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1.发明申请SUBSTITUTED CYCLOPROPLY COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT 有权取代的环状化合物，包含这些化合物的组合物和处理方法公开(公告)号：US20140057893A1
公开(公告)日：2014-02-27
申请号：US14110332
申请日：2012-04-05
申请人： Scott Edmondson , Zhiqiang Guo , Harold B. Wood , Andrew W. Stamford , Michael W. Miller , Duane E. DeMong , Gregori J. Morriello , Rajan Anand , Vincent J. Colandrea , Megan Macala , Milana Maletic , Cheng Zhu , Yuping Zhu , Wanying Sun , Kake Zhao , Yong Huang , Joel M. Harris , Lehua Chang , Nam Fung Kar , Zhiyong Hu , Liping Wang , Bowei Wang , Ping Liu , Jason W. Szewczyk , William B. Geiss
发明人： Scott Edmondson , Zhiqiang Guo , Harold B. Wood , Andrew W. Stamford , Michael W. Miller , Duane E. DeMong , Gregori J. Morriello , Rajan Anand , Vincent J. Colandrea , Megan Macala , Milana Maletic , Cheng Zhu , Yuping Zhu , Wanying Sun , Kake Zhao , Yong Huang , Joel M. Harris , Lehua Chang , Nam Fung Kar , Zhiyong Hu , Liping Wang , Bowei Wang , Ping Liu , Jason W. Szewczyk , William B. Geiss
IPC分类号： C07D513/04 , C07D413/14 , C07D413/04 , C07D498/04 , C07D405/04 , C07D471/04 , C07D487/04 , C07D401/12 , C07D211/22
CPC分类号： C07D513/04 , A61K9/4858 , C07D211/22 , C07D401/12 , C07D405/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04
摘要： Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included
摘要翻译： 公开了取代的式I的环丙基化合物及其药学上可接受的盐可用于治疗或预防2型糖尿病和类似病状。 该化合物可用作G蛋白偶联受体GPR-119的激动剂。 还包括药物组合物和治疗方法
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2.发明授权Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment 有权取代的环丙基化合物，含有这些化合物的组合物和处理方法公开(公告)号：US08957062B2
公开(公告)日：2015-02-17
申请号：US14110332
申请日：2012-04-05
申请人： Scott Edmondson , Zhiqiang Guo , Harold B. Wood , Andrew W. Stamford , Michael W. Miller , Duane E. DeMong , Gregori J. Morriello , Rajan Anand , Vincent J. Colandrea , Megan Macala , Milana Maletic , Cheng Zhu , Yuping Zhu , Wanying Sun , Kake Zhao , Yong Huang , Joel M. Harris , Lehua Chang , Nam Fung Kar , Zhiyong Hu , Liping Wang , Bowei Wang , Ping Liu , Jason W. Szewczyk , William B. Geiss
发明人： Scott Edmondson , Zhiqiang Guo , Harold B. Wood , Andrew W. Stamford , Michael W. Miller , Duane E. DeMong , Gregori J. Morriello , Rajan Anand , Vincent J. Colandrea , Megan Macala , Milana Maletic , Cheng Zhu , Yuping Zhu , Wanying Sun , Kake Zhao , Yong Huang , Joel M. Harris , Lehua Chang , Nam Fung Kar , Zhiyong Hu , Liping Wang , Bowei Wang , Ping Liu , Jason W. Szewczyk , William B. Geiss
IPC分类号： C07D513/04 , C07D401/12 , C07D413/14 , C07D413/04 , C07D211/22 , C07D405/04 , C07D471/04 , C07D487/04 , C07D498/04 , A61K9/48 , C07D417/14 , C07D495/04
CPC分类号： C07D513/04 , A61K9/4858 , C07D211/22 , C07D401/12 , C07D405/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04
摘要： Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译： 公开了取代的式I的环丙基化合物及其药学上可接受的盐可用于治疗或预防2型糖尿病和类似病症。 该化合物可用作G蛋白偶联受体GPR-119的激动剂。 还包括药物组合物和治疗方法。
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3.发明申请公开(公告)号：US20110028461A1
公开(公告)日：2011-02-03
申请号：US12936275
申请日：2009-03-23
申请人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Bart Harper , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Harvey Wendt , Cheng Zhu
发明人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Bart Harper , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Harvey Wendt , Cheng Zhu
IPC分类号： A61K31/4439 , C07D417/14 , A61K31/502 , C07D413/14 , A61K31/5355 , A61P13/00 , A61P13/10
CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D487/04 , C07D495/04
摘要： The present invention provides compounds of Formula I, pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
摘要翻译： 本发明提供式I化合物，其药物组合物及其用于治疗或预防由β-肾上腺素能受体激活介导的疾病的方法。
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4.发明申请公开(公告)号：US20090253705A1
公开(公告)日：2009-10-08
申请号：US12417239
申请日：2009-04-02
申请人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Cheng Zhu
发明人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Cheng Zhu
IPC分类号： A61K31/506 , C07D417/12 , C07D403/12 , C07D495/04 , C07D401/12 , A61K31/427 , A61K31/428 , A61K31/517 , A61K31/501 , A61K31/502 , A61K31/4439 , A61K31/41 , A61K31/437 , A61P13/10
CPC分类号： C07D487/04 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04
摘要： The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
摘要翻译： 本发明提供式（I）的化合物，其药物组合物及其用于治疗或预防由β3肾上腺素受体激活介导的疾病的方法。
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公开(公告)号：US08247415B2
公开(公告)日：2012-08-21
申请号：US12417239
申请日：2009-04-02
申请人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Cheng Zhu
发明人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Cheng Zhu
IPC分类号： C07D237/30 , C07D239/90 , C07D221/02 , C07D277/60 , A61K31/502 , A61K31/517 , A61K31/435 , A61K31/428 , A61P13/10 , A61P13/06
CPC分类号： C07D487/04 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04
摘要： The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
摘要翻译： 本发明提供式（I）化合物，其药物组合物及其用于治疗或预防由β-肾上腺素能受体激活介导的疾病的方法。
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公开(公告)号：US08653260B2
公开(公告)日：2014-02-18
申请号：US13527934
申请日：2012-06-20
申请人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Ding-Ming Shen , Liping Wang , Cheng Zhu
发明人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Ding-Ming Shen , Liping Wang , Cheng Zhu
IPC分类号： C07D253/08 , C07D487/04 , C07D495/04 , C07D239/80 , C07D241/12 , C07D265/06 , C07D237/14 , C07D237/16 , C07D237/32 , A61P13/06
CPC分类号： C07D487/04 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04
摘要： The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
摘要翻译： 本发明提供式（I）的化合物，其药物组合物及其用于治疗或预防由β3肾上腺素受体激活介导的疾病的方法。
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公开(公告)号：US08501786B2
公开(公告)日：2013-08-06
申请号：US12936275
申请日：2009-03-23
申请人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Bart Harper , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Harvey Wendt , Cheng Zhu
发明人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Bart Harper , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Harvey Wendt , Cheng Zhu
IPC分类号： A61K31/443 , A61K31/4436 , A61K31/4439 , C07D401/14 , C07D413/14 , C07D417/14
CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D487/04 , C07D495/04
摘要： The present invention provides compounds of Formula I, pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
摘要翻译： 本发明提供式I化合物，其药物组合物及其用于治疗或预防由β3肾上腺素受体激活介导的疾病的方法。
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公开(公告)号：US08399480B2
公开(公告)日：2013-03-19
申请号：US12936221
申请日：2009-04-02
申请人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Cheng Zhu
发明人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Cheng Zhu
IPC分类号： A61K43/90 , A01K31/44 , C07D237/00
CPC分类号： C07D487/04 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04
摘要： The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
摘要翻译： 本发明提供式（I）化合物，其药物组合物及其用于治疗或预防由β-肾上腺素能受体激活介导的疾病的方法。
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9.发明申请公开(公告)号：US20120258963A1
公开(公告)日：2012-10-11
申请号：US13527934
申请日：2012-06-20
申请人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Cheng Zhu
发明人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Cheng Zhu
IPC分类号： A61K31/41 , C07D403/12 , C07D413/12 , A61K31/427 , A61K31/428 , A61P13/00 , A61K31/416 , A61K31/4178 , A61K31/502 , A61K31/53 , A61K31/5355 , A61P13/10 , C07D417/12 , A61K31/4192
CPC分类号： C07D487/04 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04
摘要： The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
摘要翻译： 本发明提供式（I）化合物，其药物组合物及其用于治疗或预防由β-肾上腺素能受体激活介导的疾病的方法。
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10.发明申请公开(公告)号：US20110028481A1
公开(公告)日：2011-02-03
申请号：US12936221
申请日：2009-04-02
申请人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Cheng Zhu
发明人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Cheng Zhu
IPC分类号： A61K31/427 , C07D417/12 , C07D403/12 , A61K31/428 , A61K31/502 , A61P13/10
CPC分类号： C07D487/04 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04
摘要： The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
摘要翻译： 本发明提供式（I）化合物，其药物组合物及其用于治疗或预防由β-肾上腺素能受体激活介导的疾病的方法。
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