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公开(公告)号：US08338412B2
公开(公告)日：2012-12-25
申请号：US13107802
申请日：2011-05-13
申请人： Guy W. Bemis , Francesco G. Salituro , John P. Duffy , John E. Cochran , Edmund M. Harrington , Mark A. Murcko , Keith P. Wilson , Michael Su , Vincent P. Galullo
发明人： Guy W. Bemis , Francesco G. Salituro , John P. Duffy , John E. Cochran , Edmund M. Harrington , Mark A. Murcko , Keith P. Wilson , Michael Su , Vincent P. Galullo
IPC分类号： C07D487/04 , A61K31/5025
CPC分类号： C07D213/70 , C07D213/56 , C07D213/75 , C07D237/18 , C07D241/12 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/04 , C07D471/04 , C07D487/04 , C07F9/6561
摘要： The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
摘要翻译： 本发明涉及p38的抑制剂，哺乳动物蛋白激酶涉及细胞增殖，细胞死亡和对细胞外刺激的反应。 本发明还涉及生产这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病的方法。
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公开(公告)号：US07951809B2
公开(公告)日：2011-05-31
申请号：US12062495
申请日：2008-04-03
申请人： Guy W. Bemis , Francesco G. Salituro , John P. Duffy , John E. Cochran , Edmund M. Harrington , Mark A. Murcko , Keith P. Wilson , Michael Su , Vincent P. Galullo
发明人： Guy W. Bemis , Francesco G. Salituro , John P. Duffy , John E. Cochran , Edmund M. Harrington , Mark A. Murcko , Keith P. Wilson , Michael Su , Vincent P. Galullo
IPC分类号： C07D239/70 , A61K31/519
CPC分类号： C07D213/70 , C07D213/56 , C07D213/75 , C07D237/18 , C07D241/12 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/04 , C07D471/04 , C07D487/04 , C07F9/6561
摘要： The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
摘要翻译： 本发明涉及p38的抑制剂，哺乳动物蛋白激酶涉及细胞增殖，细胞死亡和对细胞外刺激的反应。 本发明还涉及生产这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病的方法。
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公开(公告)号：US07205305B2
公开(公告)日：2007-04-17
申请号：US10622320
申请日：2003-07-17
申请人： Guy W Bemis , Francesco G Salituro , John P Duffy , John E Cochran , Edmund M Harrington , Mark A Murcko , Keith P Wilson , Michael Su , Vincent P Galullo
发明人： Guy W Bemis , Francesco G Salituro , John P Duffy , John E Cochran , Edmund M Harrington , Mark A Murcko , Keith P Wilson , Michael Su , Vincent P Galullo
IPC分类号： C07D213/02 , C07D213/89 , A61K31/44
CPC分类号： C07D213/70 , C07D213/56 , C07D213/75 , C07D237/18 , C07D241/12 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/04 , C07D471/04 , C07D487/04 , C07F9/6561
摘要： The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
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公开(公告)号：US07365072B2
公开(公告)日：2008-04-29
申请号：US11298324
申请日：2005-12-08
申请人： Guy W Bemis , Francesco G Salituro , John P Duffy , John E Cochran , Edmund M Harrington , Mark A Murcko , Keith P Wilson , Michael Su , Vincent P Galullo
发明人： Guy W Bemis , Francesco G Salituro , John P Duffy , John E Cochran , Edmund M Harrington , Mark A Murcko , Keith P Wilson , Michael Su , Vincent P Galullo
IPC分类号： C07D487/04 , A61K31/5025
CPC分类号： C07D213/70 , C07D213/56 , C07D213/75 , C07D237/18 , C07D241/12 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/04 , C07D471/04 , C07D487/04 , C07F9/6561
摘要： The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
摘要翻译： 本发明涉及p38的抑制剂，哺乳动物蛋白激酶涉及细胞增殖，细胞死亡和对细胞外刺激的反应。 本发明还涉及生产这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病的方法。
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公开(公告)号：US06608060B1
公开(公告)日：2003-08-19
申请号：US09336266
申请日：1999-06-14
申请人： Guy W. Bemis , Francesco Gerald Salituro , John Patrick Duffy , John E. Cochran , Edmund Martin Harrington , Mark A. Murko , Keith P. Wilson , Michael Su , Vincent P. Galullo
发明人： Guy W. Bemis , Francesco Gerald Salituro , John Patrick Duffy , John E. Cochran , Edmund Martin Harrington , Mark A. Murko , Keith P. Wilson , Michael Su , Vincent P. Galullo
IPC分类号： C07D48704
CPC分类号： C07D213/70 , C07D213/56 , C07D213/75 , C07D237/18 , C07D241/12 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/04 , C07D471/04 , C07D487/04 , C07F9/6561
摘要： The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
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公开(公告)号：US20090203702A1
公开(公告)日：2009-08-13
申请号：US12062495
申请日：2008-04-03
申请人： Guy W. Bemis , Francesco Gerald Salituro , John Patrick Duffy , John E. Cochran , Edmund Martin Harrington , Mark A. Murcko , Keith P. Wilson , Michael Su , Vincent P. Galullo
发明人： Guy W. Bemis , Francesco Gerald Salituro , John Patrick Duffy , John E. Cochran , Edmund Martin Harrington , Mark A. Murcko , Keith P. Wilson , Michael Su , Vincent P. Galullo
IPC分类号： A61K31/5025 , C07D487/04 , C07D471/04 , A61K31/519 , A61P29/00 , A61P37/00 , A61P25/00
CPC分类号： C07D213/70 , C07D213/56 , C07D213/75 , C07D237/18 , C07D241/12 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/04 , C07D471/04 , C07D487/04 , C07F9/6561
摘要： The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
摘要翻译： 本发明涉及p38的抑制剂，哺乳动物蛋白激酶涉及细胞增殖，细胞死亡和对细胞外刺激的反应。 本发明还涉及生产这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病的方法。
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公开(公告)号：US07368467B2
公开(公告)日：2008-05-06
申请号：US11075629
申请日：2005-03-07
IPC分类号： A61K31/4184 , C07D233/54 , C07D235/04 , C07D403/12
CPC分类号： C07D233/84 , A61K31/4164 , A61K31/4178 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D417/12 , C07D417/14
摘要： The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
摘要翻译： 本发明涉及化合物，包含该化合物的组合物，以及使用该化合物和化合物组合物的方法。 本文所述的化合物，组合物和方法可用于治疗性调节离子通道功能，以及治疗疾病和疾病症状，特别是由某些钙通道亚型靶标介导的那些症状。
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公开(公告)号：US20110281878A1
公开(公告)日：2011-11-17
申请号：US13107802
申请日：2011-05-13
申请人： Guy W. Bemis , Francesco Gerald Salituro , John Patrick Duffy , John E. Cochran , Edmund Martin Harrington , Mark A. Murko , Keith P. Wilson , Michael Su , Vincent P. Galullo
发明人： Guy W. Bemis , Francesco Gerald Salituro , John Patrick Duffy , John E. Cochran , Edmund Martin Harrington , Mark A. Murko , Keith P. Wilson , Michael Su , Vincent P. Galullo
IPC分类号： A61K31/5025 , C07D471/04 , A61K31/519 , A61P29/00 , A61P37/00 , A61P31/12 , A61P19/08 , A61P35/00 , A61P31/00 , A61P25/28 , A61P37/08 , A61P9/10 , A61P13/12 , A61P7/00 , A61P43/00 , A61P9/00 , A61P7/02 , A61P1/18 , A61P11/06 , A61P11/00 , A61P19/04 , A61P17/00 , A61P5/14 , A61P3/10 , A61P7/06 , A61P31/14 , A61P21/04 , A61P1/00 , A61P1/04 , A61P17/06 , A61P37/06 , A61P19/02 , A61P19/10 , A61P35/02 , A61P35/04 , C07D487/04
CPC分类号： C07D213/70 , C07D213/56 , C07D213/75 , C07D237/18 , C07D241/12 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/04 , C07D471/04 , C07D487/04 , C07F9/6561
摘要： The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
摘要翻译： 本发明涉及p38的抑制剂，哺乳动物蛋白激酶涉及细胞增殖，细胞死亡和对细胞外刺激的反应。 本发明还涉及生产这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病的方法。
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公开(公告)号：US20100267697A1
公开(公告)日：2010-10-21
申请号：US12518342
申请日：2007-12-11
申请人： Vincent P. Galullo , Robert Zelle , Danielle Soenen , Christopher Todd Baker , Paul Will , Hormoz Mazdiyasni , Jinsong Guo , Andrew Fensome , Jeffrey Curtis Kern , William Jay Moore , Edward George Melenski , Justin Kaplan
发明人： Vincent P. Galullo , Robert Zelle , Danielle Soenen , Christopher Todd Baker , Paul Will , Hormoz Mazdiyasni , Jinsong Guo , Andrew Fensome , Jeffrey Curtis Kern , William Jay Moore , Edward George Melenski , Justin Kaplan
IPC分类号： A61K31/5513 , A61K31/55 , A61K31/54 , A61K31/535 , A61K31/5355 , A61K31/4995 , A61K31/501 , A61K31/497 , A61K31/506 , A61K31/44 , A61K31/4725 , A61K31/426 , A61K31/4709 , A61K31/4458 , A61K31/4453 , A61K31/4402 , A61K31/445 , A61K31/166 , C07D403/04 , C07D401/04 , C07D413/04 , C07D417/04 , C07D413/12 , C07D403/12 , C07D241/36 , C07D497/10 , C07D217/00 , C07D215/00 , C07D401/12 , C07D211/98 , C07D213/04 , C07D405/12 , C07D213/73 , C07D277/593 , C07C233/42
CPC分类号： C07D213/72 , C07D277/42
摘要： The present teachings provide compounds of Formula (I) and pharmaceutically acceptable salts, hydrates, and esters thereof, wherein Ar, R1, R2, R3, p, and X are defined herein. The present teachings also provide processes for producing said compounds and their pharmaceutically acceptable salts, hydrates and esters, and methods of treating a pathological condition or disorder, or alleviating a symptom thereof, using said compounds including their pharmaceutically acceptable salts, hydrates and esters. The compounds can be useful in modulating ion channel activity including treating a variety of conditions associated with the abnormal modulation of one or more voltage-gated calcium channels.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐，水合物和酯，其中Ar，R 1，R 2，R 3，p和X如本文所定义。 本教导还提供使用所述化合物，包括其药学上可接受的盐，水合物和酯来制备所述化合物及其药学上可接受的盐，水合物和酯的方法，以及治疗病理状况或病症或减轻其症状的方法。 该化合物可用于调节离子通道活性，包括治疗与一个或多个电压门控钙通道的异常调节相关的多种病症。
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公开(公告)号：US07547717B2
公开(公告)日：2009-06-16
申请号：US10592269
申请日：2005-03-07
申请人： Robert Zelle , Vincent P. Galullo
发明人： Robert Zelle , Vincent P. Galullo
IPC分类号： A61K31/4164 , C07D233/30
CPC分类号： C07D233/42 , C07D233/84 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D413/12 , C07D417/06 , C07D417/12
摘要： The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
摘要翻译： 本发明涉及化合物，包含该化合物的组合物，以及使用该化合物和化合物组合物的方法。 本文所述的化合物，组合物和方法可用于治疗性调节离子通道功能，以及治疗疾病和疾病症状，特别是由某些钙通道亚型靶标介导的那些症状。
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