公开(公告)号：US5186922A

公开(公告)日：1993-02-16

申请号：US462740

申请日：1990-01-08

申请人： William E. Shell ,  Jackie R. See

发明人： William E. Shell ,  Jackie R. See

IPC分类号： A61K9/16 ,  A61K49/04

CPC分类号： A61K49/0419 ,  A61K9/1658

摘要： The invention relates to an inexpensive and easy to use method of visualizing an arterial circulation, using biodegradable microspheres which are permeated with an imaging energy absorbent contrast material, such as an X-ray absorbent material, which enables the diagnosis of pulmonary embolism. The microspheres may be comprised of a variety of materials, including human albumin, and may be dyed with a number of X-ray absorbent materials, or other imaging energy absorbent materials. The microspheres are injected into the bloodstream at a particular location such that they travel through the desired circulation, e.g. an arterial circulation and ultimately become lodged in the capillaries of a tissue of interest. Upon exposure of the arterial circulation to X-rays, blood vessels therein containing the microspheres will absorb the X-rays, causing them to show on a developed X-ray film in contrast to other blood vessels and body tissue which do not contain the microspheres that transmit the X-rays. The microspheres are designed to dissolve into the bloodstream within fifteen to thirty minutes after their introduction, the X-ray dye or other contrast material being ultimately excreted from the body via the urine or metabolized by the liver.

摘要翻译： 本发明涉及一种便宜且易于使用的可视化动脉循环的方法，该方法使用能够诊断肺栓塞的诸如X射线吸收材料的成像能量吸收剂造影材料渗透的可生物降解的微球。 微球可以由各种材料组成，包括人白蛋白，并且可以用许多X射线吸收材料或其它成像能量吸收材料染色。 将微球注射到特定位置的血流中，使得它们穿过期望的循环，例如， 动脉循环并最终成为感兴趣的组织的毛细血管。 当将动脉循环暴露于X射线时，其中含有微球的血管将吸收X射线，导致它们显现在显影的X射线胶片上，与其它不含微球的血管和身体组织相反 传输X射线。 微球被设计成在引入后十五到三十分钟内溶解到血液中，X射线染料或其他对比物质最终通过尿液从身体排出或被肝脏代谢。

公开(公告)号：US4955878A

公开(公告)日：1990-09-11

申请号：US281430

申请日：1988-12-08

申请人： Jackie R. See ,  William E. Shell

发明人： Jackie R. See ,  William E. Shell

IPC分类号： A61K31/557 ,  A61K49/04

CPC分类号： A61K49/04 ,  A61K31/557

摘要： A kit for preventing or treating arterial dysfunction resulting from an angioplasty procedure and particularly, in myocardial angioplasty procedures in human beings. The kit provides the materials necessary to introduce a selected amount of an intraarterial prostaglandin compound into an artery, such as a coronary artery, in which an angioplasty procedure is to occur and an intravenous prostaglandin compound. The prostaglandin compound will provide cyto-protection and provide antithrombotic effects and antiplatelet effects and antispasmatic effects. A composition is also provided for reducing dysfunction in angioplasty procedures and comprises a selected amount of a carrier and a prostaglandin compound carried in a specified amount and which carrier does not alter the prostaglandin compound and releases the prostaglandin compound at a rate sufficient to dilate blood vessels to thereby produce the required efficacy. The kit is a prepackaged combination of components which provides for the complete administration of the prostaglandin compound before, during and after the angioplasty procedure.

摘要翻译： 用于预防或治疗由血管成形术程序产生的动脉功能障碍的试剂盒，特别是在人类的心肌血管成形术程序中。 该试剂盒提供了将选定数量的动脉内前列腺素化合物引入到其中将发生血管成形术程序的动脉（例如冠状动脉）和静脉内前列腺素化合物所需的材料。 前列腺素化合物将提供细胞保护作用，提供抗血栓形成和抗血小板作用及抗血栓作用。 还提供了用于减少血管成形术程序中的功能障碍的组合物，并且包括选定量的载体和前列腺素化合物，所述载体和前列腺素化合物以特定量携带，并且所述载体不改变前列腺素化合物并以足以扩张血管的速率释放前列腺素化合物 从而产生所需的功效。 该试剂盒是预先包装的组分组合，其在血管成形术程序之前，期间和之后提供前列腺素化合物的完整给药。

公开(公告)号：US4811741A

公开(公告)日：1989-03-14

申请号：US899161

申请日：1986-08-22

申请人： William E. Shell ,  Jackie R. See

发明人： William E. Shell ,  Jackie R. See

IPC分类号： A61D13/00 ,  A61B5/026 ,  A61B5/0275 ,  A61K49/00 ,  A61K51/12 ,  G01N33/58 ,  A61B5/02

CPC分类号： A61B5/0275 ,  A61K49/0004 ,  A61K51/1255 ,  A61K2123/00 ,  Y10T436/13

摘要： A process for making a volumetric determination of the quantity of a fluid, such as a liquid, by evaluation of a small sample of that fluid. The method comprises labeling microspheres with a non-radioactive substance and introducing the labeled microspheres into a body of fluid for which a determination is to be made. The microspheres are allowed to disperse in the body of fluid. Thereafter, a sample of the fluid which is of know or measurable volume, is selected. The number of microspheres present in the sample is then determined, from which a calculation of the volumetric measurement of the fluid may be made. The process is also adaptable to measuring the flow rate of a moving stream of fluid, since volume is one of the parameters of flow rate, and is also adaptable to determine the percentages of fluid components present in a mixture thereof.

摘要翻译： 通过评估该流体的小样品来进行流体（例如液体）的量的体积测定的方法。 该方法包括用非放射性物质标记微球，并将标记的微球引入要进行测定的液体中。 允许微球分散在体液中。 此后，选择具有已知或可测量体积的流体样品。 然后确定样品中存在的微球的数量，由此可以计算流体的体积测量值。 该方法还适于测量流动流动的流速，因为体积是流速参数之一，并且还适用于确定其混合物中存在的流体组分的百分比。

公开(公告)号：US4865850A

公开(公告)日：1989-09-12

申请号：US904410

申请日：1986-09-08

申请人： William E. Shell ,  Jackie R. See

发明人： William E. Shell ,  Jackie R. See

IPC分类号： A61K9/16 ,  A61K9/18 ,  A61K31/575 ,  A61K35/413

CPC分类号： A61K31/575 ,  A61K35/413 ,  A61K9/167 ,  Y10S514/909 ,  Y10S514/951 ,  Y10T428/2989

摘要： A method and a composition for accumulating and the binding of food fats in an animal body gastrointestinal tract. The method and composition rely upon non-biodegradable collagen particles, such as microspheres, having a size of at least two microns and a fat receptor, such as bile, capable of having food fat adhered thereto on the surface of the particles. These particles are sufficiently large so that they do not pass through the surface mucosa of the gastrointestinal tract and permit the particles with the food fat to pass through the gastrointestinal tract and out of the body through animal excretion.

公开(公告)号：US4820732A

公开(公告)日：1989-04-11

申请号：US848233

申请日：1986-04-04

申请人： William E. Shell ,  Jackie R. See

发明人： William E. Shell ,  Jackie R. See

IPC分类号： A61K31/557 ,  A61K49/04 ,  A61K31/19

CPC分类号： A61K49/04 ,  A61K31/557

摘要： A method for reducing dysfunction in angioplasty procedures and particularly, in myocardial angioplasty procedures in human beings is desired. The method involves the introduction of a selected amount of intra-arterial prostaglandin compound into an artery, such as a coronary artery, in which an angioplasty procedure is to occur. The prostaglandin compound will provide cyto-protection and provide antithrombotic effects and antiplatelet effects and antispasmatic effects. The prostaglandin compound is administered in a pharmacological amount, that is, an amount substantially greater than the prostaglandin which would be generated by a normal myocardial artery when insulated and thus, constitutes an administration substantially greater than an amount which would be administered in a replacement therapy. A composition is also provided for reducing dysfunction in angioplasty procedures and comprises a selected amount of a carrier and a prostaglandin compound carried in a specified amount and which carrier does not alter the prostaglandin compound and releases the prostaglandin compound at a rate sufficient to dilate blood vessels to thereby produce the required efficacy. A prepackaged combination of components provides for the complete administration of the prostaglandin compound before, during and after the angioplasty procedure.

摘要翻译： 需要一种降低血管成形术程序的功能障碍的方法，特别是人心肌血管成形术中的功能障碍。 该方法包括将选择量的动脉内前列腺素化合物引入到其中将发生血管成形术程序的动脉（例如冠状动脉）中。 前列腺素化合物将提供细胞保护作用，提供抗血栓形成和抗血小板作用及抗血栓作用。 前列腺素化合物以药理学量施用，即，当绝缘时，由正常心肌动脉产生的明显大于前列腺素的量，因此构成显着大于在替代疗法中施用的量的给药 。 还提供了用于减少血管成形术程序中的功能障碍的组合物，并且包括选定量的载体和前列腺素化合物，所述载体和前列腺素化合物以特定量携带，并且所述载体不改变前列腺素化合物并以足以扩张血管的速率释放前列腺素化合物 从而产生所需的功效。 预先包装的组分组合提供了在血管成形术程序之前，期间和之后完全给予前列腺素化合物。

公开(公告)号：US5718917A

公开(公告)日：1998-02-17

申请号：US573408

申请日：1995-12-15

申请人： Jackie R. See

发明人： Jackie R. See

IPC分类号： A61K9/00 ,  A61K9/127 ,  A61K31/557 ,  A61K31/5575 ,  A61P13/02 ,  A61P15/00

CPC分类号： A61K31/5575 ,  A61K9/0034 ,  A61K9/127 ,  A61K9/1272

摘要： A method for the treatment of erectile dysfunction comprises instilling intra meatally an aqueous solution containing prostaglandin-containing liposomes and a detergent for lysing the liposomes. A pharmaceutical composition for treating erectile dysfunction comprises a two-component system. The first component comprises a predetermined amount of lyophilized prostaglandin-containing liposomes. The second component comprises a predetermined volume of an aqueous solution containing a detergent, preferably PEG(9) octylphenyl ether, for lysing the liposomes. Dissolution of the lyophilized prostaglandin-containing liposomes yields a liquid composition suitable for application to the penis, preferably intra meatally, to effect erection.

摘要翻译： 用于治疗勃起功能障碍的方法包括在肉内施用含有含前列腺素的脂质体的水溶液和用于裂解脂质体的洗涤剂。 用于治疗勃起功能障碍的药物组合物包括双组分体系。 第一组分包含预定量的含冻干前列腺素的脂质体。 第二组分包含预定体积的含有洗涤剂的水溶液，优选PEG（9）辛基苯基醚，用于裂解脂质体。 含有冻干的含前列腺素的脂质体的溶解产生适合于阴茎的液体组合物，优选在肉内进行勃起。

公开(公告)号：US08313477B2

公开(公告)日：2012-11-20

申请号：US13041307

申请日：2011-03-04

申请人： Jackie R. See ,  Carl J. Buczek ,  John W. Matthews

发明人： Jackie R. See ,  Carl J. Buczek ,  John W. Matthews

IPC分类号： A61M31/00

CPC分类号： A61B5/4839 ,  A61B5/0073 ,  A61B5/0084

摘要： A device and methods for the real-time monitoring of stem cells in a stem cell transplant. The device comprises a linear member and particle detection device configured to occupy the lumen of a catheter while the catheter is in place to administer a stem cell transplant to a delivery site in the body of a patient. Monitoring of the stem cells permits the device to provide signals to a computer processor for the determination of one or more characteristics of stem cells in the stem cell transplant.

摘要翻译： 用于干细胞移植中干细胞的实时监测的装置和方法。 该装置包括线性构件和颗粒检测装置，其构造成在导管就位时占据导管的内腔，以将干细胞移植物施用于患者体内的递送部位。 监测干细胞允许装置向计算机处理器提供信号，以确定干细胞移植物中干细胞的一个或多个特征。

公开(公告)号：US6117449A

公开(公告)日：2000-09-12

申请号：US7297

申请日：1998-01-14

申请人： Jackie R. See ,  Darryl M. See

发明人： Jackie R. See ,  Darryl M. See

IPC分类号： A61K9/127 ,  A61K9/48 ,  A61K39/12 ,  A61K39/21 ,  A61K39/29 ,  A61K39/39

CPC分类号： A61K9/4891 ,  A61K39/12 ,  A61K39/29 ,  A61K39/39 ,  A61K9/127 ,  A61K2039/542 ,  A61K2039/55555 ,  C12N2730/10134 ,  C12N2770/24234 ,  C12N2770/32334

摘要： A method is provided for inducing a systemic immune response to an antigen selected from hepatitis B and hepatitis C antigens in a mammal. The method comprises orally administering lyophilized multilamellar liposomes containing the antigen. The liposomes have a size of from 20 nm to 20 microns. The antigen-containing liposomes are absorbed in the Peyer's patches of the gut. Sufficient antigen-containing liposomes are taken up by macrophages in the Peyer's patches to induce a systemic immune response to the antigen.

摘要翻译： 提供了一种用于诱导哺乳动物中选自乙型肝炎和丙型肝炎抗原的抗原的全身免疫应答的方法。 该方法包括口服含有抗原的冻干多层脂质体。 脂质体具有20nm至20微米的尺寸。 含抗原的脂质体被吸收在肠道的派耶尔斑块中。 含有足够的含抗原的脂质体被淋巴细胞的巨噬细胞吸收以诱导对抗原的全身免疫应答。

公开(公告)号：US4616658A

公开(公告)日：1986-10-14

申请号：US706151

申请日：1985-02-27

申请人： William Shell ,  Jackie R. See

发明人： William Shell ,  Jackie R. See

IPC分类号： A61D13/00 ,  A61B5/026 ,  A61B5/0275 ,  A61K49/00 ,  A61K51/12 ,  G01N33/58 ,  A61B5/02

CPC分类号： A61B5/0275 ,  A61K49/0004 ,  A61K51/1255 ,  A61K2123/00 ,  Y10T436/13

摘要： A safe and inexpensive method of measuring blood flow in experimental animals using non-radioactively labeled microspheres is provided. The microspheres may be comprised of a variety of materials, including latex and agarose, and may be labeled with colored dyes or by linkage to enzymes, plant enzymes being preferred because they do not occur naturally in an animal's system. After injection and circulation of the microspheres throughout the animal's system, blood flow to particular tissue may be measured by counting the number of microspheres in the tissue sample, the initial number of microspheres in the animal's blood stream having been measured shortly after injection. In the case of microspheres labeled with colored dyes, the spheres may be counted in tissue either after separation from the tissue or while still trapped in the tissue's capillaries. Techniques for separating the microspheres from blood and tissue are also provided.

摘要翻译： 提供了一种使用非放射性标记微球测量实验动物血流量的安全且廉价的方法。 微球可以包括各种材料，包括胶乳和琼脂糖，并且可以用有色染料或通过连接酶进行标记，植物酶是优选的，因为它们不是天然存在于动物系统中。 在整个动物系统中注射和循环微球后，可以通过计数组织样品中的微球的数量，即在注射后不久测量的动物血流中的微球的初始数量来测量到特定组织的血流量。 在用有色染料标记的微球的情况下，球体可以在从组织分离之后或当仍被捕获在组织的毛细血管中时被计数在组织中。 还提供了从血液和组织中分离微球的技术。

公开(公告)号：US20130251785A1

公开(公告)日：2013-09-26

申请号：US13802445

申请日：2013-03-13

申请人： Elliot B. Lander ,  Jackie R. See

发明人： Elliot B. Lander ,  Jackie R. See

IPC分类号： A61K9/127 ,  A61K31/726 ,  A61K31/728

CPC分类号： A61K9/127 ,  A61K9/0034 ,  A61K31/726 ,  A61K31/727 ,  A61K31/728

摘要： A medicament for treating cystitis and a method of treatment are provided. An agent to repair the damaged glycosaminoglycan (“GAG”) layers lining the urothelium, noted in cystitis, such as pentosan polysulfate, hyaluronic acid, chondroitin, etc., is provided in a liposomal carrier. Cystitis is treated by intravesically administering to a patient a therapeutically effective dose of the medicament.

摘要翻译： 提供了一种治疗膀胱炎的药物和治疗方法。 在脂质体载体中提供了修复在膀胱炎中记载的尿路上皮的受损葡萄糖胺聚糖（“GAG”）层，例如戊聚糖多糖，透明质酸，软骨素等。 通过向患者施用治疗有效剂量的药物来治疗膀胱炎。