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公开(公告)号：US20160145289A1
公开(公告)日：2016-05-26
申请号：US14894927
申请日：2014-05-30
申请人： James W. JANETKA , Zhenfu HAN , Scott HULTGREN , Jerry PINKNER , Corinne CUSUMANO , WASHINGTON UNIVERSITY
IPC分类号： C07H15/203 , A61K45/06 , A61K31/7064 , A61K31/706 , A61K31/7056 , A61K31/7042 , A61K31/7034 , C07H15/26
CPC分类号： C07H15/203 , A61K31/7034 , A61K31/7042 , A61K31/7056 , A61K31/706 , A61K31/7064 , A61K45/06 , C07H15/26
摘要： The present invention encompasses compounds and methods for treating and preventing bacterial infections specifically urinary tract infections and those caused by bacteria containing type 1 pili and FimH. The present invention also encompasses compounds and methods for treating inflammatory bowel disease specifically Crohn's Disease.
摘要翻译： 本发明包括用于治疗和预防细菌感染的化合物和方法，特别是尿路感染以及由含有1型皮脂和FimH的细菌引起的细菌感染。 本发明还包括用于特异性克罗恩病治疗炎症性肠病的化合物和方法。
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公开(公告)号：US20120309701A1
公开(公告)日：2012-12-06
申请号：US13453991
申请日：2012-04-23
IPC分类号： A61K31/7034 , C07H19/056 , A61K31/7056 , C07H15/22 , A61P13/02 , A61K31/7048 , A61K31/7042 , A61K31/706 , A61P31/04 , C07H15/207 , A61K31/7036
CPC分类号： C07H15/20 , A01N43/10 , A01N43/16 , A01N43/38 , A01N43/42 , A01N43/52 , A01N43/54 , A01N43/76 , A01N43/78 , A01N47/36 , A01N55/08 , A61K31/505 , A61K31/7034 , A61K31/7042 , A61K31/7048 , A61K31/7056 , A61K31/706 , C07D309/10 , C07H15/203 , C07H15/207 , C07H15/22 , C07H15/26 , C07H19/056
摘要： The present invention encompasses compounds and methods for treating urinary tract infections.
摘要翻译： 本发明包括用于治疗尿路感染的化合物和方法。
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公开(公告)号：US11130780B2
公开(公告)日：2021-09-28
申请号：US15556804
申请日：2016-03-02
申请人： James W. Janetka , Zhenfu Han , Peter Harris , Partha Karmakar
发明人： James W. Janetka , Zhenfu Han , Peter Harris , Partha Karmakar
IPC分类号： A61K51/04 , A61K51/08 , C07K5/12 , A61K38/00 , C07K5/09 , C07K5/11 , C07K5/103 , C07K5/097 , G01N33/58 , A61K47/64 , A61K49/00 , C07B59/00 , C07D277/64 , C07K5/072 , C07K5/078 , C07K5/107
摘要： The present invention generally relates to compounds that are useful for inhibiting one or more of hepatocyte growth factor activator, matriptase, hepsin, Factor Xa, or thrombin. The present invention also relates to various methods of using the inhibitor compounds including treating a malignancy, a pre-malignant condition, or cancer by administering an effective amount of the inhibitor to a subject in need thereof.
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公开(公告)号：US20180066015A1
公开(公告)日：2018-03-08
申请号：US15556804
申请日：2016-03-02
申请人： James W. Janetka , Zhenfu Han , Peter Harris , Partha Karmakar
发明人： James W. Janetka , Zhenfu Han , Peter Harris , Partha Karmakar
IPC分类号： C07K5/09 , C07K5/072 , C07D277/64 , A61K49/00 , A61K51/08 , A61K51/04 , C07B59/00 , C07K5/12 , C07K5/078 , C07K5/103 , C07K5/107
CPC分类号： C07K5/0815 , A61K38/00 , A61K47/64 , A61K49/0052 , A61K49/0056 , A61K51/0453 , A61K51/08 , C07B59/002 , C07B59/008 , C07B2200/05 , C07D277/64 , C07K5/06095 , C07K5/06156 , C07K5/0817 , C07K5/0821 , C07K5/1005 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1019 , C07K5/126 , G01N33/582 , G01N2800/7028
摘要： The present invention generally relates to compounds that are useful for inhibiting one or more of hepatocyte growth factor activator, matriptase, hepsin, Factor Xa, or thrombin. The present invention also relates to various methods of using the inhibitor compounds including treating a malignancy, a pre-malignant condition, or cancer by administering an effective amount of the inhibitor to a subject in need thereof.
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公开(公告)号：US08937167B2
公开(公告)日：2015-01-20
申请号：US13453991
申请日：2012-04-23
IPC分类号： A61K31/7034 , A61K31/7042 , A61K31/706 , C07H15/207 , C07H19/056 , C07H15/22
CPC分类号： C07H15/20 , A01N43/10 , A01N43/16 , A01N43/38 , A01N43/42 , A01N43/52 , A01N43/54 , A01N43/76 , A01N43/78 , A01N47/36 , A01N55/08 , A61K31/505 , A61K31/7034 , A61K31/7042 , A61K31/7048 , A61K31/7056 , A61K31/706 , C07D309/10 , C07H15/203 , C07H15/207 , C07H15/22 , C07H15/26 , C07H19/056
摘要： The present invention encompasses compounds and methods for treating urinary tract infections.
摘要翻译： 本发明包括用于治疗尿路感染的化合物和方法。
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