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    Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis
    1.
    发明授权
    Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis 失效
    计算机控制稀有细胞的方法和装置，包括胎儿细胞，基于诊断

    公开(公告)号：US07945391B2

    公开(公告)日：2011-05-17

    申请号：US11273229

    申请日：2005-11-14

    申请人： Petros Tsipouras ,  Triantafyllos Tafas

    发明人： Petros Tsipouras ,  Triantafyllos Tafas

    IPC分类号： G06F19/00 ,  G06K9/00 ,  G06K9/20 ,  G06K9/78

    CPC分类号： G06K9/00127 ,  B01J2219/00693 ,  B01J2219/00702 ,  C12Q1/6806 ,  G01N1/2813 ,  G01N1/312 ,  G01N15/1475 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/5005 ,  G01N35/1002 ,  G01N35/1011 ,  G01N2015/1006 ,  G01N2035/1034 ,  G06K9/0014 ,  G06T7/0012 ,  G06T2207/30024

    摘要： A computer controlled method for detecting and diagnosing a rare cell type in a tissue sample is provided, said method comprising treating the tissue sample such that it generates a first signal indicative of the presence at a location of a rare cell, detecting the first signal, treating the location at which the first signal is detected to generate a second signal indicative of a diagnostically useful cellular characteristic and detecting the second signal. The first signal can be morphological or a color present in a sought cell either before or after staining. The second signal can be generated by in situ PCR or PCR in situ hybridization. In one preferred embodiment, the rare cell type is a fetal cell in a maternal blood tissue sample, said sample consisting of a smear of unenriched maternal blood. In another embodiment, the method is used to diagnose or genotype cancer cells in a blood or tissue biopsy sample.

    摘要翻译： 提供了一种用于检测和诊断组织样本中的稀有细胞类型的计算机控制方法，所述方法包括处理组织样本，使得其产生指示在罕见细胞的位置存在的第一信号，检测第一信号， 处理检测到第一信号的位置以产生指示诊断有用的细胞特征的第二信号并检测第二信号。 在染色之前或之后，第一信号可以是形态学或寻找细胞中存在的颜色。 第二信号可以通过原位PCR或PCR原位杂交产生。 在一个优选实施方案中，稀有细胞类型是母体血液组织样品中的胎儿细胞，所述样品由未培养的母体血液的涂片组成。 在另一个实施方案中，该方法用于诊断或基因型血液或组织活检样本中的癌细胞。

    IMAGER SYSTEM
    6.
    发明申请
    IMAGER SYSTEM 失效
    IMAGER系统

    公开(公告)号：US20070222880A1

    公开(公告)日：2007-09-27

    申请号：US11689948

    申请日：2007-03-22

    申请人： Triantafyllos Tafas

    发明人： Triantafyllos Tafas

    IPC分类号： H04N5/335

    CPC分类号： H04N5/238 ,  H04N5/2254 ,  H04N5/235 ,  H04N5/2355

    摘要： An imager system is disclosed comprising a image intensifier and a CMOS image sensor. The system provides fast capture speed and high sensitivity.

    摘要翻译： 公开了一种包括图像增强器和CMOS图像传感器的成像系统。 该系统提供快速捕获速度和高灵敏度。

    Composing microscope
    10.
    发明授权
    Composing microscope 失效
    组成显微镜

    公开(公告)号：US06320174B1

    公开(公告)日：2001-11-20

    申请号：US09442172

    申请日：1999-11-16

    申请人： Triantafyllos Tafas ,  Petros Tsipouras

    发明人： Triantafyllos Tafas ,  Petros Tsipouras

    IPC分类号： G02B606

    CPC分类号： G02B26/105 ,  G02B6/06 ,  G02B21/002 ,  G02B21/361 ,  G02B21/364

    摘要： The present invention provides a composing microscope for scanning a large area of a specimen in a minimal amount of time. In a first embodiment, the composing microscope has a plurality of optical sensors and a plurality of optical projecting systems arranged adjacent to each other. Each of the projecting systems acquires an image from one location of a specimen and projects the image on one of the optical sensors for digitalizing the image. An image acquisition device is connected to the optical sensors for simultaneously storing the digitalized images with information of their locations on the specimen. In a second embodiment, a composing microscope has an optical sensor and a plurality of optical projecting systems arranged adjacent to each other in rows. Each of the optical projecting systems has a first end for acquiring an image at one location of a specimen and a second end. An optical reflector moveable with respect to the second ends of the optical projecting systems receives the images from a row of the optical projecting systems at the second ends and projects the images on the optical sensor, and the optical sensor simultaneously digitalizes the images. An image acquisition device simultaneously receives and stores the digitalized images with information of their locations on the specimen. In a third embodiment, a composing microscope has an optical sensor and a plurality of optical projecting systems arranged adjacent to each other. The projecting system has a first end and a second end connected to the optical sensor. Each of the optical projecting systems acquires an image of one location of a specimen at the first end and projects the image on the optical sensor for digitalizing the image. An image acquisition device is connected to the optical sensor for storing the digitalized images with information of their locations on the specimen.

    摘要翻译： 本发明提供了一种用于以最小的时间扫描大面积的样本的组合显微镜。 在第一实施例中，构图显微镜具有彼此相邻布置的多个光学传感器和多个光学投影系统。 每个投影系统从样本的一个位置获取图像，并将图像投影在其中一个光学传感器上，以使图像数字化。 图像获取装置连接到光学传感器，用于将数字化图像与其位置的信息同时存储在样本上。 在第二实施例中，构图显微镜具有光学传感器和多个彼此相邻布置的光学投影系统。 每个光学投影系统具有用于在样本的一个位置处获取图像的第一端和第二端。 相对于光学投影系统的第二端可移动的光学反射器在第二端处接收来自一系列光学投影系统的图像，并将图像投射在光学传感器上，并且光学传感器同时对图像进行数字化。 图像采集装置同时接收并存储具有它们在样本上的位置的信息的数字化图像。 在第三实施例中，构图显微镜具有彼此相邻布置的光学传感器和多个光学投影系统。 投影系统具有连接到光学传感器的第一端和第二端。 每个光学投影系统获取在第一端处的样本的一个位置的图像，并将图像投影在用于数字化图像的光学传感器上。 图像获取装置连接到光学传感器，用于将数字化图像存储在样本上的位置信息。