-
公开(公告)号：US06608060B1
公开(公告)日：2003-08-19
申请号：US09336266
申请日：1999-06-14
申请人： Guy W. Bemis , Francesco Gerald Salituro , John Patrick Duffy , John E. Cochran , Edmund Martin Harrington , Mark A. Murko , Keith P. Wilson , Michael Su , Vincent P. Galullo
发明人： Guy W. Bemis , Francesco Gerald Salituro , John Patrick Duffy , John E. Cochran , Edmund Martin Harrington , Mark A. Murko , Keith P. Wilson , Michael Su , Vincent P. Galullo
IPC分类号： C07D48704
CPC分类号： C07D213/70 , C07D213/56 , C07D213/75 , C07D237/18 , C07D241/12 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/04 , C07D471/04 , C07D487/04 , C07F9/6561
摘要： The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
-
公开(公告)号：US20130338159A1
公开(公告)日：2013-12-19
申请号：US13995889
申请日：2011-12-19
IPC分类号： A61K31/5377 , A61K31/506 , C07D417/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D401/14 , A61K45/06
CPC分类号： C07D403/14 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The present invention includes novel methods of treating a disease or disorder characterized by hyperactivity of Vps34, and compound as Vps34 inhibitors; particularly compounds of Formula I or a pharmaceutically acceptable salt thereof, as well as methods of treating a disease, disorder, or syndrome associated with Vps34 inhibition, particularly hyperproliferative diseases. The present invention also includes pharmaceutical compositions including compounds of formula I and pharmaceutically acceptable salts thereof.
摘要翻译： 本发明包括治疗以Vps34多动症为特征的疾病或病症的新方法，以及作为Vps34抑制剂的化合物; 特别是式I化合物或其药学上可接受的盐，以及治疗与Vps34抑制，特别是过度增殖性疾病相关的疾病，病症或综合征的方法。 本发明还包括包含式I化合物及其药学上可接受的盐的药物组合物。
-
公开(公告)号：US6147080A
公开(公告)日：2000-11-14
申请号：US862925
申请日：1997-06-10
IPC分类号： A61K31/4375 , A61K31/44 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/519 , A61K31/5377 , A61P7/02 , A61P9/10 , A61P19/08 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/00 , A61P43/00 , C07D213/56 , C07D213/61 , C07D213/70 , C07D213/75 , C07D237/18 , C07D241/12 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D471/04 , C07D487/04 , C07F9/6561
CPC分类号： C07D213/70 , C07D213/56 , C07D213/75 , C07D237/18 , C07D241/12 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/04 , C07D471/04 , C07D487/04 , C07F9/6561
摘要： The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The compounds are of the class of pyrido [1,2-c] pyrimidin-3-one or 1,2-dihydro-pyrido [1,2-c] pyrimidin-3-one derivatives, useful as inhibitors of p38. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
摘要翻译： 本发明涉及p38的抑制剂，哺乳动物蛋白激酶涉及细胞增殖，细胞死亡和对细胞外刺激的反应。 该化合物是可用作p38抑制剂的吡啶并[1,2-c]嘧啶-3-酮或1,2-二氢 - 吡啶并[1,2-c]嘧啶-3-酮衍生物。 本发明还涉及生产这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病的方法。
-
公开(公告)号：US20090291942A1
公开(公告)日：2009-11-26
申请号：US12468706
申请日：2009-05-19
申请人： Ivan Cornella Taracido , Edmund Martin Harrington , René Hersperger , René Lattmann , Wolfgang Miltz , Klaus Weigand
发明人： Ivan Cornella Taracido , Edmund Martin Harrington , René Hersperger , René Lattmann , Wolfgang Miltz , Klaus Weigand
IPC分类号： A61K31/55 , A61K31/5377 , A61K31/497 , A61K31/437 , C07D471/04
CPC分类号： C07D471/04
摘要： The invention relates to novel imidazopyridine derivatives and to their use in the treatment of diseases and disorders which may e.g. involve angiogenesis and/or pain, including autoimmune and inflammatory diseases.
摘要翻译： 本发明涉及新的咪唑并吡啶衍生物及其在治疗疾病和病症中的用途， 涉及血管发生和/或疼痛，包括自身免疫和炎性疾病。
-
公开(公告)号：US20090203702A1
公开(公告)日：2009-08-13
申请号：US12062495
申请日：2008-04-03
申请人： Guy W. Bemis , Francesco Gerald Salituro , John Patrick Duffy , John E. Cochran , Edmund Martin Harrington , Mark A. Murcko , Keith P. Wilson , Michael Su , Vincent P. Galullo
发明人： Guy W. Bemis , Francesco Gerald Salituro , John Patrick Duffy , John E. Cochran , Edmund Martin Harrington , Mark A. Murcko , Keith P. Wilson , Michael Su , Vincent P. Galullo
IPC分类号： A61K31/5025 , C07D487/04 , C07D471/04 , A61K31/519 , A61P29/00 , A61P37/00 , A61P25/00
CPC分类号： C07D213/70 , C07D213/56 , C07D213/75 , C07D237/18 , C07D241/12 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/04 , C07D471/04 , C07D487/04 , C07F9/6561
摘要： The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
摘要翻译： 本发明涉及p38的抑制剂，哺乳动物蛋白激酶涉及细胞增殖，细胞死亡和对细胞外刺激的反应。 本发明还涉及生产这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病的方法。
-
公开(公告)号：US08685993B2
公开(公告)日：2014-04-01
申请号：US13995889
申请日：2011-12-19
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D403/14 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The present invention includes novel methods of treating a disease or disorder characterized by hyperactivity of Vps34, and compound as Vps34 inhibitors; particularly compounds of Formula I or a pharmaceutically acceptable salt thereof, as well as methods of treating a disease, disorder, or syndrome associated with Vps34 inhibition, particularly hyperproliferative diseases. The present invention also includes pharmaceutical compositions including compounds of formula I and pharmaceutically acceptable salts thereof.
摘要翻译： 本发明包括治疗以Vps34多动症为特征的疾病或病症的新方法，以及作为Vps34抑制剂的化合物; 特别是式I化合物或其药学上可接受的盐，以及治疗与Vps34抑制，特别是过度增殖性疾病相关的疾病，病症或综合征的方法。 本发明还包括包含式I化合物及其药学上可接受的盐的药物组合物。
-
公开(公告)号：US20110281878A1
公开(公告)日：2011-11-17
申请号：US13107802
申请日：2011-05-13
申请人： Guy W. Bemis , Francesco Gerald Salituro , John Patrick Duffy , John E. Cochran , Edmund Martin Harrington , Mark A. Murko , Keith P. Wilson , Michael Su , Vincent P. Galullo
发明人： Guy W. Bemis , Francesco Gerald Salituro , John Patrick Duffy , John E. Cochran , Edmund Martin Harrington , Mark A. Murko , Keith P. Wilson , Michael Su , Vincent P. Galullo
IPC分类号： A61K31/5025 , C07D471/04 , A61K31/519 , A61P29/00 , A61P37/00 , A61P31/12 , A61P19/08 , A61P35/00 , A61P31/00 , A61P25/28 , A61P37/08 , A61P9/10 , A61P13/12 , A61P7/00 , A61P43/00 , A61P9/00 , A61P7/02 , A61P1/18 , A61P11/06 , A61P11/00 , A61P19/04 , A61P17/00 , A61P5/14 , A61P3/10 , A61P7/06 , A61P31/14 , A61P21/04 , A61P1/00 , A61P1/04 , A61P17/06 , A61P37/06 , A61P19/02 , A61P19/10 , A61P35/02 , A61P35/04 , C07D487/04
CPC分类号： C07D213/70 , C07D213/56 , C07D213/75 , C07D237/18 , C07D241/12 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/04 , C07D471/04 , C07D487/04 , C07F9/6561
摘要： The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
摘要翻译： 本发明涉及p38的抑制剂，哺乳动物蛋白激酶涉及细胞增殖，细胞死亡和对细胞外刺激的反应。 本发明还涉及生产这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病的方法。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.018 秒)
