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51 条记录 (耗时 0.031 秒)

    Anti-CD98 antibody
    1.
    发明授权
    Anti-CD98 antibody 有权
    抗CD98抗体

    公开(公告)号：US08486402B2

    公开(公告)日：2013-07-16

    申请号：US13106280

    申请日：2011-05-12

    申请人： Tomoyuki Tahara ,  Yoshikatsu Kanai ,  Hitoshi Endou ,  Shiro Kataoka ,  Kazumasa Hasegawa ,  Tetsuya Yoshino

    发明人： Tomoyuki Tahara ,  Yoshikatsu Kanai ,  Hitoshi Endou ,  Shiro Kataoka ,  Kazumasa Hasegawa ,  Tetsuya Yoshino

    IPC分类号： A61K38/00

    CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76

    摘要： A human antibody or a functional fragment thereof having specific binding ability to CD98 which is derived from the cell membrane of cancer cells and is in the form of a complex with a protein having an amino acid transporter activity (for example, LAT1) is disclosed. This antibody binds to CD98 in the form of a dimer with LAT1 on the surface of cancer cells, specifically attacks cancer cells expressing CD98 via the immune system by ADCC or CDC, and further inhibits amino acid uptake of the cancer cells via LAT1, to suppress growth of the cancer cells. Accordingly, a preventive and therapeutic agent for cancer comprising this antibody or a fragment thereof, which acts on various cancers, is specific to cancer, and causes no side effect, is provided.

    摘要翻译： 公开了具有来自癌细胞的细胞膜的与CD98特异性结合能力并与具有氨基酸转运蛋白活性的蛋白质（例如LAT1）形成复合物的形式的人抗体或其功能片段。 该抗体以癌细胞表面的LAT1二聚体形式结合CD98，特异性地通过ADCC或CDC通过免疫系统侵袭表达CD98的癌细胞，并进一步通过LAT1抑制癌细胞的氨基酸摄取，抑制 癌细胞的生长。 因此，提供了作用于各种癌症的该抗体或其片段的癌症的预防和治疗剂，其对癌症是特异性的，并且不产生副作用。

    DNA encoding a testicular carnitine transporter
    5.
    发明授权
    DNA encoding a testicular carnitine transporter 有权
    编码睾丸肉碱转运蛋白的DNA

    公开(公告)号：US07582447B2

    公开(公告)日：2009-09-01

    申请号：US11824895

    申请日：2007-07-03

    申请人： Hitoshi Endou ,  Yoshikatsu Kanai ,  Atsushi Enomoto

    发明人： Hitoshi Endou ,  Yoshikatsu Kanai ,  Atsushi Enomoto

    IPC分类号： C07H21/04 ,  C07K14/435 ,  C12N7/01 ,  C12N5/10 ,  C12N15/00 ,  C12P21/02

    CPC分类号： C07K14/47 ,  C12Q1/6883 ,  C12Q2600/158

    摘要： It is intended to identify and provide a novel carnitine transporter gene participating in carnitine transport in the testis and epididymis and carnitine transporter which is a protein encoded by the gene. A protein comprising the amino acid sequence represented by SEQ ID NO: 2 or an amino acid sequence derived therefrom by deletion, substitution or addition of one to several amino acids and being capable of transporting carnitine or its analog; and a gene encoding this protein.

    摘要翻译： 旨在鉴定并提供一种参与肉碱转运的新型肉碱转运蛋白基因，其为由该基因编码的蛋白质的睾丸和附睾和肉碱转运蛋白。 包含由SEQ ID NO：2表示的氨基酸序列的蛋白质或通过缺失，取代或添加1至数个氨基酸并能够转运肉碱或其类似物的氨基酸序列衍生的氨基酸序列; 和编码该蛋白质的基因。

    Neutral amino acid transporter and gene thereof
    7.
    发明申请
    Neutral amino acid transporter and gene thereof 有权

    公开(公告)号：US20050019811A1

    公开(公告)日：2005-01-27

    申请号：US10913256

    申请日：2004-08-05

    申请人： Hitoshi Endou ,  Yoshikatsu Kanai

    发明人： Hitoshi Endou ,  Yoshikatsu Kanai

    IPC分类号： C12N15/09 ,  A01K67/027 ,  A61K31/711 ,  A61K38/00 ,  A61K39/395 ,  A61K48/00 ,  A61P35/00 ,  C07K14/705 ,  C07K16/28 ,  C12N5/10 ,  C12N15/12 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/53 ,  G01N33/566 ,  G01N33/577 ,  C07H21/04 ,  G01N33/567

    CPC分类号： C07K14/705 ,  A01K2217/05 ,  A61K38/00

    摘要： A novel amino acid transporter molecule mediating transportation of amino acids, which are nutrients essentially required in the survival and proliferation of various normal cells constituting a living body and various pathology-associated abnormal cells such as tumor cells, into cells and being expressed specifically in tumor cells compared with normal cells; and drugs for treating various pathogenic conditions such as tumor (cancer) which are obtained by identifying and isolating the above amino acid transporter molecule and identifying a substance capable of inhibiting the biological activity and/or expression of this molecule. Intensive studies were made to identify a tumor cell membrane surface molecule associating or interacting with a cell membrane surface 4F2hc molecule seemingly playing an important role in the activation of an unknown amino acid transporter. As a result, a gene encoding the novel amino acid transporter molecule, which mediates the incorporation of various neutral amino acids, various drugs or physiological substances into cells, has been found out and a substance capable of inhibiting the incorporation of amino acids via this molecule and thus inhibiting the proliferation of tumor cells has been also found out.

    Neutral amino acid transporter and gene thereof
    8.
    发明申请
    Neutral amino acid transporter and gene thereof 有权

    公开(公告)号：US20050003490A1

    公开(公告)日：2005-01-06

    申请号：US10913191

    申请日：2004-08-05

    申请人： Hitoshi Endou ,  Yoshikatsu Kanai

    发明人： Hitoshi Endou ,  Yoshikatsu Kanai

    IPC分类号： C12N15/09 ,  A01K67/027 ,  A61K31/711 ,  A61K38/00 ,  A61K39/395 ,  A61K48/00 ,  A61P35/00 ,  C07K14/705 ,  C07K16/28 ,  C12N5/10 ,  C12N15/12 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/53 ,  G01N33/566 ,  G01N33/577 ,  C07H21/04 ,  G01N33/567

    CPC分类号： C07K14/705 ,  A01K2217/05 ,  A61K38/00

    摘要： A novel amino acid transporter molecule mediating transportation of amino acids, which are nutrients essentially required in the survival and proliferation of various normal cells constituting a living body and various pathology-associated abnormal cells such as tumor cells, into cells and being expressed specifically in tumor cells compared with normal cells; and drugs for treating various pathogenic conditions such as tumor (cancer) which are obtained by identifying and isolating the above amino acid transporter molecule and identifying a substance capable of inhibiting the biological activity and/or expression of this molecule. Intensive studies were made to identify a tumor cell membrane surface molecule associating or interacting with a cell membrane surface 4F2hc molecule seemingly playing an important role in the activation of an unknown amino acid transporter. As a result, a gene encoding the novel amino acid transporter molecule, which mediates the incorporation of various neutral amino acids, various drugs or physiological substances into cells, has been found out and a substance capable of inhibiting the incorporation of amino acids via this molecule and thus inhibiting the proliferation of tumor cells has been also found out.

    Neutral amino acid transporter and gene thereof
    9.
    发明授权
    Neutral amino acid transporter and gene thereof 有权
    中性氨基酸转运蛋白及其基因

    公开(公告)号：US07666999B2

    公开(公告)日：2010-02-23

    申请号：US10913191

    申请日：2004-08-05

    申请人： Hitoshi Endou ,  Yoshikatsu Kanai

    发明人： Hitoshi Endou ,  Yoshikatsu Kanai

    IPC分类号： C07K16/00 ,  C07K16/28

    CPC分类号： C07K14/705 ,  A01K2217/05 ,  A61K38/00

    摘要： A novel amino acid transporter molecule mediating transportation of amino acids, which are nutrients essentially required in the survival and proliferation of various normal cells constituting a living body and various pathology-associated abnormal cells such as tumor cells, into cells and being expressed specifically in tumor cells compared with normal cells; and drugs for treating various pathogenic conditions such as tumor (cancer) which are obtained by identifying and isolating the above amino acid transporter molecule and identifying a substance capable of inhibiting the biological activity and/or expression of this molecule. Intensive studies were made to identify a tumor cell membrane surface molecule associating or interacting with a cell membrane surface 4F2hc molecule seemingly playing an important role in the activation of an unknown amino acid transporter. As a result, a gene encoding the novel amino acid transporter molecule, which mediates the incorporation of various neutral amino acids, various drugs or physiological substances into cells, has been found out and a substance capable of inhibiting the incorporation of amino acids via this molecule and thus inhibiting the proliferation of tumor cells has been also found out.

    摘要翻译： 介导氨基酸运输的新型氨基酸转运蛋白分子，其是构成活体的各种正常细胞的存活和增殖以及各种病理学相关异常细胞如肿瘤细胞基本上需要的营养素，并且在肿瘤中特异性表达 细胞与正常细胞相比; 以及用于治疗通过鉴定和分离上述氨基酸转运蛋白分子并鉴定能够抑制该分子的生物活性和/或表达的物质而获得的各种病原性病症如肿瘤（癌症）的药物。 进行了深入研究，以确定与细胞膜表面缔合或相互作用的肿瘤细胞膜表面分子4F2hc分子在未知氨基酸转运蛋白的活化中似乎起着重要作用。 结果，已经发现了编码新的氨基酸转运蛋白分子的基因，其介导各种中性氨基酸，各种药物或生理物质掺入细胞中，并且能够通过该分子抑制氨基酸的掺入的物质 从而也发现抑制肿瘤细胞的增殖。

    Method using neutral amino acid transporter expressing cell
    10.
    发明授权
    Method using neutral amino acid transporter expressing cell 有权
    使用中性氨基酸转运蛋白表达细胞的方法

    公开(公告)号：US07335482B2

    公开(公告)日：2008-02-26

    申请号：US10913263

    申请日：2004-08-05

    申请人： Hitoshi Endou ,  Yoshikatsu Kanai

    发明人： Hitoshi Endou ,  Yoshikatsu Kanai

    IPC分类号： G01N33/53

    CPC分类号： C07K14/705 ,  A01K2217/05 ,  A61K38/00

    摘要： A novel amino acid transporter molecule mediating transportation of amino acids, which are nutrients essentially required in the survival and proliferation of various normal cells constituting a living body and various pathology-associated abnormal cells such as tumor cells, into cells and being expressed specifically in tumor cells compared with normal cells; and drugs for treating various pathogenic conditions such as tumor (cancer) which are obtained by identifying and isolating the above amino acid transporter molecule and identifying a substance capable of inhibiting the biological activity and/or expression of this molecule. Intensive studies were made to identify a tumor cell membrane surface molecule associating or interacting with a cell membrane surface 4F2hc molecule seemingly playing an important role in the activation of an unknown amino acid transporter. As a result, a gene encoding the novel amino acid transporter molecule, which mediates the incorporation of various neutral amino acids, various drugs or physiological substances into cells, has been found out and a substance capable of inhibiting the incorporation of amino acids via this molecule and thus inhibiting the proliferation of tumor cells has been also found out.

    摘要翻译： 介导氨基酸运输的新型氨基酸转运蛋白分子，其是构成活体的各种正常细胞的存活和增殖以及各种病理学相关异常细胞如肿瘤细胞基本上需要的营养素，并且在肿瘤中特异性表达 细胞与正常细胞相比; 以及用于治疗通过鉴定和分离上述氨基酸转运蛋白分子并鉴定能够抑制该分子的生物活性和/或表达的物质而获得的各种病原性病症如肿瘤（癌症）的药物。 进行了深入研究，以确定与细胞膜表面缔合或相互作用的肿瘤细胞膜表面分子4F2hc分子在未知氨基酸转运蛋白的活化中似乎起着重要作用。 结果，已经发现了编码新的氨基酸转运蛋白分子的基因，其介导各种中性氨基酸，各种药物或生理物质掺入细胞中，并且能够通过该分子抑制氨基酸的掺入的物质 从而也发现抑制肿瘤细胞的增殖。