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    4-substituted piperidine compound
    3.
    发明授权
    4-substituted piperidine compound 失效
    4-取代的哌啶化合物

    公开(公告)号：US06906083B2

    公开(公告)日：2005-06-14

    申请号：US10296379

    申请日：2001-06-21

    Applicant: Yoichi Iimura ,  Takashi Kosasa

    Inventor： Yoichi Iimura ,  Takashi Kosasa

    IPC: A61P25/14 ,  A61P25/28 ,  A61P43/00 ,  C07D211/32 ,  A61K31/445 ,  C07D211/06

    CPC classification number: C07D211/32

    Abstract: The present invention provides a novel compound having a superior acetylcholinesterase inhibitory action. It provides a compound represented by the formula: (In the formula, R1 represents a group represented by the formula: (wherein, R3, R4, R5 and R6 are the same as or different from each other and each represents a hydrogen atom, an optionally substituted C1-6 alkoxy group and the like; and m represents an integer from 0 to 6) and the like; and R2 represents a hydrogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted C2-6 alkenyl group or an optionally substituted C2-6 alkynyl group), a salt thereof or a hydrate of them.

    Abstract translation: 本发明提供具有优异乙酰胆碱酯酶抑制作用的新型化合物。 它提供由下式表示的化合物：（式中，R 1表示由下式表示的基团：（其中R 3，R 4， R 5，R 5和R 6彼此相同或不同，各自表示氢原子，任选取代的C 1-6烷基， 烷氧基等; m表示0〜6的整数）等; R 2表示氢原子，可以具有取代基的C 1-6烷基， 任选取代的C 2-6亚烷基或任选取代的C 2-6烯基），其盐或它们的水合物。

    Nitrile compound
    4.
    发明授权
    Nitrile compound 失效
    腈化合物

    公开(公告)号：US06667412B1

    公开(公告)日：2003-12-23

    申请号：US09914349

    申请日：2001-08-27

    Applicant: Yuichi Suzuki ,  Noboru Yamamoto ,  Koki Kawano ,  Teiji Kimura ,  Koichi Ito ,  Satoshi Nagato ,  Yoshihiko Norimine ,  Yoichi Iimura

    Inventor： Yuichi Suzuki ,  Noboru Yamamoto ,  Koki Kawano ,  Teiji Kimura ,  Koichi Ito ,  Satoshi Nagato ,  Yoshihiko Norimine ,  Yoichi Iimura

    IPC: C07C25536

    CPC classification number: C07D295/145 ,  C07C255/36 ,  C07C255/41 ,  C07D295/14

    Abstract: The present invention provides a novel nitrile compound useful as an intermediate for the production of, for example, N,N-substituted cyclic amine derivatives or phenylacetonitrile derivatives that are useful as a medicine. Specifically it provides a nitrile carboxylic acid compound, nitrile ester compound and nitrile alcohol compound. That is, it provides a nitrile compound represented by the following formula (I): wherein R1 and R2 means substituents; m means 0 or an integer of from 1 to 6; n means 0 or an integer of from 1 to 5; and R3 means carboxyl group, a lower alkoxycarbonyl group or hydroxymethyl group.

    Abstract translation: 本发明提供了可用作制备例如可用作药物的N，N-取代的环胺衍生物或苯乙腈衍生物的中间体的新型腈化合物。 具体地说，它提供了一种腈羧酸化合物，腈酯化合物和腈醇化合物。 也就是说，它提供由下式（I）表示的腈化合物：其中R 1和R 2表示取代基; m表示0或1〜6的整数; n表示0或1至5的整数; R 3表示羧基，低级烷氧基羰基或羟甲基。

    JNK inhibitors
    6.
    发明授权
    JNK inhibitors 有权
    JNK抑制剂

    公开(公告)号：US07432375B2

    公开(公告)日：2008-10-07

    申请号：US10548163

    申请日：2004-03-05

    Applicant: Piotr Graczyk ,  Afzal Khan ,  Gurpreet Bhatia ,  Yoichi Iimura

    Inventor： Piotr Graczyk ,  Afzal Khan ,  Gurpreet Bhatia ,  Yoichi Iimura

    IPC: C07D471/02 ,  C07D491/02 ,  C07D498/02 ,  C07D513/02 ,  C07D515/02

    CPC classification number: C07D471/04

    Abstract: The present invention provides novel compounds of formula (I) and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.

    Abstract translation: 本发明提供新的式（I）化合物及其在抑制c-Jun N-末端激酶中的用途。 本发明进一步提供这些化合物在药物中的用途，特别是在预防和/或治疗与凋亡和/或炎症相关的神经变性疾病中的用途。

    4-Substituted piperidine compound
    7.
    发明申请
    4-Substituted piperidine compound 审中-公开
    4-取代的哌啶化合物

    公开(公告)号：US20050026895A1

    公开(公告)日：2005-02-03

    申请号：US10931033

    申请日：2004-09-01

    Applicant: Yoichi Iimura ,  Takashi Kosasa

    Inventor： Yoichi Iimura ,  Takashi Kosasa

    IPC: A61P25/14 ,  A61P25/28 ,  A61P43/00 ,  C07D211/32 ,  A61K31/55 ,  A61K31/454 ,  A61K31/4709

    CPC classification number: C07D211/32

    Abstract: The present invention provides a novel compound having a superior acetylcholinesterase inhibitory action. It provides a compound represented by the formula: (In the formula, R1 represents a group represented by the formula: (wherein, R3, R4, R5 and R6 are the same as or different from each other and each represents a hydrogen atom, an optionally substituted C1-6 alkoxy group and the like; and m represents an integer from 0 to 6) and the like; and R2 represents a hydrogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted C2-6 alkenyl group or an optionally substituted C2-6 alkynyl group), a salt thereof or a hydrate of them.

    Abstract translation: 本发明提供具有优异乙酰胆碱酯酶抑制作用的新型化合物。 它提供由下式表示的化合物：（在该式中，R 1表示由下式表示的基团：其中R 3，R 4，R 5和R 6为 相同或不同，各自表示氢原子，任选取代的C 1-6烷氧基等; m表示0〜6的整数）等; R 2表示氢原子， 任选取代的C 1-6烷基，任选取代的C 2-6烯基或任选取代的C 2-6炔基），其盐或它们的水合物。

    (1-Indanone)-(1,2,3,6-tetrahydropyridine) compounds
    8.
    发明授权
    (1-Indanone)-(1,2,3,6-tetrahydropyridine) compounds 失效
    （1-茚满酮） - （1,2,3,6-四氢吡啶）化合物

    公开(公告)号：US07378425B2

    公开(公告)日：2008-05-27

    申请号：US10940747

    申请日：2004-09-15

    Applicant: Yoichi Iimura ,  Takashi Kosasa ,  Yoshiharu Yamanishi

    Inventor： Yoichi Iimura ,  Takashi Kosasa ,  Yoshiharu Yamanishi

    IPC: C07D211/70 ,  A61K31/44

    CPC classification number: A61K31/44 ,  C07D211/70

    Abstract: The present invention provides an excellent sigma receptor binding agent and/or acetylcholinesterase inhibitor containing an (1-indanone)-(1,2,3,6-tetrahydropyridine) compound. More specifically, it provides an (1-indanone)-(1,2,3,6-tetrahydropyridine) compound represented by the following formula, a pharmacologically acceptable salt thereof or a hydrate thereof: In the formula (I), R1, R2, R3 and R4 are the same as or different from each other.

    Abstract translation: 本发明提供了含有（1-二氢茚酮） - （1,2,3,6-四氢吡啶）化合物的优异的σ受体结合剂和/或乙酰胆碱酯酶抑制剂。 更具体地说，它提供由下式表示的（1-二氢茚酮） - （1,2,3,6-四氢吡啶）化合物，其药理学上可接受的盐或其水合物：在式（I）中，R < R 1，R 2，R 3，R 4和R 4彼此相同或不同。

    (1-Indanone)-(1,2,3,6-tetrahydropyridine) compounds
    10.
    发明申请
    (1-Indanone)-(1,2,3,6-tetrahydropyridine) compounds 失效
    （1-茚满酮） - （1,2,3,6-四氢吡啶）化合物

    公开(公告)号：US20050124642A1

    公开(公告)日：2005-06-09

    申请号：US10940747

    申请日：2004-09-15

    Applicant: Yoichi Iimura ,  Takashi Kosasa ,  Yoshiharu Yamanishi

    Inventor： Yoichi Iimura ,  Takashi Kosasa ,  Yoshiharu Yamanishi

    IPC: A61K31/44 ,  A61P21/04 ,  A61P25/06 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P27/06 ,  A61P43/00 ,  C07D211/70

    CPC classification number: A61K31/44 ,  C07D211/70

    Abstract: The present invention provides an excellent sigma receptor binding agent and/or acetylcholinesterase inhibitor containing an (1-indanone)-(1,2,3,6-tetrahydropyridine) compound. More specifically, it provides an (1-indanone)-(1,2,3,6-tetrahydropyridine) compound represented by the following formula, a pharmacologically acceptable salt thereof or a hydrate thereof: In the formula (I), R1, R2, R3 and R4 are the same as or different from each other.

    Abstract translation: 本发明提供了含有（1-二氢茚酮） - （1,2,3,6-四氢吡啶）化合物的优异的σ受体结合剂和/或乙酰胆碱酯酶抑制剂。 更具体地说，它提供由下式表示的（1-二氢茚酮） - （1,2,3,6-四氢吡啶）化合物，其药理学上可接受的盐或其水合物：在式（I）中，R < R 1，R 2，R 3，R 4和R 4彼此相同或不同。

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