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    SOLUTION FOR REMOVING CATARACTS VIA LIQUEFRACTURE
    2.
    发明申请
    SOLUTION FOR REMOVING CATARACTS VIA LIQUEFRACTURE 审中-公开
    解决方案通过液体去除催化剂

    公开(公告)号：US20070173448A1

    公开(公告)日：2007-07-26

    申请号：US11565256

    申请日：2006-11-30

    申请人： Mandar Shah ,  Glenn Sussman ,  Donald Cohen ,  Uday Doshi ,  Kerry Markwardt

    发明人： Mandar Shah ,  Glenn Sussman ,  Donald Cohen ,  Uday Doshi ,  Kerry Markwardt

    IPC分类号： A61K38/39 ,  A61K31/717 ,  A61K31/715 ,  A61K31/765 ,  A61M31/00

    CPC分类号： A61K9/0048 ,  A61F9/00736

    摘要： An improved solution for use in the removal of cataractous lenses via liquefracture is described. The liquefracture solution contains a viscosity-enhancing agent to increase the residence time of the solution in the heating chamber of the liquefracture handpiece, thereby increasing the expulsion force of the solution from the handpiece (i.e., “pulse force”). An agent that releases gas when the liquefracture solution is heated in the handpiece may also be included in the solution, thereby also enhancing the pulse force of the solution upon expulsion from the handpiece. The solution preferably also contains a partially water-soluble agent that forms a temporarily insoluble precipitate when heated in a liquefracture handpiece. The precipitate acts as an abrasive agent when expelled with the liquefracture solution from the handpiece, thereby facilitating the cutting and disintegration of the cataractous lens material.

    摘要翻译： 描述了用于通过液压除去白内障透镜的改进的解决方案。 液化溶液含有粘度增强剂，以增加溶液在液化机构的加热室中的停留时间，从而增加溶液从手持件的排出力（即“脉冲力”）。 当液体溶液在手持件中被加热时释放气体的试剂也可以包含在溶液中，从而也可以在从手持件排出时增强溶液的脉冲力。 溶液优选还含有部分水溶性试剂，其在液化手机中加热时形成暂时不溶的沉淀。 当用液体溶液从手持件排出时，沉淀物用作研磨剂，从而有助于白内障镜片材料的切割和分解。

    INTRAOCULAR IRRIGATING SOLUTION HAVING IMPROVED FLOW CHARACTERISTICS
    3.
    发明申请
    INTRAOCULAR IRRIGATING SOLUTION HAVING IMPROVED FLOW CHARACTERISTICS 审中-公开
    具有改进流动特性的内部灌溉解决方案

    公开(公告)号：US20090258955A1

    公开(公告)日：2009-10-15

    申请号：US12423727

    申请日：2009-04-14

    申请人： Mandar V. Shah ,  Mikhail Boukhny ,  William H. Garner ,  Kerry L. Markwardt ,  Uday Doshi

    发明人： Mandar V. Shah ,  Mikhail Boukhny ,  William H. Garner ,  Kerry L. Markwardt ,  Uday Doshi

    IPC分类号： A61K47/38 ,  A61K47/02

    CPC分类号： A61K9/0048 ,  A61K38/14 ,  A61K38/39

    摘要： Improved intraocular irrigating solutions are described comprising a cellulose derivative such as hydroxypropylmethylcellulose. In addition, certain solutions of the present invention comprise glutathione and dextrose. The solutions have enhanced viscosities that reduce the risk of damage to intraocular tissues during intraocular surgical procedures by reducing the turbulence of the solutions and dampening the movement of tissue fragments and air bubbles. The solutions preferably also have modified surface tensions that more closely resemble the surface tension of the aqueous humor.

    摘要翻译： 描述了改进的眼内冲洗溶液，其包含纤维素衍生物如羟丙基甲基纤维素。 此外，本发明的某些溶液包含谷胱甘肽和葡萄糖。 该溶液具有增强的粘度，通过减少溶液的湍流并抑制组织碎片和气泡的运动，减少眼内手术过程中损伤眼内组织的风险。 溶液优选还具有更接近于房水表面张力的改性表面张力。

    Ophthalmic irrigating solution adapted for use in lasik surgery
    4.
    发明授权
    Ophthalmic irrigating solution adapted for use in lasik surgery 失效
    适用于拉米克手术的眼科冲洗液

    公开(公告)号：US06878694B2

    公开(公告)日：2005-04-12

    申请号：US10432273

    申请日：2001-11-29

    申请人： Uday Doshi ,  Kerry L. Markwardt ,  Pao-Li Wang ,  Emerson Maddox

    发明人： Uday Doshi ,  Kerry L. Markwardt ,  Pao-Li Wang ,  Emerson Maddox

    IPC分类号： A61K9/00 ,  A61K31/728 ,  A61K31/736 ,  A61K31/737 ,  A61K31/74 ,  A61K31/70

    CPC分类号： A61K31/728 ,  A61K9/0048 ,  A61K31/736 ,  A61K31/737 ,  A61K31/74

    摘要： Compositions and methods for facilitating the formulation and closure of a corneal flap during LASIK surgery are described. The compositions and methods are based on the use of one or more viscosity-enhancing agents (e.g., chondroitin sulfate) to provide an ophthalmic irrigating solution with improved coating properties and prolonged dwelling time on the cornea, thereby providing lubrication for the microkeratome used to form the corneal flap, reduce corneal epithelial abrasions, and help to produce smooth and consistent cuts with the microkeratome blade.

    摘要翻译： 描述了在LASIK手术期间促进角膜瓣的配制和闭合的组合物和方法。 组合物和方法基于使用一种或多种粘度增强剂（例如，硫酸软骨素）来提供具有改善的涂层性能和在角膜上延长的住院时间的眼用冲洗溶液，由此为用于形成的微型角膜刀提供润滑 角膜瓣，减少角膜上皮擦伤，并有助于使用微型角膜刀刀片产生平滑和一致的切口。

    Solution for removing cataracts via liquefracture
    8.
    发明授权
    Solution for removing cataracts via liquefracture 有权
    通过液压清除白内障的解决方案

    公开(公告)号：US07169755B2

    公开(公告)日：2007-01-30

    申请号：US10433166

    申请日：2001-12-11

    申请人： Mandar V. Shah ,  Glenn Sussman ,  Donald M Cohen ,  Uday Doshi ,  Kerry L. Markwardt

    发明人： Mandar V. Shah ,  Glenn Sussman ,  Donald M Cohen ,  Uday Doshi ,  Kerry L. Markwardt

    IPC分类号： A61K38/16 ,  A61M37/00

    CPC分类号： A61K9/0048 ,  A61F9/00736

    摘要： An improved solution for use in the removal of cataractous lenses via liquefracture is described. The liquefracture solution contains a viscosity-enhancing agent to increase the residence time of the solution in the heating chamber of the liquefracture handpiece, thereby increasing the expulsion force of the solution from the handpiece (i.e., “pulse force”). An agent that releases gas when the liquefracture solution is heated in the handpiece may also be included in the solution, thereby also enhancing the pulse force of the solution upon expulsion from the handpiece. The solution preferably also contains a partially water-soluble agent that forms a temporarily insoluble precipitate when heated in a liquefracture handpiece. The precipitate acts as an abrasive agent when expelled with the liquefracture solution from the handpiece, thereby facilitating the cutting and disintegration of the cataractous lens material.

    摘要翻译： 描述了用于通过液压除去白内障透镜的改进的解决方案。 液化溶液含有粘度增强剂，以增加溶液在液化机构的加热室中的停留时间，从而增加溶液从手持件的排出力（即“脉冲力”）。 当液体溶液在手持件中被加热时释放气体的试剂也可以包含在溶液中，从而也可以在从手持件排出时增强溶液的脉冲力。 溶液优选还含有部分水溶性试剂，其在液化手机中加热时形成暂时不溶的沉淀。 当用液体溶液从手持件排出时，沉淀物用作研磨剂，从而有助于白内障镜片材料的切割和分解。