Condensed compounds, their production and use
    1.
    发明授权
    Condensed compounds, their production and use 失效
    浓缩化合物,其生产和使用

    公开(公告)号:US5998433A

    公开(公告)日:1999-12-07

    申请号:US549779

    申请日:1995-11-14

    CPC分类号: C07D491/04 C07D495/04

    摘要: This invention provides new condensed furan compounds which exhibit excellent 2,3-oxidosqualene cyclase inhibition and high-density lipoprotein-cholesterol elevating activities.This invention also provides a therapeutic and prophylactic agent for hyperlipidemia, hypercholesterolemia and atherosclerosis.

    摘要翻译: PCT No.PCT / JP95 / 02062 Sec。 371日期:1995年11月14日 102(e)1995年11月14日PCT PCT 1995年10月9日PCT公布。 公开号WO96 / 11201 日期1996年04月18日本发明提供了新的缩合呋喃化合物,其表现出优异的2,3-氧化四环素环化酶抑制和高密度脂蛋白 - 胆固醇升高活性。 本发明还提供高脂血症,高胆固醇血症和动脉粥样硬化的治疗和预防剂。

    Fused imidazopyridine derivatives as antihyperlipidemic agents
    2.
    发明授权
    Fused imidazopyridine derivatives as antihyperlipidemic agents 失效
    融合的咪唑并吡啶衍生物作为抗高血脂药物

    公开(公告)号:US06235731B1

    公开(公告)日:2001-05-22

    申请号:US09155889

    申请日:1998-10-08

    IPC分类号: A61K31549

    CPC分类号: C07D513/16

    摘要: A novel compound of the formula: wherein ring Q is an optionally substituted pyridine ring; One of R0, R1 and R2 is —Y0—Z0, and the other tow groups are a hydrogen, a halogen, an optionally substituted hydroxy group, a hydrocarbon group that may be an optionally substituted hydrocarbon group or an acyl group; Y0 is a bond or an optionally substituted bivalent hydrocarbon group; Z0 is a basic group which may be bonded via oxygen, nitrogen, —CO—, —CS—, —SO2N(R3)— (where R3 is hydrogen or an optionally substituted hydrocarbon group), or S(O)n (wherein n is to 0, 1 or 2); ......... is a single bond or a double bond, or a salt thereof, which has an excellent LDL receptor up-regulating, blood-lipids lowering, blood-sugar lowering and diabetic complication-ameliorating activity.

    摘要翻译: 一种下式的新化合物:其中环Q是任选取代的吡啶环; R 0,R 1和R 2之一是-YO-Z 0,其它的三个基团是氢,卤素,任选取代的羟基,烃 可以是任意取代的烃基或酰基的基团; Y 0是一个键或任意取代的二价烃基; Z 0是可以通过氧,氮,-CO-,-CS-,-SO 2 N键合的碱性基团 (R 3) - (其中R 3是氢或任选取代的烃基)或S(O)n(其中n是0,1或2); .........是单键或 双键或其盐,其具有优异的LDL受体上调,血脂降低,血糖降低和糖尿病并发症改善活性。

    Tricyclic compounds, their production and use
    3.
    发明授权
    Tricyclic compounds, their production and use 失效
    三环化合物,其生产和使用

    公开(公告)号:US06251905B1

    公开(公告)日:2001-06-26

    申请号:US09234876

    申请日:1999-01-21

    IPC分类号: C07D40106

    CPC分类号: C07D471/16

    摘要: Tricyclic compound of the formula: wherein ring A is a nitrogen-containing heterocyclic ring, having two nitrogen atoms as the hetero-atoms, which is optionally substituted with oxo or thioxo; ring Q may optionally be substituted; Y is an optionally substituted hydrocarbon group, an optionally substituted hydroxyl group or an optionally substituted mecapto group, excluding for methyl group as Y; R1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof, having excellent PDGF-inhibiting activities, antihypertensive activities, activities of ameliorating renal diseases and activities of lowering lipid level.

    摘要翻译: 下式的三环化合物:其中环A是含氮杂环,具有两个氮原子作为杂原子,其任选被氧代或硫代取代; 环Q可任选被取代; Y是任选取代的烃基,任选取代的羟基或任选取代的mecapto基团,不包括甲基作为Y; R1是具有优异的PDGF抑制活性,抗高血压活性,改善肾脏疾病的活性和降低脂质水平的活性的氢原子,卤素原子,任选取代的烃基或酰基或其盐。

    Tricyclic nitrogen ring compounds, their production and use
    5.
    发明授权
    Tricyclic nitrogen ring compounds, their production and use 失效
    三环氮环化合物,其生产和使用

    公开(公告)号:US5958942A

    公开(公告)日:1999-09-28

    申请号:US783101

    申请日:1997-01-14

    CPC分类号: C07D471/16

    摘要: Tricyclic compound of the formula: ##STR1## wherein ring A is a nitrogen-containing heterocyclic ring, having two nitrogen atoms as the hetero-atoms, which is optionally substituted with oxo or thioxo; ring Q may optionally be substituted; Y is an optionally substituted hydrocarbon group, an optionally substituted hydroxyl group or an optionally substituted mecapto group, excluding for methyl group as Y; R.sup.1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof, having excellent PDGF-inhibiting activities, antihypertensive activities, activities of ameliorating renal diseases and activities of lowering lipid level.

    摘要翻译: 下式的三环化合物:其中环A是含氮杂环,具有两个氮原子作为杂原子,其任选被氧代或硫代基取代; 环Q可任选被取代; Y是任选取代的烃基,任选取代的羟基或任选取代的mecapto基团,不包括甲基作为Y; R1是具有优异的PDGF抑制活性,抗高血压活性,改善肾脏疾病的活性和降低脂质水平的活性的氢原子,卤素原子,任选取代的烃基或酰基或其盐。

    Pyridine derivatives, their production and use
    6.
    发明授权
    Pyridine derivatives, their production and use 失效
    吡啶衍生物,其生产和使用

    公开(公告)号:US5389658A

    公开(公告)日:1995-02-14

    申请号:US81181

    申请日:1993-06-24

    摘要: There is disclosed a pharmaceutical composition for providing antiinflammatory, antipyretic, analgesic, antiallergic, immunosuppressing or immunomodulating activity which comprises a pyridine derivative of the formula (I): ##STR1## wherein R is an optionally substituted pyridine ring, X is a oxygen atom or --S(O).sub.n --, wherein n is 0, 1 or 2, A is a bivalent C.sub.1-15 hydrocarbon residue whose branched moiety may have a substituent, Y is an oxygen or sulfur atom, R.sub.3 is a hydrogen atom or an optionally substituted hydrocarbon residue, R.sub.4 is an optionally substituted hydrocarbon residue or an optionally substituted monocyclic or bicyclic heterocyclic group, R.sub.3 and R.sub.4 may be joined together with the carbamoyl group or the thiocarbamoyl group to which they are attached to form an optionally substituted heterocyclic group, or R.sub.3 or R.sub.4 may be independently attached to A to form a ring, or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier or diluent.

    摘要翻译: 公开了一种用于提供抗炎,解热,止痛,抗过敏,免疫抑制或免疫调节活性的药物组合物,其包含式(I)的吡啶衍生物:其中R是任选取代的吡啶环,X是 氧原子或-S(O)n - ,其中n为0,1或2,A为支链部分可具有取代基的二价C1-15烃基,Y为氧或硫原子,R3为氢原子 或任选取代的烃残基,R4是任选取代的烃残基或任选取代的单环或双环杂环基,R 3和R 4可以与它们所连接的氨基甲酰基或硫代氨基甲酰基连接在一起形成任选取代的杂环 基团或R 3或R 4可以独立地连接到A上以形成环,或其药学上可接受的盐或溶剂合物,以及药学上可接受的载体或稀释剂。