公开(公告)号：US08034353B2

公开(公告)日：2011-10-11

申请号：US12280535

申请日：2007-02-16

申请人： Akira Yano ,  Toshiki Nishizawa ,  Yoshikatsu Miwa

发明人： Akira Yano ,  Toshiki Nishizawa ,  Yoshikatsu Miwa

IPC分类号： A61K39/02 ,  A61K39/04 ,  A61K39/05 ,  A61K39/08 ,  C07H21/04

CPC分类号： A61K39/0008 ,  A61K2039/543 ,  A61K2039/55516 ,  A61K2039/55544 ,  A61K2039/6037 ,  C07K14/005 ,  C07K14/4711 ,  C07K2319/00 ,  C12N2740/16222

摘要： An object of the present invention is to provide a peptide vaccine for preventing and/or treating diseases caused by amyloid β-peptide, such as Alzheimer's disease. The present invention solves the above object by providing a peptide vaccine constructed by inserting a peptide having an amino acid sequence of a cell attachment motif of a cell adhesive molecule to a peptide which consists of a peptide having an amino acid sequence of multiagretope type T-cell epitope, which has been generated immunological memory, or a peptide including the same; an linker peptide; and a peptide having an amino acid sequence of a B cell epitope which is a specific region of amyloid β-peptide or a peptide including the same.

摘要翻译： 本发明的目的是提供一种用于预防和/或治疗由淀粉样蛋白和诸如阿尔茨海默氏病等引起的疾病的肽疫苗。 本发明通过提供通过将具有细胞粘附分子的细胞附着基序的氨基酸序列的肽插入到由具有多重靶向型T-氨基酸的氨基酸序列的肽组成的肽而构成的肽疫苗来解决上述目的， 已经产生免疫记忆的细胞表位或包含其的肽; 接头肽; 以及具有B细胞表位的氨基酸序列的肽，所述B细胞表位是淀粉样蛋白的特异性区域或包含该氨基酸的肽。

公开(公告)号：US20060131899A1

公开(公告)日：2006-06-22

申请号：US10529739

申请日：2003-09-30

申请人： Junji Adachi ,  Naruaki Abe ,  Fumihiko Sato ,  Taku Fukuyama ,  Kouji Mori ,  Yoshikatsu Miwa ,  Yukiya Morita

发明人： Junji Adachi ,  Naruaki Abe ,  Fumihiko Sato ,  Taku Fukuyama ,  Kouji Mori ,  Yoshikatsu Miwa ,  Yukiya Morita

IPC分类号： B60R19/22

CPC分类号： B60R19/18 ,  B60R13/08 ,  B60R21/34 ,  B60R2019/1806 ,  B60R2019/1873

摘要： A bumper absorber for protecting pedestrians (20) is formed into a W-shaped cross-sectional configuration, as taken along a direction which is orthogonal to a longitudinal direction of the bumper absorber. The W-shaped cross sectional configuration has portions in which a front notch portion (22), an upper rear notch portion (24), and a lower rear notch portion (26) overlap with one another in a vertical direction of a vehicle. Ribs (30) are formed respectively at the upper rear notch portion (24) and the lower rear notch portion (26), and a triangular notch (32) is formed from a vehicle rear side at each of the rib (30). Further, the ribs 30 are formed at the upper rear notch portion (24) and the lower rear notch portion (26) so as to be separated from each other at predetermined intervals in a longitudinal direction of the bumper absorber, namely, in a transverse direction of the vehicle. With this structure, a rise in impact load acting on a pedestrian who is hit by a bumper can be controlled.

摘要翻译： 用于保护行人（20）的保险杠吸收体形成为沿着与保险杠吸收体的纵向方向正交的方向的W形横截面形状。 W形横截面形状具有前车削部分，其中前切口部分（22），上后切口部分（24）和下后切口部分（26）在车辆的垂直方向上彼此重叠。 在上后切口部（24）和下后切口部（26）分别形成肋（30），并且在每个肋（30）上从车辆后侧形成有三角形切口（32）。 此外，肋30形成在上后切口部（24）和下后切口部（26），以在保险杠吸收体的长度方向上以规定间隔彼此分离，即横向 车辆方向 通过这种结构，可以控制作用在由保险杠撞击的行人的冲击载荷的上升。

公开(公告)号：US5714476A

公开(公告)日：1998-02-03

申请号：US315344

申请日：1994-09-30

申请人： Yoshikatsu Miwa ,  Takashi Shibuya ,  Hiroto Chaen

发明人： Yoshikatsu Miwa ,  Takashi Shibuya ,  Hiroto Chaen

IPC分类号： A23C9/123 ,  A23C9/152 ,  A23G1/00 ,  A23G1/30 ,  A23G3/00 ,  A23G3/34 ,  A23G9/00 ,  A23L2/60 ,  A23L27/30 ,  A61K8/60 ,  A61K8/73 ,  A61K9/36 ,  A61K9/44 ,  A61K47/26 ,  A61Q11/00 ,  C07H3/04 ,  C12P19/14 ,  C12P19/18 ,  A61K31/715 ,  C12P19/12

CPC分类号： C12P19/18 ,  C12P19/14

摘要： Neotrehalose is prepared in a relatively high-yield by a process comprising allowing .beta.-galactosidase to act on a solution containing lactoneotrehalose to form neotrehalose and recoverying the resultant neotrehalose. The neotrehalose is a non-reducing oligosaccharide having a satisfiable stability and a rich- and high-quality-sweetness and is assimilated and utilized as energy source in vivo when orally administered. Neotrehalose in the form of crystal has a satisfiable handleability because it is readily soluble in water and substantially free of hygroscopicity. These render neotrehalose very useful in the fields of food-, cosmetic- and pharmaceutical-industries.

摘要翻译： 通过包括使β-半乳糖苷酶作用于含有内酯海藻糖的溶液以形成新海藻糖并回收所得的新海藻糖的方法，以相当高的产率制备新海藻糖。 新海藻糖是具有令人满意的稳定性和富含和高质量的甜度的非还原性寡糖，并且在口服给药时被同化并用作体内的能源。 晶体形式的新海藻糖具有令人满意的可操作性，因为它易溶于水并且基本上没有吸湿性。 这些使新鲜海洛糖在食品，化妆品和制药行业领域非常有用。

公开(公告)号：US5403727A

公开(公告)日：1995-04-04

申请号：US236017

申请日：1994-05-02

申请人： Yoshikatsu Miwa ,  Takashi Shibuya ,  Hiroto Chaen

发明人： Yoshikatsu Miwa ,  Takashi Shibuya ,  Hiroto Chaen

IPC分类号： A23C9/123 ,  A23C9/152 ,  A23G1/00 ,  A23G1/30 ,  A23G3/00 ,  A23G3/34 ,  A23G9/00 ,  A23L2/60 ,  A23L27/30 ,  A61K8/60 ,  A61K8/73 ,  A61K9/36 ,  A61K9/44 ,  A61K47/26 ,  A61Q11/00 ,  C07H3/04 ,  C12P19/14 ,  C12P19/18 ,  C12P19/12 ,  C13K13/00

CPC分类号： C12P19/18 ,  C12P19/14

摘要： Neotrehalose is prepared in a relatively high-yield by a process comprising allowing .beta.-galactosidase to act on a solution containing lactoneotrehalose to form neotrehalose and recovering the resultant neotrehalose. The neotrehalose is a non-reducing oligosaccharide having a satisfiable stability and a rich- and high-quality-sweetness and is assimilated and utilized as energy source in vivo when orally administered. Neotrehalose in the form of crystal has a satisfiable handleability because it is readily soluble in water and substantially free of hygroscopicity. These render neotrehalose very useful in the fields of food-, cosmetic- and pharmaceutical-industries.

摘要翻译： 通过包括使β-半乳糖苷酶作用于含有内酯海藻糖的溶液以形成新海藻糖并回收所得的新海藻糖的方法，以相当高的产率制备新海藻糖。 新海藻糖是具有令人满意的稳定性和富含和高质量的甜度的非还原性寡糖，并且在口服给药时被同化并用作体内的能源。 晶体形式的新海藻糖具有令人满意的可操作性，因为它易溶于水并且基本上没有吸湿性。 这些使新鲜海洛糖在食品，化妆品和制药行业领域非常有用。

公开(公告)号：US20100210589A1

公开(公告)日：2010-08-19

申请号：US12768625

申请日：2010-04-27

申请人： Hitoshi MITSUZUMI ,  Mika TAKAMI ,  Yoshikatsu MIWA ,  Hiroto CHAEN ,  Toshio MIYAKE

发明人： Hitoshi MITSUZUMI ,  Mika TAKAMI ,  Yoshikatsu MIWA ,  Hiroto CHAEN ,  Toshio MIYAKE

IPC分类号： A61K31/715 ,  A61P1/16

CPC分类号： A61K31/7048 ,  A23F3/163 ,  A23L2/52 ,  A23L33/10

摘要： An object of the present invention is to provide a means for improving hepatic function of mammals including humans to normal condition. The present invention achieves the above object by providing a hepatic function-improving agent comprising α-glucosyl-hesperidin as an effective ingredient.

摘要翻译： 本发明的目的是提供一种将包括人的哺乳动物的肝功能改善至正常状况的手段。 本发明通过提供包含α-葡萄糖基 - 橙皮苷作为有效成分的肝功能改善剂来实现上述目的。

公开(公告)号：US20090098061A1

公开(公告)日：2009-04-16

申请号：US11917026

申请日：2006-06-08

申请人： Shigeki Suzuki ,  Yoshikatsu Miwa ,  Nobuo Sasaki ,  Yuiichi Tei

发明人： Shigeki Suzuki ,  Yoshikatsu Miwa ,  Nobuo Sasaki ,  Yuiichi Tei

IPC分类号： A61K9/12 ,  C13K13/00 ,  A61K31/715

CPC分类号： A61K31/7016 ,  A61L31/042

摘要： The objective of the invention is to provide a solution for tissue adhesion prevention and a method for tissue adhesion prevention that are applicable to general surgery and in which covering condition during surgery is stable and convenient. The invention is the solution for tissue adhesion prevention of which the active ingredient is trehalose. Also, it contains at least one or more among antioxidants, chelates, antiseptics, hemostatics, anti-inflammatory agents, and polysaccharides, mucopolysaccharides, salts of polysaccharides and salts of mucopolysaccharides having lubricating properties. This solution for tissue adhesion prevention is provided as any form of perfusion fluid, spray fluid, solution for spray or vaporization administration, foam-like aerosol preparation, injection solution for intravenous fluids, intravenous fluid.

摘要翻译： 本发明的目的是提供一种适用于一般手术的组织粘连防止方法和组织粘连防止方法，其中手术中的覆盖状态是稳定和方便的。 本发明是用于组织粘附预防的方法，其中活性成分是海藻糖。 此外，它还含有至少一种或多种抗氧化剂，螯合物，防腐剂，止血剂，抗炎剂和多糖，粘多糖，多糖的盐和具有润滑性质的粘多糖的盐中的至少一种或多种。 用于组织粘附防止的这种解决方案提供为任何形式的灌注液，喷雾液，用于喷雾或蒸发给药的溶液，泡沫状气溶胶制剂，静脉注射液注射液，静脉注射液。

公开(公告)号：US20090023684A1

公开(公告)日：2009-01-22

申请号：US11912279

申请日：2006-04-13

申请人： Hitomi Ohta ,  Toshiharu Hanaya ,  Shigeharu Fukuda ,  Yoshikatsu Miwa ,  Toshio Miyake

发明人： Hitomi Ohta ,  Toshiharu Hanaya ,  Shigeharu Fukuda ,  Yoshikatsu Miwa ,  Toshio Miyake

IPC分类号： A61K31/715

CPC分类号： A61K31/716 ,  A61K31/702 ,  A61K31/7048 ,  A61M1/287 ,  A61K2300/00

摘要： The present invention has an object to provide a fluid for peritoneal dialysis with satisfactory body fluid removability, high biocompatibility, and improved storage stability, and the object is attained by a fluid for peritoneal dialysis containing one or more saccharides selected from cyclonigerosylnigerose, cyclomaltosylmaltose, and L-ascorbic acid 2-glucoside.

摘要翻译： 本发明的目的是提供一种用于腹膜透析的流体，其具有令人满意的体液清除性，高生物相容性和改善的储存稳定性，并且目的是通过含有一种或多种选自旋风黑素糖， L-抗坏血酸2-葡萄糖苷。

公开(公告)号：US07390039B2

公开(公告)日：2008-06-24

申请号：US11739041

申请日：2007-04-23

申请人： Junji Adachi ,  Naruaki Abe ,  Fumihiko Sato ,  Taku Fukuyama ,  Kouji Mori ,  Yoshikatsu Miwa ,  Yukiya Morita

发明人： Junji Adachi ,  Naruaki Abe ,  Fumihiko Sato ,  Taku Fukuyama ,  Kouji Mori ,  Yoshikatsu Miwa ,  Yukiya Morita

IPC分类号： B60R19/03

CPC分类号： B60R19/18 ,  B60R13/08 ,  B60R21/34 ,  B60R2019/1806 ,  B60R2019/1873

摘要： A bumper absorber for protecting pedestrians is formed into a W-shaped cross-sectional configuration, as taken along a direction which is orthogonal to a longitudinal direction of the bumper absorber. The W-shaped cross sectional configuration has portions in which a front notch portion, an upper rear notch portion, and a lower rear notch portion overlap with one another in a vertical direction of a vehicle. Ribs are formed respectively at the upper rear notch portion and the lower rear notch portion, and a triangular notch is formed from a vehicle rear side at each of the rib. Further, the ribs 30 are formed at the upper rear notch portion and the lower rear notch portion so as to be separated from each other at predetermined intervals in a longitudinal direction of the bumper absorber, namely, in a transverse direction of the vehicle. With this structure, a rise in impact load acting on a pedestrian who is hit by a bumper can be controlled.

摘要翻译： 用于保护行人的保险杠吸收体形成为沿与保险杠吸收体的长度方向正交的方向截取的W形横截面形状。 W形横截面形状具有其中前切口部分，上后切口部分和下后切口部分在车辆的垂直方向上彼此重叠的部分。 分别在上后切口部和下后切口部分形成肋，并且在每个肋处从车辆后侧形成三角形切口。 此外，肋30形成在上后切口部和下后切口部，以在缓冲器吸收体的长度方向即车辆的宽度方向上以规定间隔彼此分离。 通过这种结构，可以控制作用在由保险杠撞击的行人的冲击载荷的上升。

公开(公告)号：US07226097B2

公开(公告)日：2007-06-05

申请号：US10529739

申请日：2003-09-30

申请人： Junji Adachi ,  Naruaki Abe ,  Fumihiko Sato ,  Taku Fukuyama ,  Kouji Mori ,  Yoshikatsu Miwa ,  Yukiya Morita

发明人： Junji Adachi ,  Naruaki Abe ,  Fumihiko Sato ,  Taku Fukuyama ,  Kouji Mori ,  Yoshikatsu Miwa ,  Yukiya Morita

IPC分类号： B60R19/03

CPC分类号： B60R19/18 ,  B60R13/08 ,  B60R21/34 ,  B60R2019/1806 ,  B60R2019/1873

摘要： A bumper absorber for protecting pedestrians (20) is formed into a W-shaped cross-sectional configuration, as taken along a direction which is orthogonal to a longitudinal direction of the bumper absorber. The W-shaped cross sectional configuration has portions in which a front notch portion (22), an upper rear notch portion (24), and a lower rear notch portion (26) overlap with one another in a vertical direction of a vehicle. Ribs (30) are formed respectively at the upper rear notch portion (24) and the lower rear notch portion (26), and a triangular notch (32) is formed from a vehicle rear side at each of the rib (30). Further, the ribs 30 are formed at the upper rear notch portion (24) and the lower rear notch portion (26) so as to be separated from each other at predetermined intervals in a longitudinal direction of the bumper absorber, namely, in a transverse direction of the vehicle. With this structure, a rise in impact load acting on a pedestrian who is hit by a bumper can be controlled.

摘要翻译： 用于保护行人（20）的保险杠吸收体形成为沿着与保险杠吸收体的纵向方向正交的方向的W形横截面形状。 W形横截面形状具有前车削部分，其中前切口部分（22），上后切口部分（24）和下后切口部分（26）在车辆的垂直方向上彼此重叠。 在上后切口部（24）和下后切口部（26）分别形成肋（30），并且在每个肋（30）上从车辆后侧形成有三角形切口（32）。 此外，肋30形成在上后切口部（24）和下后切口部（26），以在缓冲器吸收体的长度方向上以规定间隔彼此分离，即横向 车辆方向 通过这种结构，可以控制作用在由保险杠撞击的行人的冲击载荷的上升。

公开(公告)号：US09155751B2

公开(公告)日：2015-10-13

申请号：US13047551

申请日：2011-03-14

申请人： Shigeki Suzuki ,  Yoshikatsu Miwa ,  Nobuo Sasaki ,  Yuiichi Tei

发明人： Shigeki Suzuki ,  Yoshikatsu Miwa ,  Nobuo Sasaki ,  Yuiichi Tei

IPC分类号： A61K31/7016 ,  A61P41/00 ,  A61K31/7048 ,  A61P39/06 ,  A61L31/04

CPC分类号： A61K31/7016 ,  A61L31/042

摘要： The objective of the invention is to provide a solution for tissue adhesion prevention and a method for tissue adhesion prevention that are applicable to general surgery and in which covering condition during surgery is stable and convenient. The invention is the solution for tissue adhesion prevention of which the active ingredient is trehalose. Also, it contains at least one or more among antioxidants, chelates, antiseptics, hemostatics, anti-inflammatory agents, and polysaccharides, mucopolysaccharides, salts of polysaccharides and salts of mucopolysaccharides having lubricating properties. This solution for tissue adhesion prevention is provided as any form of perfusion fluid, spray fluid, solution for spray or vaporization administration, foam-like aerosol preparation, injection solution for intravenous fluids, intravenous fluid.

摘要翻译： 本发明的目的是提供一种适用于一般手术的组织粘连防止方法和组织粘连防止方法，其中手术中的覆盖状态是稳定和方便的。 本发明是用于组织粘附预防的方法，其中活性成分是海藻糖。 此外，它还含有至少一种或多种抗氧化剂，螯合物，防腐剂，止血剂，抗炎剂和多糖，粘多糖，多糖的盐和具有润滑性质的粘多糖的盐中的至少一种或多种。 用于组织粘附防止的这种解决方案提供为任何形式的灌注液，喷雾液，用于喷雾或蒸发给药的溶液，泡沫状气溶胶制剂，静脉注射液注射液，静脉注射液。