公开(公告)号：US07772579B2

公开(公告)日：2010-08-10

申请号：US11804589

申请日：2007-05-18

申请人： William D. Herzog ,  Antonio Sanchez-Rubio ,  Gregory G. Cappiello ,  Ronald H. Hoffeld ,  Shane M. Tysk ,  Vincenzo Daneu ,  Thomas H. Jeys

发明人： William D. Herzog ,  Antonio Sanchez-Rubio ,  Gregory G. Cappiello ,  Ronald H. Hoffeld ,  Shane M. Tysk ,  Vincenzo Daneu ,  Thomas H. Jeys

IPC分类号： G01N15/06 ,  G01N21/49 ,  G01N21/85

CPC分类号： G01P5/20 ,  G01N2001/2223 ,  G01N2015/0088 ,  G01N2015/1075 ,  G01N2015/145

摘要： Particle detection systems without knowledge of a location and velocity of a particle passing through a volume of space, are less efficient than if knowledge of the particle location is known. An embodiment of a particle position detection system capable of determining an exact location of a particle in a fluid stream is discussed. The detection system may employ a patterned illuminating beam, such that once a particle passes through the various portions of the patterned illuminating beam, a light scattering is produced. The light scattering defines a temporal profile that contains measurement information indicative of an exact particle location. However, knowledge of the exact particle location has several advantages. These advantages include correction of systematic particle measurement errors due to variability of the particle position within the sample volume, targeting of particles based on position, capture of particles based on position, reduced system energy consumption and reduced system complexity.

摘要翻译： 不知道通过一定空间的颗粒的位置和速度的颗粒检测系统比知道颗粒位置的知识效率更低。 讨论了能够确定流体流中颗粒的确切位置的粒子位置检测系统的实施例。 检测系统可以使用图案化的照明光束，使得一旦粒子通过图案化照明光束的各个部分，就产生光散射。 光散射定义了包含指示精确粒子位置的测量信息的时间分布。 然而，确切的粒子位置的知识有几个优点。 这些优点包括校正由于样品体积内的颗粒位置的变异性引起的系统的颗粒测量误差，基于位置的颗粒靶向，基于位置的颗粒捕获，降低的系统能量消耗和降低的系统复杂性。

公开(公告)号：US20090316138A1

公开(公告)日：2009-12-24

申请号：US12124767

申请日：2008-05-21

申请人： William D. Herzog

发明人： William D. Herzog

IPC分类号： G01N21/00 ,  G01J3/00

CPC分类号： G01N15/1456 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/53 ,  G01N2021/4707 ,  G01N2021/4709 ,  G01N2021/4726

摘要： Physical property determination of a particle or classification of the particle as a function of the physical property by evaluating scattered light profile from a single particle is disclosed. The particle may include chemical structures that vibrate as a function of a physical property of the particle. The physical property may include an absorptive property of the particle or a chemical composition. From a detected scattered light spectrum, at least two anomalous dispersive regions may be identified. The physical property of the particle may be determined as a function of the at least two regions. A system employing the physical property determination can achieve sensitivities useful for low particle density applications such as detection for biological and chemical agents.

摘要翻译： 公开了通过从单个颗粒评估散射光轮廓，粒子的物理性质或颗粒的分类作为物理性质的函数。 颗粒可以包括作为颗粒的物理性质的函数振动的化学结构。 物理性质可以包括颗粒的吸收性质或化学组成。 从检测到的散射光谱中，可以识别至少两个异常色散区域。 颗粒的物理性质可以确定为至少两个区域的函数。 采用物理性质测定的系统可以实现用于低颗粒密度应用的灵敏度，例如生物和化学试剂的检测。

公开(公告)号：US09594011B2

公开(公告)日：2017-03-14

申请号：US12124767

申请日：2008-05-21

申请人： William D. Herzog

发明人： William D. Herzog

IPC分类号： G01N33/50 ,  G01N15/14 ,  G01N21/53 ,  G01N21/35 ,  G01N21/47 ,  G01N21/3577

CPC分类号： G01N15/1456 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/53 ,  G01N2021/4707 ,  G01N2021/4709 ,  G01N2021/4726

摘要： Physical property determination of a particle or classification of the particle as a function of the physical property by evaluating scattered light profile from a single particle is disclosed. The particle may include chemical structures that vibrate as a function of a physical property of the particle. The physical property may include an absorptive property of the particle or a chemical composition. From a detected scattered light spectrum, at least two anomalous dispersive regions may be identified. The physical property of the particle may be determined as a function of the at least two regions. A system employing the physical property determination can achieve sensitivities useful for low particle density applications such as detection for biological and chemical agents.

摘要翻译： 公开了通过从单个颗粒评估散射光轮廓，粒子的物理性质或颗粒的分类作为物理性质的函数。 颗粒可以包括作为颗粒的物理性质的函数振动的化学结构。 物理性质可以包括颗粒的吸收性质或化学组成。 从检测到的散射光谱中，可以识别至少两个异常色散区域。 颗粒的物理性质可以确定为至少两个区域的函数。 采用物理性质测定的系统可以实现用于低颗粒密度应用的灵敏度，例如生物和化学试剂的检测。

公开(公告)号：US08274655B2

公开(公告)日：2012-09-25

申请号：US12697399

申请日：2010-02-01

申请人： William D. Herzog

发明人： William D. Herzog

IPC分类号： G01N15/02

CPC分类号： G01N15/1459 ,  G01N2015/0046 ,  G01N2015/0088 ,  G01N2015/025

摘要： Particle detection systems configured to identify a particle in a bulk sample volume are less efficient than those configured to measure a single particle. A particle detection system according to an inventive embodiment can identify a particle in a fluid stream. The detection system may employ one or more heating stations. Each heating station may be set to a distinct temperature. The heating stations may include a light source and a light detector, such that once a particle traverses a beam provided by the light source, the light detector may measure resultant optical scattering. Based on the optical scattering with respect to temperature or temperature variation, an identification of the single particle may be obtained, thereby eliminating measurement inaccuracies associated with bulk sample volumes. The particle detection system may detect organic particles among inorganic particles in various fluid flow environments, such as for safety or quality purposes.

摘要翻译： 配置为识别大容量样品体积中的颗粒的颗粒检测系统比配置成测量单个颗粒的颗粒检测系统效率低。 根据本发明实施例的颗粒检测系统可以识别流体流中的颗粒。 检测系统可以使用一个或多个加热站。 每个加热站可以设定为不同的温度。 加热站可以包括光源和光检测器，使得一旦粒子穿过由光源提供的光束，光检测器可以测量所得到的光散射。 基于相对于温度或温度变化的光学散射，可以获得单个颗粒的识别，从而消除与体积样品体积相关的测量不准确度。 颗粒检测系统可以检测各种流体流动环境中的无机颗粒中的有机颗粒，例如为了安全或质量目的。

公开(公告)号：US20100220323A1

公开(公告)日：2010-09-02

申请号：US12697399

申请日：2010-02-01

申请人： William D. Herzog

发明人： William D. Herzog

IPC分类号： G01N15/02 ,  G01N21/00

CPC分类号： G01N15/1459 ,  G01N2015/0046 ,  G01N2015/0088 ,  G01N2015/025

摘要： Particle detection systems configured to identify a particle included in a bulk sample volume are less efficient than if measurements are to be taken of a single particle. An embodiment of a particle detection system according to an embodiment of the present invention capable of determining an identification of a particle in a fluid stream is presented. The detection system may employ one or any number of heating stations. Each heating station may be set to a distinct temperature. The heating stations may include a light source and a light detector, such that once a particle traverses a beam provided by the light source, the light detector may measure resultant optical scattering. Based on the optical scattering with respect to temperature or temperature variation, an identification of the single particle may be obtained, thereby eliminating measurement inaccuracies associated with bulk sample volumes. The particle detection system may be applied to detection of organic particles among inorganic particles in various fluid flow environments, such as for safety or quality purposes.

摘要翻译： 配置成识别包含在大容量样品体积中的颗粒的颗粒检测系统比对单个颗粒进行测量的效率更低。 提出了根据本发明的实施例的能够确定流体流中的颗粒的识别的颗粒检测系统的实施例。 检测系统可以采用一个或任何数量的加热站。 每个加热站可以设定为不同的温度。 加热站可以包括光源和光检测器，使得一旦粒子穿过由光源提供的光束，光检测器可以测量所得到的光散射。 基于相对于温度或温度变化的光学散射，可以获得单个颗粒的识别，从而消除与体积样品体积相关的测量不准确度。 颗粒检测系统可以用于在各种流体流动环境中的无机颗粒中的有机颗粒的检测，例如为了安全或质量目的。