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公开(公告)号:US12290575B2
公开(公告)日:2025-05-06
申请号:US18349855
申请日:2023-07-10
Inventor: Yana K. Reshetnyak , Oleg A. Andreev , Donald M. Engelman
IPC: A61K49/00 , A61B5/00 , A61K49/04 , A61K49/22 , C07K14/00 , C07K19/00 , C09B69/10 , C09K11/06 , G01N33/58
Abstract: The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided.
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公开(公告)号:US12124097B1
公开(公告)日:2024-10-22
申请号:US17677651
申请日:2022-02-22
Inventor: Brennan T. Phillips , James B. Owens, Jr.
CPC classification number: G02B6/4427 , G02B6/3816 , B33Y80/00
Abstract: Systems and methods for tethering a fiber optic cable to an apparatus such as an unmanned underwater vehicle (UUV) or remotely operated vehicle (ROV). The cable is a bare or tight-buffered optical fiber surrounded by a braided sheath, and is constructed so that loads experienced by the cable are not transferred from the sheath to the optical fiber. This construction enables the cable to have good tensile strength but be sufficiently lightweight so that a commercial fishing reel or any similarly scaled lightweight/portable winch system can be used, instead of large specialized deployment equipment. A tube is inserted between the sheath and the optical fiber a certain distance from the end of the cable, and then the cable and tube are inserted into a housing which attaches to the apparatus and potted using an epoxy resin.
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公开(公告)号:US20240285772A1
公开(公告)日:2024-08-29
申请号:US18106242
申请日:2023-02-06
Inventor: Fang Wang , Jacob M. Goldberg , Bradley M. Lipka , Daniel S. Honeycutt
IPC: A61K47/54 , C07D213/61 , C07D213/64 , C07D213/68 , C07D213/71 , C07D213/76 , C07D235/24 , C07D235/28 , C07D237/12 , C07D239/30 , C07D277/62
CPC classification number: A61K47/545 , C07D213/61 , C07D213/64 , C07D213/68 , C07D213/71 , C07D213/76 , C07D235/24 , C07D235/28 , C07D237/12 , C07D239/30 , C07D277/62
Abstract: Disclosed are pnictogen-containing heterocyclic compounds of Formula (I)
Each of R1, the heterocyclic ring H, A+, LG, and X− is defined herein. Also provided are methods of modifying a substrate using such a compound, conjugated biomolecules thus modified, and pharmaceutical compositions containing one of the conjugated biomolecules.-
公开(公告)号:US11958739B2
公开(公告)日:2024-04-16
申请号:US17188985
申请日:2021-03-01
Applicant: University of Rhode Island Board of Trustees
Inventor: Jason Rodger Dwyer , Y. M. Nuwan D. Y. Bandara , Brian Sheetz
IPC: B81C1/00
CPC classification number: B81C1/00547 , B81C1/00071 , B81C2201/0133 , B81C2201/0145
Abstract: The present invention provides a simple method for ablating a protective thin film on a bulk surface and roughening the underlying bulk. In an embodiment, silicon nitride thin films, which are useful as etch-stop masks in micro- and nano-fabrication, is removed from a silicon wafer's surface using a hand-held “flameless” Tesla-coil lighter. Vias created by a spatially localized electron beam from the lighter allow a practitioner to perform micro- and nano-fabrication without the conventional steps of needing a photoresist and photolithography. Patterning could be achieved with a hard mask or rastering of the spatially confined discharge, offering—with low barriers to rapid use—particular capabilities that might otherwise be out of reach to researchers without access to conventional, instrumentation-intensive micro- and nano-fabrication workflows.
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公开(公告)号:US11857509B2
公开(公告)日:2024-01-02
申请号:US16717577
申请日:2019-12-17
Inventor: Yana K. Reshetnyak , Oleg A. Andreev , Donald M. Engelman
IPC: A61K9/127 , A61K47/69 , A61K31/20 , A61K31/337 , A61K31/704 , A61K31/7105 , A61K31/711 , A61P35/00 , A61K31/713
CPC classification number: A61K9/1271 , A61K9/127 , A61K31/20 , A61K31/337 , A61K31/704 , A61K31/711 , A61K31/713 , A61K31/7105 , A61K47/6911 , A61P35/00
Abstract: The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the pHLIP polypeptide.
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公开(公告)号:US20230384261A1
公开(公告)日:2023-11-30
申请号:US18121505
申请日:2023-03-14
Inventor: Jason R Dwyer , James Hagan , Grace G.D. Han , Alejandra Gonzalez
IPC: G01N27/447 , G01N33/487 , B82Y15/00
CPC classification number: G01N27/44791 , G01N33/48721 , B82Y15/00
Abstract: Disclosed herein is the fabrication of a photo-regulated nanopore by covalently linking a photoswitch to the interior of a silicon-based membrane and related methods of translocating an analyte and distinguishing molecule types through such a nanopore.
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公开(公告)号:US11662298B1
公开(公告)日:2023-05-30
申请号:US17079027
申请日:2020-10-23
Applicant: University of Rhode Island Board of Trustees
Inventor: Dillon T. Fontaine , Anthony D. Marshall , Arun Shukla
CPC classification number: G01N17/002 , G01N33/44
Abstract: An accelerated life testing (ALT) system for the pressurization of corrosive media, such as seawater, at high pressures and at elevated temperatures (up to about 70° C.) for extended periods of time. The interior of a pressure vessel is coated in an inert ceramic/epoxy coating that provides adequate corrosion protection from the corrosive media. A fabric reinforced nitrile diaphragm separates the corrosive media from hydraulic actuating media, such as oil. The hydraulic actuating media is pressurized, which deforms the diaphragm into the corrosive media, thereby increasing the pressure. The diaphragm and supplementary flouroelastomer seals isolate the corrosive media from pressure generating, monitoring, and safety equipment. The temperature of the entire vessel and contents is maintained by complete immersion in a heated, filtered water bath. The system is particularly useful for ALT experiments on components intended for sea floor and long term deep ocean environment operations at about 6000 psi (41.4 MPa).
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公开(公告)号:US11300542B2
公开(公告)日:2022-04-12
申请号:US16804787
申请日:2020-02-28
Applicant: University of Rhode Island Board of Trustees
Inventor: Jimmie Oxley , James L. Smith , Alexander Yevdokimov , Gerald Kagan
IPC: H01J49/00 , G01N27/622 , H01J49/04 , H01J49/02
Abstract: The present disclosure describes an improved sample preparation technique and adapter device for the removal of trace materials from swabs and delivery of the trace materials into a mass spectrometer (MS) or an ion mobility spectrometer (IMS). The adapter device and technique aids the delivery of the analyte into the instrument inlet and concurrently serves as an ionization source. The technique includes the steps of positioning or shaping the swab so that a pointed analyte release corner or tip is directed toward the inlet of the MS or IMS, adding a solvent to the swab and charging the swab to create an ionized analyte spray pointed at or positioned within the inlet of the detection instrument.
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公开(公告)号:US12285462B2
公开(公告)日:2025-04-29
申请号:US18325884
申请日:2023-05-30
Inventor: Yana K. Reshetnyak , Oleg A. Andreev , Anna Moshnikova , Donald M. Engelman
Abstract: The invention features methods and compositions for eliciting an anti-tumor response in a subject comprising administering to the subject a pHLIP● construct comprising an antibody recruiting molecule linked to one or more pHLIP● peptides by a non-cleavable linker compound. The construct increases the amount of the antibody recruiting molecule on the surface of a diseased cell.
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公开(公告)号:US20240255378A1
公开(公告)日:2024-08-01
申请号:US18402623
申请日:2024-01-02
Inventor: Carmen J. Quartapella , Mookkan Periyasamy , Elizabeth Sassano , Otto J. Gregory , Godi Fischer , Tao Wei , Zakary Kinzel , Noah A. Burke
IPC: G01M13/005 , G01M13/003 , H01J37/32
CPC classification number: G01M13/005 , G01M13/003 , H01J37/32513
Abstract: Methods, systems and a self-sensing valve assembly are described for monitoring seal life. The method includes providing a valve assembly movable from an open position to a closed position and including a seal seated within the valve and in contact with a surface of the valve assembly, wherein when the seal is in operation it is subject to degradation. At least one sensor is placed for measuring micro strain on a surface of the valve assembly or within the valve assembly. The valve assembly is placed in an operation wherein the seal is subject to degradation and the operation of the valve assembly is initiated. At a time after the operation is initiated, micro strain data is recorded and at least one other property related to a condition selected from an ambient condition of operation and a condition related to degradation of the seal is recorded; and the recorded data is analyzed against baseline data associated with 100% seal life to evaluate seal life at the time after the operation is initiated as a percentage of seal life less than 100%.
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