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公开(公告)号：US20130065926A1
公开(公告)日：2013-03-14
申请号：US13601357
申请日：2012-08-31
申请人： Hassan A. PAJOUHESH , Ramesh KAUL , Yanbing DING , Yongbao ZHU , Lingyun ZHANG , Nagasree CHAKKA , Michael Edward GRIMWOOD , Jason TAN , Yuanxi ZHOU
发明人： Hassan A. PAJOUHESH , Ramesh KAUL , Yanbing DING , Yongbao ZHU , Lingyun ZHANG , Nagasree CHAKKA , Michael Edward GRIMWOOD , Jason TAN , Yuanxi ZHOU
IPC分类号： A61K31/445 , A61P29/00
CPC分类号： A61K31/5377 , A61K31/445 , A61K31/4525 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , C07D211/26 , C07D211/28 , C07D211/38 , C07D211/46 , C07D211/62 , C07D211/66 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing N-piperidinyl acetamide derivatives as shown in formula (1).
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公开(公告)号：US20090012010A1
公开(公告)日：2009-01-08
申请号：US12152488
申请日：2008-05-14
申请人： Robert Galemmo, JR. , Richard Holland , Yanbing Ding , Lingyun Zhang , Gabriel Hum , Navjot Chahal , Joseph Duffy , Christian Stevenson , Andrew Ullman
发明人： Robert Galemmo, JR. , Richard Holland , Yanbing Ding , Lingyun Zhang , Gabriel Hum , Navjot Chahal , Joseph Duffy , Christian Stevenson , Andrew Ullman
IPC分类号： A61K38/05 , C07C233/87 , C07D265/30 , A61P25/16 , A61P25/18 , A61P35/00 , A61P3/10
CPC分类号： A61K31/166 , A61K31/277 , A61K31/4453 , A61K31/5375
摘要： Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type and/or T-type calcium channel activity are disclosed. Specifically, a series of compounds containing both an amino acid functionality and multiple aromatic rings are disclosed of the general formula (1) where X is benzhydryl, or an aromatic or heteroaromatic ring.
摘要翻译： 公开了有效改善特征在于不需要的钙通道活性，特别是不需要的N型和/或T型钙通道活性的病症的方法和化合物。 具体地，公开了一系列含有氨基酸官能团和多个芳环的化合物，其通式（1）其中X是二苯甲基或芳族或杂芳族环。
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3.发明授权Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof 有权嘧啶羟基酰胺化合物作为蛋白质脱乙酰酶抑制剂及其使用方法公开(公告)号：US08614223B2
公开(公告)日：2013-12-24
申请号：US13296748
申请日：2011-11-15
申请人： John H. van Duzer , Ralph Mazitschek , Yanbing Ding , Nan Yu , Yun Cao , Yong Liu
发明人： John H. van Duzer , Ralph Mazitschek , Yanbing Ding , Nan Yu , Yun Cao , Yong Liu
IPC分类号： C07D239/42 , A61K31/505 , A61K31/506 , A61P35/00
CPC分类号： C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to novel pyrimidine hydroxy amide compounds, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
摘要翻译： 本发明涉及新颖的嘧啶羟基酰胺化合物，以及这些化合物在抑制HDAC6和治疗与HDAC6相关的各种疾病，病症或病症中的用途。
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公开(公告)号：US20100168103A1
公开(公告)日：2010-07-01
申请号：US12441364
申请日：2007-09-14
IPC分类号： A61K31/5377 , A61P25/00 , A61P25/16 , A61P25/18 , A61P3/00 , A61P9/00 , A61P15/16 , C40B40/04 , C07D401/06 , A61K31/497 , A61K31/4545 , C07D413/06
CPC分类号： A61K31/4545 , A61K31/496 , C07D211/26 , C07D401/06
摘要： Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type calcium channel activity are disclosed. Specifically, a series of diaryl piperidine compounds are disclosed of the general formula (I) where X is a linker and Y may be C, O, S or N.
摘要翻译： 公开了有效改善由不需要的钙通道活性，特别是不需要的N型钙通道活性表征的病症的方法和化合物。 具体地，公开了通式（I）的一系列二芳基哌啶化合物，其中X是连接基，Y可以是C，O，S或N.
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公开(公告)号：US07659395B2
公开(公告)日：2010-02-09
申请号：US12116920
申请日：2008-05-07
IPC分类号： C07D241/04 , C07D295/00
CPC分类号： C07D295/215 , C07D211/26 , C07D211/58 , C07D213/38 , C07D241/04 , C07D295/20 , C07D401/06 , C07D403/06 , C07D405/06
摘要： Urea derivatives which comprise compounds of the formula wherein A is H, B is piperidine and each Ar is phenyl are disclosed as useful in treating conditions such as pain, epilepsy, diabetes or prostate cancer.
摘要翻译： 包含下式化合物的尿素衍生物其中A是H，B是哌啶，每个Ar是苯基被公开用于治疗诸如疼痛，癫痫，糖尿病或前列腺癌的病症。
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公开(公告)号：US07649092B2
公开(公告)日：2010-01-19
申请号：US12111131
申请日：2008-04-28
IPC分类号： C07D241/04 , C07D295/00
CPC分类号： C07D295/215 , C07D211/26 , C07D211/58 , C07D213/38 , C07D241/04 , C07D295/20 , C07D401/06 , C07D403/06 , C07D405/06
摘要： Urea derivatives which comprise piperidine or piperazine rings and further substitution are effective in ameliorating conditions characterized by unwanted calcium ion channel activity.
摘要翻译： 包含哌啶或哌嗪环和进一步取代的尿素衍生物有助于改善以不需要的钙离子通道活性为特征的条件。
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公开(公告)号：US20090298883A1
公开(公告)日：2009-12-03
申请号：US12420793
申请日：2009-04-08
申请人： Hassan PAJOUHESH , Ramesh KAUL , Yanbing DING , Yongbao ZHU , Lingyun ZHANG , Nagasree CHAKKA , Mike GRIMWOOD , Jason TAN , Yuanxi ZHOU
发明人： Hassan PAJOUHESH , Ramesh KAUL , Yanbing DING , Yongbao ZHU , Lingyun ZHANG , Nagasree CHAKKA , Mike GRIMWOOD , Jason TAN , Yuanxi ZHOU
IPC分类号： A61K31/454 , A61K31/445 , A61P9/00 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/30 , A61P25/00 , A61P3/10 , A61P29/00 , A61P35/00 , A61P13/10 , A61P13/12 , A61P15/16
CPC分类号： A61K31/5377 , A61K31/445 , A61K31/4525 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , C07D211/26 , C07D211/28 , C07D211/38 , C07D211/46 , C07D211/62 , C07D211/66 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing N-piperidinyl acetamide derivatives as shown in formula (1).
摘要翻译： 公开了有助于改善由不希望的钙通道活性，特别是不希望的T型钙通道活性表征的病症的方法和化合物。 具体而言，是一系列含有式（1）所示的N-哌啶基乙酰胺衍生物的化合物。
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公开(公告)号：US20080280900A1
公开(公告)日：2008-11-13
申请号：US12118492
申请日：2008-05-09
申请人： Hassan PAJOUHESH , Hossein PAJOUHESH , Yanbing DING , Jason TAN , Mike GRIMWOOD , Francesco BELARDETTI , Ramesh KAUL
发明人： Hassan PAJOUHESH , Hossein PAJOUHESH , Yanbing DING , Jason TAN , Mike GRIMWOOD , Francesco BELARDETTI , Ramesh KAUL
IPC分类号： A61K31/5377 , A61K31/496 , A61P35/00
CPC分类号： A61K31/496 , A61K31/5377
摘要： Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing thienopyrimidine or oxoquinazoline derivatives are disclosed of the general formula (1) or formula (2) where X is a linker and Y is an aromatic moiety or N(R5)(R6).
摘要翻译： 公开了有助于改善由不希望的钙通道活性，特别是不希望的T型钙通道活性表征的病症的方法和化合物。 具体地说，通式（1）或式（2）公开了一系列含有噻吩并嘧啶或氧代喹唑啉衍生物的化合物，其中X为连接基，Y为芳族部分或N（R5）（R6）。
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公开(公告)号：US20120220605A1
公开(公告)日：2012-08-30
申请号：US13393374
申请日：2010-09-03
申请人： Hassan Pajouhesh , Yanbing Ding
发明人： Hassan Pajouhesh , Yanbing Ding
IPC分类号： A61K31/495 , A61P29/00 , A61P25/08 , C12N5/071 , A61P25/24 , A61P25/18 , A61P25/02 , A61P25/06 , C07D241/08 , A61P25/16
CPC分类号： C07D241/08 , A61K31/495 , A61K45/06 , A61K2300/00
摘要： Compounds of formula (I) which are useful in ameliorating conditions characterized by unwanted sodium and/or calcium channel actrvrh, particularly Nav1.7, Nav 1.8, or Cav 3.2 channel activity are disclosed. More specifically, compounds for use in the treatment of conditions such as epilepsy, cancer, pain, migraine, Parkinson's disease, depression, schizophrenia, psychosis, and tinnitus are disclosed.
摘要翻译： 公开了可用于改善由不需要的钠和/或钙通道活性，特别是Nav1.7，Nav 1.8或Cav 3.2通道活性表征的条件的式（I）化合物。 更具体地，公开了用于治疗诸如癫痫，癌症，疼痛，偏头痛，帕金森病，抑郁症，精神分裂症，精神病和耳鸣等疾病的化合物。
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10.发明申请SUBSTITUTED HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF PAIN AND EPILEPSY 审中-公开用于治疗疼痛和瘙痒的替代性异位衍生物公开(公告)号：US20120220603A1
公开(公告)日：2012-08-30
申请号：US13393369
申请日：2010-09-03
申请人： Hassan Pajouhesh , Mike Grimwood , Yongbao Zhu , Yanbing Ding , Richard Holland
发明人： Hassan Pajouhesh , Mike Grimwood , Yongbao Zhu , Yanbing Ding , Richard Holland
IPC分类号： A61K31/495 , C07D295/15 , A61K31/496 , A61P25/00 , C12N5/02 , A61P25/16 , A61P25/24 , A61P25/18 , A61P25/06 , C07D241/08 , A61P25/08
CPC分类号： C07D241/08 , C07D211/34 , C07D295/15 , C07D403/06 , C07D413/06
摘要： Compounds of formula (I) which are useful in ameliorating conditions characterized by unwanted sodium and/or calcium channel activity, particularly unwanted NaV 1.7, NaV 1.8, or CaV 3.2 channel activity are disclosed. Specifically, a series of compounds containing piperidine or piperazine linked through an amide, isoxazole or similar linker to an aryl ring are described and are shown to be useful for the treatment of pain or epilepsy. A is selected from Formulae (i) or (ii).
摘要翻译： 公开了可用于改善由不希望的钠和/或钙通道活性，特别是不需要的NaV 1.7，NaV 1.8或CaV 3.2通道活性表征的特征的式（I）化合物。 具体地说，描述了一系列含有通过酰胺，异恶唑或类似连接物与芳基环连接的哌啶或哌嗪的化合物，并被证明可用于治疗疼痛或癫痫。 A选自式（i）或（ii）。
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