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公开(公告)号：US08772474B2
公开(公告)日：2014-07-08
申请号：US13332068
申请日：2011-12-20
Applicant: Leonid Beigelman , David Bernard Smith , Jerome Deval , Vivek Kumar Rajwanshi
Inventor： Leonid Beigelman , David Bernard Smith , Jerome Deval , Vivek Kumar Rajwanshi
CPC classification number: C07H19/20 , A61K31/14 , A61K31/513 , A61K31/52 , A61K31/685 , A61K31/7072 , A61K31/7076 , A61K45/06 , C07F9/65744 , C07H17/02 , C07H19/10 , C07H19/11 , C07H19/213 , Y02A50/414 , Y02A50/465 , A61K2300/00
Abstract: Disclosed herein are cyclic nucleotide analogs, methods of synthesizing cyclic nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with cyclic nucleotide analogs.
Abstract translation: 本文公开了环状核苷酸类似物，合成环状核苷酸类似物的方法和用环状核苷酸类似物治疗疾病和/或病症如病毒感染，癌症和/或寄生虫病的方法。
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公开(公告)号：US20090253648A1
公开(公告)日：2009-10-08
申请号：US12415335
申请日：2009-03-31
Applicant: Jesse Daniel Keicher , Christopher Don Roberts , Sebastian Johannes Reinhard Liehr , Xiaoling Zheng , Marija Prhavc , Vivek Kumar Rajwanshi , Ronald Conrad Griffith , Choung U. Kim
Inventor： Jesse Daniel Keicher , Christopher Don Roberts , Sebastian Johannes Reinhard Liehr , Xiaoling Zheng , Marija Prhavc , Vivek Kumar Rajwanshi , Ronald Conrad Griffith , Choung U. Kim
IPC: A61K31/7064 , C07H19/23 , A61P31/14
CPC classification number: C07D487/16 , C07H19/00 , C07H19/22 , C07H19/23
Abstract: Disclosed are compounds represented by formulae I, II, and III, and the compositions and methods thereof for treating viral infections caused by a Flaviviridae family virus.
Abstract translation: 公开了由式I，II和III表示的化合物及其用于治疗由黄病毒科家族病毒引起的病毒感染的组合物和方法。
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3.发明申请公开(公告)号：US20090048189A1
公开(公告)日：2009-02-19
申请号：US11839380
申请日：2007-08-15
Applicant: Jesse Daniel KEICHER , Christopher Don Roberts , Sebastian Johannes Reinhard Liehr , Xiaoling Zheng , Marija Prhavc , Vivek Kumar Rajwanshi , Ronald Conrad Griffith , Choung U. Kim
Inventor： Jesse Daniel KEICHER , Christopher Don Roberts , Sebastian Johannes Reinhard Liehr , Xiaoling Zheng , Marija Prhavc , Vivek Kumar Rajwanshi , Ronald Conrad Griffith , Choung U. Kim
IPC: A61K31/7064 , C07H19/23 , A61P31/14
CPC classification number: C07H19/23
Abstract: Disclosed are tricyclic nucleoside compounds of formula (I), and methods thereof for treating viral infections mediated at least in part by a Flaviviridae family virus.
Abstract translation: 公开了式（I）的三环核苷化合物及其至少部分由黄病毒科家族病毒介导的病毒感染的方法。
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公开(公告)号：US20090226398A1
公开(公告)日：2009-09-10
申请号：US12397220
申请日：2009-03-03
Applicant: Martin Robert Leivers , Christopher Don Roberts , Sebastian Johannes Reinhard Liehr , Stephanie Anna Chan , Roopa Rai , Ryan Lauchli , Son Minh Pham , Vivek Kumar Rajwanshi , Tony Loc Ton , Adam Christopher Villa
Inventor： Martin Robert Leivers , Christopher Don Roberts , Sebastian Johannes Reinhard Liehr , Stephanie Anna Chan , Roopa Rai , Ryan Lauchli , Son Minh Pham , Vivek Kumar Rajwanshi , Tony Loc Ton , Adam Christopher Villa
IPC: A61K38/21 , C07D487/02 , A61K31/5025 , C07D413/14 , A61K31/5377 , A61P31/12
CPC classification number: C07D487/04
Abstract: Disclosed are compounds and compositions of Formula (I), pharmaceutically acceptable salts and solvates thereof, and their preparation and uses for treating viral infections mediated at least in part by a virus in the Flaviviridae family of viruses.
Abstract translation: 公开了式（I）的化合物和组合物，其药学上可接受的盐和溶剂合物，以及它们用于治疗至少部分地由病毒在黄病毒科病毒中介导的病毒感染的制备和用途。
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Patent Agency Ranking
5.发明申请公开(公告)号：US20090062223A1
公开(公告)日：2009-03-05
申请号：US12201692
申请日：2008-08-29
Applicant: Jesse Daniel Keicher , Christopher Don Roberts , Vivek Kumar Rajwanshi , Ronald Conrad Griffith , Xiaoling Zheng , Sebastian Johannes Reinhard Liehr , Marija Prhavc , Choung U. Kim , Adrian S. Ray
Inventor： Jesse Daniel Keicher , Christopher Don Roberts , Vivek Kumar Rajwanshi , Ronald Conrad Griffith , Xiaoling Zheng , Sebastian Johannes Reinhard Liehr , Marija Prhavc , Choung U. Kim , Adrian S. Ray
IPC: A61K31/7064 , C07H19/23 , A61P31/14
CPC classification number: C07H19/23
Abstract: Provided are compounds of Formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds and compositions are useful for treating viral infections caused by the Flaviviridae family of viruses.
Abstract translation: 提供式（I）的化合物或其药学上可接受的盐或溶剂化物。 化合物和组合物可用于治疗由黄病毒科病毒引起的病毒感染。
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公开(公告)号：US20120165286A1
公开(公告)日：2012-06-28
申请号：US13332068
申请日：2011-12-20
Applicant: Leonid Beigelman , David Bernard Smith , Jerome Deval , Vivek Kumar Rajwanshi
Inventor： Leonid Beigelman , David Bernard Smith , Jerome Deval , Vivek Kumar Rajwanshi
IPC: A61K31/7076 , C12N5/02 , A61K31/7072 , A61K31/7064 , A61P31/12 , A61K31/7068 , C07H19/11 , C07H19/213 , A61P31/22 , C12N9/99 , A61K31/708
CPC classification number: C07H19/20 , A61K31/14 , A61K31/513 , A61K31/52 , A61K31/685 , A61K31/7072 , A61K31/7076 , A61K45/06 , C07F9/65744 , C07H17/02 , C07H19/10 , C07H19/11 , C07H19/213 , Y02A50/414 , Y02A50/465 , A61K2300/00
Abstract: Disclosed herein are cyclic nucleotide analogs, methods of synthesizing cyclic nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with cyclic nucleotide analogs.
Abstract translation: 本文公开了环状核苷酸类似物，合成环状核苷酸类似物的方法和用环状核苷酸类似物治疗疾病和/或病症如病毒感染，癌症和/或寄生虫病的方法。
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公开(公告)号：US20120070415A1
公开(公告)日：2012-03-22
申请号：US13236486
申请日：2011-09-19
Applicant: Leonid Beigelman , Jerome Deval , David Bernard Smith , Guangyi Wang , Vivek Kumar Rajwanshi
Inventor： Leonid Beigelman , Jerome Deval , David Bernard Smith , Guangyi Wang , Vivek Kumar Rajwanshi
IPC: A61K38/21 , C07H19/073 , A61K31/7072 , C07H19/067 , A61K31/708 , C07H19/167 , C07H19/10 , C07H19/09 , A61K31/7076 , C07H19/20 , C07H19/11 , C07H19/056 , A61K31/7056 , C07H19/19 , C12N5/071 , A61P31/12 , A61P31/14 , A61P31/16 , A61K39/42 , A61K31/7105 , A61K38/47 , A61K31/7068
CPC classification number: C07H19/06 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7105 , A61K45/06 , C07H19/056 , C07H19/067 , C07H19/073 , C07H19/09 , C07H19/10 , C07H19/11 , C07H19/16 , C07H19/167 , C07H19/19 , C07H19/20 , A61K2300/00
Abstract: Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof. Examples of viral infections include a respiratory syncytial viral (RSV) and influenza infection.
Abstract translation: 本文公开了核苷，核苷酸及其类似物，包括核苷，核苷酸及其类似物中的一种或多种的药物组合物及其合成方法。 本文还公开了改善和/或治疗疾病和/或病症（包括副粘病毒和/或正粘病毒的感染）与其核苷，核苷酸和类似物的方法。 病毒感染的实例包括呼吸道合胞病毒（RSV）和流感感染。
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公开(公告)号：US20120070411A1
公开(公告)日：2012-03-22
申请号：US13236450
申请日：2011-09-19
Applicant: Leonid Beigelman , Lawrence Blatt , Guangyi Wang , Vivek Kumar Rajwanshi , Natalia Dyatkina , David Bernard Smith
Inventor： Leonid Beigelman , Lawrence Blatt , Guangyi Wang , Vivek Kumar Rajwanshi , Natalia Dyatkina , David Bernard Smith
IPC: A61K38/21 , C07H19/10 , A61K31/7076 , A61K31/708 , A61K31/7068 , A61P31/22 , C12N9/99 , C12N5/071 , A61P31/14 , A61P31/12 , A61P31/20 , C07H19/207 , A61K31/7072
CPC classification number: C07H19/067 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K38/21 , A61K45/06 , C07H19/167 , Y02A50/465 , A61K2300/00
Abstract: Disclosed herein are phosphoroamidate nucleotide analogs, methods of synthesizing phosphoroamidate nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with the phosphoroamidate nucleotide analogs.
Abstract translation: 本文公开了磷酰胺酸核苷酸类似物，合成氨基磷酸酯核苷酸类似物的方法和用氨基磷酸酯核苷酸类似物治疗疾病和/或病症如病毒感染，癌症和/或寄生虫病的方法。
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公开(公告)号：US08877731B2
公开(公告)日：2014-11-04
申请号：US13236486
申请日：2011-09-19
Applicant: Leonid Beigelman , Jerome Deval , David Bernard Smith , Guangyi Wang , Vivek Kumar Rajwanshi
Inventor： Leonid Beigelman , Jerome Deval , David Bernard Smith , Guangyi Wang , Vivek Kumar Rajwanshi
IPC: A61K31/70 , A01N43/04 , C07H19/00 , C07H19/04 , C07H19/10 , C07H19/048 , C07H19/20 , C07H19/167 , C07H19/173 , A61K31/7068 , C07H19/056 , C07H19/09 , A61K31/7056 , A61K45/06 , A61K31/7072 , A61K31/708 , A61K31/7105 , C07H19/11 , C07H19/067 , C07H19/19 , A61K31/7076 , C07H19/073
CPC classification number: C07H19/06 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7105 , A61K45/06 , C07H19/056 , C07H19/067 , C07H19/073 , C07H19/09 , C07H19/10 , C07H19/11 , C07H19/16 , C07H19/167 , C07H19/19 , C07H19/20 , A61K2300/00
Abstract: Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof. Examples of viral infections include a respiratory syncytial viral (RSV) and influenza infection.
Abstract translation: 本文公开了核苷，核苷酸及其类似物，包括核苷，核苷酸及其类似物中的一种或多种的药物组合物及其合成方法。 本文还公开了改善和/或治疗疾病和/或病症（包括副粘病毒和/或正粘病毒的感染）与其核苷，核苷酸和类似物的方法。 病毒感染的实例包括呼吸道合胞病毒（RSV）和流感感染。
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