公开(公告)号：US20170203436A1

公开(公告)日：2017-07-20

申请号：US15324723

申请日：2014-07-08

申请人： Hongxing Wei ,  Ying Zou ,  Youdong Chen ,  Miao Liu ,  Zhen Huang

发明人： Hongxing Wei ,  Ying Zou ,  Youdong Chen ,  Miao Liu ,  Zhen Huang

IPC分类号： B25J9/16 ,  G06F9/54 ,  G06F15/80

CPC分类号： B25J9/161 ,  G05B2219/33216 ,  G05B2219/34258 ,  G06F9/4887 ,  G06F9/54 ,  G06F15/80

摘要： The present invention relates to a robot hybrid system application framework based on a multi-core processor architecture. In the robot system with ARM/X86 multi-core processor as the controller, multi-core parallel processing architecture of the ARM/X86 multi-core processor is used to run the robotic hybrid system application framework comprising real-time operating system, non-real-time operating system and system supporting frame in the whole robot controller, so as to provide improved operating system services. In this application framework, a real-time operating system runs independently in one ARM/X86 core, while several non-real-time operating systems run on other ARM/X86 cores. The operating systems occupy processor resources and peripherals separately and run robotic applications with different real-time requirements. The application program can be used as a unified robot operating system (ROS) application node.

公开(公告)号：US08809357B2

公开(公告)日：2014-08-19

申请号：US13321544

申请日：2010-05-20

申请人： Zhen Huang

发明人： Zhen Huang

IPC分类号： A01N43/54 ,  A61K31/505

CPC分类号： C07H21/00 ,  C07H19/06

摘要： The present invention relates to compounds of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer; methods of preparation of the same; and methods of counducting drug discovery and research by applying the same in an investigation.

摘要翻译： 本发明涉及式（I）化合物，其衍生物或互变异构体，或所述化合物或所述互变异构体的药学上可接受的盐; 制备方法; 以及通过在调查中应用药物发现和研究的方法。

公开(公告)号：US08417971B2

公开(公告)日：2013-04-09

申请号：US12655384

申请日：2009-12-30

申请人： Zhen Huang ,  Zhongqing Li

发明人： Zhen Huang ,  Zhongqing Li

IPC分类号： G06F1/26 ,  G06F3/023

CPC分类号： G06F3/0227 ,  G06F1/26 ,  G06F1/3203 ,  G06F1/3287 ,  G06F1/3293 ,  G06F3/023 ,  Y02D10/122 ,  Y02D10/171 ,  Y02D50/20

摘要： Disclosed is a data processing device, which comprises: an input device for generating first input information; a central processor; an embedded controller, connected to the power supply, the input device and the central processor. When the data processing device is powered on, the embedded controller is adapted to control the power supply to supply power to the input device and the central processor; process the first input information as second information, which can be identified by the central processor; and send the second information to the central processor. When the data processing device is powered off or sleeping, the embedded controller is adapted to control the power supply to supply power to the input device; detect whether a terminal device comprising an operating system is connected and generate a detection result; electrically connect to the terminal device when the detection result indicates that the terminal device comprising the operating system is connected; process the first input information to obtain third input information, which can be processed by at least one program running based on the operating system in the terminal device; and send the third input information to the terminal device. The present invention provides a data processing device and data processing method for solving the inconvenient operations of the traditional handsets and the like terminal devices.

摘要翻译： 公开了一种数据处理装置，包括：用于产生第一输入信息的输入装置; 中央处理器 一个嵌入式控制器，连接到电源，输入设备和中央处理器。 当数据处理装置通电时，嵌入式控制器适于控制电源向输入装置和中央处理器供电; 将第一输入信息作为第二信息处理，其可由中央处理器识别; 并将第二信息发送到中央处理器。 当数据处理装置断电或休眠时，嵌入式控制器适于控制电源以向输入装置供电; 检测包括操作系统的终端设备是否连接并产生检测结果; 当检测结果指示包括操作系统的终端设备被连接时，电连接到终端设备; 处理第一输入信息以获得第三输入信息，其可以由基于终端设备中的操作系统运行的至少一个程序来处理; 并将第三输入信息发送到终端设备。 本发明提供一种用于解决传统手机等终端装置的不方便的数据处理装置和数据处理方法。

公开(公告)号：US20120282702A1

公开(公告)日：2012-11-08

申请号：US13553901

申请日：2012-07-20

申请人： Zhen Huang

发明人： Zhen Huang

IPC分类号： C07H21/04 ,  G01N31/00 ,  C07H21/02 ,  C07H19/048 ,  C07H19/10

CPC分类号： C07H19/073 ,  C07H5/08 ,  C07H21/04

摘要： Disclosed are compounds of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer. Also disclosed are methods of preparing compound of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer. Further disclosed are methods of conducting drug discovery and research comprises applying the compound of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer in an investigation.

摘要翻译： 公开了式（I）的化合物，其衍生物或互变异构体，或所述化合物或所述互变异构体的药学上可接受的盐。 还公开了制备式（I）化合物，其衍生物或其互变异构体或所述化合物或所述互变异构体的药学上可接受的盐的方法。 进一步披露的是进行药物发现和研究的方法包括在调查中应用式（I）化合物，其衍生物或互变异构体，或所述化合物或所述互变异构体的药学上可接受的盐。

公开(公告)号：US20120051491A1

公开(公告)日：2012-03-01

申请号：US12916691

申请日：2010-11-01

申请人： Jui-Chung Lee ,  Wen-Hung Tu ,  Guo-Zhen Huang

发明人： Jui-Chung Lee ,  Wen-Hung Tu ,  Guo-Zhen Huang

IPC分类号： G07C3/00

CPC分类号： G06K19/0773 ,  G06K19/0715

摘要： An integrated circuit includes a thermal-effect unit and a processing unit. The thermal-effect unit generates an electrical energy and forms a temporary channel when experiencing a thermal cycle. The processing unit has a thermal-cycle number, and updates the thermal-cycle number through the temporary channel in response to the electrical energy.

摘要翻译： 集成电路包括热效应单元和处理单元。 热效应单元在经历热循环时产生电能并形成临时通道。 处理单元具有热循环次数，并且响应于电能来更新通过临时通道的热循环次数。

公开(公告)号：US07982030B2

公开(公告)日：2011-07-19

申请号：US12562960

申请日：2009-09-18

申请人： Zhen Huang

发明人： Zhen Huang

IPC分类号： C07H19/173 ,  C07H21/04 ,  C07H19/00 ,  C07D239/46 ,  C07D421/04 ,  A61K31/506 ,  A61P48/00

CPC分类号： C07H19/06 ,  C07H5/08 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00

摘要： The present invention provides selenium derivatives of nucleosides, nucleoside phosphoramidites, nucleotides, nucleotide triphosphates, oligonucleotides, polynucleotides, and larger nucleic acids and methods for their synthesis. Selenium derivatives of both ribonucleic acids and deoxyribonucleic acids, as well as methods for their synthesis, crystallization and uses in structural determinations, particularly by X-ray crystallographic techniques are disclosed. The selenium derivatives of the present invention are also useful as food supplements.

摘要翻译： 本发明提供了核苷，核苷亚磷酰胺，核苷酸，核苷酸三磷酸，寡核苷酸，多核苷酸和较大的核酸的硒衍生物及其合成方法。 公开了核糖核酸和脱氧核糖核酸的硒衍生物，以及它们的合成，结晶和用于结构测定的方法，特别是通过X射线晶体学技术。 本发明的硒衍生物也可用作食品添加剂。

公开(公告)号：US20110105743A1

公开(公告)日：2011-05-05

申请号：US12933619

申请日：2009-03-20

申请人： Zhen Huang ,  Jia Sheng

发明人： Zhen Huang ,  Jia Sheng

IPC分类号： C07H1/00 ,  C07D307/02

CPC分类号： C07H19/06 ,  C07H19/16

摘要： A method is disclosed for synthesizing 2′,3′-didehydro-2′,3′-dideoxynucleosides (d4Ns) from a nucleophile-mediated elimination, such as a telluride-mediated elimination reaction. After substitution of 2,2′-anhydronucleosides with a nucleophile, such as a telluride monoanion, a telluride intermediate is formed, and its elimination leads to formation of the olefin products (d4Ns). This disclosure describes this telluride-assisted (or nucleophile-assisted) reaction and how to facilitate the substitution and elimination in order to form d4Ns.

摘要翻译： 公开了从亲核试剂介导的消除如碲化物介导的消除反应合成2'，3'-二脱氢-2'，3'-二脱氧核苷（d4Ns）的方法。 用亲核试剂（如碲化物单阴离子）代替2,2'-脱水核苷后，形成碲化物中间体，其消除导致烯烃产物（d4Ns）的形成。 本公开描述了这种碲化物辅助（或亲核试剂辅助）反应以及如何促进取代和消除以形成d4N。

公开(公告)号：US20100137573A1

公开(公告)日：2010-06-03

申请号：US12562960

申请日：2009-09-18

申请人： Zhen Huang

发明人： Zhen Huang

IPC分类号： C07H1/00 ,  C07H19/06 ,  C07H19/16

CPC分类号： C07H19/06 ,  C07H5/08 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00

摘要： The present invention provides selenium derivatives of nucleosides, nucleoside phosphoramidites, nucleotides, nucleotide triphosphates, oligonucleotides, polynucleotides, and larger nucleic acids and methods for their synthesis. Selenium derivatives of both ribonucleic acids and deoxyribonucleic acids, as well as methods for their synthesis, crystallization and uses in structural determinations, particularly by X-ray crystallographic techniques are disclosed. The selenium derivatives of the present invention are also useful as food supplements.

摘要翻译： 本发明提供了核苷，核苷亚磷酰胺，核苷酸，核苷酸三磷酸，寡核苷酸，多核苷酸和较大的核酸的硒衍生物及其合成方法。 公开了核糖核酸和脱氧核糖核酸的硒衍生物，以及它们的合成，结晶和用于结构测定的方法，特别是通过X射线晶体学技术。 本发明的硒衍生物也可用作食品添加剂。

公开(公告)号：US07601823B2

公开(公告)日：2009-10-13

申请号：US11256726

申请日：2005-10-24

申请人： Li Niu ,  Zhen Huang ,  Hua Shi ,  John T. Lis

发明人： Li Niu ,  Zhen Huang ,  Hua Shi ,  John T. Lis

IPC分类号： C07H21/02

CPC分类号： C12N15/115 ,  C12N2310/16

摘要： The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.

摘要翻译： 本发明涉及结合并抑制离子型谷氨酸受体的α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）亚型的活化的新型核酸配体或适体。 还公开了技术的新型组合，即SELEX和激光脉冲光解用于选择和筛选抑制受体功能的适体，因此可用于治疗与离子型谷氨酸受体的过度活化相关的疾病。

公开(公告)号：US07592446B2

公开(公告)日：2009-09-22

申请号：US10104995

申请日：2002-03-22

申请人： Zhen Huang

发明人： Zhen Huang

IPC分类号： C07D421/04 ,  C07D239/46 ,  C07H21/04 ,  C07H19/073 ,  A61K31/506 ,  A61K48/00

CPC分类号： C07H19/06 ,  C07H5/08 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00

摘要： The present invention provides selenium derivatives of nucleosides, nucleoside phosphoramidites, nucleotides, nucleotide triphosphates, oligonucleotides, polynucleotides, and larger nucleic acids and methods for their synthesis. Selenium derivatives of both ribonucleic acids and deoxyribonulcleic acids, as well as methods for their synthesis, crystallization and uses in structural determinations, particularly by X-ray crystallographic techniques are disclosed. The selenium derivatives of the present invention are also useful as food supplements.

摘要翻译： 本发明提供了核苷，核苷亚磷酰胺，核苷酸，核苷酸三磷酸，寡核苷酸，多核苷酸和较大的核酸的硒衍生物及其合成方法。 公开了核糖核酸和脱氧核糖核酸的硒衍生物，以及它们的合成，结晶和用于结构测定的方法，特别是通过X射线晶体学技术。 本发明的硒衍生物也可用作食品添加剂。