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    Process for preparing M- or P-substituted phenylalkanols by alkylation
    1.
    发明授权
    Process for preparing M- or P-substituted phenylalkanols by alkylation 有权
    通过烷基化制备M-或P-取代的苯基链烷醇的方法

    公开(公告)号：US08692025B2

    公开(公告)日：2014-04-08

    申请号：US13503515

    申请日：2010-10-14

    申请人： Andreas Lanver ,  Klaus Ebel ,  Karl Beck ,  Ralf Pelzer ,  Jörg Botzem ,  Ulrich Griesbach

    发明人： Andreas Lanver ,  Klaus Ebel ,  Karl Beck ,  Ralf Pelzer ,  Jörg Botzem ,  Ulrich Griesbach

    IPC分类号： C07C45/29 ,  C07C29/32

    CPC分类号： C07C29/32 ,  C07C29/56 ,  C07C45/29 ,  C07C33/20 ,  C07C47/228

    摘要： The invention relates to a process for the preparation of m- or p-substituted phenylalkanols of the formula (I) in which R1 is bonded to the phenyl ring in the m- or p-position and is C1-C5-alkyl, and R2, R3, R4 and R5, independently of one another, are hydrogen or methyl, wherein an unsubstituted phenylalkanol of the formula (II) in which R2, R3, R4 and R5 have the meanings given under formula (I) is alkylated together with a C1-C5-alkyl halide of the formula (III) R1-Hal  (III), in which R1 has the meaning given under formula (I) and Hal is halogen, in the presence of a Friedel-Crafts catalyst to give an m- or p-alkyl-substituted phenylalkanol of the formula (I), then the reaction mixture is worked-up and the desired m- or p-alkyl-substituted phenylalkanol of the formula (I) is separated off, the other formed by-products are returned to the reaction mixture and these are isomerized in the presence of a Friedel-Crafts catalyst to give the desired m- or p-alkyl-substituted phenylalkanol. From the m- or p-alkyl-substituted phenylalkanols of the formula (I), it is possible to form, by oxidation or dehydrogenation, as products of value, the corresponding aldehydes, which play an interesting role as fragrances and aroma chemicals.

    摘要翻译： 本发明涉及一种制备式（I）的间 - 或对 - 取代的苯烷醇的方法，其中R 1与m-或p-位上的苯环键合并且是C1-C5-烷基，R2 R 3，R 4和R 5彼此独立地为氢或甲基，其中R 2，R 3，R 4和R 5具有式（I）所示含义的式（II）的未取代的苯基烷醇与 其中R 1具有式（I）所示含义，Hal为卤素的式（III）R1-Hal（Ⅲ）的C1-C5烷基卤化物，在Friedel-Crafts催化剂存在下，得到m- 或式（I）的对烷基取代的苯基链烷醇，然后将反应混合物处理并分离所需的式（I）的间 - 或对 - 烷基取代的苯基烷醇，另一个形成的副产物 返回到反应混合物中，并将它们在Friedel-Crafts催化剂存在下异构化，得到所需的间 - 或对 - 烷基取代的苯基 kanol 从式（I）的间 - 或对 - 烷基取代的苯烷醇，可以通过氧化或脱氢形成作为有价值的产物，相应的醛作为香料和香气化学品起着重要的作用。

    Method for producing 2-substituted tetrahydropyranols
    3.
    发明授权
    Method for producing 2-substituted tetrahydropyranols 有权
    2-取代四氢吡喃醇的制备方法

    公开(公告)号：US08618315B2

    公开(公告)日：2013-12-31

    申请号：US13321417

    申请日：2010-05-11

    申请人： Gabriele Gralla ,  Ralf Pelzer ,  Klaus Ebel ,  Ulrich Griesbach ,  Jörg Botzem

    发明人： Gabriele Gralla ,  Ralf Pelzer ,  Klaus Ebel ,  Ulrich Griesbach ,  Jörg Botzem

    IPC分类号： C07D309/10

    CPC分类号： C07D309/12

    摘要： The present invention relates to a process for the preparation of 2-substituted 4-hydroxy-4-methyltetrahydropyranols by reacting 3-methylbut-3-en-1-ol (isoprenol) with the corresponding aldehydes in the presence of a strongly acidic cation exchanger. Specifically, the present invention relates to a corresponding process for the preparation of 2-isobutyl-4-hydroxy-4-methyltetrahydropyran by reacting isoprenol with isovaleraldehyde.

    摘要翻译： 本发明涉及通过使3-甲基丁-3-烯-1-醇（异戊二烯）与相应的醛在强酸性阳离子交换剂存在下反应制备2-取代的4-羟基-4-甲基四氢吡喃醇的方法 。 具体地说，本发明涉及通过异戊二烯与异戊醛反应制备2-异丁基-4-羟基-4-甲基四氢吡喃的相应方法。

    Electrochemical preparation of sterically hindered amines
    5.
    发明授权
    Electrochemical preparation of sterically hindered amines 有权
    空间位阻胺的电化学制备

    公开(公告)号：US07863486B2

    公开(公告)日：2011-01-04

    申请号：US12306616

    申请日：2007-06-27

    申请人： Ulrich Griesbach ,  Siegfried R. Waldvogel ,  Itamar Michael Malkowsky ,  Joern Kulisch

    发明人： Ulrich Griesbach ,  Siegfried R. Waldvogel ,  Itamar Michael Malkowsky ,  Joern Kulisch

    IPC分类号： C07C209/30 ,  C25B3/04

    CPC分类号： C25B3/04 ,  C07C209/30 ,  C07C2601/14 ,  C07C211/35 ,  C07C211/40

    摘要： The present invention relates to a process for preparing an amine, which comprises the step cathodic reduction of a corresponding oxime derivative of the general formula (I) where R is C1-6-alkyl or C2-6-alkenyl which is optionally substituted by one or more substituents selected independently from the group consisting of phenyl, O—C1-6-alkyl, NH—C1-6-alkyl, N(C1-6-alkyl)2, OH and NH2; R1 is H; C1-6-alkyl or C(O)—C1-6-alkyl and A is a 5-, 6- or 7-membered hydrocarbon ring which is saturated or has a double bond and in which at least one CH2 group may, if appropriate, be replaced by —O—, —S— —NH—, —N═ or —N(C1-6-alkyl)- and which may optionally be substituted by one or more further substituents selected independently from the group consisting of phenyl, C1-6-alkyl, O—C1-6-alkyl, NH—C1-6-alkyl, N(C1-6-alkyl)2, OH and NH2; wherein, based on the ring carbon bearing the substituent R, the oxime derivative has an excess of the R or S form of at least 10%.

    摘要翻译： 本发明涉及一种制备胺的方法，其包括通式（I）的相应肟衍生物的步骤阴极还原，其中R是C 1-6 - 烷基或任选被一个取代基取代的C 2-6 - 烯基 或更多取代基独立地选自苯基，O-C 1-6 - 烷基，NH-C 1-6 - 烷基，N（C 1-6 - 烷基）2，OH和NH 2; R1是H; C 1-6 - 烷基或C（O）-C 1-6 - 烷基，A是饱和或具有双键并且其中至少一个CH 2基团的5-，6-或7-元烃环，如果 适当地被-O - ， - S - NH - ， - N =或-N（C 1-6 - 烷基）取代，并且其可以任选地被一个或多个另外的取代基取代，所述取代基独立地选自苯基 ，C 1-6 - 烷基，O-C 1-6 - 烷基，NH-C 1-6 - 烷基，N（C 1-6 - 烷基）2，OH和NH 2; 其中，基于带有取代基R的环碳，肟衍生物具有至少10％的R或S形式的过量。

    Process for the preparation and isolation of 2-substituted tetrahydropyranols
    6.
    发明授权
    Process for the preparation and isolation of 2-substituted tetrahydropyranols 有权
    2-取代四氢吡喃醇的制备和分离方法

    公开(公告)号：US08791276B2

    公开(公告)日：2014-07-29

    申请号：US13157732

    申请日：2011-06-10

    申请人： Gabriele Gralla ,  Karl Beck ,  Margarethe Klos ,  Ulrich Griesbach

    发明人： Gabriele Gralla ,  Karl Beck ,  Margarethe Klos ,  Ulrich Griesbach

    IPC分类号： C07D309/10

    CPC分类号： C07D309/10

    摘要： Process for the preparation of 2-substituted 4-hydroxy-4-methyltetrahydropyrans of the formula (I) where the radical R1 is a straight-chain or branched alkyl or alkenyl radical having 1 to 12 carbon atoms, an optionally alkyl-substituted cycloalkyl radical having in total 3 to 12 carbon atoms or an optionally alkyl- and/or alkoxy-substituted aryl radical having in total 6 to 12 carbon atoms, comprising the reaction of 3-methylbut-3-en-1-ol of the formula (II) with an aldehyde of the formula (III) R1—CHO  (III), where the radical R1 has the same meaning as in formula (I) and where the reaction is carried out in the presence of water and in the presence of a strongly acidic cation exchanger, and then the isolation and/or the distillative separation is carried out in a dividing wall column or in an interconnection of (at least) two distillation columns in the form of a thermal coupling and one or more side take-off points at an absolute operating pressure of up to 500 mbar.

    摘要翻译： 用于制备式（I）的2-取代的4-羟基-4-甲基四氢吡喃的方法，其中基团R1是具有1至12个碳原子的直链或支链烷基或烯基，任选烷基取代的环烷基 具有总共3至12个碳原子的烷基和/或烷氧基取代的芳基，其总共包含6至12个碳原子，包括式（II）的3-甲基丁-3-烯-1-醇的反应 ）与式（III）的醛R 1-CHO（III）反应，其中基团R 1具有与式（I）中相同的含义，并且其中反应在水的存在下并且在强烈存在下进行 酸性阳离子交换剂，然后分离和/或蒸馏分离在分隔壁塔中或在热耦合形式的（至少）两个蒸馏塔的互连中进行，并且一个或多个侧向起飞点 在绝对的工作压力高达500毫巴。

    Process for the Preparation and Isolation of 2-Substituted Tetrahydropyranols
    8.
    发明申请
    Process for the Preparation and Isolation of 2-Substituted Tetrahydropyranols 有权
    2-取代的四氢吡喃醇的制备和分离方法

    公开(公告)号：US20110306779A1

    公开(公告)日：2011-12-15

    申请号：US13157732

    申请日：2011-06-10

    申请人： Gabriele Gralla ,  Karl Beck ,  Margarethe Klos ,  Ulrich Griesbach

    发明人： Gabriele Gralla ,  Karl Beck ,  Margarethe Klos ,  Ulrich Griesbach

    IPC分类号： C07D309/10

    CPC分类号： C07D309/10

    摘要： Process for the preparation of 2-substituted 4-hydroxy-4-methyltetrahydropyrans of the formula (I) where the radical R1 is a straight-chain or branched alkyl or alkenyl radical having 1 to 12 carbon atoms, an optionally alkyl-substituted cycloalkyl radical having in total 3 to 12 carbon atoms or an optionally alkyl- and/or alkoxy-substituted aryl radical having in total 6 to 12 carbon atoms, comprising the reaction of 3-methylbut-3-en-1-ol of the formula (II) with an aldehyde of the formula (III) R1—CHO  (III), where the radical R1 has the same meaning as in formula (I) and where the reaction is carried out in the presence of water and in the presence of a strongly acidic cation exchanger, and then the isolation and/or the distillative separation is carried out in a dividing wall column or in an interconnection of (at least) two distillation columns in the form of a thermal coupling and one or more side take-off points at an absolute operating pressure of up to 500 mbar.

    摘要翻译： 用于制备式（I）的2-取代的4-羟基-4-甲基四氢吡喃的方法，其中基团R1是具有1至12个碳原子的直链或支链烷基或烯基，任选烷基取代的环烷基 具有总共3至12个碳原子的烷基和/或烷氧基取代的芳基，其总共包含6至12个碳原子，包括式（II）的3-甲基丁-3-烯-1-醇的反应 ）与式（III）的醛R 1-CHO（III）反应，其中基团R 1具有与式（I）中相同的含义，并且其中反应在水的存在下并且在强烈存在下进行 酸性阳离子交换剂，然后分离和/或蒸馏分离在分隔壁塔中或在热耦合形式的（至少）两个蒸馏塔的互连中进行，并且一个或多个侧向起飞点 在绝对的工作压力高达500毫巴。

    Method For Producing Alkoxylated 2,5-Dihydrofuran But-2-Ene Derivatives Or Tetra-1,1,4,4-Alkoxylated But-2-Ene Derivatives
    10.
    发明申请
    Method For Producing Alkoxylated 2,5-Dihydrofuran But-2-Ene Derivatives Or Tetra-1,1,4,4-Alkoxylated But-2-Ene Derivatives 审中-公开
    生产烷氧基化2,5-二氢呋喃丁-2-烯衍生物或四 - 1,1,4,4-烷氧基化丁-2-烯衍生物的方法

    公开(公告)号：US20080110763A1

    公开(公告)日：2008-05-15

    申请号：US11908506

    申请日：2006-03-23

    申请人： Ingo Richter ,  Hermann Putter ,  Ulrich Griesbach ,  Nils Bottke

    发明人： Ingo Richter ,  Hermann Putter ,  Ulrich Griesbach ,  Nils Bottke

    IPC分类号： C25D3/62 ,  C07D307/02

    CPC分类号： C07D307/32 ,  C07D307/88 ,  C07D307/89 ,  C25B3/02

    摘要： A process for the preparation of 2,5-dihydrofuran derivatives substituted in the 3- or 4-position, which in the 2- or in the 5-position or at both positions each carry a C1- to C6-alkoxy radical (DHF-alkoxy derivatives 1), or 1,1,4,4-tetraalkoxy-but-2-ene derivatives substituted in the 3- or 4-position, from 2-butene-1 ,4-diol derivatives of the general formula (I) in which the radicals R1 and R2 independently of one another are hydrogen, C1- to C6-alkyl, C6- to C12-aryl or C5- to C12-cycloalkylene orR1 and R2, together with the double bond to which they are bonded, form a C6- to C12-aryl radical or a mono- or polyunsaturated C5- to C12-cycloalkyl radical,orfrom their mixture with 2,5-dihydrofuran derivatives substituted in the 3- position or 4-position, which in the 2- or in the 5-position carry a C1- to C6-alkoxy radical, by electro-chemical oxidation in the presence of a C1- to C6-monoalkyl alcohol.

    摘要翻译： 制备在3-或4-位取代的2,5-二氢呋喃衍生物的方法，其中2-或5-位或两个位置各自携带C 1 - 至C 6 - 烷氧基（DHF-烷氧基衍生物1）或在3-或4-位取代的1,1,4,4-四烷氧基 - 丁-2-烯衍生物，2 其中基团R 1和R 2彼此独立的通式（I）的1-丁烯-1,4-二醇衍生物是氢，C 1 -C 6烷基， 1〜C 6 - 烷基，C 6 - 至C 12 - 芳基或C 5〜 > - > C 12 - 亚环烷基或R 1和R 2与它们所键合的双键一起形成C < C 6 -C 12 - C 12 - 芳基或单不饱和C 5〜C 12 - 环烷基 ，或它们与3-或4-位取代的2,5-二氢呋喃衍生物的混合物，其在2-或5-位上携带C 1 H 通过在C 1 -C 6 - C 6 - 单烷基醇存在下的电化学氧化反应生成C 6〜C 6 - 烷氧基 。