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公开(公告)号:US20090227634A1
公开(公告)日:2009-09-10
申请号:US12276779
申请日:2008-11-24
申请人: Edgardo Alvira , Matthew J. Graneto , Margaret Lanahan Grapperhaus , Kaliappan Iyanar , Todd M. Maddux , Matthew W. Mahoney , Mark A. Massa , Kirby R. Sample , Michelle A. Schmidt , Ronald E. Seidel , Jon G. Selbo , Michael B. Tollefson , Richard A. Vonder Embse , Grace M. Wagner , Scott S. Woodard
发明人: Edgardo Alvira , Matthew J. Graneto , Margaret Lanahan Grapperhaus , Kaliappan Iyanar , Todd M. Maddux , Matthew W. Mahoney , Mark A. Massa , Kirby R. Sample , Michelle A. Schmidt , Ronald E. Seidel , Jon G. Selbo , Michael B. Tollefson , Richard A. Vonder Embse , Grace M. Wagner , Scott S. Woodard
IPC分类号: A61K31/4439 , A61K31/4178 , A61K31/4162 , C07D405/14 , C07D405/12
CPC分类号: C07D405/12 , C07D405/14
摘要: The invention relates to compounds of formula (I) processes for their preparation, their use as 5-lipoxygenase inhibitors and pharmaceutical compositions containing the same.
摘要翻译: 本发明涉及式(I)化合物的制备方法,它们作为5-脂肪氧合酶抑制剂的用途和含有它们的药物组合物。
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公开(公告)号:US08097733B2
公开(公告)日:2012-01-17
申请号:US12276779
申请日:2008-11-24
申请人: Edgardo Alvira , Matthew J. Graneto , Margaret Lanahan Grapperhaus , Kaliappan Iyanar , Todd Michael Maddux , Matthew William Mahoney , Mark Alan Massa , Kirby Ray Sample , Michelle Ann Schmidt , Ronald Edward Seidel , Jon Gordon Selbo , Michael Brent Tollefson , Richard Alan Vonder Embse , Grace Mary Wagner , Scott Santford Woodard
发明人: Edgardo Alvira , Matthew J. Graneto , Margaret Lanahan Grapperhaus , Kaliappan Iyanar , Todd Michael Maddux , Matthew William Mahoney , Mark Alan Massa , Kirby Ray Sample , Michelle Ann Schmidt , Ronald Edward Seidel , Jon Gordon Selbo , Michael Brent Tollefson , Richard Alan Vonder Embse , Grace Mary Wagner , Scott Santford Woodard
IPC分类号: C07D231/10
CPC分类号: C07D405/12 , C07D405/14
摘要: The invention relates to compounds of formula (I) processes for their preparation, their use as 5-lipoxygenase inhibitors and pharmaceutical compositions containing the same.
摘要翻译: 本发明涉及式(I)化合物的制备方法,它们作为5-脂肪氧合酶抑制剂的用途和含有它们的药物组合物。
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3.Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效
标题翻译: 噻吩取代的异羟肟酸衍生物作为环加氧酶-2和5-脂氧合酶抑制剂公开(公告)号:US06753344B2
公开(公告)日:2004-06-22
申请号:US10317751
申请日:2002-12-12
申请人: John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas , Hwang-Fun Lu
发明人: John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas , Hwang-Fun Lu
IPC分类号: A61K3138
CPC分类号: C07D231/12 , C07D263/32
摘要: This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
摘要翻译: 本发明涉及抗炎药物领域,具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物,组合物和方法。
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公开(公告)号:US06750338B2
公开(公告)日:2004-06-15
申请号:US10268818
申请日:2002-10-10
申请人: Matthew J. Graneto , Michael L. Vazquez , Susan J. Hartmann , Suzanne Metz , John J. Talley , David L. Brown , Richard M. Weier , Michael A. Stealey , Xiangdong Xu
发明人: Matthew J. Graneto , Michael L. Vazquez , Susan J. Hartmann , Suzanne Metz , John J. Talley , David L. Brown , Richard M. Weier , Michael A. Stealey , Xiangdong Xu
IPC分类号: C07D40104
CPC分类号: C07D401/14 , C07D231/18 , C07D339/00 , C07D401/04 , C07D405/14 , C07D409/06
摘要: This invention relates to a novel process of preparing selected 5-substituted pyrazoles useful as p38 kinase and COX-2 inhibitors.
摘要翻译: 本发明涉及制备用作p38激酶和COX-2抑制剂的选择的5-取代的吡唑的新方法。
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公开(公告)号:US06482955B2
公开(公告)日:2002-11-19
申请号:US09922819
申请日:2001-08-06
申请人: Matthew J. Graneto , Susan J. Hartmann , Suzanne Metz , John J. Talley , Michael L. Vazquez , David Brown , Richard M. Weier , Michael A. Stealey , Xiangdong Xu
发明人: Matthew J. Graneto , Susan J. Hartmann , Suzanne Metz , John J. Talley , Michael L. Vazquez , David Brown , Richard M. Weier , Michael A. Stealey , Xiangdong Xu
IPC分类号: C07D2320
CPC分类号: C07D401/14 , C07D231/18 , C07D339/00 , C07D401/04 , C07D405/14 , C07D409/06
摘要: This invention relates to a novel process of preparing selected 5-substituted pyrazoles useful as p38 kinase and COX-2 inhibitors.
摘要翻译: 本发明涉及制备用作p38激酶和COX-2抑制剂的选择的5-取代的吡唑的新方法。
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6.Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效
标题翻译: 杂环取代的异羟肟酸衍生物作为环加氧酶-2和5-脂氧合酶抑制剂公开(公告)号:US06875785B2
公开(公告)日:2005-04-05
申请号:US10254701
申请日:2002-09-25
申请人: John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas , Hwang-Fun Lu
发明人: John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas , Hwang-Fun Lu
IPC分类号: A61P29/00 , C07D231/12 , C07D263/32 , A61K31/421 , C07D413/00
CPC分类号: C07D231/12 , C07D263/32
摘要: This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
摘要翻译: 本发明涉及抗炎药物领域,具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物,组合物和方法。
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公开(公告)号:US06617324B1
公开(公告)日:2003-09-09
申请号:US10114297
申请日:2002-04-02
申请人: Ashok S. Naraian , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xi , Ish K. Khanna , Yi Yu
发明人: Ashok S. Naraian , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xi , Ish K. Khanna , Yi Yu
IPC分类号: A61K31496
CPC分类号: C07D409/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D487/04
摘要: A class of pyrazole derivatives described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA wherein R1, R2, R3 and R4 are as described in the specification.
摘要翻译: 一类描述用于治疗p38激酶介导的病症的吡唑衍生物。 特别感兴趣的化合物由式IA定义,其中R1,R2,R3和R4如说明书中所述。
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8.Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation 失效
标题翻译: 用于治疗炎症的取代的吡唑基苯磺酰胺公开(公告)号:US5563165A
公开(公告)日:1996-10-08
申请号:US457059
申请日:1995-06-01
申请人: John J. Talley , Thomas D. Penning , Paul W. Collins , Donald J. Rogier, Jr. , James W. Malecha , Julie M. Miyashiro , Stephen R. Bertenshaw , Ish K. Khanna , Matthew J. Graneto , Roland S. Rogers , Jeffery S. Carter
发明人: John J. Talley , Thomas D. Penning , Paul W. Collins , Donald J. Rogier, Jr. , James W. Malecha , Julie M. Miyashiro , Stephen R. Bertenshaw , Ish K. Khanna , Matthew J. Graneto , Roland S. Rogers , Jeffery S. Carter
IPC分类号: A61K31/415 , A61P11/06 , A61P17/06 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D495/04 , A61K31/535
CPC分类号: C07D405/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D409/04 , C07D495/04
摘要: A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1##
摘要翻译: 描述了一类吡唑基苯磺酰胺化合物用于治疗炎症和炎症相关疾病。 特别感兴趣的化合物由式I定义:(I)
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公开(公告)号:US5504215A
公开(公告)日:1996-04-02
申请号:US458079
申请日:1995-06-01
申请人: John J. Talley , Thomas D. Penning , Paul W. Collins , Donald J. Rogier, Jr. , James W. Malecha , Julie M. Miyashiro , Stephen R. Bertenshaw , Ish K. Khanna , Matthew J. Graneto , Roland S. Rogers , Jeffery S. Carter
发明人: John J. Talley , Thomas D. Penning , Paul W. Collins , Donald J. Rogier, Jr. , James W. Malecha , Julie M. Miyashiro , Stephen R. Bertenshaw , Ish K. Khanna , Matthew J. Graneto , Roland S. Rogers , Jeffery S. Carter
IPC分类号: A61K31/415 , A61P11/06 , A61P17/06 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D495/04
CPC分类号: C07D405/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D409/04 , C07D495/04
摘要: A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## or a pharmaceutically-acceptable salt thereof.
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10.Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效
标题翻译: 杂环取代的异羟肟酸衍生物作为环加氧酶-2和5-脂氧合酶抑制剂公开(公告)号:US06696477B2
公开(公告)日:2004-02-24
申请号:US09997633
申请日:2001-11-29
申请人: John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas
发明人: John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas
IPC分类号: C07D23110
CPC分类号: C07D231/12 , B60G17/018 , B60G2400/102 , B60G2400/206 , B60G2400/25 , B60G2400/60 , B60G2400/91 , B64C27/001 , B64C2027/004 , C07D263/32
摘要: This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation. Compounds of particular interest are defined by Formula I wherein A, Y, R1, R2, R3, R4 and R5 are as defined in the specification.
摘要翻译: 本发明涉及抗炎药物领域,具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物,组合物和方法。 特别感兴趣的化合物由式I定义,其中A,Y,R 1,R 2,R 3,R 4和R 5如说明书中所定义。
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