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公开(公告)号:US08372854B2
公开(公告)日:2013-02-12
申请号:US12964841
申请日:2010-12-10
IPC分类号: A01N43/90 , A61K31/519 , C07D487/00
CPC分类号: C07D487/04
摘要: Described herein are pyrrolo[2,3-d]pyrimidine compounds, their use as Janus Kinase (JAK) inhibitors, pharmaceutical compositions containing these compounds, and methods for their preparation.
摘要翻译: 本文描述的是吡咯并[2,3-d]嘧啶化合物,它们用作Janus Kinase(JAK)抑制剂,含有这些化合物的药物组合物及其制备方法。
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公开(公告)号:US07772269B2
公开(公告)日:2010-08-10
申请号:US11944732
申请日:2007-11-26
IPC分类号: A61K31/4155 , C07D231/12 , C07D309/08
CPC分类号: C07D405/12 , C07D309/08
摘要: The invention relates to the compounds of formula (I): or a pharmaceutically acceptable salt and solvate thereof, wherein R1 is F or H and to processes for the preparation of, intermediates used in the preparation of, compositions containing the uses of, such compounds. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular allergic and respiratory diseases, disorders and conditions.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐和溶剂化物,其中R 1是F或H,以及制备用于制备含这种化合物的用途的组合物的中间体的方法 。 根据本发明的化合物可用于许多疾病,病症和病症,特别是过敏和呼吸系统疾病,病症和病症。
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公开(公告)号:US20080125474A1
公开(公告)日:2008-05-29
申请号:US11944732
申请日:2007-11-26
IPC分类号: A61K31/415 , C07D231/10 , C07D309/02 , A61P11/06 , A61P29/00 , A61P11/00
CPC分类号: C07D405/12 , C07D309/08
摘要: The invention relates to the compounds of formula (I): or a pharmaceutically acceptable salt and solvate thereof, wherein R1 is F or H and to processes for the preparation of, intermediates used in the preparation of, compositions containing the uses of, such compounds. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular allergic and respiratory diseases, disorders and conditions
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐和溶剂化物,其中R 1是F或H,以及制备用于制备, 含有这些化合物的用途的组合物。 根据本发明的化合物可用于许多疾病,病症和病症,特别是过敏和呼吸系统疾病,病症和病症
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公开(公告)号:US20140088046A1
公开(公告)日:2014-03-27
申请号:US14018993
申请日:2013-09-05
申请人: Denis Billen , Michael Curtis , Richard Andrew Ewin , Richard M. Goodwin , Paul D. Johnson , Timothy Allan Johnson , Graham M. Kyne , Todd M. Maddux , Susan Mary Kult Sheehan , Rajendran Vairagoundar
发明人: Denis Billen , Michael Curtis , Richard Andrew Ewin , Richard M. Goodwin , Paul D. Johnson , Timothy Allan Johnson , Graham M. Kyne , Todd M. Maddux , Susan Mary Kult Sheehan , Rajendran Vairagoundar
IPC分类号: C07D213/40 , C07D261/08 , C07D409/04 , C07D213/64 , C07F9/6558 , C07F9/58 , C07D213/50 , C07D333/24 , C07D333/22 , C07D401/06 , C07D277/56 , C07D285/12 , C07D405/04 , C07D401/04
CPC分类号: C07D213/40 , C07D213/50 , C07D213/56 , C07D213/57 , C07D213/64 , C07D231/12 , C07D261/08 , C07D277/30 , C07D277/56 , C07D285/12 , C07D333/22 , C07D333/24 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/06 , C07D409/04 , C07D417/04 , C07F7/2208 , C07F9/58 , C07F9/65586
摘要: The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical composition containing these novel compounds, and methods for the preparation of these compounds.
摘要翻译: 本发明提供了新型酚酞衍生物,其用于治疗哺乳动物感染的药物组合物,含有这些新化合物的药物组合物,以及制备这些化合物的方法。
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公开(公告)号:US20110294826A1
公开(公告)日:2011-12-01
申请号:US12964841
申请日:2010-12-10
IPC分类号: A61K31/519 , A61P25/28 , A61P19/02 , A61P35/00 , A61P3/10 , A61P31/12 , A61P25/00 , A61P31/00 , A61P29/00 , A61P37/00 , A61P37/08 , C07D487/04 , A61P35/02
CPC分类号: C07D487/04
摘要: Described herein are pyrrolo[2,3-d]pyrimidine compounds, their use as Janus Kinase (JAK) inhibitors, pharmaceutical compositions containing these compounds, and methods for their preparation.
摘要翻译: 本文描述的是吡咯并[2,3-d]嘧啶化合物,它们用作Janus Kinase(JAK)抑制剂,含有这些化合物的药物组合物及其制备方法。
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公开(公告)号:US20090227634A1
公开(公告)日:2009-09-10
申请号:US12276779
申请日:2008-11-24
申请人: Edgardo Alvira , Matthew J. Graneto , Margaret Lanahan Grapperhaus , Kaliappan Iyanar , Todd M. Maddux , Matthew W. Mahoney , Mark A. Massa , Kirby R. Sample , Michelle A. Schmidt , Ronald E. Seidel , Jon G. Selbo , Michael B. Tollefson , Richard A. Vonder Embse , Grace M. Wagner , Scott S. Woodard
发明人: Edgardo Alvira , Matthew J. Graneto , Margaret Lanahan Grapperhaus , Kaliappan Iyanar , Todd M. Maddux , Matthew W. Mahoney , Mark A. Massa , Kirby R. Sample , Michelle A. Schmidt , Ronald E. Seidel , Jon G. Selbo , Michael B. Tollefson , Richard A. Vonder Embse , Grace M. Wagner , Scott S. Woodard
IPC分类号: A61K31/4439 , A61K31/4178 , A61K31/4162 , C07D405/14 , C07D405/12
CPC分类号: C07D405/12 , C07D405/14
摘要: The invention relates to compounds of formula (I) processes for their preparation, their use as 5-lipoxygenase inhibitors and pharmaceutical compositions containing the same.
摘要翻译: 本发明涉及式(I)化合物的制备方法,它们作为5-脂肪氧合酶抑制剂的用途和含有它们的药物组合物。
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