公开(公告)号：US20230129364A1

公开(公告)日：2023-04-27

申请号：US17786544

申请日：2020-12-22

申请人： YONSEI UNIVERSITY, UNIVERSITY - INDUSTRY FOUNDATION (UIF) ,  DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION

发明人： Youngsoo KIM ,  Jisu SHIN ,  Ki Bum HONG ,  Ji Hoon YU ,  Ji Hoon LEE ,  Da Rong KIM ,  Hui-Jeon JEON ,  Jaeyoung SONG ,  Jin Wan PARK ,  Ju Suk LEE ,  Won Seok LEE ,  Young-Kyu KIM ,  Sung Hwan KIM ,  Heeseok YOON

IPC分类号： A61K47/55 ,  C07D417/06 ,  C07D487/04 ,  C07D409/06 ,  C07D405/06 ,  C07D401/06 ,  C07D403/06 ,  C07D277/36 ,  C07D233/96

摘要： Provided are: a novel pyrrolidine derivative or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing same and having the effects of inhibiting beta-amyloid and/or tau protein aggregation, and/or breaking down beta-amyloid and/or tau protein aggregates, and/or preventing and/or treating beta-amyloid and/or tau protein-associated diseases.

公开(公告)号：US20210050514A1

公开(公告)日：2021-02-18

申请号：US16932029

申请日：2020-07-17

申请人： YONSEI UNIVERSITY, UNIVERSITY - INDUSTRY FOUNDATION (UIF) ,  Seoul National University R&DB Foundation

发明人： Ki Tae NAM ,  Ouk Hyun CHO ,  Jang-Yeon KWON ,  Min-Kyu SONG ,  Seok NAMGUNG ,  Hyeohn KIM ,  Yoon Ho LEE

IPC分类号： H01L45/00

摘要： A resistive switching memory device according to an exemplary embodiment includes: a first electrode; a second electrode formed to be separated from the first electrode; and an insulating layer formed near the first electrode and the second electrode, and changed to one of a high resistance state and a low resistance state when a conductive filament is controlled by a change of external humidity or a voltage applied through the first electrode or the second electrode.

公开(公告)号：US20200370104A1

公开(公告)日：2020-11-26

申请号：US16636585

申请日：2018-08-06

申请人： Yonsei University, University - Industry Foundation (UIF)

发明人： Sangwoo Kim ,  Junho Kim

IPC分类号： C12Q1/6834 ,  G16B20/20 ,  G06F17/18

摘要： The present invention provides a method for detection of a mutation in a nucleotide sequence, the method comprising the steps of: obtaining a plurality of target genes for one subject sample by using a gene panel including probes for the plurality of target genes; collecting multiple replicates of nucleotide sequences including nucleotide sequences being identical or non-identical with each of the plurality of target genes by sequencing each of the plurality of target genes in multiple rounds through next generation sequencing (NGS); matching the multiple replicates of nucleotide sequences with reference nucleotide sequences; determining nucleotide sequences unmatched with the reference nucleotide sequences for the plurality of target genes among the multiple replicates of nucleotide sequences; and determining candidates of nucleotide sequence mutations for the plurality of target genes in the subject sample, based on a probability of mutation for a discordant gene locus with the unmatched nucleotide sequences, the probability of mutation being calculated by a computational method according to statistical analysis of unmatched nucleotide sequences.

公开(公告)号：US10831376B2

公开(公告)日：2020-11-10

申请号：US16032817

申请日：2018-07-11

申请人： MemRay Corporation ,  YONSEI UNIVERSITY, UNIVERSITY—INDUSTRY FOUNDATION (UIF)

发明人： Myoungsoo Jung ,  Jie Zhang

IPC分类号： G06F12/02 ,  G06F3/06 ,  G06F13/16 ,  G06F12/1009

摘要： A flash-based accelerator configured to be connected to a host including a CPU and a system memory is provided. A plurality of processors execute a plurality of kernels offloaded from the host. A memory system includes a first memory that is used to map a data section of each kernel to the flash memory. A supervisor processor maps a region of the first memory pointed by a data section of a first kernel to a region of the flash memory to allow first data to move between the region of the first memory and the region of the flash memory, based on a first message which is transferred in accordance with execution of the first kernel by a first processor among the plurality of processors. A network integrates the flash backbone, the memory system, the plurality of processors, and the supervisor processor.

公开(公告)号：US10452531B1

公开(公告)日：2019-10-22

申请号：US16296850

申请日：2019-03-08

申请人： MemRay Corporation ,  YONSEI UNIVERSITY, UNIVERSITY—INDUSTRY FOUNDATION (UIF)

发明人： Myoungsoo Jung ,  Gyuyoung Park

IPC分类号： G06F12/02 ,  G06F3/06 ,  G06F9/38

摘要： A memory system including a memory subsystem and a memory controller is provided. The memory subsystem includes a plurality of first memory modules implemented by a phase-change memory and a second memory module implemented by a memory whose write speed is faster than that of the phase-change memory. The memory controller generates a non-blocking code from a plurality of sub-data into which original data are divided, writes the non-blocking code to the second memory module, writes the plurality of sub-data to the plurality of first memory modules, respectively, and reconstructs the original data from some sub-data of the plurality of sub-data which are read from some of the plurality of first memory modules and the non-blocking code read from the second memory under a predetermined condition at a read request.

公开(公告)号：US20190239494A1

公开(公告)日：2019-08-08

申请号：US16050006

申请日：2018-07-31

申请人： KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY ,  YONSEI UNIVERSITY, UNIVERSITY - INDUSTRY FOUNDATION (UIF)

发明人： SEOK GU KANG ,  JEONG HO LEE ,  JOO HO LEE ,  JEONG EUN LEE

IPC分类号： A01K67/027 ,  A61K49/00

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2267/0331 ,  A61K49/0008

摘要： The present invention relates to a brain tumor animal model that directly reflects the phenomenon in a human patient and a method of preparing the same, and more specifically, a brain tumor animal model that mutations are introduced into p53, Pten, and EGFR genes, a screening method of a therapeutic agent for a brain tumor using the animal model, and a preparing method thereof.

公开(公告)号：US20190227732A1

公开(公告)日：2019-07-25

申请号：US16357435

申请日：2019-03-19

申请人： MemRay Corporation ,  YONSEI UNIVERSITY, UNIVERSITY - INDUSTRY FOUNDATION (UIF)

发明人： Myoungsoo JUNG

IPC分类号： G06F3/06 ,  H05K1/18 ,  H01L27/22 ,  H01F10/32 ,  H01L43/02 ,  G11C11/16 ,  G06F11/10 ,  G06N20/00

摘要： A magnetoresistive memory module used as a main memory of a computing device is provided. A plurality of memory chips are mounted on a printed circuit board, and a memory controller performs data scrubbing. Each memory chip includes a plurality of magnetoresistive memory cells. Each magnetoresistive memory cell includes a magnetoresistive element and an access transistor that transfers a current to the magnetoresistive element, and has a size of a cell area that is substantially similar to a size of a DRAM cell area.

公开(公告)号：US20190171566A1

公开(公告)日：2019-06-06

申请号：US16198972

申请日：2018-11-23

申请人： MemRay Corporation ,  YONSEI UNIVERSITY, UNIVERSITY - INDUSTRY FOUNDATION (UIF)

发明人： Myoungsoo Jung ,  Donghyun Gouk ,  Miryeong Kwon ,  SungJoon Koh ,  Jie Zhang

IPC分类号： G06F12/0804 ,  G06F12/10

摘要： A memory controlling device of a computing device including a CPU, a memory, and a flash-based storage device is provided. The memory controlling device includes an address manager and an interface. The address manager aggregates a memory space of the memory and a storage space of the storage device into an expanded memory space, and handles a memory request for the expanded memory space from the CPU by using the memory space of the memory as a cache for the storage space of the storage device. The interface is used to access the memory and the storage device.

公开(公告)号：US20170235671A1

公开(公告)日：2017-08-17

申请号：US15168423

申请日：2016-05-31

申请人： MemRay Corporation ,  YONSEI UNIVERSITY, UNIVERSITY- INDUSTRY FOUNDATION (UIF)

发明人： Myoungsoo JUNG

IPC分类号： G06F12/02 ,  G06F13/40

CPC分类号： G06F12/023 ,  G06F13/4068 ,  G06F2212/251

摘要： A computing device includes a CPU, a CPU memory for CPU, a non-volatile memory, a coprocessor using the non-volatile memory, a coprocessor memory for storing data to be processed by the coprocessor or data processed by the coprocessor, and a recording medium. The recording medium includes a controller driver for the non-volatile memory and a library that are executed by the CPU. The controller driver maps the coprocessor memory to a system memory block of the CPU memory. The library moves data between the coprocessor and the non-volatile memory via the system memory block mapped to the coprocessor memory.

公开(公告)号：US09629346B2

公开(公告)日：2017-04-25

申请号：US14541252

申请日：2014-11-14

申请人： KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY ,  YONSEI UNIVERSITY, UNIVERSITY—INDUSTRY FOUNDATION (UIF)

发明人： Jeong Ho Lee ,  Dong Seok Kim ,  Jae Seok Lim ,  Hoon Chul Kang

IPC分类号： A01K67/00 ,  A01K67/033 ,  A01K67/027 ,  C12N9/12 ,  C12Q1/68

CPC分类号： A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0356 ,  C12N9/12 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Y207/11001

摘要： The present invention relates to a technique for inducing epilepsy and a non-human animal model of epilepsy. More particularly, the present invention relates to a method for inducing epilepsy in an animal, a non-human animal model of epilepsy, and a method for manufacturing the same.