公开(公告)号：US20130345296A1

公开(公告)日：2013-12-26

申请号：US13819538

申请日：2011-08-31

Applicant: Torsten Heilmann ,  Heiko Noack ,  Christian Richter ,  Sabine Post

Inventor： Torsten Heilmann ,  Heiko Noack ,  Christian Richter ,  Sabine Post

IPC: A61K31/337 ,  A61K31/27 ,  A61K31/198

CPC classification number: A61K31/337 ,  A61K31/145 ,  A61K31/164 ,  A61K45/06 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61K2300/00

Abstract: The present invention relates a pharmaceutical composition comprising a taxane and an inhibitory compound capable of inhibiting the enzyme acetaldehyde dehydrogenase e.g. disulfiram. The pharmaceutical compositions of the invention can be used to coat medical devices such as implants. Such implant can be an expansible hollow part, having at least one opening, which consists of an elastic biocompatible material that comprises elongated micro-cavities in its surface. Medical devices coated with a pharmaceutical composition of the invention exhibit an enhanced transfer of taxane from the surface of said medical device into the target tissue.

Abstract translation: 本发明涉及一种药物组合物，其包含紫杉烷和能够抑制乙醛脱氢酶的抑制化合物，例如 双硫仑 本发明的药物组合物可用于涂覆诸如植入物之类的医疗装置。 这样的植入物可以是可膨胀的中空部分，其具有至少一个开口，该开口由弹性生物相容性材料组成，该材料在其表面上包括细长的微型腔。 用本发明的药物组合物涂覆的医疗装置显示出将紫杉烷从所述医疗装置的表面增强转移到靶组织中。

公开(公告)号：US20110046724A1

公开(公告)日：2011-02-24

申请号：US12934762

申请日：2009-03-31

Applicant: Torsten Heilmann ,  Christian Richter ,  Sabine Post

Inventor： Torsten Heilmann ,  Christian Richter ,  Sabine Post

IPC: A61F2/82 ,  A61M29/00 ,  B05D3/12

CPC classification number: A61L29/14 ,  A61B17/12109 ,  A61B17/12136 ,  A61B2017/00526 ,  A61B2017/00893 ,  A61F2/82 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61L29/146 ,  A61L29/16 ,  A61L31/14 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/00 ,  A61M25/0045 ,  A61M25/10 ,  A61M25/1036 ,  A61M25/104 ,  A61M2025/0056 ,  A61M2025/0057 ,  A61M2025/1031 ,  A61M2025/105 ,  A61N1/375 ,  B05D3/12

Abstract: The present invention relates to an expansible hollow part, having at least one opening, which consists of an elastic biocompatible material and which comprises at least one biologically active substance and, optionally at least one matrix compound. The invention also provides a method of producing said expansible hollow part, a medical device covered at least partially with said hollow part, a kit-of-parts comprising said hollow part of the invention and the use of said hollow part as a therapeutic device and for protecting a medical device.

Abstract translation: 本发明涉及一种可膨胀中空部件，其具有至少一个开口，该开口由弹性生物相容性材料组成，并包括至少一种生物活性物质和至少一种基质化合物。 本发明还提供了一种制造所述可膨胀中空部件的方法，至少部分地覆盖所述中空部件的医疗装置，包括本发明的所述中空部件的零件和使用所述中空部件作为治疗装置， 用于保护医疗设备。