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    Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use
    2.
    发明申请
    Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use 有权
    微流体装置，特别是包括聚合物膜的过滤装置及其制造和使用的方法

    公开(公告)号：US20110253629A1

    公开(公告)日：2011-10-20

    申请号：US13068037

    申请日：2011-04-29

    申请人： Goran Jovanovic ,  Sundar V. Atre ,  Brian Kevin Paul ,  John Simonsen ,  Vincent Thomas Remcho ,  Chih-Hung Chang

    发明人： Goran Jovanovic ,  Sundar V. Atre ,  Brian Kevin Paul ,  John Simonsen ,  Vincent Thomas Remcho ,  Chih-Hung Chang

    IPC分类号： B01D61/24 ,  B01D35/18

    CPC分类号： B01D61/18 ,  A61M1/16 ,  A61M1/1698 ,  A61M1/3472 ,  A61M2205/3334 ,  A61M2205/3368 ,  A61M2205/50 ,  B01D63/08 ,  B01D63/088 ,  B01D71/10 ,  B01D71/68 ,  B01D2313/21 ,  B01D2313/38

    摘要： The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis devices. Generally, such devices comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. The fluids can both be liquids, gases, or a liquid and a gas, such as may be used for gas absorption into a liquid. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters; etc. Examples of devices made according to the present invention included an oxygenator, a dialzyer, microheat exchangers, etc. Particular materials had to be developed for use with certain embodiments of the device disclosed herein. For example, a new composite material was made comprising nanocrystalline cellulose filler and a polysulfone polymeric material. A dialyzer comprising the composite membrane also is disclosed. In order to make the nanocrystalline cellulose-polymer composite, a new method was devised for making an organic dispersion of nanocrystalline cellulose. The method comprised first forming an aqueous dispersion of nanocrystalline cellulose. A mixture was then formed comprising the aqueous dispersion and an organic liquid having a boiling point higher than water. The water was then selectively removed to form a second mixture comprising the nanocrystalline cellulose and the organic liquid.

    摘要翻译： 本公开描述了可用于微量流体纯化，分离和合成装置的装置。 通常，这样的装置包括流体膜，其分离流过与膜操作性相关联的多个微通道的两个或更多个流体。 流体可以是液体，气体或液体和气体，例如可以用于气体吸收到液体中。 通常，膜是半透膜，例如可以与过滤装置如透析器一起使用。 本发明的装置可以与其他微型装置组合以制造系统。 例如，所述装置可以与一个或多个微化学微生物，一个或多个微混合器，一个或多个微加热器结合; 根据本发明制造的装置的实例包括氧合器，拨动器，微热交换器等。必须开发特定的材料以用于本文公开的装置的某些实施例。 例如，制备了包含纳米晶纤维素填料和聚砜聚合物材料的新型复合材料。 还公开了包含复合膜的透析器。 为了制备纳米晶纤维素 - 聚合物复合材料，设计了一种制备纳米晶纤维素有机分散体的新方法。 该方法首先形成纳米晶体纤维素的水性分散体。 然后形成包含水分散体和沸点高于水的有机液体的混合物。 然后选择性地除去水以形成包含纳米晶体纤维素和有机液体的第二混合物。

    Microlamination method for making devices
    3.
    发明授权
    Microlamination method for making devices 失效
    微量滴定法制造装置

    公开(公告)号：US06793831B1

    公开(公告)日：2004-09-21

    申请号：US09369679

    申请日：1999-08-05

    申请人： Brian Kevin Paul ,  Richard Budd Peterson ,  Tyson Jedd Terhaar

    发明人： Brian Kevin Paul ,  Richard Budd Peterson ,  Tyson Jedd Terhaar

    IPC分类号： C25F700

    CPC分类号： B23K20/023 ,  Y10T29/30 ,  Y10T29/46 ,  Y10T156/1043 ,  Y10T156/1057 ,  Y10T156/12

    摘要： A method for fabricating devices in a pre-assembled state comprising forming plural laminae, registering the laminae, and bonding the laminae one to another is described. The plural laminae contain the substructures and structures of the device. The substructures are coupled to structures and other substructures by fixture bridges in the pre-assembled state. The substructures of the device are dissociated by eliminating the fixture bridges. The plural laminae are registered and bonded to form the device either before or after the fixture bridges are eliminated. The fixture bridges can be eliminated in a variety of ways, including vaporization by electrical current, chemical dissolution, or thermochemical dissociation. One method to selectively bond the laminae together is by microprojection welding. Microprojection welding comprises forming laminae with projections that extend from at least one planar surface of the lamina. Bonding together of laminae at selected regions is accomplished by placing the laminae between electrodes and passing a current through the electrodes. The laminae are bonded together selectively at the sites of the projections. Another method for bonding lamina involve diffusion soldering at reduced bonding pressures and temperatures to minimize flow restriction within or to features.

    摘要翻译： 描述了一种用于在预组装状态下制造器件的方法，包括形成多个层，对齐层，以及将层彼此粘合。 复数层包含设备的子结构和结构。 子结构通过预组装状态下的夹具桥耦合到结构和其他子结构。 通过消除夹具桥离解器件的子结构。 在夹具桥被消除之前或之后，将多个薄片进行登记和粘结以形成该装置。 夹具桥可以以各种方式消除，包括通过电流蒸发，化学溶解或热化学解离。 通过微喷射焊接选择性地将薄片粘合在一起的一种方法。 微投射焊接包括用从板的至少一个平坦表面延伸的突起形成薄片。 通过将薄片放置在电极之间并使电流通过电极来实现在选定区域处粘合在一起的薄片。 薄片在突出部位选择性地结合在一起。 粘合薄层的另一种方法涉及在降低的粘合压力和温度下的扩散焊接，以最小化在特征内或对特征的流动限制。

    MECS DIALYZER METHOD
    8.
    发明申请
    MECS DIALYZER METHOD 有权
    MECS DIALYZER方法

    公开(公告)号：US20120223015A1

    公开(公告)日：2012-09-06

    申请号：US13412597

    申请日：2012-03-05

    申请人： David M. Browning ,  James R. Curtis ,  Goran Nadezda Jovanovic ,  Brian Kevin Paul ,  Sundar Atre

    发明人： David M. Browning ,  James R. Curtis ,  Goran Nadezda Jovanovic ,  Brian Kevin Paul ,  Sundar Atre

    IPC分类号： B01D61/24

    CPC分类号： A61M1/16 ,  A61M2205/0244 ,  B01D61/28 ,  B01D63/081 ,  B01D63/082 ,  B01D2313/08 ,  B01D2313/14

    摘要： The present invention provides methods and apparatus for cleansing blood through hemodialysis by the process of diffusion across a membrane into dialysate. This dialyzer also removes solutes from the blood by a process of convection, where fluid and dissolved solutes pass through the membrane out of the blood. In one embodiment in accordance with the present invention, the MECS dialyzer uses a counter-flow between the dialysate and blood through a plurality of microchannels. The dialyzer comprises a plurality of flat semi-permeable membranes interleaved between microchannel sheets to define a plurality of flow channels. The stack of membranes and microchannel sheets are aligned and consolidated to form the MECS dialyzer. The MECS dialyzer acts as a flow manifold with ports and headers to collect the blood and dialysate and direct them to and from the microchannels.

    摘要翻译： 本发明提供了通过血液透析清洗血液的方法和装置，该方法和装置通过膜扩散到透析液中。 这种透析器还可以通过对流过程从血液中除去溶质，其中流体和溶解的溶质通过膜离开血液。 在根据本发明的一个实施方案中，MECS透析器通过多个微通道使用透析液和血液之间的逆流。 所述透析器包括在微通道片之间交错以形成多个流动通道的多个平坦的半透膜。 膜和微通道片的堆叠被对准和固结以形成MECS透析器。 MECS透析器充当具有端口和头部的流量歧管，用于收集血液和透析液，并将其引导到微通道和从微通道引导。

    Microreactor Process for Making Biodiesel
    9.
    发明申请
    Microreactor Process for Making Biodiesel 审中-公开
    制造生物柴油的微反应器工艺

    公开(公告)号：US20090165366A1

    公开(公告)日：2009-07-02

    申请号：US12227804

    申请日：2007-05-30

    申请人： Goran Nadezda Jovanovic ,  Brian Kevin Paul ,  James Parker ,  Ahmad Al-Dhubabian

    发明人： Goran Nadezda Jovanovic ,  Brian Kevin Paul ,  James Parker ,  Ahmad Al-Dhubabian

    IPC分类号： C10L1/19

    CPC分类号： B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00788 ,  B01J2219/00835 ,  B01J2219/00837 ,  B01J2219/00844 ,  B01J2219/0086 ,  B01J2219/00891 ,  B01J2219/00905 ,  B01J2219/00907 ,  B01J2219/00959 ,  B01J2219/00984 ,  C10G2300/1011 ,  C10L1/026 ,  C10L1/19 ,  C11C3/003 ,  Y02E50/13 ,  Y02P30/20

    摘要： Embodiments of a method for using a microreactor to produce biodiesel. For example, the method may comprise flowing a first fluid comprising an alcohol and a second fluid comprising an oil to the microreactor. Alcohols typically, but not necessarily, are lower aliphatic alcohols, including methanol, ethanol, amyl alcohol or combinations thereof. Biodiesel production can be under supercritical conditions, where such conditions typically are determined relative to the alcohol component. Suitable sources of oil products include soy, inedible tallow and grease, corn, edible tallow and lard, cotton, rapeseed, sunflower, canola, peanut, safflower, and combinations thereof. Catalysts can be used to facilitate biodiesel production, such as metal oxides, metal hydroxides, metal carbonates, alcoholic metal carbonates, alkoxides, mineral acids and enzymes. Oil conversion to biodiesel typically increases with increasing mean microreactor residence time. Certain embodiments of the present invention can include blending biodiesel produced by the method with petroleum-based products.

    摘要翻译： 使用微反应器生产生物柴油的方法的实施方案。 例如，该方法可以包括将包含醇的第一流体和包含油的第二流体流动到微反应器。 醇通常但不一定是低级脂族醇，包括甲醇，乙醇，戊醇或其组合。 生物柴油的生产可以在超临界条件下，其中通常相对于醇组分确定这些条件。 合适的石油产品来源包括大豆，不可食用的牛油和油脂，玉米，食用油脂和猪油，棉花，油菜籽，向日葵，卡诺拉油菜，花生，红花及其组合。 催化剂可用于促进生物柴油生产，例如金属氧化物，金属氢氧化物，金属碳酸盐，醇金属碳酸盐，醇盐，无机酸和酶。 石油转化为生物柴油通常随着平均微反应器停留时间的增加而增加。 本发明的某些实施方案可以包括将通过该方法生产的生物柴油与石油基产物混合。