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公开(公告)号：US10821116B2
公开(公告)日：2020-11-03
申请号：US15279939
申请日：2016-09-29
申请人： VECTURA GMBH
IPC分类号： A61K31/5578 , A61K9/00 , A61K31/191 , A61M15/00 , A61M11/00 , A61K9/08 , A61M16/00 , A61M11/06
摘要： The present invention relates to novel methods, compositions and kits useful for the treatment of pulmonary diseases such as pulmonary arterial hypertension. In particular, aerosolisable compositions of iloprost are provided which are for use in inhalation therapy. Their administration is by bolus inhalation, which is patient-friendly, effective, and well tolerated. Bolus inhalation may, for example, be achieved using an efficient nebuliser based on the vibrating mesh technology.
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公开(公告)号：US20150174343A1
公开(公告)日：2015-06-25
申请号：US14382392
申请日：2013-03-08
申请人： VECTURA GMBH
CPC分类号： A61M11/003 , A61M11/005 , A61M11/02 , A61M11/06 , A61M15/00 , A61M15/0021 , A61M15/0086 , A61M15/009 , A61M15/06 , A61M2205/75 , A61M2206/10
摘要： The invention relates to a mixing channel for an inhalation device, and in particular to a mixing channel with improved injection and mixing properties for injecting and mixing a liquid drug into an air flow streaming in the mixing channel, thereby producing an aerosol to be inhaled by a patient. One aspect of the invention relates to a mixing channel for an inhalation device, comprising an inlet opening, an outlet opening, and an injection zone located between the inlet opening and the outlet opening, wherein the injection zone has a longitudinal center axis, wherein the injection zone comprises (a) a built-in nebulizer, or (b) a detachable nebulizer, or (c) a member adapted to receive a detachable nebulizer, wherein the effective cross sectional area of the mixing channel in a plane perpendicular to the longitudinal center axis is smaller in the injection zone than upstream of the injection zone.
摘要翻译： 本发明涉及一种用于吸入装置的混合通道，特别涉及具有改进的注射和混合性能的混合通道，用于将液体药物注入和混合到在混合通道中流动的空气流中，从而产生将被 病人。 本发明的一个方面涉及一种用于吸入装置的混合通道，包括入口，出口和位于入口和出口之间的注射区，其中注射区具有纵向中心轴线，其中， 注射区域包括（a）内置雾化器，或（b）可拆卸雾化器，或（c）适于接纳可拆卸雾化器的构件，其中混合通道在垂直于纵向的平面中的有效截面面积 注射区域的中心轴比注射区域的上游小。
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公开(公告)号：US10561805B2
公开(公告)日：2020-02-18
申请号：US15517693
申请日：2015-10-09
申请人： ABLYNX N.V. , VECTURA GMBH
发明人： Koen Allosery , Erik Depla , Martin Huber , Tobias Kolb , Bernhard Müllinger , Massimiliano Germani , Juliane Schick , Maria-Laura Sargentini
摘要： Methods are provided for the treatment of RSV infections in young children. More specifically, methods are provided wherein polypeptides that bind F protein of hRSV and that neutralize RSV infection are administered to the lungs of young children at specific dose regimens.
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公开(公告)号：US10857310B2
公开(公告)日：2020-12-08
申请号：US14382392
申请日：2013-03-08
申请人： VECTURA GMBH
摘要： The invention relates to a mixing channel for an inhalation device, and in particular to a mixing channel with improved injection and mixing properties for injecting and mixing a liquid drug into an air flow streaming in the mixing channel, thereby producing an aerosol to be inhaled by a patient. One aspect of the invention relates to a mixing channel for an inhalation device, comprising an inlet opening, an outlet opening, and an injection zone located between the inlet opening and the outlet opening, wherein the injection zone has a longitudinal center axis, wherein the injection zone comprises (a) a built-in nebulizer, or (b) a detachable nebulizer, or (c) a member adapted to receive a detachable nebulizer, wherein the effective cross sectional area of the mixing channel in a plane perpendicular to the longitudinal center axis is smaller in the injection zone than upstream of the injection zone.
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公开(公告)号：US10512739B2
公开(公告)日：2019-12-24
申请号：US15517579
申请日：2015-10-09
申请人： ABLYNX N.V. , VECTURA GMBH
发明人： Koen Allosery , Martin Huber , Tobias Kolb , Bernhard Müllinger , Juliane Schick , Erik Depla
IPC分类号： A61M15/00 , A61M15/02 , C07K16/10 , A61K39/395 , A61K47/10 , A61K9/00 , A61K47/26 , A61M11/00 , A61M15/06 , A61M16/20 , A61M11/04 , A61M16/00 , A61K39/42 , A61K45/06 , A61K39/00
摘要： An inhalation device, assembly or system can include a kit and a pharmaceutical composition. The device can be adapted for administering therapeutic aerosols to pediatric patients, including neonates, infants or toddlers. The device can further include a vibrating mesh aerosol generator that can be insertable into a flow channel of the inhalation device through a lateral opening, and a valved face mask. The device can be connectable to a gas source through which a gas, such as oxygen, can be received into the flow channel at a low flow rate.
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公开(公告)号：US20170304565A1
公开(公告)日：2017-10-26
申请号：US15517579
申请日：2015-10-09
申请人： ABLYNX N.V. , VECTURA GMBH
发明人： Koen ALLOSERY , Martin HUBER , Tobias KOLB , Bernhard MÜLLINGER , Juliane SCHICK , Erik DEPLA
摘要： An inhalation device, assembly or system can include a kit and a pharmaceutical composition. The device can be adapted for administering therapeutic aerosols to pediatric patients, including neonates, infants or toddlers. The device can further include a vibrating mesh aerosol generator that can be insertable into a flow channel of the inhalation device through a lateral opening, and a valved face mask. The device can be connectable to a gas source through which a gas, such as oxygen, can be received into the flow channel at a low flow rate.
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公开(公告)号：US09486427B2
公开(公告)日：2016-11-08
申请号：US14438989
申请日：2013-09-12
申请人： VECTURA GMBH
IPC分类号： A61K31/191 , A61M15/00 , A61K9/00 , G06F19/00 , A61K9/12 , A61K31/5578
CPC分类号： A61K31/191 , A61K9/0073 , A61K9/0078 , A61K9/008 , A61K9/12 , A61K31/5578 , A61M15/0065 , A61M15/0085 , A61M15/009 , G06F19/00 , G06F19/3462 , Y02A90/26
摘要： The present invention relates to novel methods, compositions and kits useful for the treatment of pulmonary diseases such as pulmonary arterial hypertension. In particular, aerosolisable compositions of iloprost are provided which are for use in inhalation therapy. The administration is by inhalation over a short period of time, which is patient-friendly, effective, and well tolerated. Inhalation may, for example, be achieved using an efficient nebulizer based on the vibrating mesh technology.
摘要翻译： 本发明涉及可用于治疗肺部疾病如肺动脉高压的新方法，组合物和试剂盒。 特别地，提供伊洛前列素的气溶胶组合物，其用于吸入治疗。 行政当局是在短时间内吸入，这是耐心友好，有效和耐受性良好的。 吸入可以例如使用基于振动筛网技术的有效雾化器来实现。
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公开(公告)号：US08910625B2
公开(公告)日：2014-12-16
申请号：US14063115
申请日：2013-10-25
申请人： Vectura GmbH
发明人： Bernhard Mullinger , Tobias Kolb , Martin Huber , Tobias Hoffmann
CPC分类号： A61M15/009 , A61M11/005 , A61M11/042 , A61M15/00 , A61M15/002 , A61M15/0021 , A61M15/0071 , A61M15/0085 , A61M15/0091 , A61M15/025 , A61M16/0003 , A61M16/201 , A61M2016/0027 , A61M2016/003 , A61M2016/0033 , A61M2205/27 , A61M2205/276 , A61M2205/3334 , A61M2205/3584 , A61M2205/52 , A61M2205/583 , A61M2205/584 , A61M2205/6045 , A61M2205/8206
摘要： An inhalation device having a base unit, a mouthpiece, and an aerosol head is provided. The base unit has an air inlet, an air outlet opening, a groove for receiving the mouthpiece, and key lock member(s). The mouthpiece has two segments: a first segment which is insertable into the groove of the base unit and has an air inlet opening and a lateral opening for receiving an aerosol generator and a second segment with an aerosol outlet. The aerosol head has an aerosol generator, a liquid reservoir, and key lock member(s) complementary to those of the base unit. The base unit, mouthpiece and aerosol head are connectible with one another such that when engaging the members of the key lock with the complementary members, the aerosol generator is inserted into the lateral opening of the mouthpiece.
摘要翻译： 提供了具有基座单元，接口管和气溶胶头的吸入装置。 基座单元具有空气入口，出气口，用于容纳接口的槽和钥匙锁定构件。 接口具有两个部分：第一部分，其可插入基部单元的凹槽中，并且具有空气入口开口和用于接收气溶胶发生器的侧向开口和具有气溶胶出口的第二部分。 气溶胶头具有气溶胶发生器，液体储存器和与基座单元互补的键锁构件。 基座单元，接口管和气溶胶头可彼此连接，使得当将键锁的构件与互补构件接合时，气溶胶发生器插入到接口管的侧向开口中。
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公开(公告)号：US20240024590A1
公开(公告)日：2024-01-25
申请号：US18377084
申请日：2023-10-05
申请人： Vectura GmbH
CPC分类号： A61M11/003 , A61M15/0086 , A61M11/06 , A61M15/06 , A61M15/009 , A61M15/00 , A61M15/0021 , A61M11/005 , A61M11/02 , A61M2206/10 , A61M2205/75
摘要： The invention relates to a mixing channel for an inhalation device, and in particular to a mixing channel with improved injection and mixing properties for injecting and mixing a liquid drug into an air flow streaming in the mixing channel, thereby producing an aerosol to be inhaled by a patient. One aspect of the invention relates to a mixing channel for an inhalation device, comprising an inlet opening, an outlet opening, and an injection zone located between the inlet opening and the outlet opening, wherein the injection zone has a longitudinal center axis, wherein the injection zone comprises (a) a built-in nebulizer, or (b) a detachable nebulizer, or (c) a member adapted to receive a detachable nebulizer, wherein the effective cross sectional area of the mixing channel in a plane perpendicular to the longitudinal center axis is smaller in the injection zone than upstream of the injection zone.
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公开(公告)号：US10046121B2
公开(公告)日：2018-08-14
申请号：US14368730
申请日：2012-12-27
申请人： VECTURA GMBH
摘要： The invention provides an inhalation device for enabling a user to inhale at a desired inspiratory flow rate and/or pressure, comprising a feedback system configured to indicate to a user by means of a signal during an inhalation maneuver whether an inhalation parameter, such as the inspiratory flow rate, is within a predefined target range. The signal may be an optical or a non-optical signal, such as a light signal, an acoustic signal, or a tactile signal.
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