公开(公告)号：US20110145011A1

公开(公告)日：2011-06-16

申请号：US12966720

申请日：2010-12-13

申请人： William E. Shell ,  Elizabeth H. Charuvastra

发明人： William E. Shell ,  Elizabeth H. Charuvastra

IPC分类号： G06Q50/00 ,  G06Q10/00

CPC分类号： G06Q10/10 ,  G06Q50/22

摘要： A method for submitting a claim form for a dispensed medication to a patient by a point-of-care physician including determining the dispensed medication and payor for the patient by the point-of-care physician; acquiring a national provider identifier number and a non-pharmacy dispensing number for the point-of-care physician; displaying to a user a selection of data fields to the claim form; inputting into the data fields data relating to the claim including the payor and at least one of the national provider identifier number and the non-pharmacy dispensing number; transmitting to a logic switch the claim form including the payor and the at least one of the national provider identifier number and the non-pharmacy dispensing number identifying the point-of-care physician for determining the processor for the claim form; determining the pathway for the claim form based on the payor; processing the claim form by the payor; and transmitting an adjudication.

摘要翻译： 一种由护理医师向患者提交分配的药物的索赔表的方法，包括由护理医师确定分配的药物和患者的支付者; 获得护理医师的国家供应商标识号和非药房分发号; 向用户显示对索赔表格的数据字段的选择; 将包括付款人的权利要求与国家提供商标识号和非药剂分配号码中的至少一个相关联的数据字段输入到数据字段; 向所述逻辑交换机发送包括所述支付者和所述国家提供商标识符号和所述非药剂分配号码中的至少一个的所述索赔表格，所述非药剂分配号码识别所述护理医师用于确定所述权利要求表格的处理器; 根据付款人确定索赔表的途径; 由付款人处理索赔表; 并转交裁决。

公开(公告)号：US4865850A

公开(公告)日：1989-09-12

申请号：US904410

申请日：1986-09-08

申请人： William E. Shell ,  Jackie R. See

发明人： William E. Shell ,  Jackie R. See

IPC分类号： A61K9/16 ,  A61K9/18 ,  A61K31/575 ,  A61K35/413

CPC分类号： A61K31/575 ,  A61K35/413 ,  A61K9/167 ,  Y10S514/909 ,  Y10S514/951 ,  Y10T428/2989

摘要： A method and a composition for accumulating and the binding of food fats in an animal body gastrointestinal tract. The method and composition rely upon non-biodegradable collagen particles, such as microspheres, having a size of at least two microns and a fat receptor, such as bile, capable of having food fat adhered thereto on the surface of the particles. These particles are sufficiently large so that they do not pass through the surface mucosa of the gastrointestinal tract and permit the particles with the food fat to pass through the gastrointestinal tract and out of the body through animal excretion.

公开(公告)号：US4820732A

公开(公告)日：1989-04-11

申请号：US848233

申请日：1986-04-04

申请人： William E. Shell ,  Jackie R. See

发明人： William E. Shell ,  Jackie R. See

IPC分类号： A61K31/557 ,  A61K49/04 ,  A61K31/19

CPC分类号： A61K49/04 ,  A61K31/557

摘要： A method for reducing dysfunction in angioplasty procedures and particularly, in myocardial angioplasty procedures in human beings is desired. The method involves the introduction of a selected amount of intra-arterial prostaglandin compound into an artery, such as a coronary artery, in which an angioplasty procedure is to occur. The prostaglandin compound will provide cyto-protection and provide antithrombotic effects and antiplatelet effects and antispasmatic effects. The prostaglandin compound is administered in a pharmacological amount, that is, an amount substantially greater than the prostaglandin which would be generated by a normal myocardial artery when insulated and thus, constitutes an administration substantially greater than an amount which would be administered in a replacement therapy. A composition is also provided for reducing dysfunction in angioplasty procedures and comprises a selected amount of a carrier and a prostaglandin compound carried in a specified amount and which carrier does not alter the prostaglandin compound and releases the prostaglandin compound at a rate sufficient to dilate blood vessels to thereby produce the required efficacy. A prepackaged combination of components provides for the complete administration of the prostaglandin compound before, during and after the angioplasty procedure.

摘要翻译： 需要一种降低血管成形术程序的功能障碍的方法，特别是人心肌血管成形术中的功能障碍。 该方法包括将选择量的动脉内前列腺素化合物引入到其中将发生血管成形术程序的动脉（例如冠状动脉）中。 前列腺素化合物将提供细胞保护作用，提供抗血栓形成和抗血小板作用及抗血栓作用。 前列腺素化合物以药理学量施用，即，当绝缘时，由正常心肌动脉产生的明显大于前列腺素的量，因此构成显着大于在替代疗法中施用的量的给药 。 还提供了用于减少血管成形术程序中的功能障碍的组合物，并且包括选定量的载体和前列腺素化合物，所述载体和前列腺素化合物以特定量携带，并且所述载体不改变前列腺素化合物并以足以扩张血管的速率释放前列腺素化合物 从而产生所需的功效。 预先包装的组分组合提供了在血管成形术程序之前，期间和之后完全给予前列腺素化合物。

公开(公告)号：US07674482B2

公开(公告)日：2010-03-09

申请号：US11386325

申请日：2006-03-22

申请人： William E. Shell ,  Elizabeth Charuvastra

发明人： William E. Shell ,  Elizabeth Charuvastra

IPC分类号： A61K36/00 ,  A61K31/14 ,  A61K31/221 ,  A61K36/16 ,  A61K47/00

CPC分类号： A61K36/734 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/522 ,  A61K36/16 ,  A61K36/185 ,  A61K36/258 ,  A61K36/28 ,  A61K36/38 ,  A61K36/54 ,  A61K45/06 ,  Y10S514/923 ,  A61K2300/00 ,  A23V2250/2108 ,  A23V2250/0624 ,  A23V2250/0652 ,  A23V2250/2122 ,  A23V2250/304 ,  A23V2250/0618 ,  A23V2250/2106

摘要： The methods and compositions for potentiating pharmaceuticals with amino acid based medical foods provides improved cognitive function; induced and maintained sleep; reduced pain, inflammation, blood pressure, anxiety, asthma, duration of viral infection, insulin resistance, and appetite; and treated depression. The amino acid based medical foods, co-packed with at least one selected pharmaceutical, potentiate the pharmaceutical by enhancing the production of neurotransmitters through the oral administration of neurotransmitter precursors, along with natural plant and animal substances that stimulate uptake of the neurotransmitter precursors, cause release of neurotransmitters, cause disinhibition of the neuronal brake, and activate adenylate cyclase in order to avoid tachyphylaxis and prevent pharmacologic tolerance.

摘要翻译： 用氨基酸为基础的医疗食品增强药物的方法和组合提高了认知功能; 诱导和维持睡眠; 减轻疼痛，炎症，血压，焦虑，哮喘，病毒感染持续时间，胰岛素抵抗和食欲; 并治疗抑郁症。 与至少一种选择的药物共同填充的基于氨基酸的医用食品通过口服神经递质前体的增强以及刺激神经递质前体摄取的天然植物和动物物质增强神经递质的生成来增强药物 释放神经递质，导致神经元制动的解除抑制，并激活腺苷酸环化酶，以避免快速发作并防止药理学耐受。

公开(公告)号：US20080288281A1

公开(公告)日：2008-11-20

申请号：US11804085

申请日：2007-05-17

申请人： William E. Shell ,  Elizabeth Charuvastra

发明人： William E. Shell ,  Elizabeth Charuvastra

IPC分类号： G06Q50/00

CPC分类号： G06Q10/10 ,  G06F19/00 ,  G06Q50/22

摘要： A system for submitting a claim for a dispensed medication to a patient by a point-of-care physician including means acquiring at least one of the group consisting of a national practitioner number and a non pharmacy dispensing number for the point-of-care physician; means for displaying to a user a selection of data fields relating to the claim; means for inputting into the data fields data relating to the claim including the at least one of the group consisting of the national practitioner identifier number and the non pharmacy dispensing number; means for transmitting to a logic switch the claim containing the at least one of the group consisting of a national practitioner identifier number and a non pharmacy dispensing number identifying the point-of-care physician for determining the processor for the claim; means for determining the pathway for the claim based on a type of payor associated with the patient; means for processing the claim containing the at least one of the group consisting of a national practitioner identifier number and a non pharmacy dispensing number to identify the point-of-care physician; and responsive to the means for processing, means for transmitting to the point-of-care physician an adjudication regarding the claim.

摘要翻译： 一种由护理医师向患者提交分配的药物的索赔的系统，包括获取至少一个由医生护理医师的国民从业者号码和非药房分发号码组成的装置的装置 ; 用于向用户显示与所述权利要求相关的数据字段的选择的装置; 用于向所述数据域输入涉及包括由所述国民从业者标识号和非药剂分配号组成的组中的至少一个的权利要求的数据的装置; 用于向逻辑交换机发送包含所述组中的至少一个的装置，所述组由国家从业者标识符号和非药房分配号标识用于确定用于权利要求的处理器的护理医师; 用于基于与患者相关联的付款人类型来确定权利要求的途径的手段; 用于处理所述索赔的装置，其中包含由国民从业者标识符号和非药剂分配号码组成的组中的至少一个以识别护理医师; 并且响应于处理手段，用于向护理医师传送关于权利要求的裁决的手段。

公开(公告)号：US5186922A

公开(公告)日：1993-02-16

申请号：US462740

申请日：1990-01-08

申请人： William E. Shell ,  Jackie R. See

发明人： William E. Shell ,  Jackie R. See

IPC分类号： A61K9/16 ,  A61K49/04

CPC分类号： A61K49/0419 ,  A61K9/1658

摘要： The invention relates to an inexpensive and easy to use method of visualizing an arterial circulation, using biodegradable microspheres which are permeated with an imaging energy absorbent contrast material, such as an X-ray absorbent material, which enables the diagnosis of pulmonary embolism. The microspheres may be comprised of a variety of materials, including human albumin, and may be dyed with a number of X-ray absorbent materials, or other imaging energy absorbent materials. The microspheres are injected into the bloodstream at a particular location such that they travel through the desired circulation, e.g. an arterial circulation and ultimately become lodged in the capillaries of a tissue of interest. Upon exposure of the arterial circulation to X-rays, blood vessels therein containing the microspheres will absorb the X-rays, causing them to show on a developed X-ray film in contrast to other blood vessels and body tissue which do not contain the microspheres that transmit the X-rays. The microspheres are designed to dissolve into the bloodstream within fifteen to thirty minutes after their introduction, the X-ray dye or other contrast material being ultimately excreted from the body via the urine or metabolized by the liver.

摘要翻译： 本发明涉及一种便宜且易于使用的可视化动脉循环的方法，该方法使用能够诊断肺栓塞的诸如X射线吸收材料的成像能量吸收剂造影材料渗透的可生物降解的微球。 微球可以由各种材料组成，包括人白蛋白，并且可以用许多X射线吸收材料或其它成像能量吸收材料染色。 将微球注射到特定位置的血流中，使得它们穿过期望的循环，例如， 动脉循环并最终成为感兴趣的组织的毛细血管。 当将动脉循环暴露于X射线时，其中含有微球的血管将吸收X射线，导致它们显现在显影的X射线胶片上，与其它不含微球的血管和身体组织相反 传输X射线。 微球被设计成在引入后十五到三十分钟内溶解到血液中，X射线染料或其他对比物质最终通过尿液从身体排出或被肝脏代谢。

公开(公告)号：US4955878A

公开(公告)日：1990-09-11

申请号：US281430

申请日：1988-12-08

申请人： Jackie R. See ,  William E. Shell

发明人： Jackie R. See ,  William E. Shell

IPC分类号： A61K31/557 ,  A61K49/04

CPC分类号： A61K49/04 ,  A61K31/557

摘要： A kit for preventing or treating arterial dysfunction resulting from an angioplasty procedure and particularly, in myocardial angioplasty procedures in human beings. The kit provides the materials necessary to introduce a selected amount of an intraarterial prostaglandin compound into an artery, such as a coronary artery, in which an angioplasty procedure is to occur and an intravenous prostaglandin compound. The prostaglandin compound will provide cyto-protection and provide antithrombotic effects and antiplatelet effects and antispasmatic effects. A composition is also provided for reducing dysfunction in angioplasty procedures and comprises a selected amount of a carrier and a prostaglandin compound carried in a specified amount and which carrier does not alter the prostaglandin compound and releases the prostaglandin compound at a rate sufficient to dilate blood vessels to thereby produce the required efficacy. The kit is a prepackaged combination of components which provides for the complete administration of the prostaglandin compound before, during and after the angioplasty procedure.

摘要翻译： 用于预防或治疗由血管成形术程序产生的动脉功能障碍的试剂盒，特别是在人类的心肌血管成形术程序中。 该试剂盒提供了将选定数量的动脉内前列腺素化合物引入到其中将发生血管成形术程序的动脉（例如冠状动脉）和静脉内前列腺素化合物所需的材料。 前列腺素化合物将提供细胞保护作用，提供抗血栓形成和抗血小板作用及抗血栓作用。 还提供了用于减少血管成形术程序中的功能障碍的组合物，并且包括选定量的载体和前列腺素化合物，所述载体和前列腺素化合物以特定量携带，并且所述载体不改变前列腺素化合物并以足以扩张血管的速率释放前列腺素化合物 从而产生所需的功效。 该试剂盒是预先包装的组分组合，其在血管成形术程序之前，期间和之后提供前列腺素化合物的完整给药。

公开(公告)号：US4811741A

公开(公告)日：1989-03-14

申请号：US899161

申请日：1986-08-22

申请人： William E. Shell ,  Jackie R. See

发明人： William E. Shell ,  Jackie R. See

IPC分类号： A61D13/00 ,  A61B5/026 ,  A61B5/0275 ,  A61K49/00 ,  A61K51/12 ,  G01N33/58 ,  A61B5/02

CPC分类号： A61B5/0275 ,  A61K49/0004 ,  A61K51/1255 ,  A61K2123/00 ,  Y10T436/13

摘要： A process for making a volumetric determination of the quantity of a fluid, such as a liquid, by evaluation of a small sample of that fluid. The method comprises labeling microspheres with a non-radioactive substance and introducing the labeled microspheres into a body of fluid for which a determination is to be made. The microspheres are allowed to disperse in the body of fluid. Thereafter, a sample of the fluid which is of know or measurable volume, is selected. The number of microspheres present in the sample is then determined, from which a calculation of the volumetric measurement of the fluid may be made. The process is also adaptable to measuring the flow rate of a moving stream of fluid, since volume is one of the parameters of flow rate, and is also adaptable to determine the percentages of fluid components present in a mixture thereof.

摘要翻译： 通过评估该流体的小样品来进行流体（例如液体）的量的体积测定的方法。 该方法包括用非放射性物质标记微球，并将标记的微球引入要进行测定的液体中。 允许微球分散在体液中。 此后，选择具有已知或可测量体积的流体样品。 然后确定样品中存在的微球的数量，由此可以计算流体的体积测量值。 该方法还适于测量流动流动的流速，因为体积是流速参数之一，并且还适用于确定其混合物中存在的流体组分的百分比。

公开(公告)号：US4492753A

公开(公告)日：1985-01-08

申请号：US433153

申请日：1982-10-06

申请人： William E. Shell ,  Michael H. Burnam ,  Zoltan A. Tokes

发明人： William E. Shell ,  Michael H. Burnam ,  Zoltan A. Tokes

IPC分类号： G01N33/573 ,  G01N33/68 ,  C12Q1/50

CPC分类号： G01N33/573 ,  G01N33/6893 ,  G01N2800/32 ,  G01N2800/324

摘要： A method and means for determining the risk of future cardiac ischemic events in a patient after a sentinel event in that same patient, wherein levels of acid glycoprotein and CK-MB are monitored relative to predetermined threshold levels, within a prescribed time frame after the sentinel event, and these monitored levels are then correlated with the predicted likelihood of future cardiac ischemic events to classify such cardiac patients into categories of risk.

摘要翻译： 一种用于在同一患者的哨点事件之后确定患者的未来心脏缺血事件的风险的方法和手段，其中在哨兵之后的规定时间内监测相对于预定阈值水平的酸性糖蛋白和CK-MB的水平 事件，然后将这些监测的水平与未来心脏缺血事件的预测可能性相关联，以将这种心脏病患者分类为风险类别。

公开(公告)号：US08370172B2

公开(公告)日：2013-02-05

申请号：US11804085

申请日：2007-05-17

申请人： William E. Shell ,  Elizabeth Charuvastra

发明人： William E. Shell ,  Elizabeth Charuvastra

IPC分类号： G06Q50/00

CPC分类号： G06Q10/10 ,  G06F19/00 ,  G06Q50/22

摘要： A system for submitting a claim for a dispensed medication to a patient by a point-of-care physician including means acquiring at least one of the group consisting of a national practitioner number and a non pharmacy dispensing number for the point-of-care physician; means for displaying to a user a selection of data fields relating to the claim; means for inputting into the data fields data relating to the claim including the at least one of the group consisting of the national practitioner identifier number and the non pharmacy dispensing number; means for transmitting to a logic switch the claim containing the at least one of the group consisting of a national practitioner identifier number and a non pharmacy dispensing number identifying the point-of-care physician for determining the processor for the claim; means for determining the pathway for the claim based on a type of payor associated with the patient; means for processing the claim containing the at least one of the group consisting of a national practitioner identifier number and a non pharmacy dispensing number to identify the point-of-care physician; and responsive to the means for processing, means for transmitting to the point-of-care physician an adjudication regarding the claim.

摘要翻译： 一种由护理医师向患者提交分配的药物的索赔的系统，包括获取至少一个由医生护理医师的国民从业者号码和非药房分发号码组成的装置的装置 ; 用于向用户显示与所述权利要求相关的数据字段的选择的装置; 用于向所述数据域输入涉及包括由所述国民从业者标识号和非药剂分配号组成的组中的至少一个的权利要求的数据的装置; 用于向逻辑交换机发送包含所述组中的至少一个的装置，所述组由国家从业者标识符号和非药房分配号标识用于确定用于权利要求的处理器的护理医师; 用于基于与患者相关联的付款人类型来确定权利要求的途径的手段; 用于处理所述索赔的装置，其中包含由国民从业者标识符号和非药剂分配号码组成的组中的至少一个以识别护理医师; 并且响应于处理手段，用于向护理医师传送关于权利要求的裁决的手段。