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1.发明授权Production of high mannose proteins in plant culture and therapeutic uses thereof 有权植物培养中高甘露糖蛋白的生产及其治疗用途公开(公告)号：US08790641B2
公开(公告)日：2014-07-29
申请号：US12385894
申请日：2009-04-23
Applicant: Yoseph Shaaltiel , Gideon Baum , Daniel Bartfeld , Sharon Hashmueli , Ayala Lewkowicz
Inventor： Yoseph Shaaltiel , Gideon Baum , Daniel Bartfeld , Sharon Hashmueli , Ayala Lewkowicz
CPC classification number: A61K38/47 , A61K9/0053 , A61K36/23 , C07K2319/04 , C12N9/2405 , C12N9/2434 , C12N9/2465 , C12N15/8257 , C12P21/005 , C12Y302/01022 , C12Y302/01045
Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.
Abstract translation: 用于在植物培养物中生产糖基化蛋白质的装置，系统和方法，特别是具有高甘露糖糖基化的蛋白质，同时用ER信号靶向这种蛋白质和/或旁路高尔基体。 本发明进一步涉及使用转基因植物根特别是胡萝卜细胞表达和产生酶活性高甘露糖溶酶体酶的载体和方法。 更具体地，本发明涉及宿主细胞，特别是转基因悬浮的胡萝卜细胞，用于高产量表达和生产生物活性高甘露糖葡糖脑苷脂酶（GCD）的载体和方法。 本发明还提供了用于治疗溶酶体贮积病的组合物和方法。
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公开(公告)号：US08227230B2
公开(公告)日：2012-07-24
申请号：US13080692
申请日：2011-04-06
Applicant: Yoseph Shaaltiel , Gideon Baum , Daniel Bartfeld , Sharon Hashmueli , Ayala Lewkowicz
Inventor： Yoseph Shaaltiel , Gideon Baum , Daniel Bartfeld , Sharon Hashmueli , Ayala Lewkowicz
CPC classification number: A61K38/47 , A61K9/0053 , A61K36/23 , C07K2319/04 , C12N9/2405 , C12N9/2434 , C12N9/2465 , C12N15/8257 , C12P21/005 , C12Y302/01022 , C12Y302/01045
Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.
Abstract translation: 用于在植物培养物中生产糖基化蛋白质的装置，系统和方法，特别是具有高甘露糖糖基化的蛋白质，同时用ER信号靶向这种蛋白质和/或旁路高尔基体。 本发明进一步涉及使用转基因植物根特别是胡萝卜细胞表达和产生酶活性高甘露糖溶酶体酶的载体和方法。 更具体地，本发明涉及宿主细胞，特别是转基因悬浮的胡萝卜细胞，用于高产量表达和生产生物活性高甘露糖葡糖脑苷脂酶（GCD）的载体和方法。 本发明还提供了用于治疗溶酶体贮积病的组合物和方法。
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公开(公告)号：US20100196345A1
公开(公告)日：2010-08-05
申请号：US12451188
申请日：2008-04-30
Applicant: Yoseph Shaaltiel , Gideon Baum , Daniel Bartfeld , Sharon Hashmueli , Ayala Lewkowicz
Inventor： Yoseph Shaaltiel , Gideon Baum , Daniel Bartfeld , Sharon Hashmueli , Ayala Lewkowicz
CPC classification number: C12P21/005 , C07K2319/04 , C12N9/2402 , C12N15/8257 , C12Y302/01022 , C12Y302/01045
Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.
Abstract translation: 用于在植物培养物中生产糖基化蛋白质的装置，系统和方法，特别是具有高甘露糖糖基化的蛋白质，同时用ER信号靶向这种蛋白质和/或旁路高尔基体。 本发明进一步涉及使用转基因植物根特别是胡萝卜细胞表达和产生酶活性高甘露糖溶酶体酶的载体和方法。 更具体地，本发明涉及宿主细胞，特别是转基因悬浮的胡萝卜细胞，用于高产量表达和生产生物活性高甘露糖葡糖脑苷脂酶（GCD）的载体和方法。 本发明还提供了用于治疗溶酶体贮积病的组合物和方法。
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公开(公告)号：US20090208477A1
公开(公告)日：2009-08-20
申请号：US12385894
申请日：2009-04-23
Applicant: Yoseph Shaaltiel , Gideon Baum , Daniel Bartfeld , Sharon Hashmueli , Ayala Lewkowicz
Inventor： Yoseph Shaaltiel , Gideon Baum , Daniel Bartfeld , Sharon Hashmueli , Ayala Lewkowicz
CPC classification number: A61K38/47 , A61K9/0053 , A61K36/23 , C07K2319/04 , C12N9/2405 , C12N9/2434 , C12N9/2465 , C12N15/8257 , C12P21/005 , C12Y302/01022 , C12Y302/01045
Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.
Abstract translation: 用于在植物培养物中生产糖基化蛋白质的装置，系统和方法，特别是具有高甘露糖糖基化的蛋白质，同时用ER信号靶向这种蛋白质和/或旁路高尔基体。 本发明进一步涉及使用转基因植物根特别是胡萝卜细胞表达和产生酶活性高甘露糖溶酶体酶的载体和方法。 更具体地，本发明涉及宿主细胞，特别是转基因悬浮的胡萝卜细胞，用于高产量表达和生产生物活性高甘露糖葡糖脑苷脂酶（GCD）的载体和方法。 本发明还提供了用于治疗溶酶体贮积病的组合物和方法。
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公开(公告)号：US08741620B2
公开(公告)日：2014-06-03
申请号：US13555243
申请日：2012-07-23
Applicant: Yoseph Shaaltiel , Gideon Baum , Daniel Bartfeld , Sharon Hashmueli , Ayala Lewkowicz
Inventor： Yoseph Shaaltiel , Gideon Baum , Daniel Bartfeld , Sharon Hashmueli , Ayala Lewkowicz
CPC classification number: A61K38/47 , A61K9/0053 , A61K36/23 , C07K2319/04 , C12N9/2405 , C12N9/2434 , C12N9/2465 , C12N15/8257 , C12P21/005 , C12Y302/01022 , C12Y302/01045
Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.
Abstract translation: 用于在植物培养物中生产糖基化蛋白质的装置，系统和方法，特别是具有高甘露糖糖基化的蛋白质，同时用ER信号靶向这种蛋白质和/或旁路高尔基体。 本发明进一步涉及使用转基因植物根特别是胡萝卜细胞表达和产生酶活性高甘露糖溶酶体酶的载体和方法。 更具体地，本发明涉及宿主细胞，特别是转基因悬浮的胡萝卜细胞，用于高产量表达和生产生物活性高甘露糖葡糖脑苷脂酶（GCD）的载体和方法。 本发明还提供了用于治疗溶酶体贮积病的组合物和方法。
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Patent Agency Ranking
6.发明申请READTHROUGH ACETYLCHOLINESTERASE (ACHE-R) FOR TREATING OR PREVENTING PARKINSON'S DISEASE 审中-公开准备乙酰胆碱酯酶（ACHE-R）治疗或预防帕金森病公开(公告)号：US20130164288A1
公开(公告)日：2013-06-27
申请号：US13820525
申请日：2011-09-07
Applicant: Hermona Soreq , Ilya Ruderfer , Yoseph Shaaltiel
Inventor： Hermona Soreq , Ilya Ruderfer , Yoseph Shaaltiel
CPC classification number: A61K38/465 , A61K47/60 , C12N9/18 , C12Y301/01007
Abstract: A method of treating or preventing Parkinson's disease in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of AChE-R, wherein the AChE-R is devoid of an N-terminal extension. An additional method of treating or preventing Parkinson's disease in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of AChE-R, wherein the AChE-R comprises a modification for increasing bioavailability.
Abstract translation: 公开了在有需要的受试者中治疗或预防帕金森病的方法。 该方法包括向受试者施用治疗有效量的AChE-R，其中AChE-R缺乏N-末端延伸。 公开了一种在受试者中治疗或预防帕金森病的另外的方法。 该方法包括向受试者施用治疗有效量的AChE-R，其中AChE-R包含用于提高生物利用度的修饰。
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7.发明授权公开(公告)号：US08119406B2
公开(公告)日：2012-02-21
申请号：US11665344
申请日：2005-10-11
Applicant: Yoseph Shaaltiel , Sharon Hashmueli , Daniel Bartfeld , Gideon Baum , Tal Ratz , Einat Mizrachi , Yehava Forester
Inventor： Yoseph Shaaltiel , Sharon Hashmueli , Daniel Bartfeld , Gideon Baum , Tal Ratz , Einat Mizrachi , Yehava Forester
CPC classification number: C12N15/8258 , C07K16/00 , C07K2317/13
Abstract: A system and method for production of antibodies in plant cell culture, which results in highly functional antibodies, produced with a high level of expression efficiency. The present invention also encompasses host cells, vectors and methods for mass production of full size assembled immunoglobulins.
Abstract translation: 用于在植物细胞培养物中产生抗体的系统和方法，其产生具有高水平表达效率产生的高度功能的抗体。 本发明还包括用于批量生产全尺寸组装的免疫球蛋白的宿主细胞，载体和方法。
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公开(公告)号：US20080038232A1
公开(公告)日：2008-02-14
申请号：US11790991
申请日：2007-04-30
Applicant: Yoseph Shaaltiel , Gideon Baum , Daniel Bartfeld , Sharon Hashmueli , Ayala Lewkowicz
Inventor： Yoseph Shaaltiel , Gideon Baum , Daniel Bartfeld , Sharon Hashmueli , Ayala Lewkowicz
IPC: A61K38/00 , A01N65/00 , A61P43/00 , C07H21/04 , C07K14/00 , C12N1/20 , C12N5/08 , C12N9/24 , C12P21/06
CPC classification number: A61K38/47 , A61K9/0053 , A61K36/23 , C07K2319/04 , C12N9/2405 , C12N9/2434 , C12N9/2465 , C12N15/8257 , C12P21/005 , C12Y302/01022 , C12Y302/01045
Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.
Abstract translation: 用于在植物培养物中生产糖基化蛋白质的装置，系统和方法，特别是具有高甘露糖糖基化的蛋白质，同时用ER信号靶向这种蛋白质和/或旁路高尔基体。 本发明进一步涉及使用转基因植物根特别是胡萝卜细胞表达和产生酶活性高甘露糖溶酶体酶的载体和方法。 更具体地，本发明涉及宿主细胞，特别是转基因悬浮的胡萝卜细胞，用于高产量表达和生产生物活性高甘露糖葡糖脑苷脂酶（GCD）的载体和方法。 本发明还提供了用于治疗溶酶体贮积病的组合物和方法。
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公开(公告)号：US20120282231A1
公开(公告)日：2012-11-08
申请号：US13555243
申请日：2012-07-23
Applicant: Yoseph Shaaltiel , Gideon Baum , Daniel Bartfeld , Sharon Hashmueli , Ayala Lewkowicz
Inventor： Yoseph Shaaltiel , Gideon Baum , Daniel Bartfeld , Sharon Hashmueli , Ayala Lewkowicz
CPC classification number: A61K38/47 , A61K9/0053 , A61K36/23 , C07K2319/04 , C12N9/2405 , C12N9/2434 , C12N9/2465 , C12N15/8257 , C12P21/005 , C12Y302/01022 , C12Y302/01045
Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.
Abstract translation: 用于在植物培养物中生产糖基化蛋白质的装置，系统和方法，特别是具有高甘露糖糖基化的蛋白质，同时用ER信号靶向这种蛋白质和/或旁路高尔基体。 本发明进一步涉及使用转基因植物根特别是胡萝卜细胞表达和产生酶活性高甘露糖溶酶体酶的载体和方法。 更具体地，本发明涉及宿主细胞，特别是转基因悬浮的胡萝卜细胞，用于高产量表达和生产生物活性高甘露糖葡糖脑苷脂酶（GCD）的载体和方法。 本发明还提供了用于治疗溶酶体贮积病的组合物和方法。
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公开(公告)号：US07951557B2
公开(公告)日：2011-05-31
申请号：US11790991
申请日：2007-04-30
Applicant: Yoseph Shaaltiel , Gideon Baum , Daniel Bartfeld , Sharon Hashmueli , Ayala Lewkowicz
Inventor： Yoseph Shaaltiel , Gideon Baum , Daniel Bartfeld , Sharon Hashmueli , Ayala Lewkowicz
CPC classification number: A61K38/47 , A61K9/0053 , A61K36/23 , C07K2319/04 , C12N9/2405 , C12N9/2434 , C12N9/2465 , C12N15/8257 , C12P21/005 , C12Y302/01022 , C12Y302/01045
Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.
Abstract translation: 用于在植物培养物中生产糖基化蛋白质的装置，系统和方法，特别是具有高甘露糖糖基化的蛋白质，同时用ER信号靶向这种蛋白质和/或旁路高尔基体。 本发明进一步涉及使用转基因植物根特别是胡萝卜细胞表达和产生酶活性高甘露糖溶酶体酶的载体和方法。 更具体地，本发明涉及宿主细胞，特别是转基因悬浮的胡萝卜细胞，用于高产量表达和生产生物活性高甘露糖葡糖脑苷脂酶（GCD）的载体和方法。 本发明还提供了用于治疗溶酶体贮积病的组合物和方法。
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