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    Neurotrophic factor protein and uses thereof
    3.
    发明授权
    Neurotrophic factor protein and uses thereof 有权
    神经营养因子蛋白及其用途

    公开(公告)号：US07452969B2

    公开(公告)日：2008-11-18

    申请号：US10648361

    申请日：2003-08-27

    申请人： Mart Saarma ,  Juha Lauren ,  Päivi Lindholm ,  Tonis Timmusk ,  Raimo Tuominen

    发明人： Mart Saarma ,  Juha Lauren ,  Päivi Lindholm ,  Tonis Timmusk ,  Raimo Tuominen

    IPC分类号： C07K1/00 ,  C12N5/00 ,  C12P21/06 ,  C12P21/04

    CPC分类号： C07K14/475 ,  A61K48/00

    摘要： The present invention discloses a novel neurotrophic factor protein, MANF2 and a genetic sequence encoding the same. The molecule will be useful in the development of a range of therapeutics and diagnostics useful in the treatment, prophylaxis and/or diagnosis of MANF2 dependent conditions. The molecule of the present invention is also a useful effector of primary and central neurons, especially dopaminergic neurons at the central nervous system and growth factor genes.

    摘要翻译： 本发明公开了一种新型神经营养因子，人FOF和编码其的遗传序列。 该分子可用于开发可用于治疗，预防和/或诊断MANF2依赖性病症的一系列治疗和诊断。 本发明的分子也是中枢神经元，特别是中枢神经系统和生长因子基因的多巴胺能神经元的有用的效应子。

    Mammalian neuralized family transcriptional regulators and uses
    6.
    发明申请
    Mammalian neuralized family transcriptional regulators and uses 审中-公开
    哺乳动物神经系统转录调节因子和用途

    公开(公告)号：US20060160103A1

    公开(公告)日：2006-07-20

    申请号：US11125970

    申请日：2005-05-09

    申请人： Kaia Palm ,  Tonis Timmusk

    发明人： Kaia Palm ,  Tonis Timmusk

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/475

    CPC分类号： C07K14/71 ,  A61K38/00 ,  C07K14/82

    摘要： The disclosure relates to isolated polynucleotides and purified polypeptides of the Neu family of proteins, which have been shown to demonstrate transcriptional regulatory activity. For example, the purified polynucleotide can encode a Neu polypeptide, wherein the Neu polypeptide comprises at least one neuralized homology repeat domain and a C3HC4 RING-zinc finger domain is disclosed. A purified Neu polypeptide, wherein the Neu polypeptide comprises at least one neuralized homology repeat domain and a C3HC4 RING-zinc finger domain is disclosed. Antibodies capable of specifically binding to the disclosed Neu polypeptides are disclosed. Vectors expressing the disclosed Neu protein coding regions and host cells containing the vectors are disclosed. Methods of making the Neu proteins disclosed are also provided, as are method of identifying binding partners that interact with a Neu protein family member.

    摘要翻译： 本公开涉及已经显示表现出转录调节活性的Neu家族蛋白质的分离的多核苷酸和纯化多肽。 例如，纯化的多核苷酸可以编码Neu多肽，其中Neu多肽包含至少一个神经化同源重复结构域和C3HC4 RING-锌指结构域。 纯化的Neu多肽，其中所述Neu多肽包含至少一个神经化同源重复结构域和C3HC4 RING-锌指结构域。 公开了能够特异性结合所公开的Neu多肽的抗体。 公开了表达所公开的Neu蛋白编码区的载体和含有载体的宿主细胞。 还提供制备所公开的Neu蛋白的方法，以及鉴定与Neu蛋白家族成员相互作用的结合配偶体的方法。

    Novel neurotrophic factor protein and uses thereof
    8.
    发明申请
    Novel neurotrophic factor protein and uses thereof 有权
    新型神经营养因子蛋白及其用途

    公开(公告)号：US20060084619A1

    公开(公告)日：2006-04-20

    申请号：US10648361

    申请日：2003-08-27

    申请人： Mart Saarma ,  Juha Lauren ,  Paivi Lindholm ,  Tonis Timmusk ,  Raimo Tuominen

    发明人： Mart Saarma ,  Juha Lauren ,  Paivi Lindholm ,  Tonis Timmusk ,  Raimo Tuominen

    IPC分类号： A61K48/00 ,  C07K14/475 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/475 ,  A61K48/00

    摘要： The present invention discloses a novel neurotrophic factor protein, MANF2 and a genetic sequence encoding the same. The molecule will be useful in the development of a range of therapeutics and diagnostics useful in the treatment, prophylaxis and/or diagnosis of MANF2 dependent conditions. The molecule of the present invention is also a useful effector of primary and central neurons, especially dopaminergic neurons at the central nervous system and growth factor genes.

    摘要翻译： 本发明公开了一种新型神经营养因子，人FOF和编码其的遗传序列。 该分子可用于开发可用于治疗，预防和/或诊断MANF2依赖性病症的一系列治疗和诊断。 本发明的分子也是中枢神经元，特别是中枢神经系统和生长因子基因的多巴胺能神经元的有用的效应子。

    Mammalian neuralized family transcriptional regulators and uses therefor
    10.
    发明授权
    Mammalian neuralized family transcriptional regulators and uses therefor 失效
    哺乳动物神经系统转录调节因子及其用途

    公开(公告)号：US06962985B2

    公开(公告)日：2005-11-08

    申请号：US09808387

    申请日：2001-03-14

    申请人： Kaia Palm ,  Tonis Timmusk

    发明人： Kaia Palm ,  Tonis Timmusk

    IPC分类号： A61K38/00 ,  C07K14/71 ,  C07K14/82 ,  C07H21/02

    CPC分类号： C07K14/71 ,  A61K38/00 ,  C07K14/82

    摘要： The disclosure relates to isolated polynucleotides and purified polypeptides of the Neu family of proteins, which have been shown to demonstrate transcriptional regulatory activity. For example, the purified polynucleotide can encode a Neu polypeptide, wherein the Neu polypeptide comprises at least one neuralized homology repeat domain and a C3HC4 RING-zinc finger domain is disclosed. A purified Neu polypeptide, wherein the Neu polypeptide comprises at least one neuralized homology repeat domain and a C3HC4 RING-zinc finger domain is disclosed. Antibodies capable of specifically binding to the disclosed Neu polypeptides are disclosed. Vectors expressing the disclosed Neu protein coding regions and host cells containing the vectors are disclosed. Methods of making the Neu proteins disclosed are also provided, as are method of identifying binding partners that interact with a Neu protein family member.

    摘要翻译： 本公开涉及已经显示表现出转录调节活性的Neu家族蛋白质的分离的多核苷酸和纯化多肽。 例如，纯化的多核苷酸可以编码Neu多肽，其中Neu多肽包含至少一个神经化同源重复结构域和C3HC4 RING-锌指结构域。 纯化的Neu多肽，其中所述Neu多肽包含至少一个神经化同源重复结构域和C3HC4 RING-锌指结构域。 公开了能够特异性结合所公开的Neu多肽的抗体。 公开了表达所公开的Neu蛋白编码区的载体和含有载体的宿主细胞。 还提供制备所公开的Neu蛋白的方法，以及鉴定与Neu蛋白家族成员相互作用的结合配偶体的方法。