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公开(公告)号：US08168191B2
公开(公告)日：2012-05-01
申请号：US12113822
申请日：2008-05-01
CPC分类号： C12N5/0636 , A61K39/00 , A61K39/0011 , A61K48/00 , A61K2039/5154 , A61K2039/5156
摘要： The present invention relates to a T lymphocyte having an activity to induce a T lymphocyte recognizing an antigen and a technique to use the T lymphocyte.
摘要翻译： 本发明涉及具有诱导T淋巴细胞识别抗原的活性的T淋巴细胞和使用T淋巴细胞的技术。
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公开(公告)号：US08003770B2
公开(公告)日：2011-08-23
申请号：US11991964
申请日：2006-09-07
CPC分类号： C07K14/705 , A61K35/12 , A61K38/00 , C07K14/7051 , C12N5/0636 , C12N2501/515 , C12N2510/00
摘要： A polypeptide comprising a polypeptide consisting of an amino acid sequence shown in SEQ ID NO: 5 of Sequence Listing or a polypeptide consisting of an amino acid sequence having deletion, addition, insertion or substitution of one to several amino acid residues in the sequence, the polypeptide being capable of constituting an HLA-A24-restricted, MAGE-A4143-151-specific T cell receptor together with a polypeptide consisting of an amino acid sequence shown in SEQ ID NO: 2 of Sequence Listing.
摘要翻译： 一种多肽，其包含由序列表的SEQ ID NO：5所示的氨基酸序列组成的多肽或由序列中一至数个氨基酸残基的缺失，添加，插入或取代的氨基酸序列组成的多肽， 能够构成HLA-A24限制性MAGE-A4143-151特异性T细胞受体的多肽以及由序列表的SEQ ID NO：2所示的氨基酸序列组成的多肽。
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公开(公告)号：USD334668S
公开(公告)日：1993-04-13
申请号：US702692
申请日：1991-05-20
申请人： Yoshihiro Miyahara
设计人： Yoshihiro Miyahara
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公开(公告)号：US09018006B2
公开(公告)日：2015-04-28
申请号：US13811778
申请日：2011-07-25
IPC分类号： C12N5/0783 , C07K16/28 , A61K39/00
CPC分类号： C12N5/0637 , A61K35/17 , A61K2039/505 , A61K2039/507 , C07K16/2809 , C07K16/2845 , C07K2317/73 , C07K2317/74 , C12N5/0636 , C12N2501/2302 , C12N2501/2325 , C12N2501/51 , C12N2501/515 , C12N2501/599 , C12N2501/727
摘要： The present invention provides materials and methods related to culturing stable Treg cells or in vivo expansion of stable Treg cells, the cells made by the methods, treatments for various inflammatory/autoimmune pathologies and transplant/graft rejection, and related materials. Ex vivo induction and expansion of the stable Tregs is described, including use of inducing compositions, such as certain mAbs and other compounds, along with expansion medium comprising IL-2. In vivo expansion of stable Treg cells and treatments for various inflammatory/autoimmune pathologies and transplant/graft rejection are described, including the use of mAbs and their variants.
摘要翻译： 本发明提供了与培养稳定的Treg细胞或稳定的Treg细胞的体内扩增相关的材料和方法，通过该方法制备的细胞，各种炎症/自身免疫病理学和移植/移植排斥的治疗以及相关材料。 描述稳定的Treg的离体诱导和扩增，包括使用诱导组合物，例如某些mAb和其它化合物，以及包含IL-2的扩增培养基。 描述了稳定的Treg细胞的体内扩增和各种炎症/自身免疫病理学和移植/移植排斥的治疗，包括使用mAb及其变体。
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公开(公告)号：US20130280208A1
公开(公告)日：2013-10-24
申请号：US13811778
申请日：2011-07-25
IPC分类号： C12N5/0783 , A61K35/14
CPC分类号： C12N5/0637 , A61K35/17 , A61K2039/505 , A61K2039/507 , C07K16/2809 , C07K16/2845 , C07K2317/73 , C07K2317/74 , C12N5/0636 , C12N2501/2302 , C12N2501/2325 , C12N2501/51 , C12N2501/515 , C12N2501/599 , C12N2501/727
摘要： The present invention provides materials and methods related to culturing stable Treg cells or in vivo expansion of stable Treg cells, the cells made by the methods, treatments for various inflammatory/autoimmune pathologies and transplant/graft rejection, and related materials. Ex vivo induction and expansion of the stable Tregs is described, including use of inducing compositions, such as certain mAbs and other compounds, along with expansion medium comprising IL-2. In vivo expansion of stable Treg cells and treatments for various inflammatory/autoimmune pathologies and transplant/graft rejection are described, including the use of mAbs and their variants.
摘要翻译： 本发明提供了与培养稳定的Treg细胞或稳定的Treg细胞的体内扩增相关的材料和方法，通过该方法制备的细胞，各种炎症/自身免疫病理学和移植/移植排斥的治疗以及相关材料。 描述稳定的Treg的离体诱导和扩增，包括使用诱导组合物，例如某些mAb和其它化合物，以及包含IL-2的扩增培养基。 描述了稳定的Treg细胞的体内扩增和各种炎症/自身免疫病理学和移植/移植排斥的治疗，包括使用mAb及其变体。
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公开(公告)号：US20110256114A1
公开(公告)日：2011-10-20
申请号：US13167414
申请日：2011-06-23
CPC分类号： C07K14/705 , A61K35/12 , A61K38/00 , C07K14/7051 , C12N5/0636 , C12N2501/515 , C12N2510/00
摘要： A polypeptide comprising a polypeptide consisting of an amino acid sequence shown in SEQ ID NO: 5 of Sequence Listing or a polypeptide consisting of an amino acid sequence having deletion, addition, insertion or substitution of one to several amino acid residues in the sequence, the polypeptide being capable of constituting an HLA-A24-restricted, MAGE-A4143-151-specific T cell receptor together with a polypeptide consisting of an amino acid sequence shown in SEQ ID NO: 2 of Sequence Listing.
摘要翻译： 一种多肽，其包含由序列表的SEQ ID NO：5所示的氨基酸序列组成的多肽或由序列中一至数个氨基酸残基的缺失，添加，插入或取代的氨基酸序列组成的多肽， 能够构成HLA-A24限制性MAGE-A4143-151特异性T细胞受体的多肽以及由序列表的SEQ ID NO：2所示的氨基酸序列组成的多肽。
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公开(公告)号：USD358036S
公开(公告)日：1995-05-09
申请号：US10611
申请日：1993-07-12
申请人： Yoshihiro Miyahara
设计人： Yoshihiro Miyahara
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公开(公告)号：US09243227B2
公开(公告)日：2016-01-26
申请号：US13431542
申请日：2012-03-27
IPC分类号： C12N5/00 , C12N5/0783 , A61K39/00 , A61K48/00
CPC分类号： C12N5/0636 , A61K39/00 , A61K39/0011 , A61K48/00 , A61K2039/5154 , A61K2039/5156
摘要： The present invention relates to a T lymphocyte having an activity to induce a T lymphocyte recognizing an antigen and a technique to use the T lymphocyte.
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公开(公告)号：US20120238012A1
公开(公告)日：2012-09-20
申请号：US13431542
申请日：2012-03-27
IPC分类号： C12N5/10 , C12N5/0783
CPC分类号： C12N5/0636 , A61K39/00 , A61K39/0011 , A61K48/00 , A61K2039/5154 , A61K2039/5156
摘要： The present invention relates to a T lymphocyte having an activity to induce a T lymphocyte recognizing an antigen and a technique to use the T lymphocyte.
摘要翻译： 本发明涉及具有诱导T淋巴细胞识别抗原的活性的T淋巴细胞和使用T淋巴细胞的技术。
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公开(公告)号：US20090324566A1
公开(公告)日：2009-12-31
申请号：US11991964
申请日：2006-09-07
IPC分类号： A61K45/00 , C07K14/00 , C07K16/00 , C07H21/00 , C12N15/74 , C12N5/10 , A61K31/7088 , A61P35/00
CPC分类号： C07K14/705 , A61K35/12 , A61K38/00 , C07K14/7051 , C12N5/0636 , C12N2501/515 , C12N2510/00
摘要： A polypeptide comprising a polypeptide consisting of an amino acid sequence shown in SEQ ID NO: 5 of Sequence Listing or a polypeptide consisting of an amino acid sequence having deletion, addition, insertion or substitution of one to several amino acid residues in the sequence, the polypeptide being capable of constituting an HLA-A24-restricted, MAGE-A4143-151-specific T cell receptor together with a polypeptide consisting of an amino acid sequence shown in SEQ ID NO: 2 of Sequence Listing.
摘要翻译： 一种多肽，其包含由序列表的SEQ ID NO：5所示的氨基酸序列组成的多肽或由序列中一至数个氨基酸残基的缺失，添加，插入或取代的氨基酸序列组成的多肽， 能够构成HLA-A24限制性MAGE-A4143-151特异性T细胞受体的多肽以及由序列表的SEQ ID NO：2所示的氨基酸序列组成的多肽。
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