公开(公告)号：US20250059499A1

公开(公告)日：2025-02-20

申请号：US18573200

申请日：2022-06-22

Applicant: THE UNIVERSITY OF BRITISH COLUMBIA ,  SIMON FRASER UNIVERSITY

Inventor： Jayachandran N. KIZHAKKEDATHU ,  Erika M.J. SIREN ,  Jonathan C. CHOY ,  Haiming D. LUO ,  Stephen G. WITHERS ,  Caigan DU ,  Winnie ENNS

IPC: C12N5/00 ,  C07K5/113 ,  C07K7/06 ,  C07K7/08

Abstract: Provided herein are compounds including a linear polyglycerol, a peptide tag, with either a linker-sugar-sialic acid moiety or a sulfate group, a preservation solutions including the compounds, methods for using the compounds or the preservation solutions to cell surface engineering (CSE) of a cell, a tissue, an organ for transplant, and methods for making the compounds. In particular, the CSE may recapitulate or rebuild glycocalyx on the luminal endothelial surface of an organ to limit immune rejection of the organ after transplant.

公开(公告)号：US20250051428A1

公开(公告)日：2025-02-13

申请号：US18785939

申请日：2024-07-26

Applicant: The University of British Columbia ,  ProMIS Neurosciences, Inc.

Inventor： Neil R. Cashman ,  Steven S. Plotkin ,  Judith Maxwell Silverman ,  Ebrima Gibbs ,  Johanne Kaplan

IPC: C07K16/18 ,  A61K38/17 ,  A61K39/00 ,  A61K49/00 ,  A61P25/28 ,  G01N33/68

Abstract: The disclosure pertains to antibodies that bind A-beta oligomers and methods of making and using said antibodies.

公开(公告)号：US20250042758A1

公开(公告)日：2025-02-06

申请号：US18718609

申请日：2022-12-14

Applicant: THE UNIVERSITY OF BRITISH COLUMBIA

Inventor： Curtis BERLINGUETTE ,  Zishuai ZHANG

IPC: C01F11/18 ,  B01D53/14 ,  B01D53/62 ,  B01D53/78 ,  C09D5/16 ,  C09D127/18 ,  C09K9/00

Abstract: Particles of a carbonate compound, such as calcium carbonate, in an amorphous form may be precipitated from solution, freeze dried and compressed to form transparent or translucent objects. The objects may, for example comprise blocks, bricks or other shapes that may be used in construction of buildings. Advantageously the carbonate compound may incorporate carbonate ions obtained by capture of carbon dioxide from an atmosphere of air, flue gas, exhaust gas or the like. Captured carbon may be sequestered in the objects indefinitely.

公开(公告)号：US20250017544A1

公开(公告)日：2025-01-16

申请号：US18773341

申请日：2024-07-15

Applicant: The University of British Columbia

Inventor： Anthony Cooper ,  Yousif Murad

IPC: A61B6/50 ,  A61B6/00 ,  A61B6/12 ,  G06T7/00 ,  G06T7/60 ,  G06T7/73 ,  G06V10/25 ,  G06V10/26 ,  G06V10/774 ,  G06V10/82

Abstract: Systems and methods for performing a pediatric lower limb alignment assessment by: receiving a pediatric lower limb radiographic image; identifying a plurality of regions of interest in the radiographic image using a first artificial intelligence model such that each one of the plurality of regions of interest contains at least one of a plurality of anatomical features of interest; determining a plurality of landmark locations for each one of the plurality of identified regions of interest in the radiographic image using a second AI model; and calculating one or more parameter values representative of the pediatric lower limb alignment based on a geometric relationship between the plurality of landmark locations.

公开(公告)号：US12186724B2

公开(公告)日：2025-01-07

申请号：US18653698

申请日：2024-05-02

Applicant: The University of British Columbia

Inventor： Jordan Mackenzie ,  Dominic Mark Martinez ,  Sean Matthew Delfel ,  Michael Buchen ,  Rami Younes

IPC: B01J14/00 ,  C08J3/02

Abstract: A method for transporting a material (which may be a viscous fluid) in a conduit defined by a conduit-defining surface comprises: flowing a first fluid and a second fluid in a flow direction within the conduit; contacting the first and second fluids to one another at a contact region to thereby facilitate a reaction creating a reaction product in an interface region that extends downstream from the contact region, wherein the reaction product is an elastic-solid; and transporting the material in the flow direction within the conduit. At locations downstream of interface region, the reaction product creates a barrier between the viscous fluid and the conduit-defining surface.

公开(公告)号：US12173055B2

公开(公告)日：2024-12-24

申请号：US17014425

申请日：2020-09-08

Applicant: The University of British Columbia

Inventor： Neil R. Cashman ,  Steven S. Plotkin

IPC: C07K7/64 ,  A61K38/00 ,  A61K39/00 ,  A61K39/385 ,  A61K47/64 ,  A61K51/10 ,  A61P25/28 ,  A61P37/06 ,  C07K5/10 ,  C07K5/11 ,  C07K5/113 ,  C07K5/117 ,  C07K7/06 ,  C07K14/47 ,  C07K16/18 ,  G01N33/68

Abstract: The disclosure pertains to N-terminal epitopes identified in A-beta, including conformational epitopes, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.

公开(公告)号：US12171833B2

公开(公告)日：2024-12-24

申请号：US17797627

申请日：2021-02-06

Applicant: The University of British Columbia

Inventor： Veronika Schmitt ,  John K. Jackson ,  Martin E. Gleave ,  Claudia Kesch

IPC: A61K47/34 ,  A61K9/00 ,  A61K31/337 ,  A61K31/7068 ,  A61K47/10 ,  A61K47/32 ,  A61K47/36

Abstract: This invention provides compositions for controlled localized depositing of one or more drugs within a subject. More particularly, described herein are compositions comprising a) a polyethylene glycol (PEG) composition having a first low molecular weight PEG (Mw between 200-500 Da) and a second low molecular weight PEG (Mw between 500-2000 Da) and b) a mucoadhesive in polymer. Alternatively, composition may comprise a) a polyethylene glycol (PEG) composition having a first low molecular weight PEG (Mw between 200-500 Da) and a second low molecular weight PEG (Mw between 500-2000 Da), b) a water insoluble polymer and c) a mucoadhesive polymer. Furthermore, the composition may further comprise one or more drugs. Also provided are methods of manufacturing and administering the compositions described herein, which are used as biodegradable, injectable mucoadhesive low-viscosity pastes.

公开(公告)号：US20240391153A1

公开(公告)日：2024-11-28

申请号：US18749620

申请日：2024-06-21

Applicant: The University of British Columbia

Inventor： Jordan MACKENZIE ,  Dominic Mark MARTINEZ ,  Rami YOUNES ,  Michael BUCHEN

IPC: B29C48/30 ,  B29C48/00 ,  B29C48/21 ,  B29C48/32 ,  B29K33/00 ,  B29K105/00 ,  B29K105/16 ,  B29L23/00

Abstract: Example methods and apparatus for creating a reaction product. An example method comprises flowing a first fluid in a flow direction in a first conduit in a multilayer extrusion reactor apparatus. The first fluid may be characterized by inertial forces dominating viscous forces of the first fluid. The method flows a second fluid in a flow direction in a second conduit in the apparatus. The first and second fluids may be miscible with one another. The method shapes the first and second conduits to provide an interface region between the first and second fluids. The method permits a reaction to create a reaction product in the interface region. The reaction product may mitigate flow-disrupting mixing between the first and second fluids.

公开(公告)号：US20240386249A1

公开(公告)日：2024-11-21

申请号：US18199865

申请日：2023-05-19

Applicant: The University of British Columbia

Inventor： William Harvey ,  Saeid Naderiparizi ,  Vaden Masrani ,  Christian Dietrich Weilbach ,  Frank Wood

IPC: G06N3/047 ,  G06N7/01

Abstract: Methods, systems, and techniques for generating one or more conditionally dependent data entries using a probabilistic generative model, and for training that model. The probabilistic generative model is trained using a plurality of data generation tasks respectively corresponding to a plurality of vectors each having a sequence of differently indexed data entries that are conditionally dependent on each other. Each of the data generation tasks involves generating at least one latent data entry selected from the sequence of data entries in response to being provided at least one index for each of the at least one latent data entry. Training can be performed by minimizing an expected value of a denoising loss over all training stages.

公开(公告)号：US12134572B2

公开(公告)日：2024-11-05

申请号：US18317660

申请日：2023-05-15

Applicant: THE UNIVERSITY OF BRITISH COLUMBIA

Inventor： Fariborz Taghipour

IPC: C02F1/32 ,  H05K1/02 ,  H05K1/18 ,  H05K7/20 ,  C02F103/02

Abstract: A UV reactor irradiates a flow of fluid with UV radiation. The reactor comprises: a fluid conduit defined by a heat conducting conduit body comprising one or more heat conducting walls for permitting a flow of fluid therethrough; a UV-LED operatively connected to a PCB and oriented for directing radiation into the fluid conduit. The PCB comprises a heat conducting substrate having a first surface. The conduit body is in thermal contact with the first surface of the heat conducting substrate. Heat is dissipated from the UV-LED via the heat conducting substrate, the thermal contact between the first surface of the heat conducting substrate and the heat conducting conduit body, and from the one or more heat conducting walls of the heat conducting conduit body to the fluid flowing through the fluid conduit.