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公开(公告)号：US08877731B2
公开(公告)日：2014-11-04
申请号：US13236486
申请日：2011-09-19
IPC分类号： A61K31/70 , A01N43/04 , C07H19/00 , C07H19/04 , C07H19/10 , C07H19/048 , C07H19/20 , C07H19/167 , C07H19/173 , A61K31/7068 , C07H19/056 , C07H19/09 , A61K31/7056 , A61K45/06 , A61K31/7072 , A61K31/708 , A61K31/7105 , C07H19/11 , C07H19/067 , C07H19/19 , A61K31/7076 , C07H19/073
CPC分类号： C07H19/06 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7105 , A61K45/06 , C07H19/056 , C07H19/067 , C07H19/073 , C07H19/09 , C07H19/10 , C07H19/11 , C07H19/16 , C07H19/167 , C07H19/19 , C07H19/20 , A61K2300/00
摘要： Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof. Examples of viral infections include a respiratory syncytial viral (RSV) and influenza infection.
摘要翻译： 本文公开了核苷，核苷酸及其类似物，包括核苷，核苷酸及其类似物中的一种或多种的药物组合物及其合成方法。 本文还公开了改善和/或治疗疾病和/或病症（包括副粘病毒和/或正粘病毒的感染）与其核苷，核苷酸和类似物的方法。 病毒感染的实例包括呼吸道合胞病毒（RSV）和流感感染。
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公开(公告)号：US20120165286A1
公开(公告)日：2012-06-28
申请号：US13332068
申请日：2011-12-20
IPC分类号： A61K31/7076 , C12N5/02 , A61K31/7072 , A61K31/7064 , A61P31/12 , A61K31/7068 , C07H19/11 , C07H19/213 , A61P31/22 , C12N9/99 , A61K31/708
CPC分类号： C07H19/20 , A61K31/14 , A61K31/513 , A61K31/52 , A61K31/685 , A61K31/7072 , A61K31/7076 , A61K45/06 , C07F9/65744 , C07H17/02 , C07H19/10 , C07H19/11 , C07H19/213 , Y02A50/414 , Y02A50/465 , A61K2300/00
摘要： Disclosed herein are cyclic nucleotide analogs, methods of synthesizing cyclic nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with cyclic nucleotide analogs.
摘要翻译： 本文公开了环状核苷酸类似物，合成环状核苷酸类似物的方法和用环状核苷酸类似物治疗疾病和/或病症如病毒感染，癌症和/或寄生虫病的方法。
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公开(公告)号：US20120071434A1
公开(公告)日：2012-03-22
申请号：US13236435
申请日：2011-09-19
IPC分类号： A61K31/7072 , C07H19/20 , A61K31/7076 , A61P31/12 , C12N5/071 , A61P31/22 , A61P31/18 , A61P31/16 , A61P31/20 , C07H19/10 , A61P31/14
CPC分类号： C07H19/10 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K45/06 , C07H19/06 , C07H19/16 , C07H19/20 , Y02A50/414 , Y02A50/465 , A61K2300/00
摘要： Disclosed herein are phosphorothioate nucleotide analogs, methods of synthesizing phosphorothioate nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with the phosphorothioate nucleotide analogs.
摘要翻译： 本文公开了硫代磷酸酯核苷酸类似物，合成硫代磷酸酯核苷酸类似物的方法和用硫代磷酸酯核苷酸类似物治疗疾病和/或病症如病毒感染，癌症和/或寄生虫病的方法。
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公开(公告)号：US20120070415A1
公开(公告)日：2012-03-22
申请号：US13236486
申请日：2011-09-19
IPC分类号： A61K38/21 , C07H19/073 , A61K31/7072 , C07H19/067 , A61K31/708 , C07H19/167 , C07H19/10 , C07H19/09 , A61K31/7076 , C07H19/20 , C07H19/11 , C07H19/056 , A61K31/7056 , C07H19/19 , C12N5/071 , A61P31/12 , A61P31/14 , A61P31/16 , A61K39/42 , A61K31/7105 , A61K38/47 , A61K31/7068
CPC分类号： C07H19/06 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7105 , A61K45/06 , C07H19/056 , C07H19/067 , C07H19/073 , C07H19/09 , C07H19/10 , C07H19/11 , C07H19/16 , C07H19/167 , C07H19/19 , C07H19/20 , A61K2300/00
摘要： Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof. Examples of viral infections include a respiratory syncytial viral (RSV) and influenza infection.
摘要翻译： 本文公开了核苷，核苷酸及其类似物，包括核苷，核苷酸及其类似物中的一种或多种的药物组合物及其合成方法。 本文还公开了改善和/或治疗疾病和/或病症（包括副粘病毒和/或正粘病毒的感染）与其核苷，核苷酸和类似物的方法。 病毒感染的实例包括呼吸道合胞病毒（RSV）和流感感染。
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公开(公告)号：US20100331397A1
公开(公告)日：2010-12-30
申请号：US12822088
申请日：2010-06-23
申请人： Leonid Beigelman , Lawrence Blatt , Harri Lönnberg , Roopa Rai , Guangyi Wang , Thomas Horn , Julian Symons , Antitsa Simitrova Stoycheva , Dean Ng , Jerome Deval
发明人： Leonid Beigelman , Lawrence Blatt , Harri Lönnberg , Roopa Rai , Guangyi Wang , Thomas Horn , Julian Symons , Antitsa Simitrova Stoycheva , Dean Ng , Jerome Deval
IPC分类号： A61K31/7088 , C07H21/00 , A61P31/04 , A61P31/12 , A61P35/00
CPC分类号： A61K31/7088 , C07H21/02 , Y02A50/387 , Y02A50/414 , Y02A50/465
摘要： Disclosed herein are compounds that activate RNaseL, methods of synthesizing compounds that activate RNaseL and the use of compounds that activate RNaseL for treating and/or ameliorating a disease or a condition, such as a viral infection, a bacterial infection, cancer and/or parasitic disease.
摘要翻译： 本文公开的是激活RNaseL的化合物，合成活化RNaseL的化合物的方法和使用激活RNaseL的化合物来治疗和/或改善疾病或病症如病毒感染，细菌感染，癌症和/或寄生虫 疾病。
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公开(公告)号：US08871737B2
公开(公告)日：2014-10-28
申请号：US13236435
申请日：2011-09-19
IPC分类号： A61K31/70 , C07H19/04 , C07H19/10 , C07H19/20 , C07H19/06 , A61K31/7072 , C07H19/16 , A61K45/06 , A61K31/7076
CPC分类号： C07H19/10 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K45/06 , C07H19/06 , C07H19/16 , C07H19/20 , Y02A50/414 , Y02A50/465 , A61K2300/00
摘要： Disclosed herein are phosphorothioate nucleotide analogs, such as thiophosphoroamidate prodrugs and thiophosphates (including α-thiomonophosphates, α-thiodiphosphates, and α-thiotriphosphates), methods of synthesizing phosphorothioate nucleotide analogs, such as thiophosphoramidate prodrugs, and thiophosphates and methods of treating viral infections, such as HCV, cancer, and/or parasitic diseases with the phosphorothioate nucleotide analogs, such as thiophosphoramidate prodrugs, and thiophosphates.
摘要翻译： 本文公开了硫代磷酸酯核苷酸类似物，例如硫代磷酰胺酸酯前药和硫代磷酸酯（包括α-硫代磷酸酯，α-硫代二磷酸酯和α-硫代三磷酸酯），合成硫代磷酸酯核苷酸类似物如硫代磷酰胺酸酯前药和硫代磷酸酯的方法和治疗病毒感染的方法， 例如具有硫代磷酸酯核苷酸类似物的HCV，癌症和/或寄生虫病，例如硫代磷酰胺酸酯前药和硫代磷酸酯。
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公开(公告)号：US08772474B2
公开(公告)日：2014-07-08
申请号：US13332068
申请日：2011-12-20
CPC分类号： C07H19/20 , A61K31/14 , A61K31/513 , A61K31/52 , A61K31/685 , A61K31/7072 , A61K31/7076 , A61K45/06 , C07F9/65744 , C07H17/02 , C07H19/10 , C07H19/11 , C07H19/213 , Y02A50/414 , Y02A50/465 , A61K2300/00
摘要： Disclosed herein are cyclic nucleotide analogs, methods of synthesizing cyclic nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with cyclic nucleotide analogs.
摘要翻译： 本文公开了环状核苷酸类似物，合成环状核苷酸类似物的方法和用环状核苷酸类似物治疗疾病和/或病症如病毒感染，癌症和/或寄生虫病的方法。
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