公开(公告)号：US20080085379A1

公开(公告)日：2008-04-10

申请号：US11859047

申请日：2007-09-21

申请人： Vassil Boiadjiev ,  Gilbert Brown ,  Lal Pinnaduwage ,  Thomas Thundat ,  Peter Bonnesen ,  Gudrun Goretzki

发明人： Vassil Boiadjiev ,  Gilbert Brown ,  Lal Pinnaduwage ,  Thomas Thundat ,  Peter Bonnesen ,  Gudrun Goretzki

IPC分类号： B05D3/10

CPC分类号： G01N29/022 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00 ,  G01N2291/0256 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427

摘要： Highly sensitive sensor platforms for the detection of specific reagents, such as chromate, gasoline and biological species, using microcantilevers and other microelectromechanical systems (MEMS) whose surfaces have been modified with photochemically attached organic monolayers, such as self-assembled monolayers (SAM), or gold-thiol surface linkage are taught. The microcantilever sensors use photochemical hydrosilylation to modify silicon surfaces and gold-thiol chemistry to modify metallic surfaces thereby enabling individual microcantilevers in multicantilever array chips to be modified separately. Terminal vinyl substituted hydrocarbons with a variety of molecular recognition sites can be attached to the surface of silicon via the photochemical hydrosilylation process. By focusing the activating UV light sequentially on selected silicon or silicon nitride hydrogen terminated surfaces and soaking or spotting selected metallic surfaces with organic thiols, sulfides, or disulfides, the microcantilevers are functionalized. The device and photochemical method are intended to be integrated into systems for detecting specific agents including chromate groundwater contamination, gasoline, and biological species.

摘要翻译： 用于检测特定试剂（如铬酸盐，汽油和生物物种）的高灵敏度传感器平台，使用微型悬臂梁和其表面已经用光化学附着的有机单层如自组装单层（SAM）进行了改性的其他微机电系统（MEMS） 或金 - 硫醇表面连接。 微悬臂传感器使用光化学氢化硅烷化来改性硅表面和金 - 硫醇化学，以改变金属表面，从而使多单元阵列芯片中的单个微悬臂梁可以单独修改。 具有多种分子识别位点的末端乙烯基取代的烃可以通过光化学氢化硅烷化方法连接到硅的表面。 通过将激活的UV光依次聚焦在选定的硅或氮化硅氢终止表面上，并用有机硫醇，硫化物或二硫化物浸泡或点样选定的金属表面，微悬臂梁被功能化。 该装置和光化学方法旨在集成到用于检测特定试剂的系统中，包括铬酸盐地下水污染物，汽油和生物物质。

公开(公告)号：US20060057026A1

公开(公告)日：2006-03-16

申请号：US11152627

申请日：2005-06-14

申请人： Vassil Boiadjiev ,  Gilbert Brown ,  Lal Pinnaduwage ,  Thomas Thundat ,  Peter Bonnesen ,  Gudrun Goretzki

发明人： Vassil Boiadjiev ,  Gilbert Brown ,  Lal Pinnaduwage ,  Thomas Thundat ,  Peter Bonnesen ,  Gudrun Goretzki

IPC分类号： G01N31/00 ,  G01N27/416 ,  B32B37/02 ,  B05D5/12 ,  B05D3/00

CPC分类号： G01N29/022 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00 ,  G01N2291/0256 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427

摘要： Highly sensitive sensor platforms for the detection of specific reagents, such as chromate, gasoline and biological species, using microcantilevers and other microelectromechanical systems (MEMS) whose surfaces have been modified with photochemically attached organic monolayers, such as self-assembled monolayers (SAM), or gold-thiol surface linkage are taught. The microcantilever sensors use photochemical hydrosilylation to modify silicon surfaces and gold-thiol chemistry to modify metallic surfaces thereby enabling individual microcantilevers in multicantilever array chips to be modified separately. Terminal vinyl substituted hydrocarbons with a variety of molecular recognition sites can be attached to the surface of silicon via the photochemical hydrosilylation process. By focusing the activating UV light sequentially on selected silicon or silicon nitride hydrogen terminated surfaces and soaking or spotting selected metallic surfaces with organic thiols, sulfides, or disulfides, the microcantilevers are functionalized. The device and photochemical method are intended to be integrated into systems for detecting specific agents including chromate groundwater contamination, gasoline, and biological species.

摘要翻译： 用于检测特定试剂（如铬酸盐，汽油和生物物种）的高灵敏度传感器平台，使用微型悬臂梁和其表面已经用光化学附着的有机单层如自组装单层（SAM）进行了改性的其他微机电系统（MEMS） 或金 - 硫醇表面连接。 微悬臂传感器使用光化学氢化硅烷化来改性硅表面和金 - 硫醇化学，以改变金属表面，从而使多单元阵列芯片中的单个微悬臂梁可以单独修改。 具有多种分子识别位点的末端乙烯基取代的烃可以通过光化学氢化硅烷化方法连接到硅的表面。 通过将激活的UV光依次聚焦在选定的硅或氮化硅氢终止表面上，并用有机硫醇，硫化物或二硫化物浸泡或点样选定的金属表面，微悬臂梁被功能化。 该装置和光化学方法旨在集成到用于检测特定试剂的系统中，包括铬酸盐地下水污染物，汽油和生物物质。

公开(公告)号：US20060191320A1

公开(公告)日：2006-08-31

申请号：US11059170

申请日：2005-02-16

申请人： Lal Pinnaduwage ,  Thomas Thundat ,  Gilbert Brown ,  John Hawk ,  Vassil Boiadjiev

发明人： Lal Pinnaduwage ,  Thomas Thundat ,  Gilbert Brown ,  John Hawk ,  Vassil Boiadjiev

IPC分类号： G01N29/02 ,  G01N29/00

CPC分类号： G01N29/022 ,  G01N29/036 ,  G01N29/2418 ,  G01N2291/0224 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0427

摘要： A chemically functionalized cantilever system has a cantilever coated on one side thereof with a reagent or biological species which binds to an analyte. The system is of particular value when the analyte is a toxic chemical biological warfare agent or an explosive.

摘要翻译： 化学功能化的悬臂系统在其一侧上具有悬臂，其具有结合分析物的试剂或生物物质。 当分析物是有毒化学生物战剂或爆炸物时，该系统是特别有价值的。

公开(公告)号：US20060032289A1

公开(公告)日：2006-02-16

申请号：US11052556

申请日：2005-02-07

申请人： Lal Pinnaduwage ,  Dechang Yi ,  Thomas Thundat ,  John Hawk

发明人： Lal Pinnaduwage ,  Dechang Yi ,  Thomas Thundat ,  John Hawk

IPC分类号： G01N27/14

CPC分类号： G01N29/036 ,  G01N33/0057 ,  G01N2291/0256

摘要： A two-track piezoresistive cantilever detects explosives in ambient air by measuring resistance changes in the cantilever when one piezoresistive track is pulse heated to cause deflagration of explosive adhered to the surface of the cantilever. The resistance measurement is through the second piezoresistive track, which is located at the most resistance-sensitive area. The resistance change of this track is caused by the temperature change of the cantilever as well as the bending of the cantilever due to bi-material thermal expansion. The detecting method using this novel cantilever avoids the use of any optical components such as a laser and position sensing detector (PSD), which are necessary in traditional detecting systems using cantilevers. Therefore, it can extremely reduce the complexity of the detecting system and make a portable chemical detection system possible that is small, less expensive, and able to be mass produced and is particularly useful for the detection of explosives.

摘要翻译： 双轨压阻悬臂通过测量一个压阻磁道被脉冲加热时的悬臂梁的电阻变化来检测环境空气中的爆炸物，从而引起附着在悬臂表面的爆炸物爆燃。 电阻测量是通过位于最电阻敏感区域的第二压阻磁道。 该轨道的电阻变化是由于悬臂的温度变化以及由于双材料热膨胀引起的悬臂的弯曲引起的。 使用这种新颖的悬臂的检测方法避免使用诸如激光和位置感测检测器（PSD）的任何光学部件，这在使用悬臂的传统检测系统中是必需的。 因此，能够极大地降低检测系统的复杂性，使便携式化学检测系统成本小，成本低廉，能够批量生产，对爆炸物的检测特别有用。

公开(公告)号：US20070175760A1

公开(公告)日：2007-08-02

申请号：US11731952

申请日：2007-04-02

申请人： Thomas Thundat ,  Thomas Ferrell ,  Gilbert Brown

发明人： Thomas Thundat ,  Thomas Ferrell ,  Gilbert Brown

IPC分类号： G01N27/00

CPC分类号： G01N27/305

摘要： A method, system, and apparatus are provided for separating molecules, such as biomolecules. The method, system, and apparatus utilize an electrochemical cell having at least to electrodes, one electrode comprising a photo-sensitive material capable of generating a photopotential. Molecules are moved through an electrolyte medium between the at least two electrodes based upon localized photopotentials.

摘要翻译： 提供了一种分离分子的方法，系统和装置，例如生物分子。 该方法，系统和装置利用至少具有电极的电化学电池，一个电极包括能够产生光致电位的光敏材料。 基于局部的光电势，分子在至少两个电极之间移动通过电解质介质。

公开(公告)号：US20180266404A1

公开(公告)日：2018-09-20

申请号：US15923496

申请日：2018-03-16

申请人： Sean Preston Wagner ,  Thomas Thundat

发明人： Sean Preston Wagner ,  Thomas Thundat

IPC分类号： F03H99/00

CPC分类号： F03H99/00

摘要： This patent seeks to describe a design and method of production of a solid state radiometric thruster for the intent of producing a new method of powered flight at varying scales of operation. By using modern nano-manufacturing techniques it is possible to create surface microstructures of the same size as the mean free path for gases at any desired operational pressure, allowing for radiometric forces to be harnessed for propulsion even when the total part dimensions are several orders of magnitude larger than would normally allow this effect to create a noticeable force.

公开(公告)号：US20160209369A1

公开(公告)日：2016-07-21

申请号：US14995998

申请日：2016-01-14

申请人： Vakhtang Putkaradze ,  Arindam Phani ,  Prashanthi Kovur ,  Thomas Thundat

发明人： Vakhtang Putkaradze ,  Arindam Phani ,  Prashanthi Kovur ,  Thomas Thundat

IPC分类号： G01N29/036 ,  G01N33/00

CPC分类号： G01N29/036 ,  G01N29/022 ,  G01N33/0027 ,  G01N2291/0215 ,  G01N2291/02809

摘要： A dissipation-based sensor includes a single resonator with a nano-structured surface. The sensor exhibits improved sensitivity, up to about 2 orders of magnitude higher than a single resonator without a nano-structured surface. The sensor operates by measuring and estimating the fluid friction per oscillation cycle, operating in normal conditions without vacuum (e.g., in air or other ambient gas) at room temperature. The sensor can provide measurement data at a speed that is orders of magnitude faster than pre-existing resonance-based methods, as it is based on measurements from a few cycles only. The dissipation-based sensor may be utilized in a broad range of fast, inexpensive, hand-held measuring devices. Additionally, the sensor is capable of operating at standard temperature and pressure.

摘要翻译： 基于耗散的传感器包括具有纳米结构表面的单个谐振器。 该传感器具有提高的灵敏度，比没有纳米结构表面的单个谐振器高出约2个数量级。 传感器通过测量和估计每个振荡周期的流体摩擦力，在正常条件下在室温下无真空（例如在空气或其它环境气体中）运行。 传感器可以以比现有的基于共振的方法快几个数量级的速度提供测量数据，因为它仅基于几个周期的测量。 基于耗散的传感器可以用于宽范围的快速，便宜的手持测量装置中。 此外，传感器能够在标准温度和压力下运行。

公开(公告)号：US20070220979A1

公开(公告)日：2007-09-27

申请号：US11386023

申请日：2006-03-21

申请人： Ming Su ,  Thomas Thundat ,  David Hedden

发明人： Ming Su ,  Thomas Thundat ,  David Hedden

IPC分类号： G01N29/04 ,  G01N9/24

CPC分类号： G01N29/075 ,  G01N29/0681 ,  G01N29/2418 ,  G01N2291/0423 ,  G01N2291/044 ,  G01N2291/048 ,  G01N2291/102

摘要： A method and apparatus for identifying a sample, involves illuminating the sample with light of varying wavelengths, transmitting an acoustic signal against the sample from one side and receiving a resulting acoustic signal on another side, detecting a change of phase in the acoustic signal corresponding to the light of varying wavelengths, and analyzing the change of phase in the acoustic signal for the varying wavelengths of illumination to identify the sample. The apparatus has a controlled source for illuminating the sample with light of varying wavelengths, a transmitter for transmitting an acoustic wave, a receiver for receiving the acoustic wave and converting the acoustic wave to an electronic signal, and an electronic circuit for detecting a change of phase in the acoustic wave corresponding to respective ones of the varying wavelengths and outputting the change of phase for the varying wavelengths to allow identification of the sample. The method and apparatus can be used to detect chemical composition or visual features. A transmission mode and a reflection mode of operation are disclosed.

摘要翻译： 用于识别样品的方法和装置包括用变化波长的光照射样品，从一侧向样品传输声信号，并在另一侧接收所得到的声信号，检测对应于 变化波长的光，并分析用于变化的照明波长的声信号中的相位变化以识别样品。 该装置具有用于用不同波长的光照射样品的受控源，用于传输声波的发射器，用于接收声波并将声波转换为电子信号的接收器，以及用于检测变化的电子电路 声波中相应于相应变化波长的相位，并输出变化波长的相位变化，以允许样本的识别。 该方法和装置可用于检测化学成分或视觉特征。 公开了传输模式和反射操作模式。

公开(公告)号：US20070220978A1

公开(公告)日：2007-09-27

申请号：US11639184

申请日：2006-12-14

申请人： Ming Su ,  Thomas Thundat ,  David Hedden

发明人： Ming Su ,  Thomas Thundat ,  David Hedden

IPC分类号： G01N29/00

CPC分类号： G01N29/075 ,  G01N29/0681 ,  G01N29/2418 ,  G01N2291/012 ,  G01N2291/02466 ,  G01N2291/0423 ,  G01N2291/0427 ,  G01N2291/044 ,  G01N2291/048 ,  G01N2291/102

摘要： A method and apparatus for identifying a sample, involves illuminating the sample with light of varying wavelengths, transmitting an acoustic signal against the sample from one portion and receiving a resulting acoustic signal on another portion, detecting a change of phase in the acoustic signal corresponding to the light of varying wavelengths, and analyzing the change of phase in the acoustic signal for the varying wavelengths of illumination to identify the sample. The apparatus has a controlled source for illuminating the sample with light of varying wavelengths, a transmitter for transmitting an acoustic wave, a receiver for receiving the acoustic wave and converting the acoustic wave to an electronic signal, and an electronic circuit for detecting a change of phase in the acoustic wave corresponding to respective ones of the varying wavelengths and outputting the change of phase for the varying wavelengths to allow identification of the sample. The method and apparatus can be used to detect chemical composition or visual features. A transmission mode and a reflection mode of operation are disclosed. The method and apparatus can be applied at nanoscale to detect molecules in a biological sample.

摘要翻译： 用于识别样品的方法和装置包括用变化的波长的光照射样品，从一个部分发射针对样品的声信号，并在另一部分上接收所得到的声信号，检测对应的声信号中的相位变化 变化波长的光，并分析用于变化的照明波长的声信号中的相位变化以识别样品。 该装置具有用于用不同波长的光照射样品的受控源，用于传输声波的发射器，用于接收声波并将声波转换成电子信号的接收器，以及用于检测变化的电子电路 声波中相应于相应变化波长的相位，并输出变化波长的相位变化，以允许样本的识别。 该方法和装置可用于检测化学成分或视觉特征。 公开了传输模式和反射操作模式。 该方法和装置可应用于纳米尺度以检测生物样品中的分子。

公开(公告)号：US20060047283A1

公开(公告)日：2006-03-02

申请号：US10926216

申请日：2004-08-25

申请人： Boyd Evans ,  Thomas Thundat ,  Richard Komistek ,  Douglas Dennis ,  Mohamed Mahfouz

发明人： Boyd Evans ,  Thomas Thundat ,  Richard Komistek ,  Douglas Dennis ,  Mohamed Mahfouz

IPC分类号： A61F2/30 ,  A61F2/38

CPC分类号： A61F2/38 ,  A61B5/0031 ,  A61B5/076 ,  A61B5/1076 ,  A61B5/412 ,  A61B5/4519 ,  A61B5/4523 ,  A61B5/4528 ,  A61B5/6846 ,  A61F2/32 ,  A61F2/3877 ,  A61F2/40 ,  A61F2/4657 ,  A61F2002/4672 ,  A61F2002/488 ,  Y10S623/914

摘要： A device for providing in vivo diagnostics of loads, wear, and infection in orthopedic implants having at least one load sensor associated with the implant, at least one temperature sensor associated with the implant, at least one vibration sensor associated with the implant, and at least one signal processing device operatively coupled with the sensors. The signal processing device is operable to receive the output signal from the sensors and transmit a signal corresponding with the output signal.