公开(公告)号：US20100040665A1

公开(公告)日：2010-02-18

申请号：US12593909

申请日：2008-03-31

申请人： Alvaro Meana Infiesta ,  Eva Garcia Perez ,  Veronica Garcia Diaz ,  Jose Luis Jorcano Noval ,  Marcela Del Rio Nechaevsky ,  Fernando Larcher Laguzzi ,  Blanca Duarte Gonzalez ,  Almudena Holguin Fernandez

发明人： Alvaro Meana Infiesta ,  Eva Garcia Perez ,  Veronica Garcia Diaz ,  Jose Luis Jorcano Noval ,  Marcela Del Rio Nechaevsky ,  Fernando Larcher Laguzzi ,  Blanca Duarte Gonzalez ,  Almudena Holguin Fernandez

IPC分类号： A61F2/00 ,  C12N11/02 ,  A61L27/22 ,  C07K1/00

CPC分类号： A61L27/60 ,  A61L27/227 ,  A61L27/38

摘要： The present invention belongs to the field of tissue engineering and specifically relates to a method for obtaining three-dimensional structures for tissue engineering and to the structures obtained by said method. The invention also relates to an ex vivo method for regenerating a tissue using the three-dimensional structures of the invention and to the use of the structures thus treated for their transplanting to the area to be regenerated of the patient.

摘要翻译： 本发明属于组织工程领域，具体涉及获得组织工程三维结构的方法以及通过所述方法得到的结构。 本发明还涉及使用本发明的三维结构再生组织的离体方法以及如此处理的用于其移植到待再生区域的结构的用途。

公开(公告)号：US07122373B1

公开(公告)日：2006-10-17

申请号：US09313292

申请日：1999-05-13

申请人： Lewis T. Williams ,  Jaime Escobedo ,  Michael A. Innis ,  Pablo Dominguez Garcia ,  Julie Sudduth-Klinger ,  Christoph Reinhard ,  Klaus Giese ,  Filippo Randazzo ,  Giulia C. Kennedy ,  David Pot ,  Altaf Kassam ,  George Lamson ,  Radoje Drmanac ,  Radomir Crkvenjakov ,  Mark Dickson ,  Snezana Drmanac ,  Ivan Labat ,  Dena Leshkowitz ,  David Kita ,  Veronica Garcia ,  Lee William Jones ,  Birgit Stache-Crain

发明人： Lewis T. Williams ,  Jaime Escobedo ,  Michael A. Innis ,  Pablo Dominguez Garcia ,  Julie Sudduth-Klinger ,  Christoph Reinhard ,  Klaus Giese ,  Filippo Randazzo ,  Giulia C. Kennedy ,  David Pot ,  Altaf Kassam ,  George Lamson ,  Radoje Drmanac ,  Radomir Crkvenjakov ,  Mark Dickson ,  Snezana Drmanac ,  Ivan Labat ,  Dena Leshkowitz ,  David Kita ,  Veronica Garcia ,  Lee William Jones ,  Birgit Stache-Crain

IPC分类号： C12N5/10 ,  C12N15/63 ,  C12N15/11

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/106

摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.

摘要翻译： 本发明涉及对应于这些多核苷酸的基因和由该基因表达的蛋白质的新型人多核苷酸及其变体，其编码的多肽及其变体。 本发明还涉及使用这种新型人多核苷酸的诊断和治疗剂，其相应的基因或基因产物，例如这些基因和蛋白质，包括探针，反义构建体和抗体。

公开(公告)号：US06964868B1

公开(公告)日：2005-11-15

申请号：US09297648

申请日：1999-01-28

申请人： Lewis T. Williams ,  Jaime Escobedo ,  Michael A. Innis ,  Pablo Dominguez Garcia ,  Julie Sudduth-Klinger ,  Christoph Reinhard ,  Klaus Giese ,  Filippo Randazzo ,  Giulia C. Kennedy ,  David Pot ,  Altaf Kassam ,  George Lamson ,  Radoje Drmanac ,  Radomir Crkvenjakov ,  Mark Dickson ,  Snezana Drmanac ,  Ivan Labat ,  Dena Leshkowitz ,  David Kita ,  Veronica Garcia ,  Lee William Jones ,  Birgit Stache-Crain

发明人： Lewis T. Williams ,  Jaime Escobedo ,  Michael A. Innis ,  Pablo Dominguez Garcia ,  Julie Sudduth-Klinger ,  Christoph Reinhard ,  Klaus Giese ,  Filippo Randazzo ,  Giulia C. Kennedy ,  David Pot ,  Altaf Kassam ,  George Lamson ,  Radoje Drmanac ,  Radomir Crkvenjakov ,  Mark Dickson ,  Snezana Drmanac ,  Ivan Labat ,  Dena Leshkowitz ,  David Kita ,  Veronica Garcia ,  Lee William Jones ,  Birgit Stache-Crain

IPC分类号： C07K14/47 ,  C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63

CPC分类号： C07K14/4748

摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.

摘要翻译： 本发明涉及对应于这些多核苷酸的基因和由该基因表达的蛋白质的新型人多核苷酸及其变体，其编码的多肽及其变体。 本发明还涉及使用这种新型人多核苷酸的诊断和治疗剂，其相应的基因或基因产物，例如这些基因和蛋白质，包括探针，反义构建体和抗体。

公开(公告)号：US20050227917A1

公开(公告)日：2005-10-13

申请号：US10779543

申请日：2004-02-12

申请人： Lewis Williams ,  Jaime Escobedo ,  Michael Innis ,  Pablo Garcia ,  Julie Sudduth-Klinger ,  Christoph Reinhard ,  Klaus Giese ,  Filippo Randazzo ,  Giulia Kennedy ,  David Pot ,  Altaf Kassam ,  George Lamson ,  Zhijun He ,  Elizabeth Scott ,  Guozhong Zhang ,  Theresa May ,  Doreen Sakamoto ,  Radoje Drmanac ,  Radomir Crkvenjakov ,  Mark Dickson ,  Snezana Drmanac ,  Ivan Labat ,  Dena Leshkowitz ,  David Kita ,  Veronica Garcia ,  Lee Jones ,  Birgit Stache-Crain

发明人： Lewis Williams ,  Jaime Escobedo ,  Michael Innis ,  Pablo Garcia ,  Julie Sudduth-Klinger ,  Christoph Reinhard ,  Klaus Giese ,  Filippo Randazzo ,  Giulia Kennedy ,  David Pot ,  Altaf Kassam ,  George Lamson ,  Zhijun He ,  Elizabeth Scott ,  Guozhong Zhang ,  Theresa May ,  Doreen Sakamoto ,  Radoje Drmanac ,  Radomir Crkvenjakov ,  Mark Dickson ,  Snezana Drmanac ,  Ivan Labat ,  Dena Leshkowitz ,  David Kita ,  Veronica Garcia ,  Lee Jones ,  Birgit Stache-Crain

IPC分类号： A61K38/17 ,  C07H21/04 ,  C07K14/47 ,  C12Q1/68 ,  G01N33/574

CPC分类号： A61K38/1709 ,  C07K14/47 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/574

摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.

摘要翻译： 本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。 这些多核苷酸可用于各种诊断和治疗方法。 本发明还提供减少癌细胞生长的方法。 这些方法可用于治疗癌症。