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1.发明授权公开(公告)号：US12168720B2
公开(公告)日：2024-12-17
申请号：US17310653
申请日：2020-02-18
Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE CAEN NORMANDIE , ECOLE NATIONALE SUPERIEURE D'INGENIEURS DE CAEN
Inventor： Isabelle Dez , Annie-Claude Gaumont , Jean-Nicolas Noël
Abstract: A method for synthesising polymers through devulcanisation from waste containing elastomers, the method including: a) contacting the waste containing elastomers with a solvent in the presence of a devulcanisation agent, b) heating the mixture produced in step a), at a temperature of between 20° C. and 250° C. for a period of between 15 minutes and 24 hours in the presence of a devulcanisation agent, the concentration of devulcanisation agent, and the ratio between the concentration of devulcanisation agent, expressed as parts per hundred of elastomer (phr) and a volume of solvent, expressed in ml, is: greater than 0.3 phr/ml of solvent or less than 0.2 phr/ml of solvent when the method is carried out in air, greater than 0.06 phr/ml of solvent when the method is carried out in an inert atmosphere.
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公开(公告)号：US20240366804A1
公开(公告)日：2024-11-07
申请号：US18291666
申请日：2022-07-29
Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITE DE CAEN NORMANDIE , CENTRE HOSPITALIER UNIVERSITAIRE DE CAEN NORMANDIE
Inventor： Thomas BONNARD , Charlène JACQMARCQ , Maxime GAUBERTI , Sara MARTINEZ DE LIZARRONDO , Denis VIVIEN
Abstract: The present invention relates to novel biocompatible imaging particles comprising superparamagnetic iron oxide (SPIO) assembled into submicromiter-sized clusters within a biodegradable polycathecolamine or polyserotonine matrix, their synthesis and use in imaging techniques. These particles overcome the issues of toxicity and unreliable signal of the molecules from the prior art by providing similar contrast to that of the microparticles of iron oxide and rapidly disassemble into isolated SPIO particles once they reach the acidic lysosomal compartment of the MPS cells, thus enabling their digestion. The present invention is thus directed to a particle having a hydrodynamic diameter comprised between 100 nm and 2000 nm, said particle comprising nanoparticles of iron oxide embedded within a matrix of polycathecolamine or polyserotonine, each of said nanoparticles of iron oxide being coated by a polymer which is different from polycathecolamine or polyserotonine
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3.发明公开公开(公告)号：US20230298778A1
公开(公告)日：2023-09-21
申请号：US18018346
申请日：2021-07-22
Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , ECOLE NATIONALE SUPERIEURE D'INGENIEURS DE CAEN , UNIVERSITE DE CAEN NORMANDIE
Inventor： Alexis BOILEAU , Christophe CIBERT , Adrian DAVID , Arnaud FOUCHET , Fabrice GOURBILLEAU , Christophe LABBÉ , Ulrike LÜDERS , Gilles POULLAIN
CPC classification number: H01B1/08 , C03C17/3417 , C23C14/28 , C23C14/34 , C23C14/088 , C23C14/083 , C03C2217/94 , C03C2218/151 , C03C2218/154
Abstract: The present invention relates to a multilayer conductive system of metal oxides comprising:
i. a substrate;
ii. a layer of a crystalline binary metal oxide deposited on the substrate (i); and
iii. a layer of a crystalline conductive metal oxide having a crystalline structure of perovskite type superposed over the layer of binary metal oxide (ii);
the binary metal oxide of the layer (ii) having a local lattice mismatch of less than 5% with respect to that of the metal oxide of the layer (iii);
provided that when the metal oxide of perovskite type of the layer (iii) is a crystalline transparent conductive metal oxide, the substrate (i) is transparent and the thickness of the crystalline binary metal oxide layer (ii) is-
公开(公告)号：US20230298165A1
公开(公告)日：2023-09-21
申请号：US18006490
申请日：2021-07-23
Applicant: INSTIT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE DE CAEN NORMANDIE
Inventor： Robin DE FLORES , Gaëlle CHETELAT , Brigitte LANDEAU , Sophie DAUTRICOURT
CPC classification number: G06T7/0012 , A61B5/055 , G06T2207/30016 , G06T2207/10088 , G06T2207/20084
Abstract: The invention relates to neuroimaging techniques and more specifically to methods and systems for identifying and/or predicting the occurrence of neurodegenerative diseases (such as Alzheimer's disease) or cognitive impairment in a subject, based on magnetic resonance images (MRI). Anatomical and functional MRI brain images are combined to build functional connectivity maps of one or more medial temporal lobe (MTL) subregions of the brain of a subject. Functional connectivity networks associated to the anterior temporal (AT) and posterior medial (PM) hippocampal network are then identified. A metric based on the degree of functional connectivity in both networks can be used as a tool to detect functional changes associated to cognitive decline caused by neurodegenerative diseases.
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公开(公告)号：US20210024551A1
公开(公告)日：2021-01-28
申请号：US16764805
申请日：2018-11-16
Inventor： Mohamad EL ROZ , Sami LAKHDAR , Igor TELEGEIEV
IPC: C07F7/18 , C08F2/50 , C08F222/10 , C08F216/16
Abstract: The present invention relates to a compound of formula (I) below: in which:
R1 represents, in particular, an alkylene group comprising from 1 to 6 carbon atoms;
R2 and R3 are, in particular, H;
n is 0, 1, 2 or 3; and R4 is chosen from the group consisting of: NO2, ORa, SRa and NRaRb, wherein Ra and Rb are as defined above;
R5 and R6, identical or different, represent an alkyl or alkoxy group comprising from 1 to 6 carbon atoms; and
R7, R8 and R9, identical or different, represent an alkyl group comprising from 2 to 6 carbon atoms.-
Patent Agency Ranking
公开(公告)号：US20200171178A1
公开(公告)日：2020-06-04
申请号：US16628288
申请日：2018-07-05
Inventor： Anne-Elodie LAFARGUE , Cecile PERRIO
IPC: A61K51/04 , C07D403/06
Abstract: The application relates to a compound with the following formula (I): its preparation method, its synthesis intermediates and its uses as an imaging agent of hypoxia.
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公开(公告)号：US20190284098A1
公开(公告)日：2019-09-19
申请号：US16345664
申请日：2017-10-20
Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE CAEN NORMANDIE , ECOLE NATIONALE SUPERIEURE D'INGENIEURS CAEN , UNIVERSITE DE VALENCIENNES ET DU HAINAUT CAMBRESIS , ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPEMENT DE METHODES ET PROCESSUS INDUSTRIELS - ARMINES
Inventor： Sylvain MARINEL , Etienne SAVARY , François-Xavier LEFEVRE , Jérôme LECOURT , Sébastien SAUNIER , Pauline CHANIN-LAMBERT
Abstract: A field of thermal treatment of ceramic materials is provided, and relates to a method for thermal treatment of a solid ceramic part in a microwave cavity, the direction of the electrical field E being substantially uniform in an empty cavity, comprising the steps that consist of placing, in the cavity, at least one ceramic part surrounded by at least one first susceptor with dimensions, material and arrangement configured to emit infrared radiation, each first susceptor including at least one first main surface, each first main surface being an adjusted surface in which the cone distances are parallel to the electrical field E, and of emitting the microwaves into the cavity.
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公开(公告)号：US20190247416A1
公开(公告)日：2019-08-15
申请号：US16330956
申请日：2017-09-15
Applicant: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , FONDATION IMAGINE , UNIVERSITE PARIS DESCARTES , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITE DE CAEN NORMANDIE , CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE CAEN
Inventor： Olivier HERMINE , Flavia GUILLEM , Gandhi DAMAJ , Sophia LADRAA
IPC: A61K31/7105 , A61K31/497
CPC classification number: A61K31/7105 , A61K31/497 , A61K31/713 , A61P35/00 , A61P35/04 , C12N15/00 , C12N15/113 , C12N2310/14 , C12N2310/531
Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of systemic mastocytosis. The inventors showed the effect of KPT-251 treatment on SCF-dependent human Mast cell (MC) line without KIT mutation (WT ROSA) and on two factor-independent MC lines with KIT mutations : ROSA Δ 417-419 insY and ROSA D816V. KPT is a Selective Inhibitor of Nuclear Export (SINE) that specifically inhibits the activity of the exportin-1 (XPO1). KPT-251 treatment induces minimal toxicity in non-cancerous hematopoietic cells both in vitro and in vivo. In particular, the present invention relates a method of treating systemic mastocytosis in patient in need thereof comprising administering to the patient a therapeutically effective amount of a XPO1 inhibitor.
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公开(公告)号：US20240228477A1
公开(公告)日：2024-07-11
申请号：US17909916
申请日：2021-03-12
Applicant: CENTRE REGIONAL DE LUITTE CONTRE LE CANCER FRANCOIS BACLESSE , UNIVERSITE DE CAEN NORMANDIE , INSTITUT NATIONAL DE LA SANTE DE LA RECHERCHE MEDICALE
Inventor： Anne-Sophie VOISIN-CHIRET , Charline KIEFFER , Nicolas GUEDENEY , Camille DENIS , Martina DE PASCALE , Laurent POULAIN , Louis, Bastien WEISWALD , Hippolyte PAYSANT
IPC: C07D417/14 , A61K47/54 , C07D401/14
CPC classification number: C07D417/14 , A61K47/545 , C07D401/14
Abstract: The present disclosure relates to compounds, compositions and methods for treating cancers and disorders of cell proliferation and more particularly, methods of making and using compounds that modulate at least one of the proteins chosen from Bcl-2, Mcl-1, Bcl-xL, Bcl-w, Bfl-1 and Bcl-B, in particular Bcl-2 protein, or Bcl-xL and/or Mcl-1 proteins. The compounds may be contained in pharmaceutical compositions and used as therapeutic agents.
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公开(公告)号：US11756194B2
公开(公告)日：2023-09-12
申请号：US17258307
申请日：2019-06-27
Applicant: VILNIAUS UNIVERSITETAS , UNIVERSITE DE CAEN NORMANDIE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , CENTRE REGIONAL FRANCOIS BACLESSE
Inventor： Laurent Poulain , Arvydas Laurinavicius , Benoît Plancoulaine , Nicolas Elie
CPC classification number: G06T7/0012 , G06F16/55 , G06T7/60 , G06T2207/30004
Abstract: Computer-implemented process on an image of a biological sample The present invention relates to a computer-implemented process to automatically analyze a digital image (103) of abiological sample (101). The process involves a change (203) from a first color space to a second color space. Then, fits are performed taking into account several dimensions of the second color space to classify pixels.
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