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公开(公告)号：US11130780B2
公开(公告)日：2021-09-28
申请号：US15556804
申请日：2016-03-02
申请人： James W. Janetka , Zhenfu Han , Peter Harris , Partha Karmakar
发明人： James W. Janetka , Zhenfu Han , Peter Harris , Partha Karmakar
IPC分类号： A61K51/04 , A61K51/08 , C07K5/12 , A61K38/00 , C07K5/09 , C07K5/11 , C07K5/103 , C07K5/097 , G01N33/58 , A61K47/64 , A61K49/00 , C07B59/00 , C07D277/64 , C07K5/072 , C07K5/078 , C07K5/107
摘要： The present invention generally relates to compounds that are useful for inhibiting one or more of hepatocyte growth factor activator, matriptase, hepsin, Factor Xa, or thrombin. The present invention also relates to various methods of using the inhibitor compounds including treating a malignancy, a pre-malignant condition, or cancer by administering an effective amount of the inhibitor to a subject in need thereof.
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公开(公告)号：US20180066015A1
公开(公告)日：2018-03-08
申请号：US15556804
申请日：2016-03-02
申请人： James W. Janetka , Zhenfu Han , Peter Harris , Partha Karmakar
发明人： James W. Janetka , Zhenfu Han , Peter Harris , Partha Karmakar
IPC分类号： C07K5/09 , C07K5/072 , C07D277/64 , A61K49/00 , A61K51/08 , A61K51/04 , C07B59/00 , C07K5/12 , C07K5/078 , C07K5/103 , C07K5/107
CPC分类号： C07K5/0815 , A61K38/00 , A61K47/64 , A61K49/0052 , A61K49/0056 , A61K51/0453 , A61K51/08 , C07B59/002 , C07B59/008 , C07B2200/05 , C07D277/64 , C07K5/06095 , C07K5/06156 , C07K5/0817 , C07K5/0821 , C07K5/1005 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1019 , C07K5/126 , G01N33/582 , G01N2800/7028
摘要： The present invention generally relates to compounds that are useful for inhibiting one or more of hepatocyte growth factor activator, matriptase, hepsin, Factor Xa, or thrombin. The present invention also relates to various methods of using the inhibitor compounds including treating a malignancy, a pre-malignant condition, or cancer by administering an effective amount of the inhibitor to a subject in need thereof.
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3.发明授权Methods for forming peptides and peptide conjugates and peptides and peptide conjugates compositions formed thereby 有权用于形成由此形成的肽和肽缀合物和肽和肽缀合物组合物的方法公开(公告)号：US08895696B1
公开(公告)日：2014-11-25
申请号：US13596954
申请日：2012-08-28
IPC分类号： C07K2/00 , C07K1/06 , C07K1/113 , C07K1/36 , C07K5/103 , C07D207/16 , C07K9/00 , C07C311/19 , C07K1/107 , C07D233/64 , C07K5/062 , C07K7/06
CPC分类号： C07K1/1075 , C07C311/19 , C07D207/16 , C07D233/64 , C07K5/0606 , C07K5/06069 , C07K5/06165 , C07K5/101 , C07K7/06 , C07K9/001
摘要： Methods for building peptide chains containing sulfonyl modified amines at the N-terminus, or, within amino acid side chains, of a growing peptide in a solid-phase peptide synthesis are described. Further, compositions having a sulfonyl modified amine attached to the N-terminus, or within an amino acid side chain, of a polypeptide containing three or more amino acid residues are described.
摘要翻译： 描述了在固相肽合成中在生长肽的N-末端或氨基酸侧链中构建含有磺酰基改性胺的肽链的方法。 此外，描述了具有连接到含有三个或更多个氨基酸残基的多肽的N末端或在氨基酸侧链内的磺酰基修饰的胺的组合物。
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