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    Production of biotin
    3.
    发明授权
    Production of biotin 失效
    生物素生产

    公开(公告)号：US06361978B1

    公开(公告)日：2002-03-26

    申请号：US08840059

    申请日：1997-04-24

    申请人： Tatsuo Hoshino ,  Akira Asakura ,  Tatsuya Kiyasu ,  Yoshie Nagahashi

    发明人： Tatsuo Hoshino ,  Akira Asakura ,  Tatsuya Kiyasu ,  Yoshie Nagahashi

    IPC分类号： C12P1718

    CPC分类号： C12N9/93 ,  C12N9/13 ,  C12P17/186

    摘要： The present invention provides processes for making biotin from desthiobiotin by either contacting desthiobiotin with an enzyme reaction mixture containing bioB gene product and nifU gene product and/or nifS gene product and isolating the biotin or cultivating a microorganism transformed with DNA encoding the bioB gene product, nifU gene product and nifS gene product and isolating the biotin.

    摘要翻译： 本发明提供通过将脱硫生物素与含有bioB基因产物和nifU基因产物和/或nifS基因产物的酶反应混合物接触来生产脱氧生物素的生物素的方法，并分离生物素或培养用编码bioB基因产物的DNA转化的微生物， nifU基因产物和nifS基因产物，并分离生物素。

    Method Of Producing Compound Having Anti-Hcv Activity
    5.
    发明申请
    Method Of Producing Compound Having Anti-Hcv Activity 审中-公开
    生产具有抗Hcv活性的化合物的方法

    公开(公告)号：US20110098477A1

    公开(公告)日：2011-04-28

    申请号：US11988003

    申请日：2006-06-27

    申请人： Masahiro Aoki ,  Yoshie Nagahashi ,  Hideyuki Kato ,  Tatsuya Ito ,  Miyako Masubuchi ,  Toru Okuda

    发明人： Masahiro Aoki ,  Yoshie Nagahashi ,  Hideyuki Kato ,  Tatsuya Ito ,  Miyako Masubuchi ,  Toru Okuda

    IPC分类号： C07D213/55 ,  C07C229/36 ,  C12P13/04

    CPC分类号： C07C229/36 ,  C07C231/14 ,  C12P13/02 ,  C07C235/76

    摘要： There is provided a convenient and inexpensive method of producing a compound which has a high activity of inhibiting replication of hepatitis C virus (HCV) and is useful for preventing and treating a liver disease caused by HCV infection.It is a method of biologically producing a compound represented by the formula (1): [wherein A represents a hydrogen atom, a straight or branched alkyl group having 1 to 8 carbon atoms, or the like], or a pharmaceutically acceptable salt thereof, a method comprising adding an amino acid derivative represented by the formula (3): [wherein A has the same meaning as defined for the compound of the above formula (1); and R represents a hydrogen atom, a straight or branched alkyl group having 1 to 8 carbon atoms, or the like], or a salt thereof into the fungal mycelium or the culture medium/culture broth of a filamentous fungal strain having an ability to produce the compound represented by the formula (2): to thereby cause the fungal strain to directly produce the compound of the formula (1).

    摘要翻译： 提供了一种方便且廉价的生产具有抑制丙型肝炎病毒（HCV）复制活性的化合物的方法，并且可用于预防和治疗由HCV感染引起的肝脏疾病。 生物地制造式（1）表示的化合物或其药学上可接受的盐的方法：[其中A表示氢原子，碳原子数1〜8的直链或支链烷基等] 包括加入由式（3）表示的氨基酸衍生物的方法：[其中A具有与上述式（1）的化合物相同的含义; R表示氢原子，碳原子数为1〜8的直链或支链烷基等，或其盐形成具有生产能力的丝状真菌菌株的真菌菌丝体或培养液/培养液 由式（2）表示的化合物：由此使真菌菌株直接生成式（1）的化合物。

    Gene encoding vitamin b6 phosphate phosphatase and use thereof
    7.
    发明授权
    Gene encoding vitamin b6 phosphate phosphatase and use thereof 有权
    编码维生素B6磷酸磷酸酶的基因及其用途

    公开(公告)号：US07598066B2

    公开(公告)日：2009-10-06

    申请号：US10528845

    申请日：2003-09-23

    申请人： Tatsuo Hoshino ,  Yoshie Nagahashi ,  Masaaki Tazoe

    发明人： Tatsuo Hoshino ,  Yoshie Nagahashi ,  Masaaki Tazoe

    IPC分类号： C12N9/16 ,  C12N15/70 ,  C12N1/21 ,  C12N1/16 ,  C12P21/06 ,  C12P17/00 ,  C12P17/12 ,  C07H21/04

    CPC分类号： C12N9/16 ,  C12P17/12

    摘要： Disclosed is an isolated DNA encoding vitamin B6 phosphate phosphatase selected from the group consisting of: (a) a DNA sequence represented in SEQ ID NO:9; (b) a DNA sequence which encodes a polypeptide having vitamin B6 phosphate phosphatase activity and hybridizes under standard conditions to the DNA sequence defined in (a) or a fragment of thereof; (c) a DNA sequence which encodes a polypeptide having vitamin B6 phosphate phosphatase activity, wherein said polypeptide is at least 70% identical to the amino acid sequence represented in SEQ ID NO:10; (d) a DNA sequence which encodes a polypeptide having vitamin B6 phosphate phosphatase activity and is at least 70% identical to the DNA sequence represented in SEQ ID NO:9; (e) a degenerate DNA sequence of any one of (a) to (c).

    摘要翻译： 公开了编码选自以下的维生素B6磷酸磷酸酶的分离DNA：（a）SEQ ID NO：9所示的DNA序列; （b）编码具有维生素B6磷酸酯酶活性的多肽的DNA序列，并在标准条件下与（a）中定义的DNA序列或其片段杂交; （c）编码具有维生素B6磷酸酯酶活性的多肽的DNA序列，其中所述多肽与SEQ ID NO：10所示氨基酸序列至少70％相同; （d）编码具有维生素B6磷酸酯酶活性并与SEQ ID NO：9所示DNA序列至少70％相同的多肽的DNA序列; （e）（a）至（c）中任一项的简并DNA序列。

    Gene encoding vitamin b6 phosphate phosphatase and use thereof
    8.
    发明申请
    Gene encoding vitamin b6 phosphate phosphatase and use thereof 有权
    编码维生素B6磷酸磷酸酶的基因及其用途

    公开(公告)号：US20060263862A1

    公开(公告)日：2006-11-23

    申请号：US10528845

    申请日：2003-09-23

    申请人： Tatsuo Hoshino ,  Yoshie Nagahashi ,  Masaaki Tazoe

    发明人： Tatsuo Hoshino ,  Yoshie Nagahashi ,  Masaaki Tazoe

    IPC分类号： C12P17/00 ,  C12N9/16 ,  C12N15/74 ,  C12N1/21

    CPC分类号： C12N9/16 ,  C12P17/12

    摘要： Disclosed is an isolated DNA encoding vitamin B6 phosphate phosphatase selected from the group consisting of: (a) a DNA sequence represented in SEQ ID NO:9; (b) a DNA sequence which encodes a polypeptide having vitamin B6 phosphate phosphatase activity and hybridizes under standard conditions to the DNA sequence defined in (a) or a fragment of thereof; (c) a DNA sequence which encodes a polypeptide having vitamin B6 phosphate phosphatase activity, wherein said polypeptide is at least 70% identical to the amino acid sequence represented in SEQ ID NO: 10; (d) a DNA sequence which encodes a polypeptide having vitamin B6 phosphate phosphatase activity and is at least 70% identical to the DNA sequence represented in SEQ ID NO:9; (e) a degenerate DNA sequence of any one of (a) to (c).

    摘要翻译： 公开了编码选自以下的维生素B 6磷酸磷酸酶的分离DNA：（a）SEQ ID NO：9所示的DNA序列; （b）编码具有维生素B 6磷酸磷酸酶活性的多肽的DNA序列，并在标准条件下与（a）中定义的DNA序列或其片段杂交; （c）编码具有维生素B 6磷酸磷酸酶活性的多肽的DNA序列，其中所述多肽与SEQ ID NO：10所示氨基酸序列至少70％相同; （d）编码具有维生素B 6磷酸磷酸酶活性的多肽的DNA序列，与SEQ ID NO：9所示的DNA序列至少70％相同; （e）（a）至（c）中任一项的简并DNA序列。