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    Resorbable Calcium Phosphate Based Biopolymer-Cross-Linked Bone Replacement Material
    4.
    发明申请
    Resorbable Calcium Phosphate Based Biopolymer-Cross-Linked Bone Replacement Material 审中-公开
    可再生磷酸钙生物聚合物交联骨替代材料

    公开(公告)号：US20090280179A1

    公开(公告)日：2009-11-12

    申请号：US12223899

    申请日：2007-02-09

    申请人： Hans-Georg Neumann ,  Ernst-Dieter Klinkenberg ,  Frieder Schauer ,  Ulrike Lindequist ,  Wolf-Dieter Juelich ,  Annett Mikolasch ,  Katrin Manda

    发明人： Hans-Georg Neumann ,  Ernst-Dieter Klinkenberg ,  Frieder Schauer ,  Ulrike Lindequist ,  Wolf-Dieter Juelich ,  Annett Mikolasch ,  Katrin Manda

    IPC分类号： A61K9/00 ,  A61F2/28

    CPC分类号： C09J175/04 ,  A61L24/043 ,  C08G18/10 ,  C08G18/428 ,  C08G18/6446 ,  C08L89/00 ,  C09J189/00 ,  Y10T428/2982 ,  C08L67/04 ,  C08G18/64

    摘要： A resorbable bone replacement material made of calcium phosphate particles of different phases which are embedded in an inventive-specific cross-linked collagen matrix. The goal is to form a non-brittle, bone replacement moulded body having a positive fit, i.e. having a shape which is anatomic and/or corresponds to the defect, which perfectly fills the bone defect and can be resorbed thereby. Said goal is achieved by producing the bone replacement material made of a mixture of calcium phosphate particles which is embedded in an inventive cross-linked collagen matrix. In particular, the collagen cross-linking is achieved by a Laccase-induced peptide cross-linking and suitable bridge molecules. Essentially substituted dihydroxyarmotes and/or substrates of the lignolytic polyphenoloxidases, such as Laccases, are suitable as bridge molecules. Also, monocyclic ortho-dihydroxyaromates, monocyclic para-dihydroxyaromates, bicyclic monohydroxyaromates, polycyclic monohydroxyaromates, bicyclic dihydroxyaromates, polycyclic dihydroxyaromates, bicyclic trihydroxyaromates, polycyclic trihydroxyaromates, or mixtures thereof are used. The inventive hydroxyaromates are not part of a polymer chain as opposed to the known conchal adhesive.

    摘要翻译： 由不同相的磷酸钙颗粒制成的可再吸收的骨置换材料，其嵌入本发明的交联胶原基质中。 目的是形成具有正配合的非脆性骨置换模制体，即具有解剖学和/或对应于缺陷的形状，其完全填充骨缺损并且可被其吸收。 所述目标通过生产嵌入本发明的交联胶原基质中的由磷酸钙颗粒的混合物制成的骨置换材料来实现。 特别地，胶原交联通过漆酶诱导的肽交联和合适的桥分子实现。 基本上取代的二羟基咪唑和/或木素分解多酚氧化酶的底物如漆酶适用作桥分子。 此外，使用单环邻二羟基溴化物，单环对二羟基溴酸盐，双环单羟基溴化物，多环单羟基溴酸盐，双环二羟基溴化物，多环二羟基溴化物，双环三羟基溴酸盐，多环三羟基溴酸盐或其混合物。 本发明的羟基红酸盐不是聚合物链的一部分，而不是已知的螺旋状粘合剂。