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公开(公告)号：US20120116146A1
公开(公告)日：2012-05-10
申请号：US13286920
申请日：2011-11-01
IPC分类号： A61M36/04
CPC分类号： A61N5/1027 , A61N2005/1003 , A61N2005/1021
摘要： A brachytherapy system for treating metastases on and around a patient's spinous process is provided. The device generally includes a catheter member having a proximal portion, a distal portion, and at least one lumen extending therethrough. The distal portion of the catheter member includes first and second branch members that are adapted to be positioned on opposed sides of a patient's spinous process. The device further includes first and second elongate anchoring elements disposed on the first and second branch members, and optionally can include at least one centering mechanism disposed within each of the first and second anchoring elements.
摘要翻译： 提供了一种用于治疗患者棘突周围转移的近距离放射治疗系统。 该装置通常包括具有近端部分，远侧部分和延伸穿过其中的至少一个内腔的导管部件。 导管构件的远端部分包括适于定位在患者棘突的相对侧上的第一和第二分支构件。 该装置还包括设置在第一和第二分支构件上的第一和第二细长锚固元件，并且可选地可包括设置在第一和第二锚固元件的每一个内的至少一个定中心机构。
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2.发明授权Brachytherapy method and applicator for treatment of metastatic lesions in a load bearing region 失效近距离放射治疗方法和施放器用于治疗承载区域的转移性病变公开(公告)号：US07905822B2
公开(公告)日：2011-03-15
申请号：US10995087
申请日：2004-11-22
IPC分类号： A61N5/00
CPC分类号： A61N5/1027 , A61N5/1014 , A61N2005/1011
摘要： A brachytherapy applicator for treatment of metastic lesions in a load bearing region is provided. The applicator comprises an elongate tube body having a proximal and a distal end and defining an open internal area. A fixation element located on an outer portion of the tube allows the applicator to be fixed in position in relation to a target region while delivering a dose of therapeutic radiation. The fixation element can fix the applicator to tissue and/or a stabilization element implanted within a patient. A source of radiation positioned within the elongate body, before, during, or after implantation of the applicator, provides the therapeutic radiation.
摘要翻译： 本发明提供一种用于治疗负重区域中的甲状腺病变的近距离放射治疗仪。 涂抹器包括具有近端和远端并限定开放内部区域的细长管体。 位于管的外部的固定元件允许施用器相对于目标区域固定在适当位置，同时递送一定剂量的治疗辐射。 固定元件可以将施用器固定到植入在患者体内的组织和/或稳定元件。 定位在细长体内，在施用器植入之前，之中或之后的辐射源提供治疗辐射。
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公开(公告)号：US07381178B2
公开(公告)日：2008-06-03
申请号：US11260643
申请日：2005-10-27
CPC分类号： A61F2/446 , A61F2002/30777 , A61F2002/30785 , A61F2002/30858 , A61F2002/4475 , A61M25/10 , A61M29/02 , A61M2210/1003 , A61N5/1027 , A61N2005/1005 , A61N2005/1021
摘要： A radiotherapy system, and preferably a brachytherapy system, for delivering radiation to tissue surrounding an interstitial space is provided. While the system can be used for a variety of purposes, the system is preferably used to treat spinal metastases. In general, the system includes a catheter member having a proximal end, a distal end, and an inner lumen extending therethrough, and a structural support adapted to fit within an interstitial space in load bearing portion of a patient's body and having an internal space for removably receiving the distal end of the catheter member. At least one anchoring element can be disposed proximate to the distal end of the catheter. The anchoring element is preferably adapted to fit within the internal space in the structural support so as to anchor the distal end of the catheter therein. The system further includes a radiation source disposable within the internal space of the structural support through the lumen in the catheter for delivering radiation to tissue surrounding the interstitial space.
摘要翻译： 提供了放射治疗系统，优选近距离放射治疗系统，用于将辐射递送到间质空间周围的组织。 尽管该系统可用于各种目的，但该系统优选用于治疗脊柱转移。 通常，该系统包括具有近端，远端和延伸穿过其中的内腔的导管构件，以及适于装配在患者身体的承载部分中的间隙空间内的结构支撑件，并具有用于 可移除地接收导管构件的远端。 至少一个锚定元件可以布置成靠近导管的远端。 锚固元件优选地适于装配在结构支撑件内的内部空间中，以便将导管的远端固定在其中。 该系统还包括通过导管中的内腔在结构支撑件的内部空间内一次性放射的辐射源，用于将辐射传送到围绕间隙空间的组织。
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公开(公告)号：US06695760B1
公开(公告)日：2004-02-24
申请号：US10269555
申请日：2002-10-11
IPC分类号： A61N500
CPC分类号： A61F2/446 , A61F2002/30777 , A61F2002/30785 , A61F2002/30858 , A61F2002/4475 , A61M25/10 , A61M29/02 , A61M2210/1003 , A61N5/1027 , A61N2005/1005 , A61N2005/1021
摘要： A radiotherapy system, and preferably a brachytherapy system, for delivering radiation to tissue surrounding an interstitial space is provided. While the system can be used for a variety of purposes, the system is preferably used to treat spinal metastases. In general, the system includes a catheter member having a proximal end, a distal end, and an inner lumen extending therethrough, and a structural support adapted to fit within an interstitial space in load bearing portion of a patient's body and having an internal space for removably receiving the distal end of the catheter member. At least one anchoring element can be disposed proximate to the distal end of the catheter. The anchoring element is preferably adapted to fit within the internal space in the structural support so as to anchor the distal end of the catheter therein. The system further includes a radiation source disposable within the internal space of the structural support through the lumen in the catheter for delivering radiation to tissue surrounding the interstitial space.
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公开(公告)号：US06482142B1
公开(公告)日：2002-11-19
申请号：US09464727
申请日：1999-12-16
IPC分类号： A61N500
CPC分类号： A61N5/1015 , A61N2005/1005
摘要： An interstitial brachytherapy apparatus of the invention delivers radioactive emissions in an asymmetric fashion to target tissue surrounding a surgical extraction site. The apparatus includes an expandable outer surface element defining an apparatus spatial volume, a radiation source disposed within the apparatus volume, and a means for providing predetermined asymmetric isodose curves within the target tissue. In one configuration, asymmetric isodose curves are created in the target tissue by shaping or locating the radiation source so as to be asymmetrically placed with respect to a longitudinal axis of the apparatus. In other configurations, asymmetric radiopaque shielding is provided between the radiation source and the target tissue. A surgical procedure using the apparatus is also described.
摘要翻译： 本发明的间质近程放射治疗装置以不对称方式递送放射性排放物以靶向外科提取部位周围的组织。 该装置包括限定装置空间体积的可扩张外表面元件，设置在装置体积内的辐射源，以及用于在目标组织内提供预定的不对称等剂量曲线的装置。 在一种构型中，通过使辐射源成形或定位以相对于装置的纵向轴线不对称地在目标组织中产生非对称等剂量曲线。 在其它构造中，在辐射源和目标组织之间提供不对称的不透射线屏蔽。 还描述了使用该装置的外科手术。
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公开(公告)号：US5913813A
公开(公告)日：1999-06-22
申请号：US900021
申请日：1997-07-24
申请人： Jeffery A. Williams , Christopher H. Porter , Jeffrey F. Williamson , James F. Dempsey , Timothy J. Patrick , James B. Stubbs
发明人： Jeffery A. Williams , Christopher H. Porter , Jeffrey F. Williamson , James F. Dempsey , Timothy J. Patrick , James B. Stubbs
CPC分类号： A61N5/1015 , A61N2005/1021
摘要： An instrument for use in brachytherapy comprises a concentric arrangement of inner and outer distensible, spherical chambers disposed near the proximal end of a catheter body where one of the chambers is made to contain a radioactive material with the other chamber containing a radiation absorptive material, the apparatus functioning to provide a more uniform absorbed dose profile in tissue surrounding a cavity created by the removal of a tumor. An alternative embodiment includes non-spherical inner and outer chambers whose respective walls are spaced equidistant over the entire surfaces thereof.
摘要翻译： 用于近距离放射治疗的仪器包括内和外扩张的球形腔室的同心布置，其设置在导管体的近端附近，其中一个腔室被制成为容纳放射性材料，而另一腔室包含放射线吸收材料， 该装置用于在通过去除肿瘤产生的腔体周围的组织中提供更均匀的吸收剂量分布。 替代实施例包括非球形的内室和外室，其各个壁在其整个表面上间隔开等间隔。
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公开(公告)号：US07524275B2
公开(公告)日：2009-04-28
申请号：US10714586
申请日：2003-11-14
IPC分类号： A61N5/00
CPC分类号： A61M25/1011 , A61M25/1002 , A61M2025/1013 , A61M2025/105 , A61M2025/1075 , A61N5/1015
摘要： An interstitial brachytherapy apparatus and methods for treating proliferative tissue disorders with radiation and a surface delivered treatment agent. The brachytherapy device includes an insertion member having proximal and distal portions and at least one lumen extending therethrough. An expandable surface member is mated to the distal portion of the insertion member and includes a treatment agent releasably mated thereon. When the brachytherapy device is positioned within a tissue cavity and the expandable surface member is expanded, at least a portion of the treatment agent is delivered to tissue surrounding the tissue cavity.
摘要翻译： 间质近距离放射治疗装置和用辐射治疗增生性组织疾病和表面递送治疗剂的方法。 近程放射治疗装置包括具有近端部分和远端部分以及延伸穿过其中的至少一个内腔的插入部件。 可膨胀表面构件配合到插入构件的远端部分，并且包括可释放地配合在其上的处理剂。 当近程放射治疗装置定位在组织腔内并且可膨胀表面构件膨胀时，至少一部分治疗剂被递送到组织腔周围的组织。
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公开(公告)号：US07524274B2
公开(公告)日：2009-04-28
申请号：US10704161
申请日：2003-11-07
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61N5/1049
摘要： A system for treating tissue surrounding a resected cavity that is subject to a proliferative tissue disorder is provided. The system includes a tissue fixation device including a catheter body member having a proximal end, a distal end, an inner lumen, and an expandable surface element disposed proximate to the distal end of the body member, the expandable surface element sized and configured to reproducibly position tissue surrounding a resected tissue cavity in a predetermined geometry upon expansion. After expansion of the expandable surface element within a resected tissue cavity, an external radiation device positioned outside the resected cavity delivers a dose of radiation to the tissue surrounding the expandable surface element.
摘要翻译： 提供了一种用于治疗受到增殖性组织障碍的切除腔周围的组织的系统。 所述系统包括组织固定装置，所述组织固定装置包括具有近端，远端，内腔和邻近所述主体构件的远端设置的可扩张表面元件的导管本体构件，所述可扩张表面元件的尺寸和构造可再现 在扩张后以预定几何形状围绕切除的组织腔的位置组织。 在可切除的组织腔内的可膨胀表面元件膨胀之后，位于被切除腔外的外部辐射装置向可扩张表面元件周围的组织递送剂量的辐射。
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9.发明授权Interstitial brachytherapy apparatus and method for treatment of proliferative tissue diseases 有权间质近距离放射治疗装置及治疗增生性组织疾病的方法公开(公告)号：US06413204B1
公开(公告)日：2002-07-02
申请号：US09293524
申请日：1999-04-15
IPC分类号： A61N500
CPC分类号： A61N5/1015 , A61N2005/1021
摘要： An interstitial brachytherapy apparatus for delivering radioactive emissions to an internal body location includes a catheter body member having a proximal end and distal end, an inner spatial volume disposed proximate to the distal end of the catheter body member, an outer spatial volume defined by an expandable surface element disposed proximate to the distal end of the body member in a surrounding relation to the inner spatial volume, and a radiation source disposed in the inner spatial volume.
摘要翻译： 用于将放射性排放物输送到内部身体位置的间质近程放射治疗装置包括具有近端和远端的导管本体构件，邻近导管本体构件的远端设置的内部空间体积，由可扩张的 表面元件以与内部空间体积的周围关系靠近本体构件的远端布置，以及设置在内部空间体积中的辐射源。
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10.发明授权Brachytherapy apparatus and method for treating a target tissue through an external surface of the tissue 有权近距离放射治疗装置和通过组织的外表面处理靶组织的方法公开(公告)号：US07494457B2
公开(公告)日：2009-02-24
申请号：US10704344
申请日：2003-11-07
IPC分类号： A61M36/00
CPC分类号： A61N5/1015 , A61N2005/1021
摘要： A brachytherapy device is provided for treating a target tissue through an external surface area of the target tissue. The device includes an insertion member having a proximal portion, a distal portion, and at least one lumen extending therethrough. A fluid retaining member is mated to the distal portion of the insertion member and has a first surface shaped to conform to a predetermined external surface area of a tissue to be treated, and a cavity formed therein in fluid communication with the at least one lumen in the insertion member. A plurality of anchor members can be distributed about a periphery of the first surface to anchor the first surface to an external surface area of a tissue to be treated.
摘要翻译： 提供了一种近距离放射治疗装置，用于通过靶组织的外表面区域处理靶组织。 该装置包括具有近端部分，远侧部分和延伸穿过其中的至少一个内腔的插入部件。 流体保持构件配合到插入构件的远端部分，并且具有成形为符合要处理的组织的预定外表面区域的第一表面和形成在其中的与所述至少一个内腔流体连通的空腔 插入构件。 多个锚固构件可以围绕第一表面的周边分布，以将第一表面锚定到待处理组织的外表面区域。
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