公开(公告)号：US20100075961A1

公开(公告)日：2010-03-25

申请号：US12513232

申请日：2007-10-31

申请人： James E. Sheppeck ,  John L. Gilmore ,  T. G. Murali Dhar ,  Hai-Yun Xiao ,  Jianmin Wang ,  Bingwei Vera Yang ,  Lidia M. Doweyko

发明人： James E. Sheppeck ,  John L. Gilmore ,  T. G. Murali Dhar ,  Hai-Yun Xiao ,  Jianmin Wang ,  Bingwei Vera Yang ,  Lidia M. Doweyko

IPC分类号： A61K31/416 ,  C07D231/56 ,  C07D413/12 ,  A61K31/5377 ,  A61P3/00 ,  A61P29/00 ,  A61P37/00

CPC分类号： C07D231/56 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12

摘要： Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including inflammatory and immune diseases, obesity and diabetes having the structure of formula (I), its enantiomers, diastereomers, or a pharmaceutically acceptable salt, or hydrate, thereof, wherein X is (Ia); or X is (Ib); or X is (Ic); (Id) is heterocycle or heteroaryl; E is —N—, —NR1—, —O—, —S—, —SO2— or —CR2—; F is —N—, —NR1a—, —O—, —S—, —SO2— or —CR2a—; G is N, —NR1b—, —O—, —S—, —SO2— or —CR2b—, provided that the E-F-G containing heterocyclic ring formed does not contain a S—S or S—O bond, and at least one of E, F and G is a heteroatom; J, Ja, M, Ma, Q, Rx, Ry, R1, R1a, R1b, R2, R2a, R2b, and R3 to R21, Z, Za, Zb, and Zc are as defined above.

摘要翻译： 提供了新的非甾体化合物，其可用于治疗与调节糖皮质激素受体，AP-1和/或NF-κB活性相关的疾病，包括具有式（I）结构的炎性和免疫疾病，肥胖症和糖尿病 ），其对映异构体，非对映异构体或其药学上可接受的盐或水合物，其中X为（Ia）; 或X为（Ib）; 或X为（Ic）; （Id）是杂环或杂芳基; E是-N-，-NR1 - ， - O - ， - S - ， - SO2-或-CR2-; F是-N-，-NR1 - ， - O - ， - S - ， - SO2-或-CR2a-; G是N，-NR1b - ， - O - ， - S - ， - SO2-或-CR2b-，条件是所形成的含有EFG的杂环不含S-S或S-O键， E，F和G是杂原子; J，Ja，M，Ma，Q，Rx，Ry，R1，R1a，R1b，R2，R2a，R2b和R3至R21，Z，Za，Zb和Zc如上所定义。

公开(公告)号：US08198311B2

公开(公告)日：2012-06-12

申请号：US12513232

申请日：2007-10-31

申请人： James E. Sheppeck ,  John L. Gilmore ,  T. G. Murali Dhar ,  Hai-Yun Xiao ,  Jianmin Wang ,  Bingwei Vera Yang ,  Lidia M. Doweyko

发明人： James E. Sheppeck ,  John L. Gilmore ,  T. G. Murali Dhar ,  Hai-Yun Xiao ,  Jianmin Wang ,  Bingwei Vera Yang ,  Lidia M. Doweyko

IPC分类号： A61K31/416 ,  C07D231/56

CPC分类号： C07D231/56 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12

摘要： Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including inflammatory and immune diseases, obesity and diabetes having the structure of formula (I), its enantiomers, diastereomers, or a pharmaceutically acceptable salt, or hydrate, thereof, wherein X is (Ia); or X is (Ib); or X is (Ic); (Id) is heterocycle or heteroaryl; E is —N—, —NR1—, —O—, —S—, —SO2— or —CR2—; F is —N—, —NR1a—, —O—, —S—, —SO2— or —CR2a—; G is N, —NR1b—, —O—, —S—, —SO2— or —CR2b—, provided that the E-F-G containing heterocyclic ring formed does not contain a S—S or S—O bond, and at least one of E, F and G is a heteroatom; J, Ja, M, Ma, Q, Rx, Ry, R1, R1a, R1b, R2, R2a, R2b, and R3 to R21, Z, Za, Zb, and Zc are as defined above.

摘要翻译： 提供了新的非甾体化合物，其可用于治疗与调节糖皮质激素受体，AP-1和/或NF-κB活性相关的疾病，包括具有式（I）结构的炎性和免疫疾病，肥胖症和糖尿病 ），其对映异构体，非对映异构体或其药学上可接受的盐或水合物，其中X为（Ia）; 或X为（Ib）; 或X为（Ic）; （Id）是杂环或杂芳基; E是-N-，-NR1 - ， - O - ， - S - ， - SO2-或-CR2-; F是-N-，-NR1 - ， - O - ， - S - ， - SO2-或-CR2a-; G是N，-NR1b - ， - O - ， - S - ， - SO2-或-CR2b-，条件是所形成的含有EFG的杂环不含S-S或S-O键， E，F和G是杂原子; J，Ja，M，Ma，Q，Rx，Ry，R1，R1a，R1b，R2，R2a，R2b和R3至R21，Z，Za，Zb和Zc如上所定义。

公开(公告)号：US20210198132A1

公开(公告)日：2021-07-01

申请号：US17160640

申请日：2021-01-28

申请人： Jianmin Wang

发明人： Jianmin Wang

IPC分类号： C02F3/12 ,  C02F3/02 ,  C02F3/30 ,  C02F3/22 ,  B01F3/04 ,  F17D1/00

摘要： Described herein are methods and devices for treating water, wastewater, and organic wastes. The methods and devices are mixed by using hydraulic surge mixers. This surge mixer is driven by gas and can provide occasional surges of water using large bubbles which are able to move great volume of liquid while minimizing dissolved oxygen transfer to the surrounding liquid. Use of the devices and processes herein provides a simple, eloquent approach to water and wastewater treatment with less operation and maintenance costs than conventional devices and/or processes. The same surge lifting device can also be installed in other reactors to mix the tank content and enhance reaction with reduced energy use and maintenance needs.

公开(公告)号：US20160304370A1

公开(公告)日：2016-10-20

申请号：US15178921

申请日：2016-06-10

申请人： Jianmin Wang

发明人： Jianmin Wang

IPC分类号： C02F3/12 ,  B01F3/04 ,  C02F3/22 ,  C02F3/02 ,  C02F3/30

CPC分类号： C02F3/1284 ,  B01F3/04531 ,  B01F2003/04879 ,  B01F2003/04943 ,  B01F2215/0052 ,  C02F1/283 ,  C02F3/02 ,  C02F3/223 ,  C02F3/2893 ,  C02F3/301 ,  C02F3/302 ,  C02F3/303 ,  C02F3/308 ,  C02F2209/14 ,  C02F2209/22 ,  F17D1/00 ,  Y02W10/15

摘要： Described herein are methods and devices for treating water, wastewater, and organic wastes. The methods and devices are mixed by using hydraulic surge mixers. This surge mixer is driven by gas and can provide occasional surges of water using large bubbles which are able to move great volume of liquid while minimizing dissolved oxygen transfer to the surrounding liquid. Use of the devices and processes herein provides a simple, eloquent approach to water and wastewater treatment with less operation and maintenance costs than conventional devices and/or processes. The same surge lifting device can also be installed in other reactors to mix the tank content and enhance reaction with reduced energy use and maintenance needs.

摘要翻译： 本文描述了用于处理水，废水和有机废物的方法和装置。 该方法和装置通过使用液压浪涌混合器进行混合。 该浪涌混合器由气体驱动，并且可以使用能够移动大量液体同时使溶解氧转移到周围液体的大气泡产生偶尔的水浪涌。 这些装置和工艺的使用提供了一种简单而有力的方式来处理水和污水处理，其操作和维护成本比常规设备和/或工艺要少。 相同的浪涌提升装置也可以安装在其他反应器中，以混合罐内容物，并加强反应，减少能源的使用和维护需求。

公开(公告)号：US09469366B2

公开(公告)日：2016-10-18

申请号：US14871655

申请日：2015-09-30

申请人： Jianmin Wang ,  Sumi Wang

发明人： Jianmin Wang ,  Sumi Wang

IPC分类号： B62D61/00 ,  B62K15/00 ,  B62K5/06 ,  B62K5/027 ,  B62K13/08

CPC分类号： B62K15/008 ,  B62K5/027 ,  B62K5/06 ,  B62K13/08 ,  B62K15/00 ,  B62K2015/003 ,  B62K2204/00

摘要： A portable foldable electric tricycle that can be folded to form a trolley suitcase shape and a chair includes a folding frame connecting a front wheel assembly and handlebar assembly to a seat. The front wheel assembly includes an electric motor to drive the front wheel. A backrest and rear wheel assembly are hinge connected with the seat by oppositely disposed four bar linkages. A stand is hinge connected to the seat. The folding frame, front wheel assembly and handlebar assembly can be folded to a position within the seat and the stand folded to a position in which it supports the seat to define the chair configuration of the electric tricycle. The backrest and rear wheel assembly can be folded to non-extended positions in which they are disposed adjacent the seat to define the trolley suitcase configuration of the case.

摘要翻译： 可折叠以形成手推车手提箱形状的便携式可折叠电动三轮车和椅子包括将前轮组件和车把组件连接到座椅的折叠框架。 前轮组件包括用于驱动前轮的电动马达。 靠背和后轮组件通过相对设置的四个杆连杆与座铰接连接。 支架铰链连接到座椅上。 折叠框架，前轮组件和把手组件可以折叠到座椅内的位置，并且展台折叠到其支撑座椅的位置，以限定电动三轮车的椅子构型。 靠背和后轮组件可以被折叠到非延伸位置，在该位置上它们邻近座椅设置，以限定壳体的手推车手提箱配置。

公开(公告)号：US08519298B2

公开(公告)日：2013-08-27

申请号：US12731798

申请日：2010-03-25

申请人： Jianmin Wang ,  Craig Metzner ,  Gregory W. Schuh

发明人： Jianmin Wang ,  Craig Metzner ,  Gregory W. Schuh

IPC分类号： B23K26/00 ,  B23K26/14 ,  B23K26/02

CPC分类号： B23K26/0676 ,  B23K26/40 ,  B23K2101/40 ,  B23K2103/50 ,  G02B27/283

摘要： A dual-beam laser cutting system uses laser beam polarization to output two identical laser beams. The dual identical laser beams are spaced appropriately to simultaneously cut a water thus increasing the laser cutting system's throughput as compared to a single-laser cutting system. In one implementation, the dual-beam laser cutting system 100 utilizes a beam expander 220, two half-wave plates 224, 238, a polarizing beam splitter 228, a mirror 236, and two lenses 234, 242 to provide two identical laser beams 202, 204 from a single laser source 214. The identical laser beams 202, 204 are tuned to have the same power, cross-sectional diameter, and polarization direction. One of the half-wave plates 224 is rotated to yield laser beams with the same power. The other half-wave plate 238 is rotated to yield laser beams with the same polarization direction.

摘要翻译： 双光束激光切割系统使用激光束偏振来输出两个相同的激光束。 与单激光切割系统相比，双重相同的激光束被适当地间隔开以同时切割水，从而增加激光切割系统的吞吐量。 在一个实施方案中，双光束激光切割系统100利用光束扩展器220，两个半波片224,238，偏振分束器228，反射镜236和两个透镜234,242来提供两个相同的激光束202 ，204来自单个激光源214.相同的激光束202,204被调谐为具有相同的功率，横截面直径和偏振方向。 半波片224中的一个旋转以产生具有相同功率的激光束。 旋转另一个半波片238以产生具有相同偏振方向的激光束。

公开(公告)号：US08238670B2

公开(公告)日：2012-08-07

申请号：US12278270

申请日：2007-02-08

申请人： Jianmin Wang ,  Xin Ji

发明人： Jianmin Wang ,  Xin Ji

IPC分类号： G06K9/62 ,  G06K9/68

CPC分类号： G06K9/4642 ,  G06K9/00664 ,  G06K9/4652

摘要： In an image classification method, dividing an input image into blocks; obtaining block features of each block of the image; performing an evaluation of each block based on the block features thereof; obtaining image features based on the evaluations of the blocks of the image; and classifying the image based on the image features into pre-defined categories.

摘要翻译： 在图像分类方法中，将输入图像划分成块; 获取图像的每个块的块特征; 基于其块特征对每个块进行评估; 基于图像的块的评估获得图像特征; 并将基于图像特征的图像分类为预定义的类别。

公开(公告)号：US20110233176A1

公开(公告)日：2011-09-29

申请号：US12731798

申请日：2010-03-25

申请人： Jianmin Wang ,  Craig Metzner ,  Gregory W. Schuh

发明人： Jianmin Wang ,  Craig Metzner ,  Gregory W. Schuh

IPC分类号： B23K26/00 ,  G02B5/30 ,  G02B27/28

CPC分类号： B23K26/0676 ,  B23K26/40 ,  B23K2101/40 ,  B23K2103/50 ,  G02B27/283

摘要： A dual-beam laser cutting system uses laser beam polarization to output two identical laser beams. The dual identical laser beams are spaced appropriately to simultaneously cut a water thus increasing the laser cutting system's throughput as compared to a single-laser cutting system. In one implementation, the dual-beam laser cutting system 100 utilizes a beam expander 220, two half-wave plates 224, 238, a polarizing beam splitter 228, a mirror 236, and two lenses 234, 242 to provide two identical laser beams 202, 204 from a single laser source 214. The identical laser beams 202, 204 are tuned to have the same power, cross-sectional diameter, and polarization direction. One of the half-wave plates 224 is rotated to yield laser beams with the same power. The other half-wave plate 238 is rotated to yield laser beams with the same polarization direction.

摘要翻译： 双光束激光切割系统使用激光束偏振来输出两个相同的激光束。 与单激光切割系统相比，双重相同的激光束被适当地间隔开以同时切割水，从而增加激光切割系统的吞吐量。 在一个实施方案中，双光束激光切割系统100利用光束扩展器220，两个半波片224,238，偏振分束器228，反射镜236和两个透镜234,242来提供两个相同的激光束202 ，204来自单个激光源214.相同的激光束202,204被调谐为具有相同的功率，横截面直径和偏振方向。 半波片224中的一个旋转以产生具有相同功率的激光束。 旋转另一个半波片238以产生具有相同偏振方向的激光束。

公开(公告)号：US06677754B2

公开(公告)日：2004-01-13

申请号：US10072090

申请日：2002-02-08

申请人： Joachim Kestler ,  Arne Reykowski ,  Jianmin Wang

发明人： Joachim Kestler ,  Arne Reykowski ,  Jianmin Wang

IPC分类号： G01V300

CPC分类号： G01R33/28

摘要： A magnetic resonance apparatus has magnet systems which respectively generate a basic magnetic field, gradient magnetic fields and a high-frequency magnetic field. A start element is connected to an end element via a coaxial cable. The coaxial cable is divided into at least two cable sections that are coupled to one another via a transformer having transformer coils. The transformer coils are directly connected to inner conductors of the respective coaxial cable sections and are connected to outer conductors of the respective coaxial cable sections via tuning capacitors.

摘要翻译： 磁共振装置具有分别产生基本磁场，梯度磁场和高频磁场的磁体系统。 启动元件通过同轴电缆连接到端部元件。 同轴电缆被分成至少两个电缆部分，其经由具有变压器线圈的变压器彼此耦合。 变压器线圈直接连接到各个同轴电缆部分的内部导体，并通过调谐电容器连接到各个同轴电缆部分的外部导体。

公开(公告)号：US06542768B1

公开(公告)日：2003-04-01

申请号：US09624383

申请日：2000-07-27

申请人： Rainer Kuth ,  Arne Reykowski ,  Hubertus Fischer ,  Jianmin Wang

发明人： Rainer Kuth ,  Arne Reykowski ,  Hubertus Fischer ,  Jianmin Wang

IPC分类号： G01V300

CPC分类号： G01R33/3692 ,  A61B5/0008 ,  A61B5/02055 ,  A61B5/055 ,  G01R33/341

摘要： The energy supply device for a signal pickup or signal generator for use in or at a magnetic resonance tomography device has a double layer capacitor of high capacitance and high power density. Charging of the double layer capacitor can occur via an integrated charging coil that derives charging energy from the high-frequency and/or gradient fields of the device.

摘要翻译： 用于或在磁共振断层摄影装置中使用的用于信号拾取或信号发生器的能量供应装置具有高电容和高功率密度的双层电容器。 双层电容器的充电可以通过从装置的高频和/或梯度场导出充电能量的集成充电线圈发生。