragments of the peptide HB-107 (SEQ ID NO:1), which itself is a fragment of the antimicrobial protein cecropin B, and exhibit cell stimulatory, migratory and anti-inflammatory properties. As keratinocytes are especially sensitive to these effects, the disclosed peptides comprise a useful agent for the medical treatment of injury to the skin, such as from diabetic ulcers. The peptides also are effective in preventing and reversing skin surface damage resulting from various environmental insults. Importantly, the therapeutic effects of the peptides manifest at concentrations equal to or greater than those of peptide HB-107, and thus represent a less expensive, more versatile means for developing effective therapies. Methods for the production and use of these peptides are also disclosed.

    摘要翻译： 披露具有四至十四个残基的肽具有生物活性。 这些肽构成肽HB-107（SEQ ID NO：1）的短片段，其本身是抗微生物蛋白质天蚕素B的片段，并且具有细胞刺激性，迁移性和抗炎性质。 由于角质形成细胞对这些作用特别敏感，所公开的肽包括用于治疗皮肤损伤（例如糖尿病性溃疡）的有用试剂。 这些肽也有效地预防和逆转由各种环境污染引起的皮肤表面损伤。 重要的是，肽的治疗效果以等于或大于肽HB-107的浓度表现，因此代表开发有效疗法的较便宜，更通用的手段。 还公开了生产和使用这些肽的方法。

    Protective skin care peptides
    9.
    发明申请
    Protective skin care peptides 有权
    保护性皮肤护理肽

    公开(公告)号：US20090142280A1

    公开(公告)日：2009-06-04

    申请号：US12290236

    申请日：2008-10-28

    申请人： Lijuan Zhang ,  Scott Harris ,  Timothy J. Falla

    发明人： Lijuan Zhang ,  Scott Harris ,  Timothy J. Falla

    IPC分类号： A61K9/12 ,  C07K5/117 ,  C12N5/06 ,  A61P29/00 ,  A61K38/07

    CPC分类号： C07K5/1024 ,  A61K8/64 ,  A61K38/00 ,  A61K2800/782 ,  A61Q19/08

    摘要： The disclosed invention provides tetrapeptides with the amino acid sequence proline-glutamine-glutamate-X (P-Q-E-X), where X can be either lysine (K) or isoleucine (I). These tetrapeptides inhibit ultraviolet light (UV)-induced expression of the pro-inflammatory cytokine interleukin-6 (IL-6) by skin epithelial cells and fibroblasts. Furthermore, the tetrapeptides repress the upregulation of matrix metalloproteinase-1 (MMP-1) by skin fibroblasts induced by either direct exposure to UV rays or treatment with media conditioned by UV-treated keratinocytes. The small size and bio-activity of the tetrapeptides render them suitable for use in therapies directed to inflammatory skin disorders and as active ingredients in skin care products.

    摘要翻译： 所公开的发明提供四肽与氨基酸序列脯氨酸 - 谷氨酰胺 - 谷氨酸酯-X（P-Q-E-X），其中X可以是赖氨酸（K）或异亮氨酸（I）。 这些四肽通过皮肤上皮细胞和成纤维细胞抑制紫外线（UV）诱导的促炎细胞因子白细胞介素-6（IL-6）的表达。 此外，四肽通过直接暴露于紫外线诱导的皮肤成纤维细胞抑制基质金属蛋白酶-1（MMP-1）的上调或通过经紫外线处理的角质形成细胞调节的培养基来治疗。 四肽的小尺寸和生物活性使其适合用于治疗炎症性皮肤病症和作为皮肤护理产品中的活性成分。

    Antimicrobial hexapeptides
    10.
    发明授权
    Antimicrobial hexapeptides 有权
    抗菌六肽

    公开(公告)号：US07407940B2

    公开(公告)日：2008-08-05

    申请号：US11350192

    申请日：2006-02-08

    申请人： Timothy J. Falla ,  Lijuan Zhang ,  Scott M. Harris

    发明人： Timothy J. Falla ,  Lijuan Zhang ,  Scott M. Harris

    IPC分类号： A61K38/08 ,  C07K7/06

    CPC分类号： C07K7/06 ,  A61K38/00 ,  Y02A50/473

    摘要： The invention encompasses hexapeptides consisting of alternating hydrophobic residues (B) at positions 2, 4, and 6, hydrophilic, charged residues (X) at positions 1 and 3, and a naphthylalanine (Nal), an aliphatic or aromatic residue (O) at position five, represented generally by the formula XBXBOB, which exhibit antimicrobial activity against infections caused by a variety of pathogens. These pathogens may include gram positive or negative bacteria, acid-fast bacteria such as mycobacteria, parasites, dermatophytes, or fungal pathogens. Typical fungal pathogens include Candida albicans and typical dermatophytes include Trichophyton rubrum and Trichophyton mentagrophytes. The hexapeptides of the present invention exhibit antifungal activity, antibacterial activity, desirable stability, and lack toxicity to the mammal receiving treatment.

    摘要翻译： 本发明包括由位置2,4和6处的交替的疏水性残基（B），位置1和3的亲水性带电残基（X）和萘丙氨酸（Nal），脂族或芳族残基（O））组成的六肽 位置5，通常由式XBXBOB表示，其表现出针对由各种病原体引起的感染的抗微生物活性。 这些病原体可以包括革兰氏阳性或阴性细菌，耐酸细菌如分枝杆菌，寄生虫，皮肤真菌或真菌病原体。 典型的真菌病原体包括白色念珠菌和典型的皮肤癣菌包括红色毛癣菌和引发毛癣菌。 本发明的六肽对接受治疗的哺乳动物具有抗真菌活性，抗菌活性，理想的稳定性和缺乏毒性。