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    METHOD FOR PRODUCING LITHIUM IRON PHOSPHATE
    1.
    发明申请
    METHOD FOR PRODUCING LITHIUM IRON PHOSPHATE 审中-公开
    生产磷酸铁锂的方法

    公开(公告)号：US20120032119A1

    公开(公告)日：2012-02-09

    申请号：US13203326

    申请日：2010-03-10

    申请人： Tomoyuki Tahara ,  Minoru Sakai

    发明人： Tomoyuki Tahara ,  Minoru Sakai

    IPC分类号： H01B1/04 ,  H01M4/58 ,  C01B25/45

    CPC分类号： H01M4/5825 ,  C01B25/45 ,  H01M4/136 ,  H01M10/0525

    摘要： A method for producing lithium iron phosphate includes: an aqueous solution preparing step of preparing an aqueous solution containing a phosphoric acid and a carboxylic acid; a first forming step of adding iron particles containing 0.5 mass % or more of oxygen to the aqueous solution, and making the phosphoric acid and the carboxylic acid and the iron particles react with each other in the aqueous solution under an oxidizing atmosphere, to form a first reaction liquid is formed by; the second forming step of adding a lithium source to the first reaction liquid obtained in the synthesizing step to form a second reaction liquid; the precursor forming step of drying the second reaction liquid to form a lithium iron phosphate precursor; and the primary baking step of baking the lithium iron phosphate precursor under a non-oxidizing atmosphere thus obtaining lithium iron phosphate.

    摘要翻译： 制造磷酸铁锂的方法包括：制备含有磷酸和羧酸的水溶液的水溶液制备步骤; 在水溶液中添加含有0.5质量％以上的铁的铁粒子的第一形成工序，在氧化气氛下使磷酸，羧酸和铁粒子在水溶液中相互反应，形成 第一反应液体由...形成; 第二形成步骤，在合成步骤中获得的第一反应液中加入锂源以形成第二反应液; 前体形成步骤，干燥第二反应液体以形成磷酸铁锂前体; 以及在非氧化性气氛下焙烧磷酸铁锂前体的一次烘烤工序，得到磷酸铁锂。

    Monoclonal antibody
    2.
    发明授权
    Monoclonal antibody 失效
    单克隆抗体

    公开(公告)号：US07592005B2

    公开(公告)日：2009-09-22

    申请号：US10451947

    申请日：2001-12-26

    申请人： Tomoyuki Tahara

    发明人： Tomoyuki Tahara

    IPC分类号： A61K39/395 ,  C12P21/08 ,  G01N33/53

    CPC分类号： C07K16/2896 ,  A61K47/6849 ,  A61K2039/505 ,  C07K16/30 ,  C07K2317/77

    摘要： A monoclonal antibody or a functional fragment thereof that binds to a human BST2 antigen existing on the cell surface and can be localized through internalization into the cell, a complex comprising the monoclonal antibody or a functional fragment thereof and a therapeutic agent, and a pharmaceutical composition comprising, as an active ingredient, the complex.

    摘要翻译： 结合存在于细胞表面上的人BST2抗原的单克隆抗体或其功能片段，并且可以通过内化进入细胞来定位，包含单克隆抗体或其功能片段和治疗剂的复合物和药物组合物 作为活性成分的复合物。

    Therapeutic agent for periodontal disease
    3.
    发明申请
    Therapeutic agent for periodontal disease 审中-公开
    牙周病治疗剂

    公开(公告)号：US20070036734A1

    公开(公告)日：2007-02-15

    申请号：US10549289

    申请日：2004-03-17

    申请人： Tomoyuki Tahara ,  Yoshimitsu Abiko ,  Hiromasa Yoshie ,  Tetsuo Kobayashi ,  Toshio Umemoto ,  Nobushiro Hamada

    发明人： Tomoyuki Tahara ,  Yoshimitsu Abiko ,  Hiromasa Yoshie ,  Tetsuo Kobayashi ,  Toshio Umemoto ,  Nobushiro Hamada

    IPC分类号： A61K39/40 ,  C07K16/12 ,  A61K8/96 ,  G01N33/554 ,  C12N5/06

    CPC分类号： C07K16/1257 ,  A61K2039/505 ,  C07K16/1203 ,  C07K2317/77

    摘要： The present invention provides a human monoclonal antibody that has both activity of inhibiting the aggregation of pathogenic bacteria involved in periodontal diseases and activity of promoting sterilization by leukocytes, that is preferably a monoclonal antibody against 40-kDa OMP, which inhibits the binding of hemin, and that causes no concerns such as side effects. The present invention further provides an agent that acts against periodontal diseases containing the monoclonal antibody. The present invention relates to an antibody binding to 40-kDa OMP or a functional fragment thereof having at least one of (1) activity of inhibiting the coaggregation of P. gingivalis, (2) activity of promoting human neutrophilic phagocytosis, and (3) activity of inhibiting the binding of hemin to 40-kDa OMP.

    摘要翻译： 本发明提供一种具有抑制牙周疾病病原菌聚集的活性和促进白细胞灭活的活性的人单克隆抗体，其优选为40kDa OMP的单克隆抗体，其抑制血红素的结合， 并且不会引起副作用等问题。 本发明还提供了一种对含有单克隆抗体的牙周病作用的药剂。 本发明涉及结合40-kDa OMP的抗体或其功能片段，其具有以下至少一种：（1）抑制牙龈卟啉单胞菌共聚的活性，（2）促进人嗜中性粒细胞吞噬作用的活性，和（3） 抑制血红素与40-kDa OMP结合的活性。

    METHOD FOR PRODUCING LITHIUM IRON PHOSPHATE
    6.
    发明申请
    METHOD FOR PRODUCING LITHIUM IRON PHOSPHATE 审中-公开
    生产磷酸铁锂的方法

    公开(公告)号：US20140127111A1

    公开(公告)日：2014-05-08

    申请号：US14122354

    申请日：2012-02-27

    申请人： Tomoyuki Tahara

    发明人： Tomoyuki Tahara

    IPC分类号： C01B25/45

    CPC分类号： C01B25/45 ,  H01M4/5825

    摘要： A method for producing lithium iron phosphate includes an aqueous solution preparation step of preparing an aqueous solution containing a phosphoric acid and a hydroxycarboxylic acid; a first preparation step of adding iron particles containing 0.1 to 2 mass % oxygen to the aqueous solution, and reacting the phosphoric acid and the hydroxycarboxylic acid in the aqueous solution with the iron particles in an oxidizing atmosphere to prepare a first reaction liquid; a second preparation step of adding a lithium source to the first reaction liquid to prepare a second reaction liquid; a third preparation step of adding a carbon source to the second reaction liquid to prepare a third reaction liquid; a precursor formation step of drying the third reaction liquid to form a lithium iron phosphate precursor; and a calcination step of calcining the lithium iron phosphate precursor in a non-oxidizing atmosphere to produce lithium iron phosphate.

    摘要翻译： 制造磷酸铁锂的方法包括制备含有磷酸和羟基羧酸的水溶液的水溶液制备步骤; 在水溶液中添加含有0.1〜2质量％的氧的铁粒子，在氧化气氛中使磷酸和羟基羧酸与铁粒子在氧化气氛中反应，制备第一反应液的第一制备工序; 第二制备步骤，将锂源添加到第一反应液中以制备第二反应液; 第三制备步骤，向第二反应液中加入碳源以制备第三反应液; 干燥第三反应液以形成磷酸铁锂前体的前体形成步骤; 以及在非氧化性气氛中煅烧磷酸铁锂前体以制备磷酸铁锂的煅烧步骤。

    Anti-CD98 antibody
    10.
    发明授权
    Anti-CD98 antibody 有权
    抗CD98抗体

    公开(公告)号：US08486402B2

    公开(公告)日：2013-07-16

    申请号：US13106280

    申请日：2011-05-12

    申请人： Tomoyuki Tahara ,  Yoshikatsu Kanai ,  Hitoshi Endou ,  Shiro Kataoka ,  Kazumasa Hasegawa ,  Tetsuya Yoshino

    发明人： Tomoyuki Tahara ,  Yoshikatsu Kanai ,  Hitoshi Endou ,  Shiro Kataoka ,  Kazumasa Hasegawa ,  Tetsuya Yoshino

    IPC分类号： A61K38/00

    CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76

    摘要： A human antibody or a functional fragment thereof having specific binding ability to CD98 which is derived from the cell membrane of cancer cells and is in the form of a complex with a protein having an amino acid transporter activity (for example, LAT1) is disclosed. This antibody binds to CD98 in the form of a dimer with LAT1 on the surface of cancer cells, specifically attacks cancer cells expressing CD98 via the immune system by ADCC or CDC, and further inhibits amino acid uptake of the cancer cells via LAT1, to suppress growth of the cancer cells. Accordingly, a preventive and therapeutic agent for cancer comprising this antibody or a fragment thereof, which acts on various cancers, is specific to cancer, and causes no side effect, is provided.

    摘要翻译： 公开了具有来自癌细胞的细胞膜的与CD98特异性结合能力并与具有氨基酸转运蛋白活性的蛋白质（例如LAT1）形成复合物的形式的人抗体或其功能片段。 该抗体以癌细胞表面的LAT1二聚体形式结合CD98，特异性地通过ADCC或CDC通过免疫系统侵袭表达CD98的癌细胞，并进一步通过LAT1抑制癌细胞的氨基酸摄取，抑制 癌细胞的生长。 因此，提供了作用于各种癌症的该抗体或其片段的癌症的预防和治疗剂，其对癌症是特异性的，并且不产生副作用。