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11 条记录 (耗时 0.018 秒)

    Detection method for C-RAF-1 genes
    2.
    发明授权
    Detection method for C-RAF-1 genes 失效
    C-RAF-1基因检测方法

    公开(公告)号：US5869308A

    公开(公告)日：1999-02-09

    申请号：US831317

    申请日：1997-04-01

    申请人： Ulf R. Rapp ,  Stephen M. Storm

    发明人： Ulf R. Rapp ,  Stephen M. Storm

    IPC分类号： A61K39/00 ,  C07K14/82 ,  C12Q1/68 ,  C12N9/12 ,  C07H21/04

    CPC分类号： A61K39/0011 ,  C07K14/82 ,  C12Q1/6886 ,  A61K39/00 ,  C12Q2600/106

    摘要： The present invention relates to (1) a method of identifying an individual at an increased risk for developing cancer, (2) a method for determining a prognosis in patients afflicted with cancer, and (3) a method for determining the proper course of treatment for a patient afflicted with cancer; comprising: amplifying a region of the c-raf-1 gene.

    摘要翻译： 本发明涉及（1）识别发生癌症风险增加的个体的方法，（2）确定患有癌症的患者的预后的方法，以及（3）确定适当治疗过程的方法 对于患有癌症的患者; 包括：扩增c-raf-1基因的区域。

    MICROORGANISMS AS CARRIERS OF NUCLEOTIDE SEQUENCES CODING FOR ANTIGENS AND PROTEIN TOXINS, PROCESS OF MANUFACTURING AND USES THEREOF
    4.
    发明申请
    MICROORGANISMS AS CARRIERS OF NUCLEOTIDE SEQUENCES CODING FOR ANTIGENS AND PROTEIN TOXINS, PROCESS OF MANUFACTURING AND USES THEREOF 有权
    微生物作为核苷酸序列编码抗原和蛋白质毒素的方法，其制造方法及其用途

    公开(公告)号：US20110287037A1

    公开(公告)日：2011-11-24

    申请号：US11939254

    申请日：2007-11-13

    申请人： Ivaylo Nikolov Gentschev ,  Joachim Fensterle ,  Ulf R. Rapp ,  Werner Goebel

    发明人： Ivaylo Nikolov Gentschev ,  Joachim Fensterle ,  Ulf R. Rapp ,  Werner Goebel

    IPC分类号： A61K35/66 ,  A61K39/12 ,  A61K39/02 ,  A61K39/145 ,  A61P37/00 ,  A61P35/00 ,  A61P35/02 ,  A61P31/00 ,  A61P31/12 ,  A61P31/04 ,  A61P29/00 ,  A61P31/16 ,  C12N1/21 ,  C12N15/63 ,  A61K39/00

    CPC分类号： C12N15/62 ,  A61K39/00 ,  A61K2039/5156 ,  A61K2039/523 ,  A61K2039/6037 ,  C07K2319/02 ,  C07K2319/035 ,  C07K2319/036 ,  C07K2319/55 ,  C12N15/625 ,  Y02A50/472 ,  Y02A50/476 ,  Y02A50/484

    摘要： The invention relates to a microorganism as a carrier of nucleotide sequences coding for antigens and protein toxins comprising the following components: (I) at least one nucleotide sequence coding for at least one complete or partial antigen of at least one wild-type or mutated protein; and (II) at least one nucleotide sequence coding for at least one protein toxin and/or at least one protein toxin subunit; and (III) a) at least one nucleotide sequence coding for at least one transport system which enables the expression of the expression products of component (I) and component (II) on the outer surface of the microorganism and/or enables the secretion of the expression products of component (I) and component (II); and/or coding for at least one signal sequence which enables the secretion of the expression products of component (I) and component (II); and/or (III) b) optionally, at least one nucleotide sequence coding for at least one protein for lysing the microorganism in the cytosol of mammalian cells and for intracellularly releasing plasmids or expression vectors, which are contained in the lysed microorganism; and (IV) at least one nucleotide sequence for at least one activation sequence for the expression of one or more of components (I) to (III), wherein said activation sequence can be activated in the microorganism and/or is tissue cell-specific, tumor cell-specific, macrophage-specific, dendrite-specific, lymphocyte-specific, function-specific or non-cell-specific”; wherein any of components (I) to (IV) can be present either once or several times and either identical or different. Also disclosed are a process of manufacturing thereof, corresponding plasmids or expression vectors and uses of the microorganism as a medicament.

    摘要翻译： 本发明涉及作为编码抗原和蛋白质毒素的核苷酸序列的载体的微生物，其包含以下组分：（I）编码至少一种野生型或突变型蛋白质的至少一种完整或部分抗原的至少一种核苷酸序列 ; 和（II）编码至少一种蛋白质毒素和/或至少一种蛋白质毒素亚基的至少一个核苷酸序列; 和（III）a）至少一个编码至少一种能够在组织（I）和组分（II）的表达产物在微生物外表面上表达的转运系统的核苷酸序列和/或使得能够分泌 组分（I）和组分（II）的表达产物; 和/或编码能够分泌组分（I）和组分（II）的表达产物的至少一种信号序列; 和/或（III）b）任选地至少一种编码至少一种蛋白质的核酸序列，用于裂解哺乳动物细胞的细胞质中的微生物和细胞内释放质粒或表达载体，所述质粒或表达载体包含在裂解的微生物中; 至少一个用于表达一种或多种组分（I）至（III）的活化序列的至少一个核苷酸序列，其中所述活化序列可以在微生物中活化和/或是组织细胞特异性 ，肿瘤细胞特异性，巨噬细胞特异性，枝晶特异性，淋巴细胞特异性，功能特异性或非细胞特异性“; 其中组分（I）至（IV）中的任何一种可以存在一次或几次，并且相同或不同。 还公开了其制备方法，相应的质粒或表达载体以及微生物作为药物的用途。

    Raf protein kinase therapeutics
    5.
    发明授权
    Raf protein kinase therapeutics 失效
    Raf蛋白激酶治疗

    公开(公告)号：US06689560B1

    公开(公告)日：2004-02-10

    申请号：US08207954

    申请日：1994-03-18

    申请人： Ulf R. Rapp ,  Harald App ,  Stephen M. Storm

    发明人： Ulf R. Rapp ,  Harald App ,  Stephen M. Storm

    IPC分类号： C12Q168

    CPC分类号： C12N15/1135 ,  A61K38/00 ,  C07K14/82

    摘要： It is a general object of this invention to provide a DNA segment comprising a Raf gene in an antisense orientation downstream of a promoter. It is a specific object of this invention to provide a method of inhibiting Raf expression comprising expressing an antisense Raf gene in a cell such that said Raf expression is inhibited. It is a further object of the invention to provide a method of inhibiting Raf kinase activity comprising replacement of a serine or threonine amino acid within the Raf gene for a non-phosphorylated amino acid.

    摘要翻译： 本发明的一般目的是提供一种包含在启动子下游的反义方向的Raf基因的DNA区段。 本发明的具体目的是提供抑制Raf表达的方法，包括在细胞中表达反义Raf基因，使得所述Raf表达被抑制。 本发明的另一个目的是提供一种抑制Raf激酶活性的方法，包括在非磷酸化氨基酸的Raf基因内替换丝氨酸或苏氨酸氨基酸。

    Anti-tumor vaccine
    8.
    发明授权
    Anti-tumor vaccine 失效
    抗肿瘤疫苗

    公开(公告)号：US5156841A

    公开(公告)日：1992-10-20

    申请号：US236947

    申请日：1988-08-26

    申请人： Ulf R. Rapp

    发明人： Ulf R. Rapp

    IPC分类号： A61K39/00 ,  C07K14/82

    CPC分类号： C07K14/82 ,  A61K39/0011 ,  A61K39/00

    摘要： An antitumor vaccine utilizing oncoproteins as immunogen is disclosed. The oncoprotein could be administered either as isolated, substantially pure product or expressed through a recombinant vaccinia virus containing either the complete coding sequence for the oncoprotein(s) or portions thereof.

    摘要翻译： 公开了使用癌蛋白作为免疫原的抗肿瘤疫苗。 癌蛋白可以作为分离的，基本上纯的产物施用，或通过含有癌蛋白或其部分的完整编码序列的重组痘苗病毒来表达。