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37 条记录 (耗时 0.109 秒)

    Endogenous retrovirus up-regulated in prostate cancer
    5.
    发明申请
    Endogenous retrovirus up-regulated in prostate cancer 审中-公开
    内源性逆转录病毒在前列腺癌中上调

    公开(公告)号：US20060275747A1

    公开(公告)日：2006-12-07

    申请号：US10498033

    申请日：2002-12-09

    申请人： Stephen Hardy ,  Pablo Garcia ,  Lewis Williams ,  Jaime Escobedo

    发明人： Stephen Hardy ,  Pablo Garcia ,  Lewis Williams ,  Jaime Escobedo

    IPC分类号： C12Q1/70

    CPC分类号： C12Q1/6886 ,  C12Q1/702 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57434

    摘要： A specific member of the HERV-K family located in chromosome 22 at 20.428 megabases (22q11.2) has been found to be preferentially and significantly up-regulated in prostate tumors. The invention provides methods for diagnosing prostate cancer, comprising the step of detecting in a patient sample the presence or absence of an expression product of the virus. The virus has five features not seen in other HERV-K members: (1) its own specific nucleotide sequence, and consequently amino acid sequences; (2) tandem 5′ LTRs; (3) a fragmented 3′ LTR; (4) an env gene interrupted by an alu insertion; and (5) unique gag sequences.

    摘要翻译： 已经发现，在20.428兆比特（22q11.2）位于22号染色体上的HERV-K家族的特异成员在前列腺肿瘤中优先显着上调。 本发明提供了诊断前列腺癌的方法，包括在患者样品中检测病毒表达产物的存在或不存在的步骤。 该病毒在其他HERV-K成员中没有看到五个特征：（1）其自身的特异核苷酸序列，因此是氨基酸序列; （2）串联5'LTR; （3）碎片3'LTR; （4）由alu插入中断的env基因; 和（5）独特的gag序列。

    Endogenous retrovirus polypeptides linked to oncogenic transformation
    6.
    发明申请
    Endogenous retrovirus polypeptides linked to oncogenic transformation 审中-公开
    与致癌转化相关的内源性逆转录病毒多肽

    公开(公告)号：US20070037147A1

    公开(公告)日：2007-02-15

    申请号：US10497786

    申请日：2002-12-09

    申请人： Pablo Garcia ,  Stephen Hardy ,  Lewis Williams ,  Jaime Escobedo

    发明人： Pablo Garcia ,  Stephen Hardy ,  Lewis Williams ,  Jaime Escobedo

    IPC分类号： C12Q1/70 ,  C12Q1/68

    CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N7/00 ,  C12N2740/10021 ,  C12N2740/10022 ,  C12Q1/6886 ,  C12Q1/702 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57434 ,  G01N2333/15

    摘要： HERV-K human endogenous retroviruses show up-regulated expression in tumors. In particular, splicing events in the env region generate a series of transcripts which utilise the +2 reading frame, relative to the env reading frame. The proteins show activity typical of transcriptional regulators, and they also have oncogenic potential. Two related proteins, PCAP2 and PCAP3, are strongly associated with breast cancer and prostate cancer, respectively. PCAP4 stimulates cell division. These proteins can be used in cancer diagnosis and therapy, and are also drug target e.g. for adjuvant therapy. The identification of these splice products is remarkable because full sequence information has been available for HERV-K viruses since 1986.

    摘要翻译： HERV-K人内源性逆转录病毒在肿瘤中表达上调。 特别地，env区域中的拼接事件产生一系列相对于env阅读框使用+2阅读框的抄本。 蛋白质表现出转录调节因子的典型活性，并且具有致癌潜力。 两种相关蛋白，PCAP2和PCAP3分别与乳腺癌和前列腺癌密切相关。 PCAP4刺激细胞分裂。 这些蛋白质可用于癌症诊断和治疗，也是药物靶标。 用于辅助治疗。 鉴于这些拼接产品是非常显着的，因为自1986年以来，全序列信息已经可用于HERV-K病毒。

    Trefoil factor 3 (TFF3) as a target for anti-cancer therapy
    8.
    发明申请
    Trefoil factor 3 (TFF3) as a target for anti-cancer therapy 审中-公开
    三叶因子3（TFF3）作为抗癌治疗的靶标

    公开(公告)号：US20050186212A1

    公开(公告)日：2005-08-25

    申请号：US10913685

    申请日：2004-08-05

    申请人： Mary Janatpour ,  Pablo Garcia ,  Christoph Reinhard

    发明人： Mary Janatpour ,  Pablo Garcia ,  Christoph Reinhard

    IPC分类号： A61B20060101 ,  A61K39/395 ,  A61K48/00 ,  C07K14/575 ,  C07K16/26 ,  C12N15/113

    CPC分类号： C12N15/1136 ,  C07K14/575 ,  C07K16/26 ,  C07K2317/34 ,  C07K2317/73 ,  C12N2310/11

    摘要： The present invention is directed to methods of treating and preventing cancer, such as cancer characterized by differential expression of trefoil factor 3 (TFF3). The methods include administering to a patient an agent that modulates TFF3 activity or expression. The present invention is further directed to reducing the physiological effects of TFF3 expression in cells, including inhibiting cell motility and resistance to apoptosis. Oligonucleotides and antibodies that can modulate expression or activity of TFF3 are also provided.

    摘要翻译： 本发明涉及治疗和预防癌症的方法，例如以三叶因子3（TFF3）的差异表达为特征的癌症。 所述方法包括向患者施用调节TFF3活性或表达的试剂。 本发明进一步涉及减少TFF3在细胞中的表达的生理作用，包括抑制细胞运动性和抗细胞凋亡。 还提供了可调节TFF3的表达或活性的寡核苷酸和抗体。

    System and Method for Measuring Movement of a Component from Rings Magnetized in a Magnetically Hard Layer
    9.
    发明申请
    System and Method for Measuring Movement of a Component from Rings Magnetized in a Magnetically Hard Layer 有权
    用于测量在磁性硬层中磁化的环的组分的运动的系统和方法

    公开(公告)号：US20110062948A1

    公开(公告)日：2011-03-17

    申请号：US12953919

    申请日：2010-11-24

    申请人： Donald C. Arns, JR. ,  Pablo Garcia

    发明人： Donald C. Arns, JR. ,  Pablo Garcia

    IPC分类号： G01B7/14

    CPC分类号： F15B15/2861 ,  F15B15/2846 ,  G01D5/00 ,  G01D5/24423 ,  G01D5/24438 ,  G01D5/24447 ,  G01D5/24476

    摘要： A position-sensing system includes a first component (e.g., a cylinder) and a second component (e.g., a piston rod) movably coupled to the first component for movement with respect thereto. A magnetically hard layer on the second component provides a recording medium. Regions of the magnetically hard layer are magnetized as magnetized rings around the second component. Magnetic-field sensors are coupled to the first component in proximity of the magnetically hard layer on the second component to sense the rings of magnetized regions. Each of the magnetic field sensors senses flux from each of the rings of magnetized regions as the second component is moving with respect to the first component and, in response to sensing the rings of magnetized regions, generates signals used to determine position of the second component.

    摘要翻译： 位置感测系统包括可移动地联接到第一部件以相对于其移动的第一部件（例如，气缸）和第二部件（例如，活塞杆）。 第二组件上的磁性硬层提供记录介质。 磁性硬层的区域被磁化为围绕第二组分的磁化环。 磁场传感器在第二部件上的磁性硬层附近耦合到第一部件以感测磁化区域的环。 当第二部件相对于第一部件移动时，每个磁场传感器感测来自磁化区域的每个环的磁通，并且响应于感测磁化区域的环，产生用于确定第二部件的位置的信号 。

    System and method of perpendicularly magnetizing position information in a magnetically hard layer of a moving component
    10.
    发明授权
    System and method of perpendicularly magnetizing position information in a magnetically hard layer of a moving component 有权
    在运动部件的磁性硬层中垂直磁化位置信息的系统和方法

    公开(公告)号：US07755350B2

    公开(公告)日：2010-07-13

    申请号：US12252342

    申请日：2008-10-15

    申请人： Donald C. Arns, Jr. ,  Pablo Garcia

    发明人： Donald C. Arns, Jr. ,  Pablo Garcia

    IPC分类号： G01B7/14

    CPC分类号： F15B15/2861 ,  F15B15/2846 ,  G01D5/00 ,  G01D5/24423 ,  G01D5/24438 ,  G01D5/24447 ,  G01D5/24476

    摘要： A position-sensing system magnetically senses the position of a piston rod moving with respect to a cylinder. A magnetically hard layer on the piston rod provides a recording medium. Information is perpendicularly magnetized in regions of the magnetically hard layer. These regions provide an encoding scheme for determining the position of the piston rod. Magnetic-field sensors are positioned over redundant tracks of magnetically recorded regions. Each magnetic-field sensor positioned over a given track senses the same magnetized regions while the piston rod moves with respect to the cylinder. Other magnetic-field sensors can sense ambient fields for use in performing common-mode rejection. A write head can dynamically repair damaged or erased regions detected by the magnetic-field sensors. Energized by a battery-backup power source, the magnetic-field sensors and associated circuitry can continue to track movement of the piston rod when the machinery is off.

    摘要翻译： 位置感测系统磁性地感测相对于气缸移动的活塞杆的位置。 活塞杆上的磁性硬层提供了一种记录介质。 信息在磁性硬层的区域中垂直磁化。 这些区域提供用于确定活塞杆的位置的编码方案。 磁场传感器位于磁记录区域的冗余轨道上。 位于给定轨道上方的每个磁场传感器在活塞杆相对于气缸移动时感测相同的磁化区域。 其他磁场传感器可以感测用于执行共模抑制的环境场。 写头可以动态修复由磁场传感器检测到的损坏或擦除的区域。 由电池备用电源供电，当机械关闭时，磁场传感器和相关电路可以继续跟踪活塞杆的运动。