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    Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis
    1.
    发明授权
    Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis 失效
    计算机控制稀有细胞的方法和装置，包括胎儿细胞，基于诊断

    公开(公告)号：US07945391B2

    公开(公告)日：2011-05-17

    申请号：US11273229

    申请日：2005-11-14

    申请人： Petros Tsipouras ,  Triantafyllos Tafas

    发明人： Petros Tsipouras ,  Triantafyllos Tafas

    IPC分类号： G06F19/00 ,  G06K9/00 ,  G06K9/20 ,  G06K9/78

    CPC分类号： G06K9/00127 ,  B01J2219/00693 ,  B01J2219/00702 ,  C12Q1/6806 ,  G01N1/2813 ,  G01N1/312 ,  G01N15/1475 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/5005 ,  G01N35/1002 ,  G01N35/1011 ,  G01N2015/1006 ,  G01N2035/1034 ,  G06K9/0014 ,  G06T7/0012 ,  G06T2207/30024

    摘要： A computer controlled method for detecting and diagnosing a rare cell type in a tissue sample is provided, said method comprising treating the tissue sample such that it generates a first signal indicative of the presence at a location of a rare cell, detecting the first signal, treating the location at which the first signal is detected to generate a second signal indicative of a diagnostically useful cellular characteristic and detecting the second signal. The first signal can be morphological or a color present in a sought cell either before or after staining. The second signal can be generated by in situ PCR or PCR in situ hybridization. In one preferred embodiment, the rare cell type is a fetal cell in a maternal blood tissue sample, said sample consisting of a smear of unenriched maternal blood. In another embodiment, the method is used to diagnose or genotype cancer cells in a blood or tissue biopsy sample.

    摘要翻译： 提供了一种用于检测和诊断组织样本中的稀有细胞类型的计算机控制方法，所述方法包括处理组织样本，使得其产生指示在罕见细胞的位置存在的第一信号，检测第一信号， 处理检测到第一信号的位置以产生指示诊断有用的细胞特征的第二信号并检测第二信号。 在染色之前或之后，第一信号可以是形态学或寻找细胞中存在的颜色。 第二信号可以通过原位PCR或PCR原位杂交产生。 在一个优选实施方案中，稀有细胞类型是母体血液组织样品中的胎儿细胞，所述样品由未培养的母体血液的涂片组成。 在另一个实施方案中，该方法用于诊断或基因型血液或组织活检样本中的癌细胞。

    Composing microscope
    5.
    发明授权
    Composing microscope 失效
    组成显微镜

    公开(公告)号：US06320174B1

    公开(公告)日：2001-11-20

    申请号：US09442172

    申请日：1999-11-16

    申请人： Triantafyllos Tafas ,  Petros Tsipouras

    发明人： Triantafyllos Tafas ,  Petros Tsipouras

    IPC分类号： G02B606

    CPC分类号： G02B26/105 ,  G02B6/06 ,  G02B21/002 ,  G02B21/361 ,  G02B21/364

    摘要： The present invention provides a composing microscope for scanning a large area of a specimen in a minimal amount of time. In a first embodiment, the composing microscope has a plurality of optical sensors and a plurality of optical projecting systems arranged adjacent to each other. Each of the projecting systems acquires an image from one location of a specimen and projects the image on one of the optical sensors for digitalizing the image. An image acquisition device is connected to the optical sensors for simultaneously storing the digitalized images with information of their locations on the specimen. In a second embodiment, a composing microscope has an optical sensor and a plurality of optical projecting systems arranged adjacent to each other in rows. Each of the optical projecting systems has a first end for acquiring an image at one location of a specimen and a second end. An optical reflector moveable with respect to the second ends of the optical projecting systems receives the images from a row of the optical projecting systems at the second ends and projects the images on the optical sensor, and the optical sensor simultaneously digitalizes the images. An image acquisition device simultaneously receives and stores the digitalized images with information of their locations on the specimen. In a third embodiment, a composing microscope has an optical sensor and a plurality of optical projecting systems arranged adjacent to each other. The projecting system has a first end and a second end connected to the optical sensor. Each of the optical projecting systems acquires an image of one location of a specimen at the first end and projects the image on the optical sensor for digitalizing the image. An image acquisition device is connected to the optical sensor for storing the digitalized images with information of their locations on the specimen.

    摘要翻译： 本发明提供了一种用于以最小的时间扫描大面积的样本的组合显微镜。 在第一实施例中，构图显微镜具有彼此相邻布置的多个光学传感器和多个光学投影系统。 每个投影系统从样本的一个位置获取图像，并将图像投影在其中一个光学传感器上，以使图像数字化。 图像获取装置连接到光学传感器，用于将数字化图像与其位置的信息同时存储在样本上。 在第二实施例中，构图显微镜具有光学传感器和多个彼此相邻布置的光学投影系统。 每个光学投影系统具有用于在样本的一个位置处获取图像的第一端和第二端。 相对于光学投影系统的第二端可移动的光学反射器在第二端处接收来自一系列光学投影系统的图像，并将图像投射在光学传感器上，并且光学传感器同时对图像进行数字化。 图像采集装置同时接收并存储具有它们在样本上的位置的信息的数字化图像。 在第三实施例中，构图显微镜具有彼此相邻布置的光学传感器和多个光学投影系统。 投影系统具有连接到光学传感器的第一端和第二端。 每个光学投影系统获取在第一端处的样本的一个位置的图像，并将图像投影在用于数字化图像的光学传感器上。 图像获取装置连接到光学传感器，用于将数字化图像存储在样本上的位置信息。

    SYSTEM FOR DETECTING INFECTIOUS AGENTS USING COMPUTER-CONTROLLED AUTOMATED IMAGE ANALYSIS
    7.
    发明申请
    SYSTEM FOR DETECTING INFECTIOUS AGENTS USING COMPUTER-CONTROLLED AUTOMATED IMAGE ANALYSIS 失效
    使用计算机控制自动图像分析检测感染性代理的系统

    公开(公告)号：US20110129138A1

    公开(公告)日：2011-06-02

    申请号：US13022348

    申请日：2011-02-07

    申请人： Triantafyllos Tafas ,  Michael Kilpatrick ,  Petros Tsipouras

    发明人： Triantafyllos Tafas ,  Michael Kilpatrick ,  Petros Tsipouras

    IPC分类号： G06K9/00

    CPC分类号： G06K9/00147 ,  C12Q1/04 ,  G01N15/1475 ,  G06K9/00127 ,  G06T7/0012 ,  G06T2207/30024

    摘要： A method for recognizing an object in an image is disclosed wherein a fractal map of the image is generated by estimating the fractal dimension of each pixel in the image. The fractal map may be segmented by thresholding and locations of candidate objects are determined. The pixel value of the image pixel corresponding to the same location where the candidate object is found in the fractal map may be compared to a threshold value. If the pixel value is greater than the threshold value, the candidate object is recognized as a valid object.

    摘要翻译： 公开了一种用于识别图像中的对象的方法，其中通过估计图像中每个像素的分形维数来生成图像的分形图。 可以通过阈值分割分形图并确定候选对象的位置。 可以将对应于在分形图中找到候选对象的相同位置的图像像素的像素值与阈值进行比较。 如果像素值大于阈值，则候选对象被识别为有效对象。

    DEVICE AND METHOD FOR DETECTING AND LOCALIZING CELLS BY MEANS OF PHOTOSENSITIVE WAVEGUIDES
    9.
    发明申请
    DEVICE AND METHOD FOR DETECTING AND LOCALIZING CELLS BY MEANS OF PHOTOSENSITIVE WAVEGUIDES 失效
    通过感光波形检测和定位细胞的装置和方法

    公开(公告)号：US20080131064A1

    公开(公告)日：2008-06-05

    申请号：US11691989

    申请日：2007-03-27

    申请人： Petros Tsipouras ,  Triantafyllos Tafas

    发明人： Petros Tsipouras ,  Triantafyllos Tafas

    IPC分类号： G02B6/02

    CPC分类号： G02B1/045 ,  G01N21/7703 ,  G01N2021/1725 ,  G01N2021/7783 ,  G02B6/02033 ,  G02B6/1221

    摘要： The present invention provides devices and methods for detection of particles, such as biological cells, in samples using a photosensitive waveguide. The photosensitive waveguide changes its transmissivity in a detectable manner in response to controlling radiation emitted from the particles. In preferred embodiments, the waveguide is two-dimensional and the position of the particles as well as their presence is obtained by scanning the waveguide in two non-parallel directions. The provided devices are preferably used to locate labeled cells. The present invention also includes control systems and methods for detecting and locating cells using the devices provided.

    摘要翻译： 本发明提供用于在使用光敏波导的样品中检测诸如生物细胞的颗粒的装置和方法。 响应于控制从颗粒发射的辐射，光敏波导以可检测的方式改变其透射率。 在优选实施例中，波导是二维的，并且颗粒的位置以及它们的存在是通过在两个非平行方向扫描波导而获得的。 所提供的装置优选用于定位标记的细胞。 本发明还包括使用所提供的设备来检测和定位单元的控制系统和方法。