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公开(公告)号：US20070072817A1
公开(公告)日：2007-03-29
申请号：US11418974
申请日：2006-05-05
CPC分类号： C07K16/22 , A61K2039/505
摘要： The present invention relates to methods and agents for reducing blood pressure. Methods and agents for reducing diastolic blood pressure, for reducing systolic blood pressure, and for reducing mean arterial pressure are also provided.
摘要翻译： 本发明涉及降低血压的方法和试剂。 还提供了用于降低舒张压，降低收缩压和降低平均动脉压的方法和试剂。
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公开(公告)号：US20070004627A1
公开(公告)日：2007-01-04
申请号：US11455199
申请日：2006-06-15
申请人： Todd Seeley , David Liu , Stephen Klaus
发明人： Todd Seeley , David Liu , Stephen Klaus
IPC分类号： A61K38/54 , A61K31/19 , A61K31/195
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/19 , A61K31/195 , A61K31/63 , A61K38/16
摘要： The invention relates to methods and compounds for treating or preventing cancer. Methods for treating or preventing cancer, for inhibiting tumor growth, reducing tumor volume, inhibiting tumor progression, inhibiting metastasis, and improving survival are provided herein.
摘要翻译： 本发明涉及治疗或预防癌症的方法和化合物。 本文提供了治疗或预防癌症，抑制肿瘤生长，减少肿瘤体积，抑制肿瘤进展，抑制转移和改善生存的方法。
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公开(公告)号：US20060251638A1
公开(公告)日：2006-11-09
申请号：US10554450
申请日：2004-06-04
申请人： Volkmar Guenzler-Pukall , Stephen Klaus , David Liu , Todd Seeley
发明人： Volkmar Guenzler-Pukall , Stephen Klaus , David Liu , Todd Seeley
CPC分类号： A61K31/63 , A61K31/00 , A61K31/4745
摘要： The invention relates to methods for conferring cytoprotection, or for inducing a cytoprotective effect, by administering a compound that inhibits HIF hydroxylase. Compounds for use in these methods are also provided.
摘要翻译： 本发明涉及通过施用抑制HIF羟化酶的化合物来赋予细胞保护作用或诱导细胞保护作用的方法。 还提供了用于这些方法的化合物。
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4.发明申请公开(公告)号：US20050282766A1
公开(公告)日：2005-12-22
申请号：US11177138
申请日：2005-07-08
申请人： Bin Wu , Todd Seeley , Lewis Williams
发明人： Bin Wu , Todd Seeley , Lewis Williams
IPC分类号： C12N15/09 , A61K31/7088 , A61K31/7105 , A61K38/00 , A61K38/55 , A61K39/395 , A61K48/00 , A61P35/00 , A61P43/00 , C12N9/12 , C12N9/99 , C12N15/113 , C07H21/04 , C07K16/40
CPC分类号： C12N15/1137 , A61K38/00 , C12N9/1205 , C12N2310/11 , C12Y207/01037
摘要： Inhibitors of KIAA0175 are provided that reduce the expression or biological activities of KIAA0175, p53 and/or p21 in a mammalian cell. KIAA0175 inhibitors include anti-sense molecules, ribozymes, antibodies and antibody fragments, proteins and polypeptides as well as small molecules. KIAA0175 inhibitors find use in compositions and methods for decreasing KIAA0175, p53 and/or p21 gene expression as well as methods for increasing the chemo and/or radiosensitivity of mammalian cells, including tumor cells, methods for decreasing the side effects of cancer therapy and methods for treating neoplastic diseases.
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公开(公告)号：US20050020487A1
公开(公告)日：2005-01-27
申请号：US10861590
申请日：2004-06-03
申请人： Stephen Klaus , Christopher Molineaux , Thomas Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd Seeley , Robert Stephenson
发明人： Stephen Klaus , Christopher Molineaux , Thomas Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd Seeley , Robert Stephenson
IPC分类号： A61K31/00 , A61K31/165 , A61K31/395 , A61P7/06 , A61K38/16
CPC分类号： C07D217/24 , A61K31/00 , A61K31/165 , A61K31/17 , A61K31/395 , A61K31/472 , C07C275/40
摘要： The present invention relates to methods and compounds for regulating or enhancing erthropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
摘要翻译： 本发明涉及用于调节或增强红细胞生成和铁代谢以及用于治疗或预防慢性疾病的铁缺乏和贫血的方法和化合物。
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