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    Process for preparing compositions containing neotrehalose
    1.
    发明授权
    Process for preparing compositions containing neotrehalose 失效
    制备含有新海藻糖的组合物的方法

    公开(公告)号：US5714476A

    公开(公告)日：1998-02-03

    申请号：US315344

    申请日：1994-09-30

    申请人： Yoshikatsu Miwa ,  Takashi Shibuya ,  Hiroto Chaen

    发明人： Yoshikatsu Miwa ,  Takashi Shibuya ,  Hiroto Chaen

    IPC分类号： A23C9/123 ,  A23C9/152 ,  A23G1/00 ,  A23G1/30 ,  A23G3/00 ,  A23G3/34 ,  A23G9/00 ,  A23L2/60 ,  A23L27/30 ,  A61K8/60 ,  A61K8/73 ,  A61K9/36 ,  A61K9/44 ,  A61K47/26 ,  A61Q11/00 ,  C07H3/04 ,  C12P19/14 ,  C12P19/18 ,  A61K31/715 ,  C12P19/12

    CPC分类号： C12P19/18 ,  C12P19/14

    摘要： Neotrehalose is prepared in a relatively high-yield by a process comprising allowing .beta.-galactosidase to act on a solution containing lactoneotrehalose to form neotrehalose and recoverying the resultant neotrehalose. The neotrehalose is a non-reducing oligosaccharide having a satisfiable stability and a rich- and high-quality-sweetness and is assimilated and utilized as energy source in vivo when orally administered. Neotrehalose in the form of crystal has a satisfiable handleability because it is readily soluble in water and substantially free of hygroscopicity. These render neotrehalose very useful in the fields of food-, cosmetic- and pharmaceutical-industries.

    摘要翻译： 通过包括使β-半乳糖苷酶作用于含有内酯海藻糖的溶液以形成新海藻糖并回收所得的新海藻糖的方法，以相当高的产率制备新海藻糖。 新海藻糖是具有令人满意的稳定性和富含和高质量的甜度的非还原性寡糖，并且在口服给药时被同化并用作体内的能源。 晶体形式的新海藻糖具有令人满意的可操作性，因为它易溶于水并且基本上没有吸湿性。 这些使新鲜海洛糖在食品，化妆品和制药行业领域非常有用。

    Process for preparing neotrehalose and its uses
    2.
    发明授权
    Process for preparing neotrehalose and its uses 失效
    制备新海藻糖及其用途的方法

    公开(公告)号：US5403727A

    公开(公告)日：1995-04-04

    申请号：US236017

    申请日：1994-05-02

    申请人： Yoshikatsu Miwa ,  Takashi Shibuya ,  Hiroto Chaen

    发明人： Yoshikatsu Miwa ,  Takashi Shibuya ,  Hiroto Chaen

    IPC分类号： A23C9/123 ,  A23C9/152 ,  A23G1/00 ,  A23G1/30 ,  A23G3/00 ,  A23G3/34 ,  A23G9/00 ,  A23L2/60 ,  A23L27/30 ,  A61K8/60 ,  A61K8/73 ,  A61K9/36 ,  A61K9/44 ,  A61K47/26 ,  A61Q11/00 ,  C07H3/04 ,  C12P19/14 ,  C12P19/18 ,  C12P19/12 ,  C13K13/00

    CPC分类号： C12P19/18 ,  C12P19/14

    摘要： Neotrehalose is prepared in a relatively high-yield by a process comprising allowing .beta.-galactosidase to act on a solution containing lactoneotrehalose to form neotrehalose and recovering the resultant neotrehalose. The neotrehalose is a non-reducing oligosaccharide having a satisfiable stability and a rich- and high-quality-sweetness and is assimilated and utilized as energy source in vivo when orally administered. Neotrehalose in the form of crystal has a satisfiable handleability because it is readily soluble in water and substantially free of hygroscopicity. These render neotrehalose very useful in the fields of food-, cosmetic- and pharmaceutical-industries.

    摘要翻译： 通过包括使β-半乳糖苷酶作用于含有内酯海藻糖的溶液以形成新海藻糖并回收所得的新海藻糖的方法，以相当高的产率制备新海藻糖。 新海藻糖是具有令人满意的稳定性和富含和高质量的甜度的非还原性寡糖，并且在口服给药时被同化并用作体内的能源。 晶体形式的新海藻糖具有令人满意的可操作性，因为它易溶于水并且基本上没有吸湿性。 这些使新鲜海洛糖在食品，化妆品和制药行业领域非常有用。

    Process for producing trehalose and sugar alcohols
    4.
    发明授权
    Process for producing trehalose and sugar alcohols 有权
    生产海藻糖和糖醇的方法

    公开(公告)号：US06200783B1

    公开(公告)日：2001-03-13

    申请号：US09157107

    申请日：1998-09-18

    申请人： Hiroto Chaen ,  Takashi Shibuya ,  Shigeharu Fukuda

    发明人： Hiroto Chaen ,  Takashi Shibuya ,  Shigeharu Fukuda

    IPC分类号： C12P1912

    CPC分类号： C07H3/04

    摘要： A process for producing or separating trehalose and/or sugar alcohols from hydrogenated saccharide mixtures containing trehalose and sugar alcohols selected from the group consisting of sorbitol, maltitol, and maltotriitol, which comprises the steps of subjecting hydrogenated saccharide mixtures containing trehalose and the sugar alcohols to column chromatography using strong-acid cation exchange resins, and successively eluting and collecting a trehalose-rich fraction and a sugar alcohol-rich fraction in this order.

    摘要翻译： 从含有海藻糖和糖醇的氢化糖混合物制备或分离海藻糖和/或糖醇的方法，所述海藻糖和糖醇选自山梨醇，麦芽糖醇和麦芽三醇，其包括以下步骤：将含有海藻糖和糖醇的氢化糖混合物 使用强酸阳离子交换树脂的柱色谱法，并依次洗脱和收集富含海藻糖的级分和富含糖醇的级分。

    Saccharide for supplementing energy to living body, and uses
    5.
    发明授权
    Saccharide for supplementing energy to living body, and uses 失效
    用于补充活体能量的糖类及用途

    公开(公告)号：US5604211A

    公开(公告)日：1997-02-18

    申请号：US347222

    申请日：1994-11-23

    申请人： Takashi Shibuya ,  Hiroto Chaen ,  Shuzo Sakai ,  Toshio Miyake

    发明人： Takashi Shibuya ,  Hiroto Chaen ,  Shuzo Sakai ,  Toshio Miyake

    IPC分类号： A23L1/09 ,  A61K31/70 ,  A61K31/715 ,  A23G3/00

    CPC分类号： A61K31/70 ,  A23L29/30

    摘要： A composition for supplementing energy to a living body containing neotrehalose as effective ingredient. Neotrehalose is a disaccharide, therefore, when used in an energy supplementing composition, provides twice as much energy as does a monosaccharide. Neotrehalose has non-reducing properties, and this renders the composition containing neotrehalose stable for a relatively-long time period.

    摘要翻译： 用于将能量补充到含有新海藻糖作为有效成分的活体的组合物。 新海藻糖是二糖，因此当用于能量补充组合物时，其能量是单糖的两倍。 新海藻糖具有非还原性，这使得含有新海藻糖的组合物在相当长的时间内稳定。

    Process for producing a particulate composition comprising crystalline trehalose dihydrate
    9.
    发明申请
    Process for producing a particulate composition comprising crystalline trehalose dihydrate 有权
    制备包含结晶海藻糖二水合物的颗粒组合物的方法

    公开(公告)号：US20150040889A1

    公开(公告)日：2015-02-12

    申请号：US14346410

    申请日：2012-09-12

    申请人： Takashi Shibuya ,  Seisuke Izawa

    发明人： Takashi Shibuya ,  Seisuke Izawa

    IPC分类号： C12P19/12 ,  C12P19/20 ,  C13K13/00

    CPC分类号： C07H3/04 ,  C07H1/00 ,  C12N9/1074 ,  C12P19/12 ,  C12P19/14 ,  C12P19/18 ,  C12P19/20 ,  C12Y204/01019 ,  C13K13/007

    摘要： A process for enabling the production of a particulate composition containing crystalline trehalose dihydrate is provided. Including allowing an α-glycosyltrehalose-forming enzyme to act on liquefied starch derived from a microorganism of the genus Arthrobacter and a trehalose-releasing enzyme derived from a microorganism of the genus Arthrobacter along with a starch debranching enzyme and a cyclomaltodextrin glucanotransferase; allowing glucoamylase to act on the resulting mixture to obtain a saccharide solution containing α,α-trehalose; precipitating crystalline α,α-trehalose dihydrate from the above saccharide solution; collecting the precipitated crystalline α,α-trehalose dihydrate by a centrifuge; and ageing and drying the collected crystals. Cyclomaltodextrin glucanotransferase derived from a microorganism of the genus Paenibacillus or a mutant enzyme thereof is used to increase the α,α-trehalose content in the saccharide solution to over 86.0% by weight, on a dry solid basis, without passing through a fractionation step by column chromatography.

    摘要翻译： 提供一种能够生产含有结晶海藻糖二水合物的颗粒组合物的方法。 包括使α-糖基海藻糖形成酶作用于源自节杆菌属微生物的液化淀粉和源自节杆菌属微生物的海藻糖释放酶以及淀粉脱支酶和环麦芽糖糊精葡聚糖转移酶; 使葡糖淀粉酶作用于所得混合物，得到含α，α-海藻糖的糖溶液; 从上述糖溶液中沉淀出结晶α，α-海藻糖二水合物; 通过离心机收集沉淀的结晶α，α-海藻糖二水合物; 并老化并干燥收集的晶体。 来自Paenibacillus属的微生物的环糊精葡聚糖转移酶或其突变酶用于将干燥固体的糖溶液中的α，α-海藻糖含量提高至86.0重量％以上，而不经过分馏步骤 柱层析。