公开(公告)号：US20240150294A1

公开(公告)日：2024-05-09

申请号：US18546525

申请日：2022-02-17

Applicant: The University of Chicago ,  Loyola University of Chicago

Inventor： Sean W. Fanning ,  Geoffrey L. Greene ,  David J. Hosfield

IPC: C07D221/20 ,  A61K45/06 ,  A61P35/00 ,  C07D401/12

CPC classification number: C07D221/20 ,  A61K45/06 ,  A61P35/00 ,  C07D401/12

Abstract: Provided is a compound of formula (I) or a pharmaceutically acceptable salt thereof, in which R1, R2, R3, R4, R5, X1, X2, and n are described herein. Also provided is a method of treating an estrogen-mediated disease requiring inhibition of estrogen receptor alpha (ER-alpha), such as cancer, in a subject or inhibiting ER-alpha in a cell with the compound of formula (I) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20250157674A1

公开(公告)日：2025-05-15

申请号：US18821279

申请日：2024-08-30

Applicant: The University of Chicago

Inventor： Ishanu Chattopadhyay

IPC: G16H50/80 ,  G16B30/00

Abstract: Systems and methods are disclosed for predicting the rise of different strains of viruses. A method comprises reading a genetic sequence of a first strain of a virus; identifying a plurality of residue indices in the genetic sequence; for each of the plurality of indices, assigning a predictor, the predictor configured to predict a residue for its assigned index based upon a residue of at least one other index, the predictors thereby forming a network; and determining, based on the network of predictors, a probability of transition of the first strain to a second strain.

公开(公告)号：US20250144156A1

公开(公告)日：2025-05-08

申请号：US18915109

申请日：2024-10-14

Applicant: The University of Chicago

Inventor： Arjun S. Raman ,  Ana Rita Almeida de Oliveira ,  Seppe Kuehn

IPC: A61K35/74 ,  A61K35/00 ,  A61K35/742 ,  A61K35/745

Abstract: The present document relates to microbial consortia and uses thereof.

公开(公告)号：US20250127814A1

公开(公告)日：2025-04-24

申请号：US18695701

申请日：2022-10-06

Applicant: THE UNIVERSITY OF CHICAGO

Inventor： Anthony KOSSIAKOFF ,  Annika SÄÄF ,  Marcin URA ,  Somnath MUKHERJEE

IPC: A61K35/17 ,  A61K40/11 ,  A61K40/15 ,  A61K40/31 ,  A61K40/42 ,  A61K45/06 ,  A61P35/00 ,  C07K16/28 ,  C12N5/0783 ,  C12N15/85 ,  G01N33/573 ,  G01N33/58

Abstract: Aspects of the present disclosure are directed to borealin-targeting polypeptides, including antibodies, antibody-drug conjugates, antibody fragments, antibody-like molecules, and chimeric receptors. Also disclosed herein are nucleic acids encoding for such borealin-targeting polypeptides and cells comprising such nucleic acids. Described are methods for detection, diagnosis, and treatment of cancer using borealin-targeting polypeptides.

公开(公告)号：US12281060B2

公开(公告)日：2025-04-22

申请号：US17594086

申请日：2020-04-02

Applicant: The University of Chicago ,  The United States of America, as Represented by the Secretary, Department of Health and Human Services ,  President and Fellows of Harvard College ,  IIT Research Institute ,  Beth Israel Deaconess Medical Center, Inc. ,  REGENTS OF THE UNIVERSITY OF MINNESOTA ,  THE TRUSTEES OF PURDUE UNIVERSITY

Inventor： Julian Solway ,  Nickolai Dulin ,  Diane Luci ,  David Maloney ,  Chan Young Park ,  Jeffrey Fredberg ,  David McCormick ,  Ramaswamy Krishnan

IPC: C07D311/46 ,  A61P11/00 ,  C07C311/46 ,  C07D207/48 ,  C07D211/96 ,  C07D277/52 ,  C07D295/26

Abstract: Disclosed herein is a class of molecules termed remodilins that are effective in treating asthma, pulmonary fibrosis, and associated disorders. The molecules ameliorate asthma and pulmonary fibrosis symptoms by various mechanisms, including inhibiting airway smooth muscle contractile protein accumulation, reducing airway constrictor hyperresponsiveness, inhibiting bronchial fibroblast transformation into myofibroblasts, and/or treating or preventing airway or pulmonary fibrosis.

公开(公告)号：US20250122240A1

公开(公告)日：2025-04-17

申请号：US18928498

申请日：2024-10-28

Applicant: The University of Chicago

Inventor： Raymond E. MOELLERING ,  Jeffrey E. MONTGOMERY

IPC: C07K7/50 ,  C07K1/04 ,  C07K1/10

Abstract: The present disclosure provides macrocyclic and macrobicyclic peptides with secondary structures that are stabilized over the corresponding non-cyclic peptides. The macrocyclic and macrobicyclic peptides are formed from peptides with adduct-forming, complementary reactive side chain moieties.

公开(公告)号：US12263351B2

公开(公告)日：2025-04-01

申请号：US16975034

申请日：2019-02-19

Applicant: The University of Chicago

Inventor： Bozhi Tian ,  Francisco Bezanilla ,  Erin Adams ,  Ramya Parameswaran ,  Yuanwen Jiang ,  João L. Carvalho-de-Souza ,  Kelliann C. Koehler ,  Michael G. Burke

IPC: A61N5/06 ,  C12N5/0783 ,  C12N5/0793 ,  A61B18/00 ,  C12N13/00

Abstract: This disclosure relates to methods for modulating activity of a cell capable of being activated by light and treating diseases with such methods. The disclosure also provides systems suitable for use in such methods, particularly systems having silicon nanostructures.

公开(公告)号：US20250092449A1

公开(公告)日：2025-03-20

申请号：US18954222

申请日：2024-11-20

Applicant: THE UNIVERSITY OF CHICAGO

Inventor： Chuan HE ,  Boxuan Simen ZHAO ,  Pradnya NARKHEDE ,  Chang LIU ,  Xiaolong CUI

IPC: C12Q1/6844 ,  C12Q1/6806

Abstract: Methods, compositions and kits are provided to amplify an amount of genomic methylated DNA that can be subsequently analyzed and/or sequenced. It has particular use with small amounts of DNA, including, but not limited to cell free DNA samples. In some embodiments, the ratio of polymerase and methyltransferase is controlled in order to provide maximum yields. In some embodiments, a dual primase/polymerase is used.

公开(公告)号：US12240890B2

公开(公告)日：2025-03-04

申请号：US16611128

申请日：2018-05-16

Applicant: The University of Chicago

Inventor： Eugene B. Chang ,  Joseph F. Pierre ,  Katharine A. Harris

IPC: C07K14/72 ,  A61K38/17 ,  A61K45/06 ,  A61P31/10

Abstract: Provided herein are compositions and methods for treating and/or preventing pathogenic fungal infection and for maintenance of microbiome commensalism. In particular, provided herein are compositions comprising modified peptide YY (PYY) peptides and therapeutic and/or prophylactic methods of use thereof.

公开(公告)号：US20250059260A1

公开(公告)日：2025-02-20

申请号：US18723099

申请日：2022-12-21

Applicant: THE UNIVERSITY OF CHICAGO

Inventor： Jenna GUTHMILLER ,  Patrick WILSON

IPC: C07K16/10 ,  A61K39/00 ,  A61K45/06 ,  A61P31/16 ,  G01N33/569

Abstract: To address the need in the art, the inventors have comprehensively characterized Aspects of the disclosure relate to novel antibody and antigen binding fragments. Further aspects relate to polypeptides comprising the antigen binding fragment(s) of the disclosure, and compositions comprising the polypeptides, antibodies, and/or antigen binding fragments of the disclosure. Also described are nucleic acids encoding an antibody or antigen binding fragment of the disclosure.