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公开(公告)号：US20120248333A1
公开(公告)日：2012-10-04
申请号：US13430174
申请日：2012-03-26
IPC分类号： G01N21/64
CPC分类号： G01N21/6456 , A61B1/00186 , A61B1/0638 , A61B1/0646 , G01N2021/6471
摘要： A diagnosis device having an illumination system configured to produce white light along an illumination path, an observation system for observing the target region in a white-light and fluorescence mode, the observation system having an observation path having at least one first image sensor for receiving a white-light image and at least one second image sensor for receiving a fluorescence image, an observation spectral filter in the observation path are configured such that light in the spectral range of the fluorescence can be fed to the second image sensor while light in the spectral ranges outside of the fluorescence is blocked. An illumination spectral filter is arranged in the illumination path and having a characteristic of the observation spectral filter such that the target region is illuminated with the whole spectral range of the white light with the exception of the spectral range of the fluorescence to be observed.
摘要翻译： 一种具有照明系统的诊断装置，被配置为沿着照明路径产生白光，观察系统用于以白光和荧光模式观察所述目标区域，所述观察系统具有观察路径，所述观察路径具有至少一个用于接收的第一图像传感器 白光图像和用于接收荧光图像的至少一个第二图像传感器，观察路径中的观察光谱滤波器被配置为使得荧光的光谱范围内的光可以被馈送到第二图像传感器，同时在 荧光外的光谱范围被阻断。 照明光谱滤光器布置在照明路径中，并且具有观察光谱滤波器的特性，使得除了要观察的荧光的光谱范围之外，白色光的整个光谱范围被照射目标区域。
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公开(公告)号：US20110235324A1
公开(公告)日：2011-09-29
申请号：US13074975
申请日：2011-03-29
CPC分类号： A61B1/07 , A61B1/043 , A61B1/063 , A61B1/0638 , A61B1/0653 , A61B1/0661 , A61B1/0669 , A61B1/0676 , A61B1/0684
摘要： A light source device for endoscopic or exoscopic applications includes a flat first light source, a second light source, an illuminating beam path that is configured to provide a first light beam emanating from the first light source for an endoscopic or exoscopic application, and a coupling device to couple a second light beam from the second light source into the illuminating beam path, whereby the coupling device is configured in such a way that at the coupling site the cross-section surface of the second light beam is smaller than the cross-section surface of the first light beam.
摘要翻译： 用于内窥镜或外窥镜应用的光源装置包括平坦的第一光源，第二光源，照明光束路径，其被配置为提供从第一光源发出的用于内窥镜或外窥镜应用的第一光束，以及耦合 将第二光束从第二光源耦合到照明光束路径中的装置，由此耦合装置被配置成使得在耦合位置处，第二光束的横截面小于横截面 第一光束的表面。
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公开(公告)号：US20060240038A1
公开(公告)日：2006-10-26
申请号：US10559663
申请日：2004-06-07
申请人： Joachim Fensterle , Werner Goebel , Ulf Rapp , Jochen Stritzker , Andreas Schmidt , Ivatlo Gentschev , Tamara Potapenko
发明人： Joachim Fensterle , Werner Goebel , Ulf Rapp , Jochen Stritzker , Andreas Schmidt , Ivatlo Gentschev , Tamara Potapenko
IPC分类号： A61K39/12
CPC分类号： A61K35/17 , A61K35/12 , A61K35/13 , A61K35/15 , A61K35/74 , A61K2035/11 , A61K2039/5152 , A61K2039/5154 , A61K2039/521 , A61K2039/522 , A61K2039/523 , Y02A50/478 , Y02A50/484
摘要： The invention relates to the use of a cell, which is charged with a micro-organism that contains foreign DNA, in particular a bacterial micro-organism, to produce a pharmaceutical composition. Preferably, the foreign DNA codes for a defined active agent and the pharmaceutical composition is designed for use in the prophylaxis or treatment of a disease that can be treated with said active agent.
摘要翻译： 本发明涉及细胞的使用，其中装有含有外来DNA的微生物，特别是细菌微生物，以产生药物组合物。 优选地，将限定的活性剂和药物组合物的外源DNA编码设计用于预防或治疗可用所述活性剂治疗的疾病。
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公开(公告)号：US5987777A
公开(公告)日：1999-11-23
申请号：US091715
申请日：1998-09-09
申请人： Werner Goebel , Karlheinz Straub
发明人： Werner Goebel , Karlheinz Straub
CPC分类号： D21G9/0063 , D21F5/042
摘要： The invention relates to a dry end for drying a material web, in particular a paper or cardboard web, having at least one drying group with a plurality of drying cylinders and web guiding rollers and at least one nozzle device for transporting the threading part of the material web along a winding path by means of at least one conveyor band. The dry end is characterised in that groups of at least two nozzle devices (17, 19, 21) located at the same side of the material web (11) follow each other in the direction of transport of the material web (11).
摘要翻译： PCT No.PCT / EP96 / 05798 371 1998年9月9日第 102（e）1998年9月9日PCT PCT 1996年12月21日PCT公布。 公开号WO97 / 23690 日期1997年7月3日本发明涉及用于干燥材料纤维网，特别是纸或纸板幅材的干燥端，其具有至少一个具有多个干燥筒和幅材引导辊的干燥组和至少一个用于输送的喷嘴装置 通过至少一个传送带，沿着卷绕路径的材料卷材的穿线部分。 干端的特征在于，位于材料纤维网（11）的同一侧的至少两个喷嘴装置（17,19,21）的组在材料纤维网（11）的输送方向上彼此相邻。
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5.发明授权Oligonucleotides for the detection of enterobacteriaceae selected from salmolysin 失效用于检测选自溶血素的肠杆菌科的寡核苷酸
公开(公告)号：US5733724A
公开(公告)日：1998-03-31
申请号：US332747
申请日：1994-11-01
申请人： Andreas Bubert , Werner Goebel , Monika Goetz , Albrecht Ludwig , Peter Schubert , Siegfried Neumann
发明人： Andreas Bubert , Werner Goebel , Monika Goetz , Albrecht Ludwig , Peter Schubert , Siegfried Neumann
CPC分类号： C12Q1/689
摘要： The invention relates to oligonucleotides which are suitable for use as nucleic acid probes or as primers for the detection of Enterobacteriaceae, in particular of pathogenic Enterobacteriaceae, such as, for example, Salmonella sp. The oligonucieotides according to the invention are selected from the salmolysin-like DNA region and possess a sequence according to one of the formulae IIIa to IIIh, or a corresponding complementary sequence: ______________________________________ GAA TAT ATT GCG TTA GAT TAA T IIIa (SEQ ID NO:19) AAA CTG AAG CTA CAG GTG CC IIIb (SEQ ID NO:20) CTT AGC AAG CTA ATT ATA AGG IIIc (SEQ ID NO:21) GGC ACG GTT GGT GCG CAT TTG G IIId (SEQ ID NO:22) GCC ATA CGT GTG GCC ATG TGA IIIe (SEQ ID NO:23) GGC GTG TGG TCA GTA ACC TGA IIIf (SEQ ID NO:24) TTG CTG GCC AGC ACG ACA CG IIIg (SEQ ID NO:25) and GAA TCA TCA CCG CCC TGA AT IIIh (SEQ ID NO:25). ______________________________________
摘要翻译： 本发明涉及适合用作核酸探针或用作检测肠杆菌科，特别是病原肠杆菌科的引物的寡核苷酸，例如沙门氏菌属。 根据本发明的寡核苷酸选自溶血素样DNA区域，并且具有根据式IIIa至IIIh之一的序列或相应的互补序列：-GAA TAT ATT GCG TTA GAT TAA T IIIa（SEQ ID NO： 19） - AAA CTG AAG CTA CAG GTG CC IIIb（SEQ ID NO：20） - CTT AGC AAG CTA ATT ATA AGG IIIc（SEQ ID NO：21）-GGC ACG GTT GGT GCG CAT TTG G IIId（SEQ ID NO：22 ） - GCC ATA CGT GTG GCC ATG TGA IIIe（SEQ ID NO：23）-GGC GTG TGG TCA GTA ACC TGA IIIf（SEQ ID NO：24）-TTG CTG GCC AGC ACG ACA CG IIIg（SEQ ID NO：25）和 - GAA TCA TCA CCG CCC TGA AT IIIh（SEQ ID NO：25）。 -
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公开(公告)号：US09072454B2
公开(公告)日：2015-07-07
申请号：US13074975
申请日：2011-03-29
CPC分类号： A61B1/07 , A61B1/043 , A61B1/063 , A61B1/0638 , A61B1/0653 , A61B1/0661 , A61B1/0669 , A61B1/0676 , A61B1/0684
摘要： A light source device for endoscopic or exoscopic applications includes a flat first light source, a second light source, an illuminating beam path that is configured to provide a first light beam emanating from the first light source for an endoscopic or exoscopic application, and a coupling device to couple a second light beam from the second light source into the illuminating beam path, whereby the coupling device is configured in such a way that at the coupling site the cross-section surface of the second light beam is smaller than the cross-section surface of the first light beam.
摘要翻译： 用于内窥镜或外窥镜应用的光源装置包括平坦的第一光源，第二光源，照明光束路径，其被配置为提供从第一光源发出的用于内窥镜或外窥镜应用的第一光束，以及耦合 将第二光束从第二光源耦合到照明光束路径中的装置，由此耦合装置被配置成使得在耦合位置处，第二光束的横截面小于横截面 第一光束的表面。
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公开(公告)号：US20140340760A1
公开(公告)日：2014-11-20
申请号：US14281023
申请日：2014-05-19
CPC分类号： G02B27/141 , G02B23/2423 , G02B27/1006 , G02B27/283
摘要： A beam combining device for combining light from a first light source and light from a second light source of a light-source device for a medical apparatus includes a body made of a transparent material, a face which reflects in at least either a dichroic or polarization-dependent manner and is situated in or on the body, which face is transparent to light having a first spectrum or a first polarization and reflects light having a second spectrum or a second polarization, and a light-entrance face on the body, which light-entrance face is provided and arranged so that light enters the beam combining device through the light-entrance face. At least either the light-entrance face or the face reflecting in a dichroic or polarization-dependent manner is curved.
摘要翻译： 用于组合来自第一光源的光和用于医疗设备的光源装置的第二光源的光束组合装置包括由透明材料制成的主体，至少反射二向色或极化的面 并且位于身体中或身体上，该面对于具有第一光谱或第一偏振的光是透明的，并且反射具有第二光谱或第二偏振的光以及身体上的光入射面，该光 提供并布置了入射面，使得光通过光入射面进入光束组合装置。 光入射面或以二向色或偏振依赖的方式反射的面中的至少一个是弯曲的。
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8.发明授权Non-pathogenic and/or attenuated bacteria capable of inducing apoptosis in macrophages, process of manufacturing and uses thereof 失效能够诱导巨噬细胞凋亡的非致病性和/或减毒细菌，制造方法及其用途公开(公告)号：US08679473B2
公开(公告)日：2014-03-25
申请号：US13364437
申请日：2012-02-02
CPC分类号： C12N1/20 , A61K35/74 , C12R1/42 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/483
摘要： The invention relates to an non-pathogenic and/or attenuated bacterium which is capable of inducing apoptosis in macrophages.
摘要翻译： 本发明涉及能诱导巨噬细胞凋亡的非致病和/或减毒细菌。
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9.发明授权Microorganisms as carriers of nucleotide sequences coding for antigens and protein toxins, process of manufacturing and uses thereof 有权微生物作为编码抗原和蛋白质毒素的核苷酸序列的载体，其制备方法及其用途公开(公告)号：US08669091B2
公开(公告)日：2014-03-11
申请号：US11939254
申请日：2007-11-13
CPC分类号： C12N15/62 , A61K39/00 , A61K2039/5156 , A61K2039/523 , A61K2039/6037 , C07K2319/02 , C07K2319/035 , C07K2319/036 , C07K2319/55 , C12N15/625 , Y02A50/472 , Y02A50/476 , Y02A50/484
摘要： A Escherichia, Salmonella, Yersinia, Vibrio, Listeria, Shigella, or Pseudomonas bacterium that has the following components: (I) a polynucleotide encoding a heterologous antigenic determinant that induces a CTL response against a tumor cell; (II) a polynucleotide encoding a heterologous protein toxin or toxin subunit; and (III) (a) a polynucleotide encoding a transport system that expresses the products of (I) and (II) on the outer surface of the bacterium or that secretes products of (I) and (II) from the bacterium; and (IV) a polynucleotide that activates the expression of one or more of (I). (II), and/Or (III) in the bacterium wherein polynucleotides (I), (II), (III) and (IV) are different from each other and polynucleotides (I), (II) and (III) encode proteins that are different from each other.
摘要翻译： 具有以下组分的大肠杆菌，沙门氏菌，耶尔森氏菌，弧菌属，利斯特氏菌属，志贺氏菌属或假单胞菌属细菌：（I）编码诱导针对肿瘤细胞的CTL应答的异源抗原决定簇的多核苷酸; （II）编码异源蛋白毒素或毒素亚基的多核苷酸; 和（III）（a）编码在细菌外表面上表达（I）和（II）的产物的运输系统的多核苷酸，或从细菌中分泌（I）和（II）的产物; 和（IV）激活（I）中的一种或多种的表达的多核苷酸。 （I），（II），（III）和（IV）彼此不同的细菌中的多核苷酸（II）和/或（III），并且多核苷酸（I），（II）和（III） 这是不同的。
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公开(公告)号：US20050244374A1
公开(公告)日：2005-11-03
申请号：US10504944
申请日：2003-02-13
IPC分类号： C12N15/09 , A61K35/74 , A61K35/76 , A61K39/00 , A61K48/00 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , C07K14/705 , C07K14/765 , C12N1/00 , C12N1/21 , C12N7/04 , C12N9/24 , C12N15/63 , C12N15/74
CPC分类号： C12Y302/01031 , A61K48/00 , A61K48/0008 , C07K14/70575 , C07K14/765 , C07K2319/02 , C12N9/16 , C12N9/2402 , C12N9/2434 , C12N15/74 , C12Y301/16001
摘要： The invention relates to an enveloped microorganism in whose genome the following components are inserted and can be expressed: I) a nucleotide sequence that encodes a directly or indirectly, antiproliferatively or cytotoxically active expression product or a plurality of said expression products, II) a nucleotide sequence that encodes or is constitutively active for a blood plasma protein under the control of a activation sequence that can be activated in the microorganism, III) optionally, a nucleotide sequence that encodes or is constitutively active for a cell-specific ligand under the control of an activation sequence that can be activated in the microorganism, IV) a nucleotide sequence for a transport system that induces expression of the expression products of components I) and II) and optionally III) on the outer surface of the microorganism or that induces secretion of the expression products of component I) and expression of component II) and optionally component III) and that is preferably constitutively active, V) optionally a nucleotide sequence for a protein used for lysis of the microorganism in the cytosol of mammalian cells and for the intracellular release of plasmids with at least one or more components I) and VI) contained in the lysed microorganism, and VI) an activation sequence that can be activated in the microorganism, and/or that is tissue-specific, tumor cell-specific, function-specific or not cell-specific, for expressing component I). The inventive microorganism is further characterized in that any of components I) to VI) can be present either single or several times, and can be either identical or different.
摘要翻译： 本发明涉及其包含的微生物，其基因组中插入以下组分并可以表达：I）编码直接或间接抗增殖或细胞活性的表达产物或多种所述表达产物的核苷酸序列，II）核苷酸 在可在微生物中活化的活化序列的控制下编码或组成型的血浆蛋白质的序列，III）任选地，编码或组成型活性的细胞特异性配体的控制下的核苷酸序列 可以在微生物中活化的活化序列，IV）诱导表达产物的转运体系的核苷酸序列，其诱导组分I）和II）和任选地III）的表达产物在微生物的外表面上，或诱导分泌 组分I）和组分II）和任选的组分III）和tha的表达产物 t优选是组成型活性的，V）任选的用于在哺乳动物细胞的细胞溶质中裂解微生物的蛋白质的核苷酸序列，以及用裂解的细胞内含有至少一种或多种组分I）和VI）的质粒的细胞内释放的核苷酸序列 微生物和VI）可以在微生物中活化的活化序列和/或组织特异性，肿瘤细胞特异性，功能特异性或非细胞特异性的表达组分I）的活化序列。 本发明的微生物的特征还在于组分I）至VI）中的任何一种可以单独或多次存在，并且可以是相同的或不同的。
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