公开(公告)号：US09132275B2

公开(公告)日：2015-09-15

申请号：US13290362

申请日：2011-11-07

Applicant: Yinghong Yu ,  Donald L. Hopper ,  Jiang Ding ,  James O. Gilkerson

Inventor： Yinghong Yu ,  Donald L. Hopper ,  Jiang Ding ,  James O. Gilkerson

IPC: A61N1/36 ,  A61N1/368

CPC classification number: A61N1/3682

Abstract: An apparatus comprises an implantable cardiac signal sensing circuit that provides an electrical cardiac signal representative of cardiac activity of a subject, an implantable therapy circuit that delivers electrical pacing stimulation energy to a heart of a subject, and a controller circuit. The controller circuit includes a chronotropic incompetence detection circuit that initiates pacing of an atrium of the subject at a rate higher than a device-indicated rate or a sensed intrinsic rate, monitor the AV interval, initiates an increase in the pacing rate while continuing the monitoring of the AV interval, calculates a change in AV intervals between a highest paced rate used in the monitoring and a lowest paced rate used in the monitoring, and indicates that the AV intervals are evidence of chronotropic incompetence when the calculated change in the AV intervals exceeds a specified threshold AV interval change value.

Abstract translation: 一种装置包括可植入心脏信号感测电路，其提供代表受试者的心脏活动的电心脏信号，将对该对象的心脏发出电起搏刺激能量的可植入治疗电路以及控制器电路。 控制器电路包括一个变时无能检测电路，其以高于设备指示速率或感测到的固有频率的速率启动对象的心房起搏，监视AV间隔，启动起搏速率的增加，同时继续监视 计算AV监视中使用的最高起搏速率和监视中使用的最低起搏速度之间的AV间隔的变化，并且指示AV间隔是当计算出的AV间隔的变化超过时间间隔无能力的证据 指定的阈值AV间隔变化值。

公开(公告)号：US08805503B2

公开(公告)日：2014-08-12

申请号：US12699457

申请日：2010-02-03

Applicant: Joseph M. Pastore ,  Rodney W. Salo ,  Gerrard M. Carlson ,  Andrew P. Kramer ,  Jiang Ding ,  Yinghong Yu

Inventor： Joseph M. Pastore ,  Rodney W. Salo ,  Gerrard M. Carlson ,  Andrew P. Kramer ,  Jiang Ding ,  Yinghong Yu

IPC: A61N1/362

CPC classification number: A61N1/36592 ,  A61B5/02405 ,  A61B5/4035 ,  A61N1/36114 ,  A61N1/368

Abstract: A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used to evaluate a plurality of parameter values for selecting an approximately optimal parameter value.

Abstract translation: 心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的传递。 产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。 在一个实施例中，HRV参数用于评估用于选择近似最佳参数值的多个参数值。

公开(公告)号：US08639334B2

公开(公告)日：2014-01-28

申请号：US11562681

申请日：2006-11-22

Applicant: Julio Spinelli ,  Yinghong Yu

Inventor： Julio Spinelli ,  Yinghong Yu

IPC: A61B5/04

CPC classification number: A61N1/365 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/3682

Abstract: Response to cardiac resynchronization therapy is predicted for a given stimulation site so that an atrioventricular delay of an implantable device administering cardiac resynchronization therapy may be set to a proper amount. The first deflection of ventricular depolarization is measured, such as through a surface electrocardiogram or through an intracardiac electrogram measured by a lead positioned in the heart at the stimulation site. The maximum deflection of the ventricular depolarization is then measured by the lead positioned at the stimulation site. The interval of time between the first deflection and the maximum deflection of the ventricular depolarization is compared to a threshold to determine whether the stimulation site is a responder site. If the interval is larger than the threshold, then the site is a responder and the atrioventricular delay of the implantable device may be set to less than the intrinsic atrioventricular delay of the patient. Otherwise, the atrioventricular may be set to approximately equal the intrinsic atrioventricular delay.

Abstract translation: 对于给定的刺激部位预测对心脏再同步治疗的响应，使得施用心脏再同步治疗的可植入装置的房室延迟可以被设定为适当的量。 测量心室去极化的第一偏转，例如通过表面心电图或通过位于刺激部位心脏中的导线测量的心内电描记图。 然后通过位于刺激部位的引线测量心室去极化的最大偏转。 将心室去极化的第一偏转和最大偏转之间的时间间隔与阈值进行比较以确定刺激位点是否是应答位点。 如果间隔大于阈值，则该位点是响应者，并且可植入装置的房室延迟可被设置为小于患者的内在房室延迟。 否则，房室可以设定为近似等于内在房室延迟。

公开(公告)号：US08626276B2

公开(公告)日：2014-01-07

申请号：US12847657

申请日：2010-07-30

Applicant: Yi Zhang ,  Scott A. Meyer ,  Jeffrey E. Stahmann ,  Carlos Alberto Ricci ,  Marina Brockway ,  Aaron R. McCabe ,  Yinghong Yu ,  Donald L. Hopper

Inventor： Yi Zhang ,  Scott A. Meyer ,  Jeffrey E. Stahmann ,  Carlos Alberto Ricci ,  Marina Brockway ,  Aaron R. McCabe ,  Yinghong Yu ,  Donald L. Hopper

IPC: A61B5/04

CPC classification number: A61N1/3702 ,  A61B5/0452 ,  A61B5/7203

Abstract: Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend ischemia using cardiac activation sequence information. Ischemia detection may involve sensing composite cardiac signals using implantable electrodes, and performing a signal separation that produces one or more cardiac activation signal vectors associated with one or more cardiac activation sequences. A change in the signal vector may be detected using subsequent separations. The change may be an elevation or depression of the ST segment of a cardiac cycle or other change indicative of myocardial ischemia, myocardial infarction, or other pathological change. The change may be used to predict, quantify, and/or qualify an event such as an arrhythmia, a myocardial infarction, or other pathologic change. Information associated with the vectors may be stored and used to track the vectors.

Abstract translation: 提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。 使用心脏信号分离来使用心脏激活序列信息来检测，监测，跟踪和/或趋势性缺血。 缺血检测可以涉及使用可植入电极感测复合心脏信号，并且执行产生与一个或多个心脏激活序列相关联的一个或多个心脏激活信号载体的信号分离。 可以使用后续分离来检测信号矢量的变化。 该变化可以是心​​脏周期的ST段的升高或抑制或指示心肌缺血，心肌梗死或其他病理变化的其它变化。 该变化可用于预测，量化和/或限定诸如心律失常，心肌梗死或其它病理变化的事件。 与矢量相关联的信息可以被存储并用于跟踪矢量。

公开(公告)号：US08612000B2

公开(公告)日：2013-12-17

申请号：US13327414

申请日：2011-12-15

Applicant: Jeffrey E. Stahmann ,  James O. Gilkerson ,  Krzysztof Z. Siejko ,  Yinghong Yu

Inventor： Jeffrey E. Stahmann ,  James O. Gilkerson ,  Krzysztof Z. Siejko ,  Yinghong Yu

IPC: A61N1/368 ,  A61N1/362 ,  A61N1/36 ,  A61N1/365

CPC classification number: A61N1/368 ,  A61N1/3627 ,  A61N1/3684

Abstract: In a pacing mode where the left ventricle is paced upon expiration of an escape interval that is reset by a right ventricular sense, there is the risk that the left ventricular pace may be delivered in the so-called vulnerable period that occurs after a depolarization and trigger an arrhythmia. To reduce this risk, a left ventricular protective period (LVPP) may be provided. Methods and devices for implementing an LVPP in the context of multi-site left ventricular pacing are described.

公开(公告)号：US08600504B2

公开(公告)日：2013-12-03

申请号：US13161851

申请日：2011-06-16

Applicant: Donald L. Hopper ,  Yinghong Yu ,  David J. Ternes

Inventor： Donald L. Hopper ,  Yinghong Yu ,  David J. Ternes

IPC: A61N1/365

CPC classification number: A61N1/368 ,  A61N1/3682

Abstract: Physiologic demand driven pacing can be used to maintain cardiac synchrony and improve hemodynamic function in patients with heart failure.

Abstract translation: 生理需求驱动起搏可用于维持心脏同步并改善心力衰竭患者的血液动力学功能。

公开(公告)号：US20130190636A1

公开(公告)日：2013-07-25

申请号：US13552996

申请日：2012-07-19

Applicant: Shibaji Shome ,  Pramodsingh Hirasingh Thakur ,  Yinghong Yu ,  Keith L. Herrmann ,  Aaron R. McCabe ,  Jiang Ding

Inventor： Shibaji Shome ,  Pramodsingh Hirasingh Thakur ,  Yinghong Yu ,  Keith L. Herrmann ,  Aaron R. McCabe ,  Jiang Ding

IPC: A61B5/0456 ,  A61B5/04

CPC classification number: A61B5/0456 ,  A61B5/04012 ,  A61N1/3684 ,  A61N1/3686 ,  A61N1/3702 ,  A61N1/37247 ,  A61N1/3918

Abstract: A system comprises a cardiac signal sensing and a processing circuit. The cardiac signal sensing circuit senses a first cardiac signal segment that includes a QRS complex and a second cardiac signal segment that includes a fiducial indicative of local ventricular activation. The processor circuit includes a site activation timer circuit configured to determine a time duration between a fiducial of the QRS complex of the first cardiac signal segment and the fiducial of the second cardiac signal segment. The processor circuit is configured to generate, using the determined time duration, an indication of optimality of placement of one or more electrodes for delivering therapy and provide the indication to at least one of a user or process.

Abstract translation: 一种系统包括心脏信号感测和处理电路。 心脏信号感测电路感测包括QRS复合物的第一心脏信号片段和包括指示局部心室激活的基准的第二心脏信号片段。 处理器电路包括站点激活定时器电路，其被配置为确定第一心脏信号段的QRS复合体的基准点与第二心脏信号段的基准点之间的持续时间。 处理器电路被配置为使用所确定的持续时间来生成用于递送治疗的一个或多个电极的放置的最佳化的指示，并向至少一个用户或过程提供指示。

公开(公告)号：US08483825B2

公开(公告)日：2013-07-09

申请号：US12336064

申请日：2008-12-16

Applicant: Yinghong Yu ,  Jiang Ding

Inventor： Yinghong Yu ,  Jiang Ding

IPC: A61N1/00

CPC classification number: A61N1/368 ,  A61B5/0452 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

Abstract: At least one of a left intraventricular conduction defect, a right intraventricular conduction defect, or no intraventricular conduction defect can be detected using received intrinsic cardiac information from a subject, and a first atrioventricular (AV) delay can be calculated using a first relationship if the left intraventricular conduction defect or no intraventricular conduction defect is detected, or a second AV delay can be calculated using a second relationship if the right intraventricular conduction defect is detected.

Abstract translation: 可以使用来自受试者的接收的固有心脏信息来检测左室内传导缺陷，右心室内传导缺陷或无心室内传导缺陷中的至少一个，并且可以使用第一关系来计算第一房室（AV）延迟，如果 如果检测到右心室传导缺陷，则检测到左心室内传导缺陷或无心室传导缺陷，或者可以使用第二关系计算第二AV延迟。

公开(公告)号：US08463380B2

公开(公告)日：2013-06-11

申请号：US13357259

申请日：2012-01-24

Applicant: Donald Hopper ,  Yinghong Yu ,  Allan C. Shuros ,  Shantha Arcot-Krishnamurthy ,  Gerrard M. Carlson ,  Jeffrey E. Stahmann

Inventor： Donald Hopper ,  Yinghong Yu ,  Allan C. Shuros ,  Shantha Arcot-Krishnamurthy ,  Gerrard M. Carlson ,  Jeffrey E. Stahmann

IPC: A61N1/362

CPC classification number: A61N1/36585 ,  A61N1/368 ,  A61N1/3682 ,  A61N1/3684

Abstract: Methods and systems to modulate timing intervals for pacing therapy are described. For each cardiac cycle, one or both of an atrioventricular (A-V) timing interval and an atrial (A-A) timing interval are modulated to oppose beat-to-beat ventricular (V-V) timing variability. Pacing therapy is delivered using the modulated timing intervals.

Abstract translation: 描述了调节起搏治疗时间间隔的方法和系统。 对于每个心动周期，房室（A-V）定时间隔和心房（A-A）定时间隔中的一个或两个被调制以抵抗搏动到心室（V-V）的时间变异性。 使用调制的定时间隔来提供起搏治疗。

公开(公告)号：US20120130220A1

公开(公告)日：2012-05-24

申请号：US13293707

申请日：2011-11-10

Applicant: Barun Maskara ,  Yinghong Yu ,  Bruce A. Tockman ,  Sunipa Saha ,  Martin McDaniel ,  Geng Zhang

Inventor： Barun Maskara ,  Yinghong Yu ,  Bruce A. Tockman ,  Sunipa Saha ,  Martin McDaniel ,  Geng Zhang

IPC: A61B5/042 ,  A61N1/36 ,  A61N1/39 ,  A61B19/00

CPC classification number: A61N1/056 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/0472 ,  A61B5/6851 ,  A61N1/37241 ,  A61N2001/0585

Abstract: Cardiac lead implantation systems, devices, and methods for lead implantation are disclosed. An illustrative cardiac lead implantation system comprises a mapping guidewire including one or more electrodes configured for sensing cardiac electrical activity, a signal analyzer including an analysis module configured for analyzing an electrocardiogram signal sensed by the mapping guidewire, and a user interface configured for monitoring one or more hemodynamic parameters within the body. The sensed electrical activity signal can be used by the analysis module to compute a timing interval associated with ventricular depolarization.

Abstract translation: 公开了用于引线植入的心脏引线植入系统，装置和方法。 示例性心脏引线植入系统包括：映射导丝，其包括被配置为感测心脏电活动的一个或多个电极;信号分析器，包括被配置用于分析由所述映射导丝所感测的心电图信号的分析模块;以及用户界面，被配置为监视一个或 更多血液动力学参数在体内。 感测的电活动信号可以被分析模块用于计算与心室去极化相关的定时间隔。