公开(公告)号：US20240118488A1

公开(公告)日：2024-04-11

申请号：US17754843

申请日：2020-10-28

申请人： UNIVERSITE DE LIMOGES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Fetah BENABID ,  Frédéric GEROME ,  Foued AMRANI ,  Jonas OSORIO ,  Frédéric DELAHAYE

IPC分类号： G02B6/032

CPC分类号： G02B6/032

摘要： An electromagnetic waveguide, such as an optical fibre, including a hollow central core surrounded by a microstructured sheath formed by an assembly of elementary cells, the microstructured sheath also including at least two elementary cells, at least one intermediate element connecting the elementary cells, the intermediate element having a cross-section with an area less than or equal to 50% of the cross-sectional area of each of the cells that it connects, the intermediate element having a refractive index less than or equal to the refractive index of each of the elementary cells that it connects.

公开(公告)号：US11678669B2

公开(公告)日：2023-06-20

申请号：US16342107

申请日：2017-10-13

申请人： UNIVERSITE DE LIMOGES ,  COVERTIS

发明人： Céline Faugeron ,  Vincent Gloaguen ,  Cédric Astier ,  Charlotte Moine

IPC分类号： C07F15/00 ,  A61K31/282 ,  A61K41/00 ,  A01N65/00 ,  A01N25/04 ,  A01N63/50

CPC分类号： A01N65/00 ,  A01N25/04 ,  A01N63/50 ,  A01N65/00 ,  A01N59/02 ,  A01N59/20 ,  A01N63/50 ,  A01N63/34

摘要： Process for conferring a protection against a pathogen upon a plant by elicitation by an aqueous composition, the active agents of which are extracted from edible fungi (parasol mushroom, pleurotus, button mushroom). An alkaline extraction is carried out, then an enzymatic hydrolysis, to obtain a fraction less than 100 kDa. The process consists in spraying the aerial parts of the plant with the composition obtained in this way; this thereby acts to combat cryptogamic diseases of plants such as vines, fruit trees, vegetable crops and cereals.

公开(公告)号：US20220244452A1

公开(公告)日：2022-08-04

申请号：US17597908

申请日：2020-07-30

申请人： UNIVERSITE DE LIMOGES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Fetah BENABID ,  Luca VINCETTI ,  Fabio GIOVANARDI

IPC分类号： G02B6/02 ,  G02B6/024 ,  H01P3/12

摘要： A field of waveguides is disclosed. A tubular electromagnetic waveguide includes a hollow central portion defined by a first set of at least seven primary hollow tubes that are distributed annually about the hollow central portion, and a second set of tubes including at least one secondary hollow tube; when there are a plurality thereof positioned annularly around the primary hollow tubes the area of the at least one secondary hollow tube is comprised between 0.35 and 0.50 times the area of the hollow central portion. The hollow tubes of the first set are substantially of same size and distant from one another.

公开(公告)号：US20210139599A1

公开(公告)日：2021-05-13

申请号：US17050403

申请日：2019-04-26

申请人： UNIVERSITE DE LIMOGES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS ,  CENTRE HOSPITALIER UNIVERSITAIRE DE LIMOGES ,  ETABLISSEMENT FRANCAIS DU SANG

发明人： Michel COGNÉ

IPC分类号： C07K16/28

摘要： The present invention relates to an recombinant nucleic acid molecule comprising an immunoglobulin heavy chain variable region (VH), an immunoglobulin light chain variable region (VL), an immunoglobulin light chain constant region (CL), an immunoglobulin heavy chain constant region (CH) corresponding to the CH1, hinge, CH2 and CHS protein domains encoded by the human pseudo-gamma gene (ψγ), and its uses for therapeutic or diagnostic purposes. The invention further relates to an antibody encoded by said recombinant nucleic acid molecule, and an expression cassette, vector, viral particle, host cell, transgenic organism or pharmaceutical composition comprising said recombinant nucleic acid molecule.

公开(公告)号：US10608403B2

公开(公告)日：2020-03-31

申请号：US16093120

申请日：2017-03-31

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE LIMOGES

发明人： Katarzyna Krupa ,  Badr Shalaby ,  Alessandro Tonello ,  Vincent Couderc

IPC分类号： G02F1/365 ,  H01S3/30 ,  H01S3/067 ,  G02F1/35

摘要： A generating device includes at least one pulsed laser source that delivers primary photons having at least one wavelength in a single spatial mode and in pulses having a high pump energy, forming means that act on the primary photons to deliver an input beam, and at least one optical fiber having at least ten modes between which the pump energy is initially distributed, and able to relocate the latter via a non-linear effect into a fundamental mode, before generating secondary photons of various wavelengths by wavelength conversions from the wavelength of the primary photons in the fundamental spatial mode.

公开(公告)号：US10398722B2

公开(公告)日：2019-09-03

申请号：US15777843

申请日：2016-11-22

申请人： Universite de Limoges ,  Centre National de la Recherche Scientifique

发明人： Laurent Delpy ,  Nivine Srour ,  Michel Cogné

IPC分类号： A61K31/713 ,  C12N15/113 ,  A61K45/06 ,  A61P35/04

摘要： The present invention concerns a treatment of diseases involving B cells, B lymphocytes or plasmocytes. In particular, it concerns an antisense oligonucleotide or a mixture of antisense oligonucleotides capable of inducing exon skipping at the RNA of the immunoglobulin heavy or light chains, for the use of same in the treatment of diseases involving B cells.

公开(公告)号：US20190255144A1

公开(公告)日：2019-08-22

申请号：US15749020

申请日：2015-07-31

申请人： NEURONAX ,  UNIVERSITE DE LIMOGES

发明人： Stephane GOBRON ,  Fabrice LALLOUE ,  Romain BIBES ,  Francois VINCENT

IPC分类号： A61K38/17 ,  A61P35/00 ,  A61K45/06

摘要： An oligopeptide isolated from an SCO-spondin glycoprotein, characterized by the sequence: —W—S—X1—W—S— X2—C—S— X3—X4—C-G- (SEQ ID NO: 1), in which X1, X2, X3 and X4 represent amino acid sequences that consist of 1 to 5 amino acids. The oligopeptide may be used as a drug for inhibiting angiogenesis, in the treatment of diseases associated with angiogenesis in humans or animals, in particular against tumor angiogenesis. The oligopeptide is suitable in particular for the treatment of brain tumors.

公开(公告)号：US10053780B2

公开(公告)日：2018-08-21

申请号：US15024582

申请日：2014-09-17

申请人： L'Air Liquide, Societe Anonyme pour l'Etude et l'Exploitation des Procedes Georges Claude ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE LIMOGES ,  UNIVERSITE DE LORRAINE

发明人： Thierry Chartier ,  Pascal Del-Gallo ,  Sebastien Doublet ,  Thierry Mazet ,  Laurent Prost ,  Nicolas Ramenatte ,  Fabrice Rossignol ,  Michel Vilasi

IPC分类号： C23C28/00 ,  B01J19/24 ,  C23C10/20 ,  B01J19/00 ,  B01J19/02 ,  F28F19/02 ,  B05D1/02 ,  C23C2/00 ,  F28D9/00 ,  F28D21/00

CPC分类号： C23C28/30 ,  B01J19/0093 ,  B01J19/02 ,  B01J19/249 ,  B01J2219/00842 ,  B01J2219/0236 ,  B05D1/02 ,  C23C2/00 ,  C23C10/20 ,  F28D9/0075 ,  F28D2021/0022 ,  F28F19/02

摘要： Process for depositing a corrosion-protection coating on at least one portion of the surfaces of a metallic substrate having at least one cavity with an equivalent diameter emm

公开(公告)号：US20170355100A1

公开(公告)日：2017-12-14

申请号：US15622410

申请日：2017-06-14

申请人： UNIVERSITE DE LIMOGES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  3DCERAM

发明人： Vincent PATELOUP ,  Victor CHARTIER ,  Christophe CHAPUT

IPC分类号： B28B1/00 ,  B33Y30/00 ,  B33Y10/00

CPC分类号： B28B1/001 ,  B29C64/205 ,  B29C64/214 ,  B33Y10/00 ,  B33Y30/00

摘要： Disclosed is a method for manufacturing a green piece made of ceramic material by the technique of additive manufacturing according to which layers of a photocurable paste are successively allowed to cure by irradiation according to a pattern defined for each layer, the first layer being formed on a working surface on a working tray, each layer, before curing, being spread by scraping a paste mass provided on the working tray, which is lowered upon each formation of a layer. According to the disclosure, when spreading at least one of the photocurable paste layers, at least one scraping blade in working position, in addition to its scraping motion or so-called pass motion, is allowed to go back and forth in its plane, according to a so-called vibration motion.

公开(公告)号：US20160320316A1

公开(公告)日：2016-11-03

申请号：US15107831

申请日：2014-12-24

申请人： UNIVERSITE DE LIMOGES ,  ONCOMEDICS

发明人： Arnaud POTHIER ,  Claire JEROME ,  Pierre BLONDY ,  Fabrice LALLOUE ,  Serge BATTU ,  Marie-Odile JAUBERTEAU ,  Philippe CARDOT ,  Christophe LAUTRETTE ,  Stephanie GIRAUD ,  Christophe MORAND DU PUCH

IPC分类号： G01N22/00 ,  G01N33/483

CPC分类号： G01N22/00 ,  G01N27/221 ,  G01N33/4833

摘要： Method for determining, in vitro, the cell aggressiveness grade of cancer cells or for detecting cancer stem cells in a cell sample originating from a solid tissue suspected of being cancerous, includes: a) dissociating the cell cluster constituting the sample into a suspension of whole and viable isolated cells, b) macroscopically sorting the cells to obtain homogeneous subpopulations, c) calibrating at least one microwave electromagnetic sensor resonating at its own resonance frequency, d) presenting the dissociated and sorted cells to the calibrated sensor, e) interrogating the sensor and determining its new resonance frequency having received the cells, f) calculating the variation in overall dielectric permittivity of the cells according to the variation in working frequency, which constitutes the electromagnetic signature of the cells. The macroscopic sorting is without prior labelling and is based on the intrinsic properties of the cells. A kit for implementing the method is also described.

摘要翻译： 在体外确定癌细胞的细胞侵袭性等级或用于检测源自疑似癌症的实体组织的细胞样品中的癌干细胞的方法包括：a）将构成样品的细胞簇解离成全部的悬浮液 和可行的分离的细胞，b）宏观地分选细胞以获得均质的亚群; c）校准至少一个以其自身共振频率谐振的微波电磁传感器，d）将解离和分选的细胞呈现给校准的传感器，e）询问传感器 并且确定其接收到所述单元的新的共振频率，f）根据构成所述单元的电磁特征的工作频率的变化来计算所述单元的总介电常数的变化。 宏观分选没有事先标记，并且基于细胞的固有特性。 还描述了用于实现该方法的套件。