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![3-[4-(PHENYLAMINOOXALYLAMINO)PHENYL]HEX-4-YNOIC ACIDS, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS A MEDICAMENT](/abs-image/US/2013/07/04/US20130172248A1/abs.jpg.150x150.jpg)
1.发明申请3-[4-(PHENYLAMINOOXALYLAMINO)PHENYL]HEX-4-YNOIC ACIDS, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS A MEDICAMENT 审中-公开3- [4-（苯甲酰氨基氨基）苯基]十六烷基-4-氨基酸，其制备方法和用作药物公开(公告)号：US20130172248A1
公开(公告)日：2013-07-04
申请号：US13734413
申请日：2013-01-04
申请人： Elisabeth DEFOSSA , Viktoria DIETRICH , Thomas KLABUNDE , Stefanie KEIL , Siegfried STENGELIN , Guido HASCHKE , Andreas HERLING , Johanna KUHLMANN-GOTTKE , Stefan BARTOSCHEK , Simon GESSLER , Angela DUDDA , Guenter BILLEN , Thomas OLPP , Joerg RIEKE-ZAPP
发明人： Elisabeth DEFOSSA , Viktoria DIETRICH , Thomas KLABUNDE , Stefanie KEIL , Siegfried STENGELIN , Guido HASCHKE , Andreas HERLING , Johanna KUHLMANN-GOTTKE , Stefan BARTOSCHEK , Simon GESSLER , Angela DUDDA , Guenter BILLEN , Thomas OLPP , Joerg RIEKE-ZAPP
IPC分类号： C07C233/56 , A61K38/28 , C07C231/02 , C07C229/42 , A61K31/196 , A61K45/06
CPC分类号： C07C233/56 , A61K31/196 , A61K38/28 , A61K45/06 , C07C229/42 , C07C231/02 , A61K2300/00
摘要： The invention relates to 3-[4-(phenylaminooxalylamino)phenyl]hex-4-ynoic acids, and to physiologically compatible salts thereof.The invention relates to compounds of the formula I in which R1, R2, R3 and R4 are each defined as specified, and to physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.
摘要翻译： 本发明涉及3- [4-（苯基氨基草酰氨基）苯基]己-4-炔酸，以及其生理上相容的盐。 本发明涉及式Ⅰ化合物，其中R 1，R 2，R 3和R 4各自定义和其生理上相容的盐。 该化合物适用于例如治疗糖尿病。
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2.发明申请(2-ARYLOXYACETYLAMINO) PHENYLPROPIONIC ACID DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND USE THEREOF AS MEDICAMENTS 有权（2-ARYLOXYACETYLAMINO）苯丙酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US20120004167A1
公开(公告)日：2012-01-05
申请号：US13176503
申请日：2011-07-05
申请人： Elisabeth DEFOSSA , Stefanie KEIL , Viktoria DIETRICH , Siegfried STENGELIN , Andreas HERLING , Guido HASCHKE , Thomas KLABUNDE
发明人： Elisabeth DEFOSSA , Stefanie KEIL , Viktoria DIETRICH , Siegfried STENGELIN , Andreas HERLING , Guido HASCHKE , Thomas KLABUNDE
IPC分类号： A61K31/197 , C07C255/43 , A61P3/10 , A61K38/28 , A61K38/27 , A61K31/702 , A61K31/40 , A61K31/403 , A61K31/472 , A61K31/4439 , A61K38/17 , A61K31/4985 , A61K31/451 , A61P3/08 , C07C229/42
CPC分类号： C07C235/24 , C07C255/44
摘要： The invention relates to substituted (2-aryloxyacetylamino)phenylpropionic acid derivatives, and to the physiologically acceptable salts thereof.The invention relates to compounds of the formula I in which R1, R2, R3, R4, R5, R6, R7, R8, R9 and A are each defined as specified, and the physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.
摘要翻译： 本发明涉及取代的（2-芳氧基乙酰基氨基）苯基丙酸衍生物及其生理上可接受的盐。 本发明涉及其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和A各自如上所定义的式Ⅰ化合物及其生理上相容的盐。 该化合物适用于例如治疗糖尿病。
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3.发明申请ARYLOXYALKYLENE-SUBSTITUTED HYDROXYPHENYLHEXYNOIC ACIDS, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS A MEDICAMENT 审中-公开芳基亚甲基取代的羟基苯甲酸，其制备方法和用作药物公开(公告)号：US20120004166A1
公开(公告)日：2012-01-05
申请号：US13176417
申请日：2011-07-05
申请人： Stefanie KEIL , Elisabeth DEFOSSA , Viktoria DIETRICH , Siegfried STENGELIN , Andreas HERLING , Guido HASCHKE , Thomas KLABUNDE
发明人： Stefanie KEIL , Elisabeth DEFOSSA , Viktoria DIETRICH , Siegfried STENGELIN , Andreas HERLING , Guido HASCHKE , Thomas KLABUNDE
IPC分类号： A61K31/192 , C07D213/65 , A61K31/44 , C07C255/57 , A61K31/277 , A61P3/10 , A61K38/28 , A61K38/27 , A61K31/702 , A61K31/40 , A61K31/403 , A61K31/472 , A61K31/4439 , A61K38/17 , A61K31/4985 , A61K31/451 , A61P3/08 , C07C59/68
CPC分类号： C07C255/54 , C07B2200/07 , C07C59/64 , C07C2601/02 , C07D213/65
摘要： The invention relates to aryloxyalkylene-substituted hydroxyphenylhexynoic acid derivatives, and to physiologically compatible salts thereof.The invention relates to compounds of the formula I in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14 and A are each defined as specified, and physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.
摘要翻译： 本发明涉及芳氧基亚烷基取代的羟基苯基炔诺酸衍生物及其生理上相容的盐。 本发明涉及式Ⅰ化合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R11，R12，R13，R14和A各自定义如上， 其中。 该化合物适用于例如治疗糖尿病。
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4.发明申请PHENYLAMINO-BENZOXAZOLE SUBSTITUTED CARBOXYLIC ACIDS, METHOD FOR THEIR PRODUCTION AND USE THEREOF AS MEDICAMENTS 审中-公开苯甲酰基苯并噻唑取代的羧酸，其生产方法及其作为药物的用途公开(公告)号：US20090149519A1
公开(公告)日：2009-06-11
申请号：US12267896
申请日：2008-11-10
申请人： Elisabeth Defossa , Markus Follmann , Thomas Klabunde , Viktoria Dietrich , Gerhard Hessler , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
发明人： Elisabeth Defossa , Markus Follmann , Thomas Klabunde , Viktoria Dietrich , Gerhard Hessler , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
IPC分类号： A61K31/423 , C07D263/48 , A61P3/10
CPC分类号： A61K31/423 , A61K45/06 , C07D263/58 , C07D413/12
摘要： This invention relates to a compound of formula I, wherein R1, R2, R6, R7, R8, R9, R10, m and X are as defined herein, or a physiologically tolerated salt thereof, its pharmaceutical composition and use for lowering blood glucose, treating diabetes, or increasing insulin release.
摘要翻译： 本发明涉及式I化合物，其中R 1，R 2，R 6，R 7，R 8，R 9，R 10，m和X如本文所定义，或其生理上耐受的盐，其药物组合物和用于降低血糖， 治疗糖尿病或增加胰岛素释放。
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5.发明授权(Cyclopropylphenyl)phenyloxamides, method for the production thereof, and use of same as a medicament 有权（环丙基苯基）苯氧基酰胺，其制备方法及其作为药物的用途公开(公告)号：US08148375B2
公开(公告)日：2012-04-03
申请号：US12724517
申请日：2010-03-16
申请人： Elisabeth Defossa , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Johanna Kuhlmann-Gottke , Stefan Bartoschek
发明人： Elisabeth Defossa , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Johanna Kuhlmann-Gottke , Stefan Bartoschek
IPC分类号： A61K31/53 , A61K36/328
CPC分类号： C07C233/56 , C07C233/88
摘要： The invention relates to (cyclopropylphenyl) phenyloxamides and their physiologically tolerated salts, and their use as a medicament.
摘要翻译： 本发明涉及（环丙基苯基）苯氧基酰胺及其生理上耐受的盐，以及它们作为药物的用途。
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6.发明申请SPIROCYCLICALLY SUBSTITUTED 1,3-PROPANE DIOXIDE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND USE THEREOF AS A MEDICAMENT 有权螺旋取代的1,3-丙二酮衍生物，其制备方法及其作为药物的用途公开(公告)号：US20120004187A1
公开(公告)日：2012-01-05
申请号：US13176333
申请日：2011-07-05
申请人： Stefanie KEIL , Elisabeth DEFOSSA , Viktoria DIETRICH , Siegfried STENGELIN , Andreas HERLING , Guido HASCHKE , Thomas KLABUNDE
发明人： Stefanie KEIL , Elisabeth DEFOSSA , Viktoria DIETRICH , Siegfried STENGELIN , Andreas HERLING , Guido HASCHKE , Thomas KLABUNDE
IPC分类号： A61K38/16 , A61K31/337 , A61P3/10 , C07D213/64 , C07D305/04 , C07C59/68 , A61K31/44 , A61K31/19
CPC分类号： C07C59/72 , C07D213/64 , C07D213/65 , C07D305/06
摘要： The invention relates to spirocyclically substituted 1,3-propane dioxide derivatives, and to the physiologically compatible salts thereof.The invention relates to compounds of the formula I in which R1, R2, R3, R4, R5, R6, R7, R8, A and X are each defined as specified, and the physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.
摘要翻译： 本发明涉及螺环取代的1,3-丙二醇衍生物及其与生理相容的盐。 本发明涉及其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，A和X各自如上所定义的式Ⅰ化合物及其生理上相容的盐。 该化合物适用于例如治疗糖尿病。
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7.发明授权4,5-diphenyl-pyrimidinylamino substituted carboxylic acids, method for the production and use thereof as medicaments 有权4,5-二苯基 - 嘧啶基氨基取代的羧酸，其制备方法和用作药物公开(公告)号：US07713988B2
公开(公告)日：2010-05-11
申请号：US12267918
申请日：2008-11-10
申请人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
发明人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
IPC分类号： C07D239/42 , A61K31/505
CPC分类号： C07D239/42
摘要： This invention relates to a compound of formula I, wherein R1, R2, R3, m, n, W, X and Y are as defined herein, or a physiologically tolerated salt thereof, its pharmaceutical composition and use for lowering blood glucose, treating diabetes, or increasing insulin release.
摘要翻译： 本发明涉及式I化合物，其中R 1，R 2，R 3，m，n，W，X和Y如本文所定义，或其生理耐受盐，其药物组合物和降血糖用途，治疗糖尿病 ，或增加胰岛素释放。
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8.发明申请4,5-DIPHENYL-PYRIMIDINYLAMINO SUBSTITUTED CARBOXYLIC ACIDS, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS 有权4,5-二苯基 - 吡啶基氨基取代的羧酸，用于生产和使用其作为药物的方法公开(公告)号：US20090149487A1
公开(公告)日：2009-06-11
申请号：US12267918
申请日：2008-11-10
申请人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
发明人： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
IPC分类号： A61K31/505 , C07D239/42 , A61P3/10
CPC分类号： C07D239/42
摘要： This invention relates to a compound of formula I, wherein R1, R2, R3, m, n, W, X and Y are as defined herein, or a physiologically tolerated salt thereof, its pharmaceutical composition and use for lowering blood glucose, treating diabetes, or increasing insulin release.
摘要翻译： 本发明涉及式I化合物，其中R 1，R 2，R 3，m，n，W，X和Y如本文所定义，或其生理耐受盐，其药物组合物和降血糖用途，治疗糖尿病 ，或增加胰岛素释放。
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9.发明授权(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments 有权（2-芳氧基乙酰氨基）苯基丙酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US08648038B2
公开(公告)日：2014-02-11
申请号：US13176503
申请日：2011-07-05
申请人： Elisabeth Defossa , Stefanie Keil , Viktoria Dietrich , Siegfried Stengelin , Andreas Herling , Guido Haschke , Thomas Klabunde
发明人： Elisabeth Defossa , Stefanie Keil , Viktoria Dietrich , Siegfried Stengelin , Andreas Herling , Guido Haschke , Thomas Klabunde
CPC分类号： C07C235/24 , C07C255/44
摘要： The invention relates to substituted (2-aryloxyacetylamino)phenylpropionic acid derivatives, and to the physiologically acceptable salts thereof.The invention relates to compounds of the formula I in which R1, R2, R3, R4, R5, R6, R7, R8, R9 and A are each defined as specified, and the physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.
摘要翻译： 本发明涉及取代的（2-芳氧基乙酰基氨基）苯基丙酸衍生物及其生理上可接受的盐。 本发明涉及其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和A各自如上所定义的式Ⅰ化合物及其生理上相容的盐。 该化合物适用于例如治疗糖尿病。
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10.发明授权Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments 有权具有氧代基的杂环取代的甲氧基苯基衍生物，其制备方法及其作为药物的用途公开(公告)号：US08530413B2
公开(公告)日：2013-09-10
申请号：US13154946
申请日：2011-06-07
申请人： Stefanie Keil , Elisabeth Defossa , Viktoria Dietrich , Siegfried Stengelin , Andreas Herling , Guido Haschke , Thomas Klabunde
发明人： Stefanie Keil , Elisabeth Defossa , Viktoria Dietrich , Siegfried Stengelin , Andreas Herling , Guido Haschke , Thomas Klabunde
CPC分类号： C07D209/34 , C07D215/227 , C07D265/36 , C07D277/68 , C07D498/04
摘要： Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicamentsThe invention relates to heterocyclically substituted methoxyphenyl derivatives with an oxo group, and to physiologically compatible salts thereof.The invention relates to compounds of the formula I in which R1, R2, R3, R4, R10, X, n, B1, B2, B3 and B4 are each defined as specified, and to the physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.
摘要翻译： 具有氧代基的杂环取代的甲氧基苯基衍生物，其制备方法及其作为药物的用途本发明涉及具有氧代基的杂环取代的甲氧基苯基衍生物及其生理上相容的盐。 本发明涉及其中R 1，R 2，R 3，R 4，R 10，X，n，B 1，B 2，B 3和B 4各自如上所定义的式Ⅰ化合物及其生理上相容的盐。 该化合物适用于例如治疗糖尿病。
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